DK181983A - 1,8-naphthyridin- og 1,5,8-azanaphthyridin-derivater, fremgangsmaade til deres fremstilling samt deres anvendelse - Google Patents

1,8-naphthyridin- og 1,5,8-azanaphthyridin-derivater, fremgangsmaade til deres fremstilling samt deres anvendelse Download PDF

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Publication number
DK181983A
DK181983A DK181983A DK181983A DK181983A DK 181983 A DK181983 A DK 181983A DK 181983 A DK181983 A DK 181983A DK 181983 A DK181983 A DK 181983A DK 181983 A DK181983 A DK 181983A
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DK
Denmark
Prior art keywords
azanaphthyridine
naphthyridine
procedures
derivatives
preparation
Prior art date
Application number
DK181983A
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English (en)
Other versions
DK181983D0 (da
Inventor
Margaret Hagar Sherlock
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/371,623 external-priority patent/US4452800A/en
Application filed by Schering Corp filed Critical Schering Corp
Publication of DK181983D0 publication Critical patent/DK181983D0/da
Publication of DK181983A publication Critical patent/DK181983A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

eventuelt substitueret C^-C^g-alkyl, R2 er H, C^-Cg-acyl eller -alkyl, C2-Cg-hydroxyalkyl, -dihydroxyalkyl, -alkenyl eller -alkynyl eller R R^NiCHg)^» hvor n er 2-6, og Ra og Rb er H, C^-Cg-alkyl eller danner sammen med N en piperidin-, morpholin-, piperazin- eller pyrrolidin-ring, eller R2 er en kation, (med den betingelse, at når X er CH, R2 er H eller acyl, Y er H, alkyl, alkoxy, CF3, CH3S02, - SCF3 eller N02, og Z er H, halogen, alkyl eller alkoxy, R^ da ikke er usubstitueret alkyl), og syreadditionssalte, hydrater og solvater deraf fremstilles ved en række forskellige fremgangsmåder.
Forbindelserne er anvendelige ved behandling af allergiske reaktioner hos pattedyr.
DK181983A 1982-04-26 1983-04-25 1,8-naphthyridin- og 1,5,8-azanaphthyridin-derivater, fremgangsmaade til deres fremstilling samt deres anvendelse DK181983A (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/371,623 US4452800A (en) 1982-04-26 1982-04-26 Salts of 3(n-butyl)-4-hydroxy-1-phenyl-1,8-naphthyridine-2(1H)-one and their use in treating chronic obstructive lung diseases
US37162382 1982-04-26
US43868182A 1982-11-03 1982-11-03
US43868182 1982-11-03

Publications (2)

Publication Number Publication Date
DK181983D0 DK181983D0 (da) 1983-04-25
DK181983A true DK181983A (da) 1983-10-27

Family

ID=27005451

Family Applications (1)

Application Number Title Priority Date Filing Date
DK181983A DK181983A (da) 1982-04-26 1983-04-25 1,8-naphthyridin- og 1,5,8-azanaphthyridin-derivater, fremgangsmaade til deres fremstilling samt deres anvendelse

Country Status (13)

Country Link
US (1) US4492702A (da)
EP (1) EP0092786B1 (da)
AU (1) AU553958B2 (da)
CA (1) CA1198109A (da)
DE (1) DE3368929D1 (da)
DK (1) DK181983A (da)
HK (1) HK20590A (da)
IE (1) IE55113B1 (da)
IL (1) IL68487A0 (da)
NZ (1) NZ204004A (da)
PH (1) PH21641A (da)
PT (1) PT76596B (da)
SG (1) SG76889G (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4628055A (en) * 1982-11-03 1986-12-09 Schering Corporation Method for treating allergic reactions and compositions therefore
US4680298A (en) * 1983-05-31 1987-07-14 Schering Corporation Tricyclic anti-allergy and use as anti-inflammatory agents
US4632923A (en) * 1984-08-15 1986-12-30 Schering Corporation Substituted hetero spiro pyridine derivatives as anti-allergy and anti-inflammatory agents
EP0144996B1 (en) * 1983-12-14 1990-02-28 Schering Corporation Substituted spiro pyridine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions
FR2567520B1 (fr) * 1984-07-11 1987-01-02 Carpibem Nouvelles phenyl-naphthyridines, leur procede de preparation, medicaments les contenant, notamment anti-ulceres
DK127086A (da) * 1985-03-25 1986-09-26 Schering Corp Substituerede 1,8-naphthyridoner, fremgangsmaader til deres fremstilling og farmaceutiske kompositioner, der indeholder disse forbindelser
WO1986007537A2 (en) * 1985-06-18 1986-12-31 Schering Corporation Pharmaceutical compositions containing azanaphthalenes
US4684727A (en) * 1985-07-29 1987-08-04 Schering Corporation Zwitterionic 1,8-naphthyridine and pyrazino[2,3-b]pyridine containing compounds useful as anti-allergic, anti-inflammatory and cycloprotective agents
US5011860A (en) * 1986-04-11 1991-04-30 Schering Corporation Aryl-substituted naphthyridine and pyridopyrazine derivatives and their use in treating hyperproliferative skin diseases
US4760073A (en) * 1986-04-11 1988-07-26 Schering Corporation Aryl-substituted naphthyridine and pyridopyrazine derivatives, useful as anti-allergic agents
US4917896A (en) * 1986-08-15 1990-04-17 Nelson Research & Development Co. Penetration enhancers for transdermal delivery of systemic agents
US4775686A (en) * 1986-10-15 1988-10-04 Schering Corporation Naphthyridine derivatives and method for treating allergic reactions
EP0267691A3 (en) * 1986-10-15 1989-08-23 Schering Corporation Use of 1-substituted naphthyridine and pyridopyrazine derivatives for the preparation of medicaments with immunosuppressor activity.
US5037826A (en) * 1986-10-15 1991-08-06 Schering Corporation 1-substituted naphthyridine and pyridopyrazine derivatives
US4916131A (en) * 1986-10-15 1990-04-10 Schering Corporation Naphthyridine derivatives and method for treating allergic reactions
US5045542A (en) * 1986-10-20 1991-09-03 Schering Corporation Immune suppression method employing aryl-substituted naphthyridine and pyridopyrazine derivatives
EP0267740A1 (en) * 1986-11-06 1988-05-18 Schering Corporation Naphthyridine and pyridopyrazine compounds and pharmaceutical usage thereof
EP0302303A3 (en) * 1987-07-22 1989-05-24 Schering Corporation Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation
US4897487A (en) * 1988-04-06 1990-01-30 Schering Corporation Process for preparing intermediates for pharmaceutically useful bicyclic compounds
US4859669A (en) * 1987-12-23 1989-08-22 Schering Corporation Antiinflammatory and anti-hyperproliferative naphthyridin-4-ones
US5079360A (en) * 1988-04-06 1992-01-07 Schering Corporation Processes for preparing bicyclic compounds and intermediates thereof
US5180823A (en) * 1988-04-06 1993-01-19 Schering Corporation Processes for preparing bicyclic compounds
US4996212A (en) * 1989-12-21 1991-02-26 Schering Corporation Antiinflammatory and anti-hyperproliferative compounds
JP2988739B2 (ja) * 1990-04-16 1999-12-13 協和醗酵工業株式会社 １，８−ナフチリジン−２−オン誘導体
MX9701600A (es) * 1994-08-29 1997-05-31 Yamanouchi Pharma Co Ltd Derivados de naftiridina novedosos y composicion medicinal de los mismos.
CN1224624C (zh) 1999-12-08 2005-10-26 格勒兰制药株式会社 1,8－二氮杂萘－2(1h)－酮衍生物
AU2002257459B2 (en) 2001-05-24 2006-12-14 Merck Frosst Canada Ltd 1-biaryl-1,8-napthyridin-4-one phosphodiesterase-4 inhibitors
GB0614471D0 (en) 2006-07-20 2006-08-30 Syngenta Ltd Herbicidal Compounds
CN102203090A (zh) * 2008-10-29 2011-09-28 巴斯夫欧洲公司 具有除草作用的取代吡啶

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4128649A (en) * 1977-06-29 1978-12-05 Sandoz, Inc. 4-Hydroxy-pyrido[2,3-b]pyridine-2(1H)-one-3-carboxylic acids and esters
JP3774543B2 (ja) * 1997-06-17 2006-05-17 株式会社日立製作所 立軸ポンプおよびその駆動装置

Also Published As

Publication number Publication date
IE830934L (en) 1983-10-26
EP0092786B1 (en) 1987-01-07
IL68487A0 (en) 1983-07-31
DE3368929D1 (de) 1987-02-12
PT76596B (en) 1986-02-27
EP0092786A3 (en) 1984-07-25
CA1198109A (en) 1985-12-17
DK181983D0 (da) 1983-04-25
SG76889G (en) 1990-04-20
PT76596A (en) 1983-05-01
PH21641A (en) 1988-01-13
NZ204004A (en) 1986-03-14
HK20590A (en) 1990-03-23
AU1392783A (en) 1983-11-03
EP0092786A2 (en) 1983-11-02
AU553958B2 (en) 1986-07-31
US4492702A (en) 1985-01-08
IE55113B1 (en) 1990-06-06

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