DK1815028T3 - Mikrobobler til affinitetsseparation - Google Patents

Mikrobobler til affinitetsseparation

Info

Publication number
DK1815028T3
DK1815028T3 DK05858304.8T DK05858304T DK1815028T3 DK 1815028 T3 DK1815028 T3 DK 1815028T3 DK 05858304 T DK05858304 T DK 05858304T DK 1815028 T3 DK1815028 T3 DK 1815028T3
Authority
DK
Denmark
Prior art keywords
microbubbles
affinity
affinity separation
methods
coated
Prior art date
Application number
DK05858304.8T
Other languages
English (en)
Inventor
Thomas Adams
Edward Jablonski
Original Assignee
Iris Molecular Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iris Molecular Diagnostics Inc filed Critical Iris Molecular Diagnostics Inc
Application granted granted Critical
Publication of DK1815028T3 publication Critical patent/DK1815028T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • G01N33/546—Synthetic resin as water suspendable particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • G01N33/547—Synthetic resin with antigen or antibody attached to the carrier via a bridging agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/76—Assays involving albumins other than in routine use for blocking surfaces or for anchoring haptens during immunisation
    • G01N2333/765—Serum albumin, e.g. HSA
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Inorganic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK05858304.8T 2004-11-03 2005-11-03 Mikrobobler til affinitetsseparation DK1815028T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62494804P 2004-11-03 2004-11-03
PCT/US2005/040162 WO2006137933A2 (en) 2004-11-03 2005-11-03 Microbubbles for affinity separation

Publications (1)

Publication Number Publication Date
DK1815028T3 true DK1815028T3 (da) 2012-01-30

Family

ID=37570908

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05858304.8T DK1815028T3 (da) 2004-11-03 2005-11-03 Mikrobobler til affinitetsseparation

Country Status (12)

Country Link
US (3) US8835186B2 (da)
EP (2) EP1815028B1 (da)
JP (2) JP5037350B2 (da)
KR (1) KR101281433B1 (da)
CN (2) CN103091485A (da)
AT (1) ATE530666T1 (da)
AU (1) AU2005333157B2 (da)
CA (1) CA2585675A1 (da)
DK (1) DK1815028T3 (da)
ES (2) ES2376578T3 (da)
PT (1) PT1815028E (da)
WO (1) WO2006137933A2 (da)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103091485A (zh) 2004-11-03 2013-05-08 艾瑞斯国际有限公司 用于亲和分离的微泡
CN101137758B (zh) 2004-11-03 2012-10-10 意力速分子诊断股份有限公司 均相分析物检测
US9952230B2 (en) * 2011-05-23 2018-04-24 Sekisui Medical Co., Ltd. Method of inhibiting nonspecific reaction in PIVKA-II assay reagent
EP2794052B1 (en) 2011-12-21 2018-08-15 3M Innovative Properties Company Bioseparation compositions and methods for using same
KR101462986B1 (ko) 2012-06-25 2014-11-19 대한민국 분변 중 요네균 신속분리를 위한 자석 나노입자를 이용한 검출방법
US20140288421A1 (en) * 2013-03-12 2014-09-25 The Regents Of The University Of California Gas vesicle ultrasound contrast agents and methods of using the same
JP6553020B2 (ja) 2013-03-15 2019-07-31 ジーピービー デット ホールディングス トゥー エルエルシー アレルギー及び自己免疫疾患に関する診断分析を行うための自動化された免疫分析計システム
WO2015198153A2 (en) 2014-01-28 2015-12-30 Targeson, Inc. Isolation of cells and biological substances using buoyant microbubbles
JP6557681B2 (ja) * 2014-05-10 2019-08-07 ダイアグノロジックス・エルエルシー 浮力を用いて薬剤を単離または濃縮するためのシステムおよび装置
US11291931B2 (en) * 2014-12-15 2022-04-05 Akadeum Life Sciences, Inc. Method and system for buoyant separation
EP3233232A4 (en) 2014-12-15 2018-11-14 Akadeum Life Sciences LLC Method and system for buoyant separation
CN107614458B (zh) 2015-05-01 2021-05-11 百进生物科技公司 稳定的纳米磁性颗粒分散体
CN113376364A (zh) 2015-08-10 2021-09-10 Essenlix 公司 步骤简化、小样品、快速、易使用的生物/化学分析装置和方法
AU2016323062A1 (en) 2015-09-14 2018-04-12 Essenlix Corp. Device and system for analyzing a sample, particularly blood, as well as methods of using the same
AU2016323072B2 (en) 2015-09-14 2019-09-19 Essenlix Corporation Device and system for collecting and analyzing vapor condensate, particularly exhaled breath condensate, as well as method of using the same
EP3892316A3 (en) * 2015-12-29 2021-11-24 Thermogenesis Corp. Cell separation devices, systems, and methods
CN109312293B (zh) 2016-04-30 2022-09-16 百进生物科技公司 用于进行磁浮分离的组合物和方法
US10705011B2 (en) * 2016-10-06 2020-07-07 Beckman Coulter, Inc. Dynamic focus system and methods
JP7061125B2 (ja) * 2016-12-16 2022-04-27 ダイアグノロジックス・エルエルシー 浮力による分離方法およびシステム
JP6667052B1 (ja) 2016-12-21 2020-03-18 エッセンリックス コーポレーション 試料を認証するためのデバイスおよび方法ならびにその使用
EP3579981A4 (en) 2017-02-07 2021-03-31 Essenlix Corporation COMPRESSED OPEN FLOW TEST AND USE
US11927560B2 (en) 2017-02-08 2024-03-12 Essenlix Corporation Bio/chemical material extraction and assay
WO2018148470A1 (en) 2017-02-08 2018-08-16 Essenlix Corporation Sample collection and handling for delayed analysis
EP3580565B1 (en) 2017-02-09 2024-05-29 Essenlix Corporation Assay using different spacing heights
US11940382B2 (en) 2017-02-09 2024-03-26 Essenlix Corporation Assay with amplification
CA3053120A1 (en) 2017-02-09 2018-08-16 Essenlix Corporation Colorimetric assays
US10966634B2 (en) 2017-02-16 2021-04-06 Essenlix Corporation Assay with textured surface
CN112689758A (zh) 2017-08-01 2021-04-20 Essenlix公司 检查药物对微生物影响的装置和方法
US11280706B2 (en) 2017-08-01 2022-03-22 Essenlix Corporation Dilution calibration
CN111492222A (zh) 2017-08-01 2020-08-04 Essenlix公司 样品收集、保持和测定
US11393561B2 (en) 2017-10-13 2022-07-19 Essenlix Corporation Devices and methods for authenticating a medical test and use of the same
US11609224B2 (en) 2017-10-26 2023-03-21 Essenlix Corporation Devices and methods for white blood cell analyses
US10807095B2 (en) 2017-10-26 2020-10-20 Essenlix Corporation Making and tracking assay card
US11237113B2 (en) 2017-10-26 2022-02-01 Essenlix Corporation Rapid pH measurement
WO2019118652A1 (en) 2017-12-12 2019-06-20 Essenlix Corporation Sample manipulation and assay with rapid temperature change
CN112534259A (zh) 2017-12-14 2021-03-19 Essenlix公司 监测毛发的装置，系统和方法
US11156606B2 (en) 2018-01-11 2021-10-26 Essenlix Corporation Homogeneous assay (II)
US11155575B2 (en) 2018-03-21 2021-10-26 Waters Technologies Corporation Non-antibody high-affinity-based sample preparation, sorbent, devices and methods
US11350909B2 (en) 2018-04-17 2022-06-07 California Institute Of Technology Cross amplitude modulation ultrasound pulse sequence
US20200009614A1 (en) 2018-07-09 2020-01-09 Akadeum Life Sciences, Inc. System and method for buoyant particle processing
US11885952B2 (en) 2018-07-30 2024-01-30 Essenlix Corporation Optics, device, and system for assaying and imaging
CN109608679B (zh) * 2018-12-10 2021-09-21 天津工业大学 一种核孔复合体接枝聚合物仿生膜制备方法
CN110354523B (zh) * 2019-07-14 2024-02-06 河北龙亿环境工程有限公司 一种具有多微孔气泡罩的新型塔板
US20220334108A1 (en) * 2019-09-26 2022-10-20 3M Innovative Properties Company Compositions and methods of detecting analytes
EP4392158A1 (en) 2021-08-26 2024-07-03 Akadeum Life Sciences, Inc. Method and system for buoyant separation
EP4399323A1 (en) * 2021-09-07 2024-07-17 Triangle Biotechnology, Inc. Targeted nanodroplet and microbubble compositions and methods for enrichment, lysis, and extraction of microbial cells

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1582956A (en) * 1976-07-30 1981-01-21 Ici Ltd Composite magnetic particles
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
DE3100535A1 (de) 1981-01-10 1982-08-12 Dr. Karl Thomae Gmbh, 7950 Biberach "neue carbonsaeure-derivate, ihre herstellung und ihre verwendung als arzneimittel"
FR2571498B1 (fr) * 1984-10-04 1988-04-08 Immunotech Sa Procede de separation de cellules utilisant des anticorps et des billes de faible densite
US4618525A (en) * 1985-06-03 1986-10-21 Minnesota Mining And Manufacturing Company Coated glass microbubbles and article incorporating them
US4824776A (en) 1985-07-25 1989-04-25 Molecular Biosystems, Inc. Method for increasing the sensitivity of nucleic acid hybridization assays
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4933447A (en) 1987-09-24 1990-06-12 Ss Pharmaceutical Co., Ltd. Quinoline derivatives
US4957656A (en) 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
US5766849A (en) 1989-07-11 1998-06-16 Gen-Probe Incorporated Methods of amplifying nucleic acids using promoter-containing primer sequence
SE9002480D0 (sv) 1990-07-23 1990-07-23 Hans Lilja Assay of free and complexed prostate-specific antigen
EP0488152A3 (en) 1990-11-30 1992-11-25 Hitachi, Ltd. Method for immunoassay and apparatus therefor
EP0529070A1 (en) 1991-02-27 1993-03-03 Amoco Corporation Methods for improving the sensitivity of hybridization assays
IE920778A1 (en) 1991-03-12 1992-09-23 Du Pont Method for specific binding assays using a releasable ligand
US5665539A (en) 1991-07-12 1997-09-09 The Regents Of The University Of California Immuno-polymerase chain reaction system for antigen detection
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
ATE239484T1 (de) 1991-10-24 2003-05-15 Isis Pharmaceuticals Inc Derivatisierte oligonukleotide mit verbessertem aufnahmevermögen
US5270184A (en) 1991-11-19 1993-12-14 Becton, Dickinson And Company Nucleic acid target generation
US6172208B1 (en) 1992-07-06 2001-01-09 Genzyme Corporation Oligonucleotides modified with conjugate groups
DE4232755A1 (de) 1992-09-26 1994-03-31 Schering Ag Mikropartikelpräparationen aus biologisch abbaubaren Mischpolymeren
JP3778925B2 (ja) 1993-01-15 2006-05-24 ザ パブリック ヘルス リサーチ インスティチュート オブ ザ シティー オブ ニューヨーク インク 高感度核酸サンドイッチハイブリダイゼーション検定法及びキット
US5985548A (en) 1993-02-04 1999-11-16 E. I. Du Pont De Nemours And Company Amplification of assay reporters by nucleic acid replication
EP0698792B1 (en) 1993-05-10 2003-07-02 Nissui Pharmaceutical Co., Ltd. Method for assaying more than one immunological ligand, and assay reagent and kit therefor
US5635602A (en) 1993-08-13 1997-06-03 The Regents Of The University Of California Design and synthesis of bispecific DNA-antibody conjugates
US5599677A (en) 1993-12-29 1997-02-04 Abbott Laboratories Immunoassays for prostate specific antigen
US5648213A (en) 1994-08-30 1997-07-15 Beckman Instruments, Inc. Compositions and methods for use in detection of analytes
JPH08178926A (ja) 1994-10-25 1996-07-12 Sumitomo Pharmaceut Co Ltd イムノアッセイプレートおよびその用途
MX9703543A (es) 1994-11-15 1997-08-30 Upjohn Co Antibacterianos de oxazina biciclica y oxazolidinona tiazina.
SE504798C2 (sv) 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
DE19524133A1 (de) 1995-07-03 1997-01-09 Bayer Ag Die Verwendung von neuen und bekannten kationischen 4,5-Dihydro-1H-1,2,3-triazoliumverbindungen als Farbstoffe, neue kationische 4,5-Dihydro-1H-1,2,3-triazoliumverbindungen und deren Herstellung
NO301198B1 (no) 1995-07-14 1997-09-22 Alcatel Kabel Norge As Kabel, fremgangsmåte og impregneringsmasse
AT403803B (de) 1996-04-19 1998-05-25 Sanochemia Ltd Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
US6165942A (en) 1996-10-03 2000-12-26 Nissan Chemical Industries, Ltd. Heterocycle-fused pyrimidinone derivative and herbicidal composition
US6083484A (en) * 1996-10-17 2000-07-04 Molecular Biosystems, Inc. Microparticles stabilized by polynuclear chromium complexes and their use as ultrasound contrast agents
US6245318B1 (en) * 1997-05-27 2001-06-12 Mallinckrodt Inc. Selectively binding ultrasound contrast agents
US6086540A (en) * 1997-10-07 2000-07-11 Molecular Biosystems, Inc. Methods of ultrasound imaging using echogenically persistent contrast agents
US6531278B1 (en) 1998-01-14 2003-03-11 Utah State University Ligand-DNA composition for capture and detection of contaminants on a solid surface
WO1999055837A2 (en) * 1998-04-28 1999-11-04 Nycomed Imaging As Improvements in or relating to separation processes
US8063190B2 (en) 1998-06-02 2011-11-22 Tom Robin Caine Boyde Nucleic acid-linked conjugates and methods for making and using them
US6214566B1 (en) 1998-11-16 2001-04-10 The Administrators Of The Tulane Educational Fund Method for detecting anti-squalene antibodies
WO2000041524A2 (en) 1999-01-11 2000-07-20 President And Fellows Of Harvard College Isothermal amplification of dna
ATE312350T1 (de) * 1999-10-13 2005-12-15 Univ British Columbia Verfahren zur identifizierung von verbindungen, die die neuronale aktivität modulieren
CA2391534A1 (en) 1999-11-15 2001-05-25 Drug Innovation & Design, Inc. Selective cellular targeting: multifunctional delivery vehicles
US7306904B2 (en) 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
US6511809B2 (en) 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
US7439016B1 (en) 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
US20020132260A1 (en) 2001-02-22 2002-09-19 Erlander Mark G. Quantitative immunohistochemistry (QIHC)
WO2002083951A1 (en) 2001-04-10 2002-10-24 Northeastern University Multiplexed ligand/protein binding assays with pna labels
EP1249500A1 (de) 2001-04-12 2002-10-16 chimera biotec GmbH Verfahren zum Nachweis einer Substanz
WO2003011824A1 (en) 2001-07-31 2003-02-13 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
DK1483585T3 (da) 2002-03-08 2009-06-22 Eidgenoess Tech Hochschule Kodede, selvsamlende kemiske biblioteker (ESACHEL)
ATE514717T1 (de) 2002-07-18 2011-07-15 Merus B V Rekombinante produktion von antikörpermischungen
US7649001B2 (en) 2002-08-12 2010-01-19 Takeda Pharmaceutical Company Limited Fused benzene derivative and use
ES2424269T3 (es) 2002-11-01 2013-09-30 Iris International, Inc. Inmuno-PCR sándwich por desplazamiento
WO2006012356A2 (en) 2004-06-23 2006-02-02 Washington University Methods for determining risk of developing regular smoking behavior
CN101084207A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
CN101137758B (zh) 2004-11-03 2012-10-10 意力速分子诊断股份有限公司 均相分析物检测
CN103091485A (zh) 2004-11-03 2013-05-08 艾瑞斯国际有限公司 用于亲和分离的微泡
US20090246781A1 (en) 2008-02-21 2009-10-01 Robert Klem Method for early determination of recurrence after therapy for prostate cancer

Also Published As

Publication number Publication date
KR101281433B1 (ko) 2013-07-02
US20110236884A1 (en) 2011-09-29
WO2006137933A2 (en) 2006-12-28
CA2585675A1 (en) 2006-12-28
ES2550177T3 (es) 2015-11-05
AU2005333157A1 (en) 2006-12-28
ATE530666T1 (de) 2011-11-15
KR20070110484A (ko) 2007-11-19
JP5037350B2 (ja) 2012-09-26
US8513032B2 (en) 2013-08-20
JP2008518973A (ja) 2008-06-05
ES2376578T3 (es) 2012-03-15
EP2302078B1 (en) 2015-07-15
US20110230644A1 (en) 2011-09-22
CN101065497A (zh) 2007-10-31
EP1815028A4 (en) 2008-09-10
EP1815028A2 (en) 2007-08-08
US20090176201A1 (en) 2009-07-09
EP2302078A1 (en) 2011-03-30
CN103091485A (zh) 2013-05-08
US8835186B2 (en) 2014-09-16
JP2012197281A (ja) 2012-10-18
PT1815028E (pt) 2012-01-24
WO2006137933A3 (en) 2007-05-03
CN101065497B (zh) 2012-11-21
EP1815028B1 (en) 2011-10-26
AU2005333157B2 (en) 2011-06-30

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