DK179682A - Fremgangsmaade til fremstilling af lysin-tryptofan-oligopeptider eller fysiologisk vaerdifulde derivater eller salte deraf - Google Patents
Fremgangsmaade til fremstilling af lysin-tryptofan-oligopeptider eller fysiologisk vaerdifulde derivater eller salte deraf Download PDFInfo
- Publication number
- DK179682A DK179682A DK179682A DK179682A DK179682A DK 179682 A DK179682 A DK 179682A DK 179682 A DK179682 A DK 179682A DK 179682 A DK179682 A DK 179682A DK 179682 A DK179682 A DK 179682A
- Authority
- DK
- Denmark
- Prior art keywords
- trytophano
- olegopeptides
- lysin
- salts
- procedure
- Prior art date
Links
- 108010038807 Oligopeptides Proteins 0.000 description 2
- 102000015636 Oligopeptides Human genes 0.000 description 2
- OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 description 1
- RCODLYOZQUAONI-UHFFFAOYSA-N C=C1C=CC2=CC=NC2=C1 Chemical group C=C1C=CC2=CC=NC2=C1 RCODLYOZQUAONI-UHFFFAOYSA-N 0.000 description 1
- 101710176384 Peptide 1 Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000000871 hypocholesterolemic effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
(Trp) . (hvor c og/eller d>0), dog saledes at mindst en af grup-α 1 2 perne R og R er en 6-metylenindol- eller beskyttet e-amino-butylrest, hvorpå o-nitrosulfenylgruppen elimineres fra reaktionsproduktet til dannelse af en forbindelse
V
eller et syreadditionssalt deraf; fra dette fjernes alle tilstedeværende aminobeskyttelsesgrupper, og om ønsket forsæbes den dannede ester af det ønskede oligopeptid (Lys) -
Si (Trp)b (Dr hvor a og b begge er >0, efterfulgt af neutralisation til opnåelse af den fri peptid 1.
Disse oligopeptider har hypokolesterolæmisk virkning.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES501583A ES501583A0 (es) | 1981-04-23 | 1981-04-23 | Un procedimiento para la preparacion de oligopeptidos lisi- na-triptofano y de sus derivados y sales fisiologicamente aprovechables |
| ES501583 | 1981-04-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK179682A true DK179682A (da) | 1982-10-24 |
Family
ID=8482278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK179682A DK179682A (da) | 1981-04-23 | 1982-04-22 | Fremgangsmaade til fremstilling af lysin-tryptofan-oligopeptider eller fysiologisk vaerdifulde derivater eller salte deraf |
Country Status (10)
| Country | Link |
|---|---|
| BE (1) | BE892932A (da) |
| CH (1) | CH657861A5 (da) |
| DE (1) | DE3213501A1 (da) |
| DK (1) | DK179682A (da) |
| ES (1) | ES501583A0 (da) |
| FR (1) | FR2504525B1 (da) |
| GB (1) | GB2097404B (da) |
| IT (1) | IT1151728B (da) |
| NL (1) | NL8201649A (da) |
| SE (1) | SE8202414L (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3823464A1 (de) * | 1988-07-11 | 1990-01-18 | Asta Pharma Ag | Neue tryptophandipeptide |
| ITMI20061607A1 (it) * | 2006-08-09 | 2008-02-10 | Maria Vincenza Carriero | Peptidi con attivita farmacologica |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5116667A (da) * | 1974-07-30 | 1976-02-10 | Shionogi Seiyaku Kk |
-
1981
- 1981-04-23 ES ES501583A patent/ES501583A0/es active Granted
-
1982
- 1982-04-10 DE DE19823213501 patent/DE3213501A1/de not_active Withdrawn
- 1982-04-15 CH CH2266/82A patent/CH657861A5/de not_active IP Right Cessation
- 1982-04-19 SE SE8202414A patent/SE8202414L/ not_active Application Discontinuation
- 1982-04-19 GB GB8211276A patent/GB2097404B/en not_active Expired
- 1982-04-20 IT IT20834/82A patent/IT1151728B/it active
- 1982-04-21 NL NL8201649A patent/NL8201649A/nl not_active Application Discontinuation
- 1982-04-22 DK DK179682A patent/DK179682A/da not_active Application Discontinuation
- 1982-04-22 BE BE0/207896A patent/BE892932A/fr not_active IP Right Cessation
- 1982-04-22 FR FR8206966A patent/FR2504525B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES8202788A1 (es) | 1982-02-16 |
| DE3213501A1 (de) | 1982-11-11 |
| IT1151728B (it) | 1986-12-24 |
| FR2504525A1 (fr) | 1982-10-29 |
| GB2097404A (en) | 1982-11-03 |
| CH657861A5 (de) | 1986-09-30 |
| GB2097404B (en) | 1985-05-30 |
| IT8220834A0 (it) | 1982-04-20 |
| SE8202414L (sv) | 1982-10-24 |
| NL8201649A (nl) | 1982-11-16 |
| ES501583A0 (es) | 1982-02-16 |
| FR2504525B1 (fr) | 1986-10-24 |
| BE892932A (fr) | 1982-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |