US4681897A
(en)
*
|
1984-01-16 |
1987-07-21 |
The Procter & Gamble Company |
Pharmaceutical products providing enhanced analgesia
|
EP0187009B1
(en)
*
|
1984-12-20 |
1988-07-06 |
The Procter & Gamble Company |
Compounds and compositions having anti-inflammatory and analgesic activity
|
GB2168976A
(en)
*
|
1984-12-20 |
1986-07-02 |
Procter & Gamble |
Amides and compositions thereof having anti-inflammatory activity
|
US4898887A
(en)
*
|
1984-12-20 |
1990-02-06 |
The Procter & Gamble Company |
Compounds and compositions having anti-inflammatory and analgesic activity
|
US4806341A
(en)
*
|
1985-02-25 |
1989-02-21 |
Rutgers, The State University Of New Jersey |
Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration
|
US4885173A
(en)
*
|
1985-05-01 |
1989-12-05 |
University Of Utah |
Methods and compositions for noninvasive dose-to-effect administration of drugs with cardiovascular or renal vascular activities
|
US4689182A
(en)
*
|
1985-12-20 |
1987-08-25 |
Warner-Lambert Company |
Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity
|
US4990533A
(en)
*
|
1985-12-20 |
1991-02-05 |
Warner-Lambert Co. |
Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity
|
GB8608818D0
(en)
*
|
1986-04-11 |
1986-05-14 |
Reckitt & Colmann Prod Ltd |
Pharmaceutical compositions
|
US4980366A
(en)
*
|
1986-08-19 |
1990-12-25 |
Warner-Lambert Co. |
Amide, sulfonamide, urea, carbamate, thiocarbamate, and thiourea derivatives of 4'hydroxybenzylamine having anti-inflammatory and analgesic activity
|
GB8626098D0
(en)
*
|
1986-10-31 |
1986-12-03 |
Euro Celtique Sa |
Controlled release hydromorphone composition
|
EP0282127B1
(en)
*
|
1987-03-09 |
1994-02-02 |
The Procter & Gamble Company |
Beta-aminoethyl-substituted phenyl compounds, and anti-inflammatory or analgesic compositions containing them
|
ATE113205T1
(de)
*
|
1988-06-17 |
1994-11-15 |
Procter & Gamble |
Anwendung von vanillin-derivaten zur herstellung eines arzneimittels zur behandlung von herpes simplex-infektion.
|
US4997853A
(en)
*
|
1988-12-02 |
1991-03-05 |
Galenpharma, Inc. |
Method and compositions utilizing capsaicin as an external analgesic
|
US5403868A
(en)
*
|
1988-12-23 |
1995-04-04 |
Sandoz Ltd. |
Capsaicin derivatives
|
US5063060A
(en)
*
|
1989-12-19 |
1991-11-05 |
Cisco Limited Partnership |
Compositions and method for treating painful, inflammatory or allergic disorders
|
CH682993A5
(de)
*
|
1990-07-06 |
1993-12-31 |
Alusuisse Lonza Services Ag |
Wagenkastenaufbau für Schienenfahrzeuge.
|
US5221692A
(en)
*
|
1991-08-22 |
1993-06-22 |
National Science Council |
Ether linked and relatively nonpungent analogues of N-nonanoyl vanillylamide
|
JP2002514221A
(ja)
*
|
1997-05-27 |
2002-05-14 |
アルゴス ファーマシューティカル コーポレーション |
カプサイシノイド及びその強化薬を含有する鎮痛薬組成物
|
CA2304096C
(en)
|
1997-09-18 |
2003-09-09 |
Skyepharma Inc. |
Sustained-release liposomal anesthetic compositions
|
NZ504188A
(en)
|
1997-11-14 |
2001-10-26 |
Skyepharma Inc |
Emulsification process for preparing multivesicular liposomes
|
US20030118645A1
(en)
*
|
1998-04-29 |
2003-06-26 |
Pather S. Indiran |
Pharmaceutical compositions for rectal and vaginal administration
|
US6974590B2
(en)
|
1998-03-27 |
2005-12-13 |
Cima Labs Inc. |
Sublingual buccal effervescent
|
US20030091629A1
(en)
*
|
1998-03-27 |
2003-05-15 |
Cima Labs Inc. |
Sublingual buccal effervescent
|
ES2325141T3
(es)
|
1998-07-17 |
2009-08-26 |
Pacira Pharmaceuticals, Inc. |
Composiciones biodegradables para la liberacion controlada de sustancias encapsuladas.
|
US20030170181A1
(en)
*
|
1999-04-06 |
2003-09-11 |
Midha Kamal K. |
Method for preventing abuse of methylphenidate
|
DE19923427A1
(de)
*
|
1999-05-21 |
2000-11-23 |
Lohmann Therapie Syst Lts |
Vorrichtung und Verfahren zur Steigerung der transdermalen Permeation von Arzneistoffen
|
US6572891B1
(en)
*
|
1999-10-23 |
2003-06-03 |
Alkaloid Ad |
Sublingual oral dosage form
|
KR20130010512A
(ko)
*
|
1999-10-29 |
2013-01-28 |
유로-셀티크 소시에떼 아노뉨 |
서방성 하이드로코돈 제형
|
US6689399B1
(en)
|
2000-03-16 |
2004-02-10 |
James R. Dickson |
Transdermal delivery of an anti-inflammatory composition
|
WO2001085158A2
(en)
*
|
2000-05-08 |
2001-11-15 |
Forskarpatent I Syd Ab |
Anandamide and structurally related lipids as vanilloid receptor modulators
|
US20050192220A1
(en)
*
|
2001-02-05 |
2005-09-01 |
Gevys Pharmaceuticas Ltd. |
Composition and method for potentiating drugs
|
US7465567B2
(en)
*
|
2001-04-16 |
2008-12-16 |
California Institute Of Technology |
Peroxide-driven cytochrome P450 oxygenase variants
|
US20030064122A1
(en)
*
|
2001-05-23 |
2003-04-03 |
Endo Pharmaceuticals, Inc. |
Abuse resistant pharmaceutical composition containing capsaicin
|
US20030096000A1
(en)
*
|
2001-05-31 |
2003-05-22 |
Solis Rosa Maria |
Encapsulation of nanosuspensions in liposomes and microspheres
|
AU2002354901A1
(en)
*
|
2001-07-16 |
2003-03-03 |
Edward Hogestatt |
Compounds with analgesic, antipyretic and/or anti-inflammatory activity
|
WO2003008563A2
(en)
*
|
2001-07-20 |
2003-01-30 |
California Institute Of Technology |
Improved cytochrome p450 oxygenases
|
US20030068375A1
(en)
|
2001-08-06 |
2003-04-10 |
Curtis Wright |
Pharmaceutical formulation containing gelling agent
|
US20150031718A1
(en)
*
|
2001-08-06 |
2015-01-29 |
Purdue Pharma L.P. |
Pharmaceutical Formulation Containing Opioid Agonist, Opioid Antagonist and Gelling Agent
|
DE10141650C1
(de)
|
2001-08-24 |
2002-11-28 |
Lohmann Therapie Syst Lts |
Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
|
US20030068276A1
(en)
*
|
2001-09-17 |
2003-04-10 |
Lyn Hughes |
Dosage forms
|
WO2003039561A1
(en)
*
|
2001-11-02 |
2003-05-15 |
Elan Corporation, Plc |
Pharmaceutical composition
|
US20040126428A1
(en)
*
|
2001-11-02 |
2004-07-01 |
Lyn Hughes |
Pharmaceutical formulation including a resinate and an aversive agent
|
EP1509182A4
(en)
*
|
2002-05-31 |
2009-12-30 |
Titan Pharmaceuticals Inc |
IMPLANTABLE POLYMERS DEVICE FOR THE DELAYED RELEASE OF BUPRENORPHINE
|
US7776314B2
(en)
|
2002-06-17 |
2010-08-17 |
Grunenthal Gmbh |
Abuse-proofed dosage system
|
GB0217056D0
(en)
*
|
2002-07-23 |
2002-08-28 |
Ass Octel |
Use
|
WO2004026262A2
(en)
*
|
2002-09-23 |
2004-04-01 |
Verion, Inc. |
Abuse-resistant pharmaceutical compositions
|
US6864271B2
(en)
|
2002-11-12 |
2005-03-08 |
The Foundation For The Lsu Health Sciences Center |
Synergistic combinations including N-acylated 4-hydroxyphenylamine derivatives
|
US7192966B2
(en)
*
|
2002-11-15 |
2007-03-20 |
Branded Products For The Future |
Pharmaceutical composition
|
SI1587506T1
(sl)
*
|
2002-12-18 |
2009-04-30 |
Algorx 101 Interchange Plaza S |
Zdravljenje s kapsaicinom
|
AU2003299691B2
(en)
|
2002-12-18 |
2008-06-05 |
Algorx Pharmaceuticals, Inc. |
Administration of capsaicinoids
|
MXPA05010450A
(es)
|
2003-03-31 |
2005-11-04 |
Titan Pharmaceuticals Inc |
Dispositivo polimerico implantable para la liberacion prolongada de agonistas de dopamina.
|
WO2004092122A2
(en)
*
|
2003-04-08 |
2004-10-28 |
Algorx Pharmaceuticals, Inc. |
Preparation and purification of synthetic capsaicin
|
EP2907503A1
(en)
|
2003-04-10 |
2015-08-19 |
Neurogesx, Inc. |
Methods and compositions for administration of TRPV1 agonists
|
US20040224037A1
(en)
*
|
2003-04-28 |
2004-11-11 |
Gonzalo Romero-Matos |
Devastating treatment against hiv/aids with capsaicin
|
US7524664B2
(en)
*
|
2003-06-17 |
2009-04-28 |
California Institute Of Technology |
Regio- and enantioselective alkane hydroxylation with modified cytochrome P450
|
DE102005005446A1
(de)
|
2005-02-04 |
2006-08-10 |
Grünenthal GmbH |
Bruchfeste Darreichungsformen mit retardierter Freisetzung
|
US20070048228A1
(en)
|
2003-08-06 |
2007-03-01 |
Elisabeth Arkenau-Maric |
Abuse-proofed dosage form
|
DE10361596A1
(de)
|
2003-12-24 |
2005-09-29 |
Grünenthal GmbH |
Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
|
DE10336400A1
(de)
|
2003-08-06 |
2005-03-24 |
Grünenthal GmbH |
Gegen Missbrauch gesicherte Darreichungsform
|
WO2005017116A2
(en)
*
|
2003-08-11 |
2005-02-24 |
California Institute Of Technology |
Thermostable peroxide-driven cytochrome p450 oxygenase variants and methods of use
|
US7201920B2
(en)
*
|
2003-11-26 |
2007-04-10 |
Acura Pharmaceuticals, Inc. |
Methods and compositions for deterring abuse of opioid containing dosage forms
|
US7862833B2
(en)
*
|
2003-12-31 |
2011-01-04 |
Cima Labs, Inc. |
Effervescent oral opiate dosage forms and methods of administering opiates
|
WO2005065317A2
(en)
|
2003-12-31 |
2005-07-21 |
Cima Labs Inc. |
Effervescent oral fentanyl dosage form
|
US20050142197A1
(en)
*
|
2003-12-31 |
2005-06-30 |
Cima Labs Inc. |
Generally linear effervescent oral fentanyl dosage form and methods of administering
|
CA2569958C
(en)
|
2004-06-12 |
2016-03-22 |
Jane C. Hirsh |
Abuse-deterrent drug formulations
|
DE102004032049A1
(de)
|
2004-07-01 |
2006-01-19 |
Grünenthal GmbH |
Gegen Missbrauch gesicherte, orale Darreichungsform
|
CN101119713A
(zh)
*
|
2004-11-24 |
2008-02-06 |
阿尔高克斯制药公司 |
类辣椒素凝胶制剂及其用途
|
US20060177380A1
(en)
*
|
2004-11-24 |
2006-08-10 |
Acura Pharmaceuticals, Inc. |
Methods and compositions for deterring abuse of orally administered pharmaceutical products
|
US20070231268A1
(en)
*
|
2004-11-24 |
2007-10-04 |
Acura Pharmaceuticals, Inc. |
Methods and compositions for deterring abuse of orally administered pharmaceutical products
|
US20060110327A1
(en)
*
|
2004-11-24 |
2006-05-25 |
Acura Pharmaceuticals, Inc. |
Methods and compositions for deterring abuse of orally administered pharmaceutical products
|
US20080152595A1
(en)
*
|
2004-11-24 |
2008-06-26 |
Acura Pharmaceuticals, Inc. |
Methods and compositions for deterring abuse of orally administered pharmaceutical products
|
DE102005005449A1
(de)
|
2005-02-04 |
2006-08-10 |
Grünenthal GmbH |
Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
|
WO2006089012A2
(en)
*
|
2005-02-14 |
2006-08-24 |
Neurogesx, Inc. |
Device for delivery of trpv1 agonists
|
US8715988B2
(en)
|
2005-03-28 |
2014-05-06 |
California Institute Of Technology |
Alkane oxidation by modified hydroxylases
|
US11214817B2
(en)
|
2005-03-28 |
2022-01-04 |
California Institute Of Technology |
Alkane oxidation by modified hydroxylases
|
EP1865933B1
(en)
*
|
2005-03-30 |
2015-11-04 |
Vanderbilt Royalty Sub L.P. |
Low-concentration capsaicin patch and methods for treating neuropathic pain
|
BRPI0610333A2
(pt)
|
2005-04-25 |
2010-06-15 |
Neurogesx Inc |
compostos agonistas de trpv1 e métodos de fazer e usar os mesmos
|
US20080069871A1
(en)
*
|
2006-07-21 |
2008-03-20 |
Vaughn Jason M |
Hydrophobic abuse deterrent delivery system
|
US7943666B2
(en)
*
|
2006-07-24 |
2011-05-17 |
Trinity Laboratories, Inc. |
Esters of capsaicin for treating pain
|
US8252559B2
(en)
*
|
2006-08-04 |
2012-08-28 |
The California Institute Of Technology |
Methods and systems for selective fluorination of organic molecules
|
WO2008016709A2
(en)
*
|
2006-08-04 |
2008-02-07 |
California Institute Of Technology |
Methods and systems for selective fluorination of organic molecules
|
SA07280459B1
(ar)
|
2006-08-25 |
2011-07-20 |
بيورديو فارما إل. بي. |
أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
|
US7645767B2
(en)
*
|
2006-08-31 |
2010-01-12 |
Trinity Laboratories, Inc. |
Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy
|
US8802401B2
(en)
*
|
2007-06-18 |
2014-08-12 |
The California Institute Of Technology |
Methods and compositions for preparation of selectively protected carbohydrates
|
TWI454288B
(zh)
|
2008-01-25 |
2014-10-01 |
Gruenenthal Chemie |
藥物劑型
|
US8158682B2
(en)
*
|
2008-09-12 |
2012-04-17 |
Vallinex, Inc. |
Instillation administration of capsaicinoids for the treatment of pain
|
CN102573805A
(zh)
|
2009-07-22 |
2012-07-11 |
格吕伦塔尔有限公司 |
热熔挤出的控制释放剂型
|
ES2560210T3
(es)
|
2009-07-22 |
2016-02-17 |
Grünenthal GmbH |
Forma de dosificación resistente a la manipulación para opiádes sensibles a la oxidación
|
CA2775890C
(en)
*
|
2009-09-30 |
2016-06-21 |
Acura Pharmaceuticals, Inc. |
Methods and compositions for deterring abuse
|
US10668060B2
(en)
|
2009-12-10 |
2020-06-02 |
Collegium Pharmaceutical, Inc. |
Tamper-resistant pharmaceutical compositions of opioids and other drugs
|
NO2629610T3
(da)
|
2010-07-27 |
2018-02-03 |
|
|
TWI516286B
(zh)
|
2010-09-02 |
2016-01-11 |
歌林達股份有限公司 |
含陰離子聚合物之抗破碎劑型
|
RU2604676C2
(ru)
|
2010-09-02 |
2016-12-10 |
Грюненталь Гмбх |
Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль
|
PE20181177A1
(es)
|
2010-12-22 |
2018-07-20 |
Purdue Pharma Lp |
Formas de dosis de liberacion controlada encerradas resistentes a manipulaciones indebidas
|
CN103327969A
(zh)
|
2010-12-23 |
2013-09-25 |
普渡制药公司 |
抗篡改固体口服剂型
|
CN103857386A
(zh)
|
2011-07-29 |
2014-06-11 |
格吕伦塔尔有限公司 |
提供药物立即释放的抗破碎片剂
|
LT2736495T
(lt)
|
2011-07-29 |
2017-11-10 |
Grünenthal GmbH |
Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu
|
WO2013071089A1
(en)
*
|
2011-11-11 |
2013-05-16 |
Slx Pharmaceuticals, Llc |
Opioid analgesics and 3-hydroxyacetanilide for treating pain
|
JP6117249B2
(ja)
|
2012-02-28 |
2017-04-19 |
グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング |
薬理学的に活性な化合物および陰イオン性ポリマーを含むタンパーレジスタント剤形
|
CA2868142A1
(en)
|
2012-04-18 |
2013-10-24 |
Grunenthal Gmbh |
Tamper resistant and dose-dumping resistant pharmaceutical dosage form
|
US10064945B2
(en)
|
2012-05-11 |
2018-09-04 |
Gruenenthal Gmbh |
Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
|
CN105101949A
(zh)
*
|
2012-11-12 |
2015-11-25 |
Api起源有限责任公司 |
水基辣椒素类物质制剂及其制备方法和应用
|
MX366159B
(es)
|
2012-11-30 |
2019-07-01 |
Acura Pharmaceuticals Inc |
Liberacion autorregulada de ingrediente farmaceutico activo.
|
EA201500742A1
(ru)
|
2013-02-05 |
2015-12-30 |
Пердью Фарма Л.П. |
Защищенные от нецелевого использования фармацевтические композиции
|
US10751287B2
(en)
|
2013-03-15 |
2020-08-25 |
Purdue Pharma L.P. |
Tamper resistant pharmaceutical formulations
|
US9737490B2
(en)
|
2013-05-29 |
2017-08-22 |
Grünenthal GmbH |
Tamper resistant dosage form with bimodal release profile
|
JP6445537B2
(ja)
|
2013-05-29 |
2018-12-26 |
グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング |
1個または複数の粒子を含有する改変防止(tamper−resistant)剤形
|
CN105682643B
(zh)
|
2013-07-12 |
2019-12-13 |
格吕伦塔尔有限公司 |
含有乙烯-醋酸乙烯酯聚合物的防篡改剂型
|
US20150133561A1
(en)
*
|
2013-11-12 |
2015-05-14 |
Vizuri Health Sciences Llc |
Aqueous based capsaicinoid formulations and methods of manufacture and use
|
AU2014356581C1
(en)
|
2013-11-26 |
2020-05-28 |
Grunenthal Gmbh |
Preparation of a powdery pharmaceutical composition by means of cryo-milling
|
CA2943728C
(en)
|
2014-03-26 |
2020-03-24 |
Sun Pharma Advanced Research Company Ltd. |
Abuse deterrent immediate release biphasic matrix solid dosage form
|
EP3142646A1
(en)
|
2014-05-12 |
2017-03-22 |
Grünenthal GmbH |
Tamper resistant immediate release capsule formulation comprising tapentadol
|
US9872835B2
(en)
|
2014-05-26 |
2018-01-23 |
Grünenthal GmbH |
Multiparticles safeguarded against ethanolic dose-dumping
|
MA40496A
(fr)
*
|
2014-08-19 |
2017-06-28 |
Mandishora Israel Muzari |
Capsacinoïdes et leurs utilisations en tant que médicaments
|
CN107889459A
(zh)
|
2015-04-24 |
2018-04-06 |
格吕伦塔尔有限公司 |
具有立即释放和对溶剂萃取的抗性的抗篡改剂型
|
US10898537B2
(en)
|
2015-07-31 |
2021-01-26 |
Delivra Inc. |
Transdermal formulations for delivery of capsaicinoids
|
US11103581B2
(en)
|
2015-08-31 |
2021-08-31 |
Acura Pharmaceuticals, Inc. |
Methods and compositions for self-regulated release of active pharmaceutical ingredient
|
EP3346991A1
(en)
|
2015-09-10 |
2018-07-18 |
Grünenthal GmbH |
Protecting oral overdose with abuse deterrent immediate release formulations
|
WO2017222575A1
(en)
|
2016-06-23 |
2017-12-28 |
Collegium Pharmaceutical, Inc. |
Process of making more stable abuse-deterrent oral formulations
|
KR102657458B1
(ko)
|
2016-11-02 |
2024-04-12 |
센트렉시온 테라퓨틱스 코포레이션 |
안정한 수성의 캡사이신 주사 가능한 제형 및 이의 의학적 용도
|
WO2018136943A1
(en)
|
2017-01-23 |
2018-07-26 |
Flex Pharma, Inc. |
Compositions and methods affecting exercise performance
|
AU2018302342B2
(en)
|
2017-07-20 |
2024-08-08 |
Centrexion Therapeutics Corporation |
Methods and compositions for treatment of pain using capsaicin
|
RU2755206C1
(ru)
|
2020-05-20 |
2021-09-14 |
Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) |
Средство пролонгированного анальгетического действия и лекарственный препарат на его основе
|
US11033495B1
(en)
|
2021-01-22 |
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