MX365051B - Nuevos compuestos hidrosolubles derivados del bencimidazol, utiles para el tratamiento de la fasciolosis. - Google Patents
Nuevos compuestos hidrosolubles derivados del bencimidazol, utiles para el tratamiento de la fasciolosis.Info
- Publication number
- MX365051B MX365051B MX2014014417A MX2014014417A MX365051B MX 365051 B MX365051 B MX 365051B MX 2014014417 A MX2014014417 A MX 2014014417A MX 2014014417 A MX2014014417 A MX 2014014417A MX 365051 B MX365051 B MX 365051B
- Authority
- MX
- Mexico
- Prior art keywords
- compounds derived
- fasciolosis
- treating
- benzimidazole
- hydrosoluble compounds
- Prior art date
Links
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 208000006275 fascioliasis Diseases 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001768 cations Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000004703 alkoxides Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001556 benzimidazoles Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a compuestos hidrosolubles derivados del bencimidazol representados por la fórmula general I: (ver Fórmula) en donde: Y1 e Y2 son independientemente O o S, y por lo menos uno de Y1 e Y2 es O; R1 y R2 son independientemente hidrógeno o un catión, ambos son hidrógeno o ambos son cationes; R3 es un alquilo que tiene de 1 a 4 átomos de carbono; R4 y R5 son independientemente halógeno o un alcóxido -OR6; R6 es arilo de 6 a 10 átomos de carbono unidos en la posición 5- o 6- del núcleo de bencimidazol.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2014014417A MX365051B (es) | 2014-11-26 | 2014-11-26 | Nuevos compuestos hidrosolubles derivados del bencimidazol, utiles para el tratamiento de la fasciolosis. |
PE2017000898A PE20171112A1 (es) | 2014-11-26 | 2015-11-25 | Nuevos compuestos hidrosolubles derivados del bencimidazol, utiles para el tratamiento de la fasciolosis |
PCT/MX2015/000154 WO2016085319A1 (es) | 2014-11-26 | 2015-11-25 | Nuevos compuestos hidrosolubles derivados del bencimidazol, utiles para el tratamiento de la fasciolosis |
US15/529,218 US10239842B2 (en) | 2014-11-26 | 2015-11-25 | Hydrosoluble compounds derived from benzimidazole used in treating fasciolosis |
BR112017010938-7A BR112017010938B1 (pt) | 2014-11-26 | 2015-11-25 | Compostos hidrossolúveis derivados do benzimidazol, composição farmacêutica e uso da composição farmacêutica |
CL2017001320A CL2017001320A1 (es) | 2014-11-26 | 2017-05-23 | Nuevos compuestos hidrosolubles derivados del bencimidazol, |
CONC2017/0005118A CO2017005118A2 (es) | 2014-11-26 | 2017-05-23 | Nuevos compuestos hidrosolubles derivados del bencimidazol, utiles para el tratamiento de la fasciolosis |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2014014417A MX365051B (es) | 2014-11-26 | 2014-11-26 | Nuevos compuestos hidrosolubles derivados del bencimidazol, utiles para el tratamiento de la fasciolosis. |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014014417A MX2014014417A (es) | 2016-05-26 |
MX365051B true MX365051B (es) | 2019-05-09 |
Family
ID=56074744
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014014417A MX365051B (es) | 2014-11-26 | 2014-11-26 | Nuevos compuestos hidrosolubles derivados del bencimidazol, utiles para el tratamiento de la fasciolosis. |
Country Status (7)
Country | Link |
---|---|
US (1) | US10239842B2 (es) |
BR (1) | BR112017010938B1 (es) |
CL (1) | CL2017001320A1 (es) |
CO (1) | CO2017005118A2 (es) |
MX (1) | MX365051B (es) |
PE (1) | PE20171112A1 (es) |
WO (1) | WO2016085319A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108003188A (zh) * | 2017-12-25 | 2018-05-08 | 长春吉大天元化学技术股份有限公司 | 一种烷基磷酸酯类化合物的新型纯化方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9103776D0 (sv) * | 1991-12-19 | 1991-12-19 | Astra Ab | New compounds |
TW200740838A (en) | 2005-07-28 | 2007-11-01 | Intervet Int Bv | Novel benzimidazole (thio)carbamates with antiparasitic activity and the synthesis thereof |
-
2014
- 2014-11-26 MX MX2014014417A patent/MX365051B/es active IP Right Grant
-
2015
- 2015-11-25 US US15/529,218 patent/US10239842B2/en not_active Expired - Fee Related
- 2015-11-25 BR BR112017010938-7A patent/BR112017010938B1/pt active IP Right Grant
- 2015-11-25 PE PE2017000898A patent/PE20171112A1/es unknown
- 2015-11-25 WO PCT/MX2015/000154 patent/WO2016085319A1/es active Application Filing
-
2017
- 2017-05-23 CL CL2017001320A patent/CL2017001320A1/es unknown
- 2017-05-23 CO CONC2017/0005118A patent/CO2017005118A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CO2017005118A2 (es) | 2017-09-20 |
US20170327470A1 (en) | 2017-11-16 |
MX2014014417A (es) | 2016-05-26 |
BR112017010938A2 (pt) | 2018-07-03 |
PE20171112A1 (es) | 2017-08-07 |
US10239842B2 (en) | 2019-03-26 |
BR112017010938B1 (pt) | 2022-08-16 |
CL2017001320A1 (es) | 2017-12-29 |
WO2016085319A1 (es) | 2016-06-02 |
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Legal Events
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FG | Grant or registration |