DK1913009T3 - Nye benzimidazol(thio)carbamater med antiparasitisk virkning samt syntese heraf - Google Patents
Nye benzimidazol(thio)carbamater med antiparasitisk virkning samt syntese herafInfo
- Publication number
- DK1913009T3 DK1913009T3 DK06777837.3T DK06777837T DK1913009T3 DK 1913009 T3 DK1913009 T3 DK 1913009T3 DK 06777837 T DK06777837 T DK 06777837T DK 1913009 T3 DK1913009 T3 DK 1913009T3
- Authority
- DK
- Denmark
- Prior art keywords
- carbon atoms
- alkyl
- carbamates
- thio
- aryl
- Prior art date
Links
- 230000002141 anti-parasite Effects 0.000 title abstract 2
- 150000004657 carbamic acid derivatives Chemical class 0.000 title abstract 2
- 125000000446 sulfanediyl group Chemical group *S* 0.000 title abstract 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 4
- BHFLSZOGGDDWQM-UHFFFAOYSA-N 1h-benzimidazole;carbamic acid Chemical class NC(O)=O.C1=CC=C2NC=NC2=C1 BHFLSZOGGDDWQM-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- HXHWSAZORRCQMX-UHFFFAOYSA-N albendazole Chemical compound CCCSC1=CC=C2NC(NC(=O)OC)=NC2=C1 HXHWSAZORRCQMX-UHFFFAOYSA-N 0.000 abstract 1
- 229960002669 albendazole Drugs 0.000 abstract 1
- 230000000507 anthelmentic effect Effects 0.000 abstract 1
- 239000003096 antiparasitic agent Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- IRHZVMHXVHSMKB-UHFFFAOYSA-N fenbendazole Chemical compound [CH]1C2=NC(NC(=O)OC)=NC2=CC=C1SC1=CC=CC=C1 IRHZVMHXVHSMKB-UHFFFAOYSA-N 0.000 abstract 1
- 229960005473 fenbendazole Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70337005P | 2005-07-28 | 2005-07-28 | |
| EP05106991 | 2005-07-28 | ||
| PCT/EP2006/064381 WO2007014846A1 (en) | 2005-07-28 | 2006-07-18 | Novel benzimidazole (thio) carbamates with antiparasitic activity and the synthesis thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1913009T3 true DK1913009T3 (da) | 2010-08-16 |
Family
ID=35462186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06777837.3T DK1913009T3 (da) | 2005-07-28 | 2006-07-18 | Nye benzimidazol(thio)carbamater med antiparasitisk virkning samt syntese heraf |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7893271B2 (da) |
| EP (1) | EP1913009B1 (da) |
| JP (1) | JP5227795B2 (da) |
| AT (1) | ATE467637T1 (da) |
| CA (1) | CA2616512A1 (da) |
| DK (1) | DK1913009T3 (da) |
| ES (1) | ES2344275T3 (da) |
| PL (1) | PL1913009T3 (da) |
| PT (1) | PT1913009E (da) |
| TW (1) | TW200740838A (da) |
| WO (1) | WO2007014846A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| CN103169708B (zh) | 2002-07-29 | 2018-02-02 | 里格尔药品股份有限公司 | 用2,4‑嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法 |
| ES2337496T3 (es) | 2005-01-19 | 2010-04-26 | Rigel Pharmaceuticals, Inc. | Profarmacos de compuestos de 2,4-pirimidindiamina y sus usos. |
| AU2007345301A1 (en) * | 2006-06-12 | 2008-07-31 | Smith And Nephew Inc | Systems, methods and devices for tibial resection |
| PL2037914T3 (pl) | 2006-06-14 | 2014-04-30 | Intervet Int Bv | Zawiesina zawierająca karbaminian benzoimidazolu i polisorbat |
| TW201410657A (zh) | 2012-08-02 | 2014-03-16 | Endo Pharmaceuticals Inc | 經取代胺基－嘧啶衍生物 |
| MX365051B (es) | 2014-11-26 | 2019-05-09 | Univ Mexico Nac Autonoma | Nuevos compuestos hidrosolubles derivados del bencimidazol, utiles para el tratamiento de la fasciolosis. |
| CA3090691A1 (en) | 2018-02-08 | 2019-08-15 | The Johns Hopkins University | Mebendazole prodrugs with enhanced solubility and oral bioavailability |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE666795A (da) | 1964-08-04 | 1966-01-13 | ||
| US3480642A (en) | 1967-03-22 | 1969-11-25 | Smithkline Corp | Process for producing 2-carbalkoxyaminobenzimidazoles |
| US3657267A (en) | 1969-06-20 | 1972-04-18 | Janssen Pharmaceutica Nv | Benzimidazole carbamates |
| BE793358A (fr) | 1971-12-27 | 1973-06-27 | Hoechst Ag | Nouveaux derives de 2-carbalcoxy-amino-benzimidazole presentantune activite anthelmintique et leur procede de preparation |
| BE795360A (fr) * | 1972-02-16 | 1973-08-13 | Merck & Co Inc | Benzimidazoles phosphoryles |
| US3929821A (en) * | 1972-12-29 | 1975-12-30 | Syntex Inc | 5 (6)-Benzene ring substituted benzimidazole-2-carbamate derivatives |
| HU169503B (da) * | 1974-02-05 | 1976-12-28 | ||
| IN142490B (da) | 1974-05-15 | 1977-07-16 | Bayer Ag | |
| US3915986A (en) | 1974-06-19 | 1975-10-28 | Smithkline Corp | Methyl 5-propylthio-2-benzimidazolecarbamate |
| US4348406A (en) | 1980-10-20 | 1982-09-07 | Schering Corporation | Novel guanidine derivatives |
| DE3247615A1 (de) | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| NZ234564A (en) * | 1986-11-21 | 1991-04-26 | Haessle Ab | 1-substituted benzimidazoles and pharmaceutical compositions |
| GB9115273D0 (en) * | 1991-07-15 | 1991-08-28 | Pfizer Ltd | Benzimidazole anthelmintics |
| SE9103776D0 (sv) | 1991-12-19 | 1991-12-19 | Astra Ab | New compounds |
| US6093734A (en) | 1998-08-10 | 2000-07-25 | Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin | Prodrugs of proton pump inhibitors |
| ATE273000T1 (de) | 1999-09-03 | 2004-08-15 | Janssen Pharmaceutica Nv | Tierarzneiformulierung zur verabreichung eines wasserunlöslichen arzneistoffes an einem zieltier durch ein wasserverteilsystem |
-
2006
- 2006-07-18 WO PCT/EP2006/064381 patent/WO2007014846A1/en active Application Filing
- 2006-07-18 DK DK06777837.3T patent/DK1913009T3/da active
- 2006-07-18 ES ES06777837T patent/ES2344275T3/es active Active
- 2006-07-18 TW TW095126250A patent/TW200740838A/zh unknown
- 2006-07-18 PL PL06777837T patent/PL1913009T3/pl unknown
- 2006-07-18 CA CA002616512A patent/CA2616512A1/en not_active Abandoned
- 2006-07-18 EP EP06777837A patent/EP1913009B1/en not_active Not-in-force
- 2006-07-18 JP JP2008523316A patent/JP5227795B2/ja not_active Expired - Fee Related
- 2006-07-18 AT AT06777837T patent/ATE467637T1/de not_active IP Right Cessation
- 2006-07-18 US US11/997,057 patent/US7893271B2/en not_active Expired - Fee Related
- 2006-07-18 PT PT06777837T patent/PT1913009E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL1913009T3 (pl) | 2010-10-29 |
| US20090131369A1 (en) | 2009-05-21 |
| ES2344275T3 (es) | 2010-08-23 |
| ATE467637T1 (de) | 2010-05-15 |
| JP2009502858A (ja) | 2009-01-29 |
| EP1913009B1 (en) | 2010-05-12 |
| JP5227795B2 (ja) | 2013-07-03 |
| PT1913009E (pt) | 2010-06-25 |
| US7893271B2 (en) | 2011-02-22 |
| EP1913009A1 (en) | 2008-04-23 |
| CA2616512A1 (en) | 2007-02-08 |
| TW200740838A (en) | 2007-11-01 |
| WO2007014846A1 (en) | 2007-02-08 |
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