DK157031C - Fremgangsmaade til fremstilling af 4'-demethyl-epipodophyllotoxin-beta-d-ethylidenglycocid og acylderivater deraf til anvendelse som udgangsmaterialer i fremgangsmaaden - Google Patents

Fremgangsmaade til fremstilling af 4'-demethyl-epipodophyllotoxin-beta-d-ethylidenglycocid og acylderivater deraf til anvendelse som udgangsmaterialer i fremgangsmaaden

Info

Publication number
DK157031C
DK157031C DK425583A DK425583A DK157031C DK 157031 C DK157031 C DK 157031C DK 425583 A DK425583 A DK 425583A DK 425583 A DK425583 A DK 425583A DK 157031 C DK157031 C DK 157031C
Authority
DK
Denmark
Prior art keywords
procedure
acyler
glycocide
epipodophyllotoxin
demethyl
Prior art date
Application number
DK425583A
Other languages
English (en)
Other versions
DK157031B (da
DK425583D0 (da
DK425583A (da
Inventor
Katsuhiko Kurabayashi
Hidefumi Kinoshita
Hitoshi Saito
Toshio Takahashi
Original Assignee
Nippon Kayaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP20618882A external-priority patent/JPS5998098A/ja
Priority claimed from JP8586883A external-priority patent/JPS59212500A/ja
Application filed by Nippon Kayaku Kk filed Critical Nippon Kayaku Kk
Publication of DK425583D0 publication Critical patent/DK425583D0/da
Publication of DK425583A publication Critical patent/DK425583A/da
Publication of DK157031B publication Critical patent/DK157031B/da
Application granted granted Critical
Publication of DK157031C publication Critical patent/DK157031C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK425583A 1982-11-26 1983-09-19 Fremgangsmaade til fremstilling af 4'-demethyl-epipodophyllotoxin-beta-d-ethylidenglycocid og acylderivater deraf til anvendelse som udgangsmaterialer i fremgangsmaaden DK157031C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP20618882 1982-11-26
JP20618882A JPS5998098A (ja) 1982-11-26 1982-11-26 ４′―デメチル―エピポドフィロトキシン―β―Ｄ―エチリデングルコシドの新規製造法
JP8586883A JPS59212500A (ja) 1983-05-18 1983-05-18 ４′−デメチル−エピポドフイロトキシン−β−Ｄ−エチリデングルコシドの新規製造法
JP8586883 1983-05-18

Publications (4)

Publication Number Publication Date
DK425583D0 DK425583D0 (da) 1983-09-19
DK425583A DK425583A (da) 1984-05-27
DK157031B DK157031B (da) 1989-10-30
DK157031C true DK157031C (da) 1990-03-26

Family

ID=26426870

Family Applications (1)

Application Number Title Priority Date Filing Date
DK425583A DK157031C (da) 1982-11-26 1983-09-19 Fremgangsmaade til fremstilling af 4'-demethyl-epipodophyllotoxin-beta-d-ethylidenglycocid og acylderivater deraf til anvendelse som udgangsmaterialer i fremgangsmaaden

Country Status (7)

Country Link
US (1) US4564675A (da)
EP (1) EP0111058B1 (da)
KR (1) KR890000763B1 (da)
DE (1) DE3374317D1 (da)
DK (1) DK157031C (da)
ES (1) ES8506324A1 (da)
FI (1) FI71942C (da)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
AU582758B2 (en) * 1984-06-28 1989-04-13 Mect Corporation Sialic acid derivatives, galactose derivatives and method for producing the same
US4895727A (en) * 1985-05-03 1990-01-23 Chemex Pharmaceuticals, Inc. Pharmaceutical vehicles for exhancing penetration and retention in the skin
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
KR890700022A (ko) * 1986-11-19 1989-03-02 원본미기재 피부 관통 유동을 감소시키는 약제 비히클
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
US5716990A (en) * 1987-03-09 1998-02-10 Cancer Research Campaign Technology Limited Drug delivery systems
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives
US4975278A (en) * 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4868291A (en) * 1987-08-20 1989-09-19 Bristol-Myers Company 4'-deshydroxyepipodophyllotoxin glucosides: synthesis and use
US4935504A (en) * 1987-12-18 1990-06-19 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-acyl derivatives
ZA886810B (en) * 1987-12-18 1989-08-30 Bristol Myers Co Epipodophyllotoxin glucoside 4'-acyl derivatives
US4958010A (en) * 1988-02-16 1990-09-18 Bristol-Myers Company Epipodophyllotoxin glucoside lactam derivatives
US5632990A (en) * 1988-04-22 1997-05-27 Cancer Research Campaign Tech. Ltd. Treatment for tumors comprising conjugated antibody A5B7 and a prodrug
US4912204A (en) * 1988-09-06 1990-03-27 Bristol-Myers Company Fluoro-substituted epipodophyllotoxin glucosides
US5061791A (en) * 1988-12-21 1991-10-29 Warner-Lambert Company 4-bromo-4'-demethylepipodophyllotoxin derivatives
DE3913326A1 (de) * 1989-04-22 1990-11-08 Behringwerke Ag Verfahren zur herstellung von etoposiden
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
FR2658824B1 (fr) * 1990-02-27 1992-07-03 Pf Medicament Tris acetyl-2",3",4' ethylidene-4",6" beta-d-glucopyranosides, leur preparation et leur utilisation pour la preparation d'ethylidene beta-d-glucopyranoside de demethyl-4' epipodophyllotoxine.
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
US5463040A (en) * 1994-06-28 1995-10-31 Teva Pharmaceutical Industries, Ltd. Method of preparing etoposide
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
US20040072889A1 (en) * 1997-04-21 2004-04-15 Pharmacia Corporation Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
CA2343803A1 (en) 1998-09-10 2000-03-23 Ragina Naidu Synthetic method for the preparation of the antineoplastic agent etoposide
US6756063B2 (en) 2001-03-29 2004-06-29 Zoltan Laboratories, Llc Methods and compositions for the treatment of human and animal cancers
US7200207B2 (en) * 2004-03-13 2007-04-03 Intrado Inc. Communication network for providing emergency services
WO2006077424A1 (en) 2005-01-21 2006-07-27 Astex Therapeutics Limited Pharmaceutical compounds
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
PL2750683T3 (pl) 2011-10-03 2018-10-31 Mx Adjuvac Ab Nanocząsteczki, sposób ich otrzymywania i ich zastosowanie jako nośnik dla związków amfipatycznych cząsteczek hydrofobowych w dziedzinach medycyny włączając leczenie raka i związki powiązane z żywnością
CN102603762A (zh) * 2012-02-14 2012-07-25 上海金和生物技术有限公司 一种依托泊甙中间体的制备方法
WO2014163558A1 (en) 2013-04-01 2014-10-09 Moreinx Ab Nanoparticles, composed of sterol and saponin from quillaja saponaria molina process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds
CN108129525B (zh) * 2017-12-28 2019-11-22 山东铂源药业有限公司 一种依托泊苷中间体的制备方法
EP3616688A1 (en) 2018-08-27 2020-03-04 Centre National de la Recherche Scientifique - CNRS Preparation of nanosuspension comprising nanocrystals of active pharmaceutical ingredients with little or no stabilizing agents
EP3669890A1 (en) 2018-12-18 2020-06-24 Croda International PLC Filamentous nanoparticles having vaccine adjuvant effect
CN115141208B (zh) * 2022-08-05 2024-03-08 贵州大学 一种含各类酯基结构的鬼臼毒素类化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6613143A (da) * 1965-09-21 1967-03-22
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
US4147860A (en) * 1976-07-13 1979-04-03 E. I. Du Pont De Nemours And Company Process for preparing nitroaromatic glycosides

Also Published As

Publication number Publication date
DK157031B (da) 1989-10-30
FI71942B (fi) 1986-11-28
US4564675A (en) 1986-01-14
EP0111058B1 (en) 1987-11-04
ES525743A0 (es) 1985-07-01
FI833334A (fi) 1984-05-27
DE3374317D1 (en) 1987-12-10
DK425583D0 (da) 1983-09-19
DK425583A (da) 1984-05-27
EP0111058A1 (en) 1984-06-20
FI71942C (fi) 1987-03-09
FI833334A0 (fi) 1983-09-19
ES8506324A1 (es) 1985-07-01
KR840006672A (ko) 1984-12-01
KR890000763B1 (ko) 1989-04-05

Similar Documents

Publication Publication Date Title
DK157031C (da) Fremgangsmaade til fremstilling af 4'-demethyl-epipodophyllotoxin-beta-d-ethylidenglycocid og acylderivater deraf til anvendelse som udgangsmaterialer i fremgangsmaaden
DK301383D0 (da) Fremgangsmade til fremstilling af imidazolderivater
DK95483A (da) Fremgangsmaade til fremstilling af tetrahydropyranderivater
DK241883D0 (da) Fremgangsmade til fremstilling af 1-sulfo-2-oxoazetidinderivater
DK372283A (da) Fremgangsmaade til fremstilling af desoxyuridinderivater
DK155984D0 (da) Fremgangsmade til fremstilling af thiadiazolderivater
DK63683D0 (da) Fremgangsmade til fremstilling af cephemderivater
DK163379A (da) Fremgangsmaade til fremstilling af substituerede 1,3-diaryl-2-imino-imidazolidiner og 2-imino-hexahydro-pyrimidiner
DK323083A (da) Fremgangsmaade til fremstilling af 19-thio-androstanderivater
DK140584A (da) Fremgangsmaade til fremstilling af carbapenemderivater
DK312584A (da) Fremgangsmaade til fremstilling af quinonderivater
DK427083D0 (da) Fremgangsmade til fremstilling af cephemderivater
DK435483D0 (da) Fremgangsmade til fremstilling af fenylcyklobutylderivater
DK261883A (da) Fremgangsmaade til fremstilling af prostaglandin-d-derivater
DK162230C (da) Fremgangsmaade til fremstilling af 2-thiacephemderivater
DK317283A (da) Fremgangsmaade til fremstilling af thiadiazolderivater
DK426683A (da) Fremgangsmaade til fremstilling af oxacephalosporinderivater
DK38493D0 (da) Fremgangsmaade til fremstilling af alkoxymethylether- og alkoxymethylesterderivater af glyceroler
DK340483D0 (da) Fremgangsmade til fremstilling af fluoralkylerede carbapenemderivater
DK482983A (da) Fremgangsmaade til fremstilling af phenylderivater
DK165583D0 (da) Fremgangsmade til fremstilling af furanderivater
DK542383D0 (da) Fremgangsmade til fremstilling af acridanonderivater
DK164283D0 (da) Fremgangsmade til fremstilling af benzimidazolderivater
DK283383D0 (da) Fremgangsmade til fremstilling af 6'-aminopenicillanoyloxymethylpenicillanat-1,1-dioxid og mellemprodukter anvendelige til fremgangsmadens udoevelse
DK88283D0 (da) Fremgangsmade til fremstilling af triazolderivater

Legal Events

Date Code Title Description
PBP Patent lapsed