DK1919514T3 - Polynucleotider kodende for isoprenoid-modificerende enzymer og fremgangsmåder til anvendelse deraf - Google Patents

Polynucleotider kodende for isoprenoid-modificerende enzymer og fremgangsmåder til anvendelse deraf

Info

Publication number
DK1919514T3
DK1919514T3 DK06785959.5T DK06785959T DK1919514T3 DK 1919514 T3 DK1919514 T3 DK 1919514T3 DK 06785959 T DK06785959 T DK 06785959T DK 1919514 T3 DK1919514 T3 DK 1919514T3
Authority
DK
Denmark
Prior art keywords
methods
polynucleotides encoding
modifying enzymes
encoding isoprenoid
isoprenoid
Prior art date
Application number
DK06785959.5T
Other languages
Danish (da)
English (en)
Inventor
Dae-Kyun Ro
Karyn Newman
Eric M Paradise
Jay D Keasling
Mario Ouellet
Rachel Eachus
Kimberly Ho
Timothy Ham
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of DK1919514T3 publication Critical patent/DK1919514T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
    • C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Nutrition Science (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
DK06785959.5T 2005-07-05 2006-06-29 Polynucleotider kodende for isoprenoid-modificerende enzymer og fremgangsmåder til anvendelse deraf DK1919514T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69706705P 2005-07-05 2005-07-05
PCT/US2006/025572 WO2007005604A2 (en) 2005-07-05 2006-06-29 Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof

Publications (1)

Publication Number Publication Date
DK1919514T3 true DK1919514T3 (da) 2012-08-20

Family

ID=37605033

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06785959.5T DK1919514T3 (da) 2005-07-05 2006-06-29 Polynucleotider kodende for isoprenoid-modificerende enzymer og fremgangsmåder til anvendelse deraf

Country Status (19)

Country Link
US (2) US8163980B2 (ja)
EP (2) EP1919514B1 (ja)
JP (1) JP2009504138A (ja)
KR (2) KR101444090B1 (ja)
CN (4) CN101495499B (ja)
AP (1) AP3827A (ja)
BR (1) BRPI0612411B8 (ja)
CA (1) CA2613469C (ja)
DK (1) DK1919514T3 (ja)
ES (2) ES2386554T3 (ja)
HK (1) HK1134495A1 (ja)
IL (1) IL188376A (ja)
MX (1) MX2008000200A (ja)
PL (1) PL1919514T3 (ja)
PT (1) PT1919514E (ja)
SG (1) SG176459A1 (ja)
SI (1) SI1919514T1 (ja)
WO (1) WO2007005604A2 (ja)
ZA (1) ZA200800889B (ja)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1778831B1 (en) 2004-07-27 2012-05-23 The Regents of The University of California Genetically modified host cells and use of same for producing isoprenoid compounds
CA2613469C (en) 2005-07-05 2014-08-12 The Regents Of The University Of California Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof
WO2007140339A2 (en) 2006-05-26 2007-12-06 Amyris Biotechnologies, Inc. Production of isoprenoids
US8257957B2 (en) 2006-09-26 2012-09-04 The Regents Of The University Of California Production of isoprenoids and isoprenoid precursors
AU2008260555B2 (en) 2007-06-01 2012-07-26 Sapphire Energy, Inc. High throughput screening of genetically modified photosynthetic organisms
WO2009036087A1 (en) 2007-09-11 2009-03-19 Sapphire Energy, Inc. Methods of producing organic products with photosynthetic organisms and products and compositions thereof
EP2444415A1 (en) * 2010-10-20 2012-04-25 Genoplante-Valor 1-Deoxy-D-xylulose 5-phosphate synthase alleles responsible for enhanced terpene biosynthesis
US10000773B2 (en) 2011-11-01 2018-06-19 Firmenich Sa Cytochrome P450 and use thereof for the enzymatic oxidation of terpenes
JP5827601B2 (ja) 2012-07-04 2015-12-02 住友ゴム工業株式会社 特定の蛋白質の発現を光応答転写因子により調整する方法、光応答転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法
SG11201500682WA (en) * 2012-09-07 2015-02-27 Sanofi Sa Fusion proteins for treating a metabolic syndrome
PL224377B1 (pl) * 2012-11-02 2016-12-30 Inst Biochemii I Biofizyki Polskiej Akademii Nauk Szczep Trichoderma atroviride, sposób otrzymywania i zastosowanie szczepu Trichoderma atroviride jako środka biobójczego
MX2016003431A (es) * 2013-09-19 2016-06-30 Firmenich & Cie Metodo para producir alcoholes fragantes.
US10457949B2 (en) * 2014-08-21 2019-10-29 Chung-Ang University Industry-Academy Cooperation Foundation rDNA NTS-based gene multiple insertion cassette set and GRAS-grade recombinant yeast strain
US20180142273A1 (en) * 2015-04-15 2018-05-24 William Marsh Rice University Iterative platform for the synthesis of alpha functionalized products
US11697830B2 (en) * 2015-04-15 2023-07-11 Ramon Gonzalez Iterative platform for the synthesis of alpha functionalized products
CN105274109B (zh) * 2015-10-30 2017-12-29 上海交通大学 一种调控基因在非分泌型腺毛中表达的启动子及其应用
CN105177007B (zh) * 2015-10-30 2017-11-10 上海交通大学 一种调控基因在非分泌型腺毛中表达的启动子及其应用
CN105483236A (zh) * 2015-12-26 2016-04-13 吉林省农业科学院 转基因植物中cry1C基因的LAMP检测引物组、试剂盒及检测方法
CN105567685B (zh) * 2016-01-18 2018-07-13 上海交通大学 AaPDR3基因启动子及其应用
EP3516048B1 (en) * 2016-09-20 2023-01-11 22nd Century Limited, LLC Trichome specific promoters for the manipulation of cannabinoids and other compounds in glandular trichomes
WO2018111194A1 (en) * 2016-12-16 2018-06-21 Temasek Life Sciences Laboratory Limited Targets for improving terpene production in rhodosporidium toruloides
EP3600361A4 (en) 2017-03-24 2021-01-06 Trait Biosciences, Inc. HIGH LEVEL IN VIVO BIOSYNTHESIS AND ISOLATION OF WATER-SOLUBLE CANNABINOIDS IN PLANT SYSTEMS
US11946059B2 (en) 2017-07-11 2024-04-02 Trait Biosciences, Inc. In vivo generation of water-soluble cannabinoids in plant cell suspension cultures
US11905543B2 (en) 2017-07-11 2024-02-20 Trait Biosceinces, Inc. In vivo generation of water-soluble acetylated cannabinoid glycoside compounds in plant cell suspension cultures
CN111465700A (zh) 2017-07-11 2020-07-28 特征生物科学公司 在酵母和植物细胞悬浮培养物中产生水溶性大麻素化合物和材料组合物
CN115176023A (zh) * 2020-01-23 2022-10-11 阿米瑞斯公司 紫穗槐-4,11-二烯12-单加氧酶变体及其用途
CN111621508B (zh) * 2020-06-11 2022-07-01 云南中烟工业有限责任公司 烟草萜类合成酶NtTPS7基因及其载体与应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5451513A (en) 1990-05-01 1995-09-19 The State University of New Jersey Rutgers Method for stably transforming plastids of multicellular plants
DK0640136T3 (da) * 1992-03-27 2003-09-01 Int Flower Dev Pty Ltd Gensekvenser der koder for enzymer i flavonoidstofskiftevejen med en flavonoid-3'-hydroxylaseaktivitet samt deres anvendelse
FR2689905B1 (fr) * 1992-04-13 1995-07-13 Orsan Procede de clonage d'une sequence d'adn codant pour une nadph cytochrome p450 reductase et sequences d'adn codant pour une nadph-cytochrome p450 reductase, notamment de plantes.
US5576198A (en) 1993-12-14 1996-11-19 Calgene, Inc. Controlled expression of transgenic constructs in plant plastids
US5545817A (en) 1994-03-11 1996-08-13 Calgene, Inc. Enhanced expression in a plant plastid
US5545818A (en) 1994-03-11 1996-08-13 Calgene Inc. Expression of Bacillus thuringiensis cry proteins in plant plastids
DK0889120T3 (da) 1994-12-09 2002-07-22 Imp College Innovations Ltd Virulensgener i VGC2-regionen af Salmonella
TR199902183T2 (xx) * 1997-03-07 1999-12-21 Novartis Ag Sitokrom P450 monoksigenazlar
US6900012B1 (en) 1997-06-03 2005-05-31 The University Of Chicago Plant artificial chromosome compositions and methods
US6083731A (en) * 1997-06-24 2000-07-04 Washington State University Research Foundation Recombinant materials and methods for the production of limonene hydroxylases
US6080849A (en) 1997-09-10 2000-06-27 Vion Pharmaceuticals, Inc. Genetically modified tumor-targeted bacteria with reduced virulence
EP0982404A1 (en) * 1998-08-27 2000-03-01 Wallaart, Thorvald Eelco DNA encoding amorpha-4,11-diene synthase
US6645747B1 (en) 1999-09-21 2003-11-11 E. I. Du Pont De Nemours And Company Cis-prenyltransferases from plants
US6369212B1 (en) 2000-02-07 2002-04-09 Korea Kumbo Petrochemical Co., Ltd. Cytochrome P450 gene highly expressed in the incompatible interaction
EP1354955A4 (en) * 2000-12-28 2005-01-05 Toyota Motor Co Ltd PROCESS FOR PREPARING PRENYL ALCOHOL
US7405057B2 (en) * 2001-03-09 2008-07-29 Board Of Trustees Of The University Of Kentucky Cytochrome P450s and uses thereof
GB0105924D0 (en) 2001-03-09 2001-04-25 Microscience Ltd Promoter
AUPR446701A0 (en) * 2001-04-18 2001-05-17 Gene Stream Pty Ltd Transgenic mammals for pharmacological and toxicological studies
JP2005503163A (ja) 2001-09-17 2005-02-03 プラント リサーチ インターナショナル ビー． ブイ． 生物的転化のための植物酵素
US20040162420A1 (en) * 2002-10-16 2004-08-19 U.S. Smokeless Tobacco Company Cloning of cytochrome p450 genes from nicotiana
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
US7192751B2 (en) * 2001-12-06 2007-03-20 The Regents Of The University Of California Biosynthesis of amorpha-4,11-diene
US6733996B2 (en) 2002-08-26 2004-05-11 Trustees Of Dartmouth College Methods for regulating gene expression using light
CA2613469C (en) * 2005-07-05 2014-08-12 The Regents Of The University Of California Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof
CA2630305A1 (en) * 2005-10-24 2007-05-03 National Research Council Of Canada A novel gene encoding amorphadiene hydroxylase and a process to produce artemisinic alcohol therewith

Also Published As

Publication number Publication date
ZA200800889B (en) 2009-09-30
PL1919514T3 (pl) 2012-10-31
BRPI0612411A8 (pt) 2017-12-26
EP1919514A2 (en) 2008-05-14
BRPI0612411B1 (pt) 2020-05-05
AP2013006962A0 (en) 2013-07-31
ES2386554T3 (es) 2012-08-22
CN101495499A (zh) 2009-07-29
CN105950667A (zh) 2016-09-21
IL188376A (en) 2012-12-31
MX2008000200A (es) 2008-04-07
KR101444090B1 (ko) 2014-09-26
SI1919514T1 (sl) 2012-08-31
CN101495499B (zh) 2013-09-04
CN106939323B (zh) 2021-07-13
IL188376A0 (en) 2008-04-13
AP3827A (en) 2016-09-30
HK1134495A1 (en) 2010-04-30
CN106939323A (zh) 2017-07-11
CN103667370A (zh) 2014-03-26
EP1919514A4 (en) 2009-12-02
SG176459A1 (en) 2011-12-29
JP2009504138A (ja) 2009-02-05
EP1919514B1 (en) 2012-05-16
KR101487304B1 (ko) 2015-01-28
EP2489672A2 (en) 2012-08-22
KR20130054468A (ko) 2013-05-24
CA2613469A1 (en) 2007-01-11
EP2489672B1 (en) 2017-01-18
KR20080031054A (ko) 2008-04-07
US8163980B2 (en) 2012-04-24
BRPI0612411A2 (pt) 2010-11-09
WO2007005604A3 (en) 2008-12-31
EP2489672A3 (en) 2013-01-09
US20100218283A1 (en) 2010-08-26
PT1919514E (pt) 2012-08-16
US20120288905A1 (en) 2012-11-15
WO2007005604A2 (en) 2007-01-11
CA2613469C (en) 2014-08-12
US8759632B2 (en) 2014-06-24
CN103667370B (zh) 2016-08-10
ES2621657T3 (es) 2017-07-04
BRPI0612411B8 (pt) 2021-05-25

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