DK177529B1 - Liposomes with improved storage stability - Google Patents
Liposomes with improved storage stability Download PDFInfo
- Publication number
- DK177529B1 DK177529B1 DKPA200901150A DKPA200901150A DK177529B1 DK 177529 B1 DK177529 B1 DK 177529B1 DK PA200901150 A DKPA200901150 A DK PA200901150A DK PA200901150 A DKPA200901150 A DK PA200901150A DK 177529 B1 DK177529 B1 DK 177529B1
- Authority
- DK
- Denmark
- Prior art keywords
- liposomes
- solution
- liposome
- concentration
- spla2
- Prior art date
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
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- 229940115080 doxil Drugs 0.000 description 1
- 238000002296 dynamic light scattering Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 230000036251 extravasation Effects 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 238000009616 inductively coupled plasma Methods 0.000 description 1
- 238000001095 inductively coupled plasma mass spectrometry Methods 0.000 description 1
- 230000016507 interphase Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
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- 210000004185 liver Anatomy 0.000 description 1
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- 229960005225 mifamurtide Drugs 0.000 description 1
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- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229940026778 other chemotherapeutics in atc Drugs 0.000 description 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 1
- 229960001756 oxaliplatin Drugs 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 230000001991 pathophysiological effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229920001308 poly(aminoacid) Polymers 0.000 description 1
- 229940065514 poly(lactide) Drugs 0.000 description 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (5)
1. En farmaceutisk komposition omfattende et sPLA2 hydro lyser bart liposom karakteriseret ved et indhold af anionisk lipid mellem 20 % og 45 %, et 5 indhold af polymer konjugeret lipid mellem 3 % og 6 % og et indhold af neutrale lipider mellem 40 % og 75 %, hvori det sPLA2 hydrolyserbare liposome omfatter * cisplatin indkapslet i liposomet, 10. en ydre opløsning, * en indre opløsning indeni liposomet, * hvori forskellen i osmolyt koncentration mellem den indre opløsning og the ydre opløsning (den ydre koncentration af osmolyte subtraheret fra den indre koncentration af osmolyt) er mellem 280 15 og 320 mM.
2. Den farmaceutiske komposition ifølge krav 1, hvori det eneste terapeutiske middel er cisplatin. 20
3) Den farmaceutiske komposition ifølge hvilket som helst af de foregående krav, hvor den indre opløsning omfatter NaCI eller KCI i en koncentration mellem 0,2-2,5 % vægt/vægt.
4. Den farmaceutiske komposition ifølge hvilket som helst af de foregående 25 krav, hvor den ydre opløsning omfatter NaCI eller KCI på en koncentration mellem 0,2-2,5 % vægt/vægt.
5. Den farmaceutiske komposition ifølge hvilket som helst af de foregående krav, hvor den indre og ydre opløsning er udvalgt fra gruppen bestående af 30 a. Indre opløsning af 0,8-1,0 % NaCI og 9-11 % sukrose og ydre opløsning på 8-12 mM fosfat buffer (pH 6,5) + 9-11 % sukrose, b. Indre opløsning af 1,6-2,0 % NaCI og ydre opløsning på 8-12 mM 35 fosfat buffer (pH 6,5) + 9-11 % sukrose, DK 177529 B1 29 c. Indre opløsning af 0,8-1,0 % NaCI og 9-11 % sukrose og ydre opløsning på 8-12 mM fosfat buffer (pH 6,5) + 0,35 % - 0,55 % NaCI + 4-6 % sukrose, 5 d. Indre opløsning af 1,6-2,0 % NaCI og ydre opløsning på 8-12 mM fosfat buffer (pH 6,5) + 0,8-1,0 % NaCI.
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200901150A DK177529B1 (en) | 2009-10-23 | 2009-10-23 | Liposomes with improved storage stability |
| EP10772956.8A EP2490671B1 (en) | 2009-10-23 | 2010-10-25 | Spla2 hydrolysable liposomes with improved storag stability |
| PT107729568T PT2490671E (pt) | 2009-10-23 | 2010-10-25 | Lipossomas hidrolizáveis por spla2 com estabilidade de armazenamento melhorada |
| CA2772973A CA2772973C (en) | 2009-10-23 | 2010-10-25 | Liposomes with improved storage stability |
| RS20140274A RS53321B (en) | 2009-10-23 | 2010-10-25 | SPLA2 HYDROLIZABLE LIPOSOMS WITH IMPROVED STORAGE STORAGE |
| PL10772956T PL2490671T3 (pl) | 2009-10-23 | 2010-10-25 | Liposomy hydrolizowane przez sPLA2 o ulepszonej trwałości w przechowywaniu |
| DK10772956.8T DK2490671T3 (da) | 2009-10-23 | 2010-10-25 | Spla2-hydrolyserbare liposomer med forbedret lagringsstabilitet |
| ES10772956.8T ES2465565T3 (es) | 2009-10-23 | 2010-10-25 | Liposomas hidrolizables por SPLA2 con mejor estabilidad de almacenamiento |
| CN201080047402.7A CN102639114B (zh) | 2009-10-23 | 2010-10-25 | 经改善贮藏稳定性的脂质体 |
| JP2012534543A JP5778160B2 (ja) | 2009-10-23 | 2010-10-25 | ｓＰＬＡ２加水分解性リポソームを含む医薬組成物 |
| US13/503,614 US9820941B2 (en) | 2009-10-23 | 2010-10-25 | SPLA2 hydrolysable liposomes with improved storage stability |
| PCT/DK2010/050283 WO2011047689A2 (en) | 2009-10-23 | 2010-10-25 | Liposomes with improved storage stability |
| SI201030638T SI2490671T1 (sl) | 2009-10-23 | 2010-10-25 | Liposomi, ki jih je mogoče hidrolizirati sPLA2 in imajo izboljšano stabilnost pri shranjevanju |
| AU2010310240A AU2010310240B2 (en) | 2009-10-23 | 2010-10-25 | sPLA2 hydrolysable liposomes with improved storage stability |
| HRP20140413AT HRP20140413T1 (hr) | 2009-10-23 | 2014-05-07 | Spla2 hidrolizirajuä†i liposomi s poboljšanim svojstvima pohranjivanja |
| CY20141100387T CY1115139T1 (el) | 2009-10-23 | 2014-05-30 | Spla2 υδρολυσιμα λιποσωματα με βελτιωμενη σταθεροτητα αποθηκευσης |
| SM201400065T SMT201400065B (it) | 2009-10-23 | 2014-06-05 | Liposomi idrolizzabili da spla2 con una miglioratastabilita'di conservazione |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200901150A DK177529B1 (en) | 2009-10-23 | 2009-10-23 | Liposomes with improved storage stability |
| DK200901150 | 2009-10-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK200901150A DK200901150A (en) | 2011-04-24 |
| DK177529B1 true DK177529B1 (en) | 2013-09-08 |
Family
ID=43533079
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DKPA200901150A DK177529B1 (en) | 2009-10-23 | 2009-10-23 | Liposomes with improved storage stability |
| DK10772956.8T DK2490671T3 (da) | 2009-10-23 | 2010-10-25 | Spla2-hydrolyserbare liposomer med forbedret lagringsstabilitet |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10772956.8T DK2490671T3 (da) | 2009-10-23 | 2010-10-25 | Spla2-hydrolyserbare liposomer med forbedret lagringsstabilitet |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9820941B2 (da) |
| EP (1) | EP2490671B1 (da) |
| JP (1) | JP5778160B2 (da) |
| CN (1) | CN102639114B (da) |
| AU (1) | AU2010310240B2 (da) |
| CA (1) | CA2772973C (da) |
| CY (1) | CY1115139T1 (da) |
| DK (2) | DK177529B1 (da) |
| ES (1) | ES2465565T3 (da) |
| HR (1) | HRP20140413T1 (da) |
| PL (1) | PL2490671T3 (da) |
| PT (1) | PT2490671E (da) |
| RS (1) | RS53321B (da) |
| SI (1) | SI2490671T1 (da) |
| SM (1) | SMT201400065B (da) |
| WO (1) | WO2011047689A2 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2123258A1 (en) | 2008-05-23 | 2009-11-25 | Liplasome Pharma A/S | Liposomes for drug delivery |
| DK177532B1 (en) | 2009-09-17 | 2013-09-08 | Bio Bedst Aps | Medical use of sPLA2 hydrolysable liposomes |
| EP2394640A1 (en) | 2010-05-21 | 2011-12-14 | MediGene AG | Improved liposomal formulations of lipophilic compounds |
| EP3138558B1 (en) * | 2014-04-30 | 2023-06-07 | FUJIFILM Corporation | Liposome composition and production method therefor |
| JP6263609B2 (ja) * | 2014-04-30 | 2018-01-17 | 富士フイルム株式会社 | リポソーム組成物及びその製造方法 |
| HUE052968T2 (hu) * | 2014-04-30 | 2021-05-28 | Fujifilm Corp | Liposzóma kompozíció és annak elõállítási eljárása |
| AU2016256979B2 (en) * | 2015-05-04 | 2021-01-28 | Versantis AG | Method for preparing transmembrane pH-gradient vesicles |
| US9725769B1 (en) | 2016-10-07 | 2017-08-08 | Oncology Venture ApS | Methods for predicting drug responsiveness in cancer patients |
| AU2017258901A1 (en) | 2016-12-30 | 2018-07-19 | Allarity Therapeutics Europe ApS | Methods for predicting drug responsiveness in cancer patients |
| AU2019200325A1 (en) * | 2018-01-31 | 2019-08-15 | Liplasome Pharma Aps | Methods for treating cancer and predicting drug responsiveness in cancer patients |
| CN110496103B (zh) * | 2018-05-18 | 2022-05-10 | 上海维洱生物医药科技有限公司 | 一种多西他赛棕榈酸酯脂质体及其制备方法 |
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| US4880635B1 (en) * | 1984-08-08 | 1996-07-02 | Liposome Company | Dehydrated liposomes |
| CA1335348C (en) | 1988-03-04 | 1995-04-25 | Yasuaki Ogawa | Liposome composition |
| JP2931981B2 (ja) * | 1988-03-04 | 1999-08-09 | 武田薬品工業株式会社 | リポソーム製剤およびその製造法 |
| FI895340A0 (fi) * | 1988-11-14 | 1989-11-09 | Bristol Myers Squibb Co | Hypertonisk cisplatin-loesning. |
| JPH05194192A (ja) * | 1991-08-21 | 1993-08-03 | Shionogi & Co Ltd | 分散性の改善された温度感受性ｍｌｖ型リポソ−ム |
| JPH069374A (ja) * | 1992-04-07 | 1994-01-18 | Banyu Pharmaceut Co Ltd | リポソ−ム製剤およびその製造法 |
| AU3559695A (en) | 1994-09-30 | 1996-04-26 | Inex Pharmaceuticals Corp. | Glycosylated protein-liposome conjugates and methods for their preparation |
| US5858397A (en) | 1995-10-11 | 1999-01-12 | University Of British Columbia | Liposomal formulations of mitoxantrone |
| ATE252372T1 (de) * | 1996-08-23 | 2003-11-15 | Sequus Pharm Inc | Liposome enthaltend cisplatin |
| FR2759293B1 (fr) * | 1997-02-11 | 1999-04-30 | Ethypharm Lab Prod Ethiques | Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie |
| ES2230268T3 (es) | 2000-02-10 | 2005-05-01 | Liplasome Pharma A/S | Sistema de liberacion de farmacos basados en lipidos. |
| PT1272160E (pt) | 2000-04-12 | 2007-04-30 | Liplasome Pharma As | Sistemas de distribuição de fármacos com base lipídica para aplicação tópica. |
| US20030026831A1 (en) | 2001-04-20 | 2003-02-06 | Aparna Lakkaraju | Anionic liposomes for delivery of bioactive agents |
| CA2383259A1 (en) | 2002-04-23 | 2003-10-23 | Celator Technologies Inc. | Synergistic compositions |
| ES2387886T3 (es) | 2001-11-13 | 2012-10-03 | Celator Pharmaceuticals, Inc. | Composiciones que transportan lípidos con una mejor estabilidad sanguínea |
| US20040022842A1 (en) | 2002-06-03 | 2004-02-05 | Mebiopharm Co., Ltd. | Liposome preparations containing oxaliplatin |
| EP1643971A2 (en) | 2003-05-22 | 2006-04-12 | Neopharm, Inc. | Liposomal formulations comprising a combination of two or more active agents |
| GB0312309D0 (en) * | 2003-05-29 | 2003-07-02 | Gaslini Children S Hospital G | Targeted liposome |
| EP1795182A4 (en) | 2004-08-31 | 2012-10-03 | Astellas Pharma Inc | LIPOSOME IMPROVING INTRACELLULAR DRUG DELIVERY |
| EP1838283B1 (en) | 2004-11-03 | 2008-12-31 | Liplasome Pharma A/S | Lipid-based drug delivery systems containing unnatural phospholipase a2 degradable lipid derivatives and the therapeutic uses thereof |
| WO2007005754A2 (en) | 2005-07-01 | 2007-01-11 | Alza Corporation | Liposomal delivery vehicle for hydrophobic drugs |
| CN101040853B (zh) * | 2006-03-22 | 2010-05-12 | 上海医药工业研究院 | 一种草乌甲素多泡脂质体及其制备方法 |
| EP2004236A2 (en) | 2006-03-23 | 2008-12-24 | Liplasome Pharma A/S | Lipid based drug delivery systems comprising phospholipase a2 degradable lipids that perform an intramolecular cyclization reaction upon hydrolysis |
| CN101557801B (zh) | 2006-07-14 | 2013-10-30 | Fmc生物聚合物联合股份有限公司 | 含有低分子量藻酸盐的水凝胶和从其制备的生物构建物 |
| CN100563646C (zh) * | 2007-07-13 | 2009-12-02 | 陈祥峰 | 一种奥沙利铂脂质体葡萄糖制剂的制备方法 |
| EP2123258A1 (en) * | 2008-05-23 | 2009-11-25 | Liplasome Pharma A/S | Liposomes for drug delivery |
-
2009
- 2009-10-23 DK DKPA200901150A patent/DK177529B1/en not_active IP Right Cessation
-
2010
- 2010-10-25 PT PT107729568T patent/PT2490671E/pt unknown
- 2010-10-25 CN CN201080047402.7A patent/CN102639114B/zh active Active
- 2010-10-25 PL PL10772956T patent/PL2490671T3/pl unknown
- 2010-10-25 AU AU2010310240A patent/AU2010310240B2/en not_active Ceased
- 2010-10-25 CA CA2772973A patent/CA2772973C/en active Active
- 2010-10-25 SI SI201030638T patent/SI2490671T1/sl unknown
- 2010-10-25 US US13/503,614 patent/US9820941B2/en active Active
- 2010-10-25 EP EP10772956.8A patent/EP2490671B1/en active Active
- 2010-10-25 JP JP2012534543A patent/JP5778160B2/ja active Active
- 2010-10-25 ES ES10772956.8T patent/ES2465565T3/es active Active
- 2010-10-25 DK DK10772956.8T patent/DK2490671T3/da active
- 2010-10-25 WO PCT/DK2010/050283 patent/WO2011047689A2/en active Application Filing
- 2010-10-25 RS RS20140274A patent/RS53321B/en unknown
-
2014
- 2014-05-07 HR HRP20140413AT patent/HRP20140413T1/hr unknown
- 2014-05-30 CY CY20141100387T patent/CY1115139T1/el unknown
- 2014-06-05 SM SM201400065T patent/SMT201400065B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1115139T1 (el) | 2016-12-14 |
| WO2011047689A2 (en) | 2011-04-28 |
| AU2010310240A1 (en) | 2012-03-22 |
| CA2772973A1 (en) | 2011-04-28 |
| DK2490671T3 (da) | 2014-06-16 |
| JP5778160B2 (ja) | 2015-09-16 |
| DK200901150A (en) | 2011-04-24 |
| JP2013508315A (ja) | 2013-03-07 |
| EP2490671A2 (en) | 2012-08-29 |
| PL2490671T3 (pl) | 2014-08-29 |
| CN102639114A (zh) | 2012-08-15 |
| EP2490671B1 (en) | 2014-03-05 |
| ES2465565T3 (es) | 2014-06-06 |
| SI2490671T1 (sl) | 2014-07-31 |
| CA2772973C (en) | 2017-08-15 |
| CN102639114B (zh) | 2015-04-01 |
| RS53321B (en) | 2014-10-31 |
| AU2010310240B2 (en) | 2015-11-26 |
| WO2011047689A3 (en) | 2011-11-17 |
| US9820941B2 (en) | 2017-11-21 |
| US20120219618A1 (en) | 2012-08-30 |
| HRP20140413T1 (hr) | 2014-07-04 |
| PT2490671E (pt) | 2014-05-30 |
| SMT201400065B (it) | 2014-07-07 |
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Legal Events
| Date | Code | Title | Description |
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| PBP | Patent lapsed |
Effective date: 20231023 |