DK136781A - Diaminopyridiner og salte heraf fremgangsmaade til fremstillinng af disse og deres anvendelse som mellemprodukter - Google Patents
Diaminopyridiner og salte heraf fremgangsmaade til fremstillinng af disse og deres anvendelse som mellemprodukterInfo
- Publication number
- DK136781A DK136781A DK136781A DK136781A DK136781A DK 136781 A DK136781 A DK 136781A DK 136781 A DK136781 A DK 136781A DK 136781 A DK136781 A DK 136781A DK 136781 A DK136781 A DK 136781A
- Authority
- DK
- Denmark
- Prior art keywords
- diaminopyridines
- intermediates
- procedures
- salts
- preparation
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C07D213/77—Hydrazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/135,100 US4297360A (en) | 1980-03-28 | 1980-03-28 | 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK136781A true DK136781A (da) | 1981-09-29 |
Family
ID=22466542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK136781A DK136781A (da) | 1980-03-28 | 1981-03-26 | Diaminopyridiner og salte heraf fremgangsmaade til fremstillinng af disse og deres anvendelse som mellemprodukter |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US4297360A (da) |
| JP (1) | JPS56150064A (da) |
| KR (1) | KR830005201A (da) |
| AT (1) | ATA143781A (da) |
| AU (1) | AU545667B2 (da) |
| BE (1) | BE888122A (da) |
| CA (1) | CA1171856A (da) |
| DE (1) | DE3112251A1 (da) |
| DK (1) | DK136781A (da) |
| ES (1) | ES8202816A1 (da) |
| FI (1) | FI810920L (da) |
| FR (2) | FR2479224A1 (da) |
| GB (1) | GB2073185B (da) |
| IE (1) | IE52712B1 (da) |
| IL (1) | IL62401A (da) |
| IT (1) | IT1136973B (da) |
| LU (1) | LU83258A1 (da) |
| NL (1) | NL8101453A (da) |
| NO (1) | NO811040L (da) |
| NZ (1) | NZ196641A (da) |
| PH (1) | PH22271A (da) |
| PT (1) | PT72743B (da) |
| SE (2) | SE8101993L (da) |
| ZA (1) | ZA812026B (da) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4420617A (en) * | 1980-03-28 | 1983-12-13 | Sterling Drug Inc. | 5(Pyridinyl)pyridin-2-amines |
| US4351941A (en) * | 1981-02-04 | 1982-09-28 | Sterling Drug Inc. | Pyridinyl-pyridines |
| US4374141A (en) * | 1981-08-17 | 1983-02-15 | Sterling Drug Inc. | 2-Substituted amino-5-(pyridinyl)-nicotinamides and their cardiotonic use |
| US4361569A (en) * | 1981-08-26 | 1982-11-30 | Sterling Drug Inc. | 3-(Hydroxy or hydroxymethyl)-6-methyl-5-(4-pyridinyl)-2(1H)-pyridinone and cardiotonic use thereof |
| US4465686A (en) * | 1981-09-08 | 1984-08-14 | Sterling Drug Inc. | 5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation |
| US4599423A (en) * | 1982-04-26 | 1986-07-08 | Sterling Drug Inc. | Preparation of 5-(hydroxy- and/or aminophenyl-6-lower-alkyl)-2(1H)-pyridinones |
| US4469699A (en) * | 1982-08-25 | 1984-09-04 | Sterling Drug Inc. | 5-(4-Thiazolyl)-6-alkyl-2(1H)-pyridinones and their cardiotonic use |
| US4539327A (en) * | 1982-08-25 | 1985-09-03 | Sterling Drug Inc. | 5-(2-Substituted-4-thiazolyl)-6-alkyl-2(1H)-pyridinones and cardiotonic use thereof |
| US4595762A (en) * | 1982-08-25 | 1986-06-17 | Sterling Drug Inc. | 5-α-bromoalkanoyl-2-oxo-3-pyridinecarbonitriles |
| US4448780A (en) * | 1982-09-03 | 1984-05-15 | Sterling Drug Inc. | N-(Lower-alkyl)-N'-[5-(pyridinyl)-2-pyridinyl]ureas and cardiotonic use thereof |
| US4463008A (en) * | 1982-11-10 | 1984-07-31 | Sterling Drug Inc. | 2-Alkoxy-5-(pyridinyl)pyridines and cardiotonic use thereof |
| US4431651A (en) * | 1982-11-18 | 1984-02-14 | Sterling Drug Inc. | 2-Pyridinones and their use as cardiotonic agents |
| US4451469A (en) * | 1982-12-16 | 1984-05-29 | Sterling Drug Inc. | Selected 6-alkyl-and 4,6-dialkyl-2(1H)-pyridinones as cardiotonics |
| US4517192A (en) * | 1983-01-31 | 1985-05-14 | Sterling Drug Inc. | 6-Alkyl-5-[4-(alkylsulfinyl or alkylsulfonyl)phenyl]-2(1H)-pyridinones and their use as cardiatonics |
| IL74373A0 (en) * | 1984-02-21 | 1985-05-31 | Lilly Co Eli | Process for the preparation of diaminopyridines |
| DE3685840D1 (de) | 1985-04-30 | 1992-08-06 | Dresden Arzneimittel | 3-cyan-pyridine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung. |
| US4895867A (en) * | 1986-06-26 | 1990-01-23 | Norwich Eaton Pharmaceuticals, Inc. | 2-(5-phenyl-2-furanyl)imidazoles useful as cardiotonic agents |
| US4882354A (en) * | 1987-12-16 | 1989-11-21 | Norwich Eaton Pharmaceuticals, Inc. | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents |
| ATE110071T1 (de) * | 1988-01-23 | 1994-09-15 | Kyowa Hakko Kogyo Kk | Pyridazinon-derivate und diese enthaltende pharmazeutische zubereitungen. |
| AU8495091A (en) * | 1990-08-21 | 1992-03-17 | Upjohn Company, The | Bisphosphonic acid derivatives as anti-arthritic agents |
| CZ403592A3 (en) * | 1992-02-20 | 1993-12-15 | Hoechst Ag | Arylcarbonylaminoalkyldihydrooxopyridines, process of their preparation and their use |
| EP0615825B1 (de) * | 1993-03-14 | 1998-11-04 | WILHELM HEDRICH VAKUUMANLAGEN GmbH & Co. KG | Verfahren und Vorrichtung zum Füllen von Giessformen mit Giessharz o. dgl. giessfähig flüssigen Medien |
| US8263585B2 (en) | 2007-05-04 | 2012-09-11 | Novartis Ag | Organic compounds |
| US8268834B2 (en) * | 2008-03-19 | 2012-09-18 | Novartis Ag | Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme |
| EP2744496A4 (en) | 2011-08-16 | 2015-04-08 | Baker Idi Heart And Diabetes Inst Holdings Ltd | FORMULATIONS WITH TAXED RELEASE |
| EP3236963B1 (en) | 2014-12-22 | 2020-01-29 | Cardiora Pty Ltd | Method of treatment |
| CN106243032A (zh) * | 2016-07-20 | 2016-12-21 | 扬子江药业集团江苏海慈生物药业有限公司 | 一种米力农的制备方法 |
| CN111377857B (zh) * | 2018-12-30 | 2023-04-18 | 鲁南制药集团股份有限公司 | 一种米力农的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1322318A (en) * | 1971-05-19 | 1973-07-04 | Sterling Drug Inc | 1-alkyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids and esters |
| US3838156A (en) * | 1973-03-29 | 1974-09-24 | Sterling Drug Inc | Certain 2-substituted-6-(3 or 4-pyridyl)-nicotinic acid derivatives |
| US4072746A (en) * | 1975-10-14 | 1978-02-07 | Sterling Drug Inc. | 3-Amino-5-(pyridinyl)-2(1H)-pyridinones |
| US4004012A (en) * | 1975-10-14 | 1977-01-18 | Sterling Drug Inc. | 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones |
-
1980
- 1980-03-28 US US06/135,100 patent/US4297360A/en not_active Expired - Lifetime
- 1980-11-06 US US06/204,726 patent/US4312875A/en not_active Expired - Lifetime
-
1981
- 1981-03-17 IL IL62401A patent/IL62401A/xx unknown
- 1981-03-24 NL NL8101453A patent/NL8101453A/nl not_active Application Discontinuation
- 1981-03-24 GB GB8109260A patent/GB2073185B/en not_active Expired
- 1981-03-25 FI FI810920A patent/FI810920L/fi not_active Application Discontinuation
- 1981-03-26 FR FR8106071A patent/FR2479224A1/fr active Granted
- 1981-03-26 ES ES500726A patent/ES8202816A1/es not_active Expired
- 1981-03-26 PT PT72743A patent/PT72743B/pt unknown
- 1981-03-26 NO NO811040A patent/NO811040L/no unknown
- 1981-03-26 DK DK136781A patent/DK136781A/da not_active Application Discontinuation
- 1981-03-26 BE BE1/10187A patent/BE888122A/fr not_active IP Right Cessation
- 1981-03-26 ZA ZA00812026A patent/ZA812026B/xx unknown
- 1981-03-27 JP JP4533581A patent/JPS56150064A/ja active Pending
- 1981-03-27 KR KR1019810001014A patent/KR830005201A/ko unknown
- 1981-03-27 IE IE700/81A patent/IE52712B1/en unknown
- 1981-03-27 AU AU68836/81A patent/AU545667B2/en not_active Ceased
- 1981-03-27 PH PH25441A patent/PH22271A/en unknown
- 1981-03-27 NZ NZ196641A patent/NZ196641A/en unknown
- 1981-03-27 CA CA000374044A patent/CA1171856A/en not_active Expired
- 1981-03-27 AT AT0143781A patent/ATA143781A/de not_active Application Discontinuation
- 1981-03-27 SE SE8101993A patent/SE8101993L/xx not_active Application Discontinuation
- 1981-03-27 LU LU83258A patent/LU83258A1/fr unknown
- 1981-03-27 DE DE19813112251 patent/DE3112251A1/de not_active Withdrawn
- 1981-03-27 IT IT20785/81A patent/IT1136973B/it active
- 1981-10-07 FR FR8118887A patent/FR2490644B1/fr not_active Expired
-
1985
- 1985-03-08 SE SE8501169A patent/SE8501169D0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB2073185A (en) | 1981-10-14 |
| IT8120785A0 (it) | 1981-03-27 |
| BE888122A (fr) | 1981-09-28 |
| NO811040L (no) | 1981-09-28 |
| ES500726A0 (es) | 1982-03-01 |
| FI810920L (fi) | 1981-09-29 |
| KR830005201A (ko) | 1983-08-03 |
| US4312875A (en) | 1982-01-26 |
| IT1136973B (it) | 1986-09-03 |
| PT72743B (en) | 1982-03-24 |
| PT72743A (en) | 1981-04-01 |
| DE3112251A1 (de) | 1982-04-01 |
| AU545667B2 (en) | 1985-07-25 |
| FR2479224A1 (fr) | 1981-10-02 |
| GB2073185B (en) | 1984-02-29 |
| IE52712B1 (en) | 1988-02-03 |
| IL62401A (en) | 1985-01-31 |
| JPS56150064A (en) | 1981-11-20 |
| ATA143781A (de) | 1986-02-15 |
| US4297360A (en) | 1981-10-27 |
| LU83258A1 (fr) | 1981-10-29 |
| NL8101453A (nl) | 1981-10-16 |
| SE8501169D0 (sv) | 1985-03-08 |
| ZA812026B (en) | 1982-04-28 |
| FR2490644A1 (da) | 1982-03-26 |
| FR2490644B1 (da) | 1984-12-14 |
| ES8202816A1 (es) | 1982-03-01 |
| IE810700L (en) | 1981-09-28 |
| AU6883681A (en) | 1981-10-08 |
| CA1171856A (en) | 1984-07-31 |
| NZ196641A (en) | 1984-03-16 |
| IL62401A0 (en) | 1981-05-20 |
| PH22271A (en) | 1988-07-14 |
| FR2479224B1 (da) | 1984-12-14 |
| SE8101993L (sv) | 1981-11-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |