DK160478A - Fremgangsmaade til fremstilling af 3-(1-piperazinyl)-1,2,4-benzotriaziner,n-oxider og pharmaceutisk acceptable salte deraf - Google Patents

Fremgangsmaade til fremstilling af 3-(1-piperazinyl)-1,2,4-benzotriaziner,n-oxider og pharmaceutisk acceptable salte deraf

Info

Publication number
DK160478A
DK160478A DK160478A DK160478A DK160478A DK 160478 A DK160478 A DK 160478A DK 160478 A DK160478 A DK 160478A DK 160478 A DK160478 A DK 160478A DK 160478 A DK160478 A DK 160478A
Authority
DK
Denmark
Prior art keywords
benzotriazines
piperazinyl
oxides
procedure
preparation
Prior art date
Application number
DK160478A
Other languages
English (en)
Inventor
W C Lumma
Original Assignee
Merck & Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Ltd filed Critical Merck & Co Ltd
Publication of DK160478A publication Critical patent/DK160478A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK160478A 1977-04-25 1978-04-12 Fremgangsmaade til fremstilling af 3-(1-piperazinyl)-1,2,4-benzotriaziner,n-oxider og pharmaceutisk acceptable salte deraf DK160478A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/790,363 US4091098A (en) 1977-04-25 1977-04-25 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides

Publications (1)

Publication Number Publication Date
DK160478A true DK160478A (da) 1978-10-26

Family

ID=25150463

Family Applications (1)

Application Number Title Priority Date Filing Date
DK160478A DK160478A (da) 1977-04-25 1978-04-12 Fremgangsmaade til fremstilling af 3-(1-piperazinyl)-1,2,4-benzotriaziner,n-oxider og pharmaceutisk acceptable salte deraf

Country Status (10)

Country Link
US (1) US4091098A (da)
JP (1) JPS53132582A (da)
CH (1) CH637391A5 (da)
DE (1) DE2817924A1 (da)
DK (1) DK160478A (da)
FR (1) FR2388810A1 (da)
GB (1) GB1568392A (da)
IT (1) IT7848954A0 (da)
NL (1) NL7803882A (da)
SE (1) SE7804125L (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2802488A1 (de) * 1978-01-20 1979-07-26 Bayer Ag 3-azolyl-benzotriazine und -benzotriazin-1-oxide, verfahren zu ihrer herstellung, sowie ihre verwendung zur bekaempfung von pflanzenkrankheiten
US5624925A (en) 1986-09-25 1997-04-29 Sri International 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents
US5175287A (en) * 1986-09-25 1992-12-29 S R I International Process for preparing 1,2,4-benzotriazine oxides
IE62911B1 (en) * 1988-03-18 1995-03-08 Stanford Res Inst Int 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents
EP0478545B1 (en) * 1989-09-18 1999-08-11 Sri International 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents
AU645681B2 (en) * 1991-05-02 1994-01-20 John Wyeth & Brother Limited Piperazine derivatives
RU2124511C1 (ru) * 1993-05-14 1999-01-10 Фармасьютикал Ко., Лтд Производные пиперазина
US6040448A (en) 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
AU9810498A (en) * 1997-10-24 1999-05-17 Neurogen Corporation 1-(2-naphthyl) and 1-(2-azanaphthyl)-4 -(1-phenylmethyl)piperazines being dopamine d4 receptor subtyp e ligands

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2489355A (en) * 1947-01-10 1949-11-29 Merck & Co Inc Benzotriazines
US3079390A (en) * 1958-12-12 1963-02-26 Searle & Co N-substituted 3-amino-1, 2, 4-benzotriazine-1-oxides
US3265693A (en) * 1964-07-13 1966-08-09 Searle & Co 3-phenyl-4-dialkylaminoalkylamino-cinnolines
US3272818A (en) * 1964-07-13 1966-09-13 Searle & Co 3-phenyl-4-piperazinylcinnolines
US3470182A (en) * 1967-02-09 1969-09-30 Sandoz Ag 4-amino-substituted quinazolines
FI193974A7 (da) * 1973-07-13 1975-01-14 Merck & Co Inc
EG12387A (en) * 1975-04-21 1978-12-31 Merck & Co Inc Process for preparing of piperazinyl pyrazines

Also Published As

Publication number Publication date
DE2817924A1 (de) 1978-11-02
FR2388810A1 (fr) 1978-11-24
JPS53132582A (en) 1978-11-18
IT7848954A0 (it) 1978-04-18
NL7803882A (nl) 1978-10-27
US4091098A (en) 1978-05-23
FR2388810B1 (da) 1980-08-08
SE7804125L (sv) 1978-10-26
GB1568392A (en) 1980-05-29
CH637391A5 (de) 1983-07-29

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Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment
PBP Patent lapsed