DK175919B1 - Ekspression af biologisk aktiv faktor XIII - Google Patents

Ekspression af biologisk aktiv faktor XIII Download PDF

Info

Publication number
DK175919B1
DK175919B1 DK198704914A DK491487A DK175919B1 DK 175919 B1 DK175919 B1 DK 175919B1 DK 198704914 A DK198704914 A DK 198704914A DK 491487 A DK491487 A DK 491487A DK 175919 B1 DK175919 B1 DK 175919B1
Authority
DK
Denmark
Prior art keywords
factor xiii
subunit
plasmid
host cell
sequence
Prior art date
Application number
DK198704914A
Other languages
Danish (da)
English (en)
Other versions
DK491487D0 (da
DK491487A (da
Inventor
Gary E Parker
Earl W Davie
Ronald L Seale
Akitada Ichinose
Julie Ann Holly
Original Assignee
Univ Washington
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington, Zymogenetics Inc filed Critical Univ Washington
Publication of DK491487D0 publication Critical patent/DK491487D0/da
Publication of DK491487A publication Critical patent/DK491487A/da
Application granted granted Critical
Publication of DK175919B1 publication Critical patent/DK175919B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • C12N9/1044—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK198704914A 1986-09-19 1987-09-18 Ekspression af biologisk aktiv faktor XIII DK175919B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90951286A 1986-09-19 1986-09-19
US90951286 1986-09-19

Publications (3)

Publication Number Publication Date
DK491487D0 DK491487D0 (da) 1987-09-18
DK491487A DK491487A (da) 1988-03-20
DK175919B1 true DK175919B1 (da) 2005-06-27

Family

ID=25427353

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198704914A DK175919B1 (da) 1986-09-19 1987-09-18 Ekspression af biologisk aktiv faktor XIII

Country Status (7)

Country Link
EP (1) EP0268772B1 (ja)
JP (4) JP2667405B2 (ja)
AT (1) ATE121776T1 (ja)
AU (1) AU615634B2 (ja)
CA (1) CA1341577C (ja)
DE (1) DE3751269T2 (ja)
DK (1) DK175919B1 (ja)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6746866B1 (en) 1986-03-12 2004-06-08 Aventis Behring Gmbh Preparation of factor XIIIa by gene manipulation
US6869790B1 (en) 1986-03-12 2005-03-22 Aventis Behring Gmbh Preparation of DNA encoding factor XIIIA
DE3621371A1 (de) * 1986-03-12 1987-09-17 Behringwerke Ag Gentechnische herstellung von faktor xiiia
JPH01216939A (ja) * 1988-02-24 1989-08-30 Hoechst Japan Kk 末熟児頭蓋内出血阻止剤
US5204447A (en) * 1988-11-14 1993-04-20 Zymogenetics, Inc. Purification of factor xiii
US5612456A (en) * 1988-11-14 1997-03-18 Zymogenetics, Inc. Factor XIII compositions
DE3906540A1 (de) * 1989-03-02 1990-09-13 Behringwerke Ag Expressionsvektoren zur synthese von proteinen in der spalthefe schizosaccharomyces pombe
DE3940651A1 (de) * 1989-12-08 1991-06-13 Behringwerke Ag Verfahren zur expression von fremdgenen in hefen
AU7586991A (en) * 1990-03-21 1991-10-21 Board Of Regents, The University Of Texas System Yeast expression vectors
JPH0478519U (ja) * 1990-11-16 1992-07-08
AU1268192A (en) * 1991-01-04 1992-08-17 Board Of Regents, The University Of Texas System Cloning and expression of tissue transglutaminases
ATE171071T1 (de) * 1991-12-31 1998-10-15 Zymogenetics Inc Verfahren und zusammensetzungen zur verminderung von blutverlust
AU5590394A (en) * 1992-11-03 1994-05-24 Oklahoma Medical Research Foundation Transglutaminase gene
ES2182840T3 (es) * 1993-03-30 2003-03-16 Hoechst Japan Factor xiii para el tratamiento de heridas de la piel.
WO1996021025A1 (en) * 1994-12-30 1996-07-11 Zymogenetics, Inc. Bovine factor xiii
WO1999058699A2 (en) * 1998-05-14 1999-11-18 Battelle Memorial Institute Transgenic plant-derived human blood coagulation factors
EP1337267B1 (en) * 2000-11-03 2007-04-25 ZymoGenetics, Inc. Use of blood coagulation factor xiii for treating haemophilia a
DE10101962B4 (de) * 2001-01-17 2006-07-27 Tad Pharma Gmbh DNA-Sequenz mit regulatorischen Bereichen zur Expression von Proteinen
US6890903B2 (en) 2001-10-09 2005-05-10 Zymogenetics Inc. Method for inhibiting the formation of seromas using factor XIII
US20080176789A1 (en) 2004-08-27 2008-07-24 Novc Nordisk Healthcare A/G Purification of Factor Xlll Polypeptides From Biological Materials
ATE540974T1 (de) 2004-11-23 2012-01-15 Zymogenetics Inc Reinigung des rekombinanten menschlichen faktors xiii
US20120101589A1 (en) 2009-05-12 2012-04-26 Hadasit Medical Research Services And Development Ltd. Prosthetic devices coated with heated cross-linked fibrin
KR101799151B1 (ko) * 2015-07-09 2017-11-17 정용식 비닐하우스의 고정 끈의 장력 조절 연결 구조체

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6029687B2 (ja) * 1978-11-07 1985-07-12 株式会社ミドリ十字 ヒト胎盤由来血液凝固第１０３因子の濃縮液の製造方法
EP0480480A3 (en) * 1984-05-11 1992-06-10 Chiron Corporation Enhanced yeast transcription employing hybrid promoter region constructs
DK27885A (da) * 1985-01-22 1986-07-23 Novo Industri As Fremstilling af peptider
DE3621371A1 (de) * 1986-03-12 1987-09-17 Behringwerke Ag Gentechnische herstellung von faktor xiiia

Also Published As

Publication number Publication date
DE3751269D1 (de) 1995-06-01
JP2002223756A (ja) 2002-08-13
EP0268772A3 (en) 1988-10-26
JPH09327296A (ja) 1997-12-22
DE3751269T2 (de) 1995-09-14
JP3077121B2 (ja) 2000-08-14
CA1341577C (en) 2008-07-22
JP2667405B2 (ja) 1997-10-27
AU615634B2 (en) 1991-10-10
EP0268772B1 (en) 1995-04-26
DK491487D0 (da) 1987-09-18
EP0268772A2 (en) 1988-06-01
JPH11127873A (ja) 1999-05-18
JP3299192B2 (ja) 2002-07-08
DK491487A (da) 1988-03-20
JPS63164890A (ja) 1988-07-08
JP3450844B2 (ja) 2003-09-29
AU7869487A (en) 1988-03-31
ATE121776T1 (de) 1995-05-15

Similar Documents

Publication Publication Date Title
DK175919B1 (da) Ekspression af biologisk aktiv faktor XIII
EP0090505B1 (en) Human antithrombin iii, dna sequences therefor, expression vehicles and cloning vectors containing such sequences and cell cultures transformed thereby, a process for expressing human antithrombin iii, and pharmaceutical compositions comprising it
EP0251505B1 (en) Recombinant purified protease nexin
DK175327B1 (da) Replicerbar ekspressionsvektor og rekombinant DNA-molekyle, som indkoder aktiv human livmodervævsplasminogen-aktivator, pattedyrscelle transformeret med vektoren og fremgangsmåde til fremstilling af aktiv human vævsplasminogen-aktivator (TPA)
AU663888B2 (en) Process for preparing human coagulation factor VIII protein complex
US4517294A (en) Human antithrombin III
US4937324A (en) Chromatographic purification of human proteins having anticoagulant and anti-inflammatory activity
JPS63313587A (ja) 微生物宿主細胞による第８因子活性を有するタンパク質の製造法、発現ベクタ−、宿主細胞、抗体
JP2004000255A (ja) 血管内皮細胞増殖因子の製造
WO1988009811A1 (en) Proteins and derivatives thereof
EP0293934B1 (en) Mutant t-PA with kringle replacement
AU621281B2 (en) Hybrid proteins
US4632981A (en) Human antithrombin III
JPH06502986A (ja) ハイブリッドプロテインｃ
IE881680L (en) Tissue plasminogen activator analogs having modified growth¹factor domains
JPH04505554A (ja) 可溶性トロンボモジュリン類似体
US5149533A (en) Modified t-PA with kringle-/replaced by another kringle
US5405946A (en) Recombinant protein S variants deficient in C4BP binding activity, compositions and therapeutic methods
EP0300030A1 (en) Human proteins having anticoagulant and anti-inflammatory activity
US5486471A (en) Tissue plasminogen activator analogs having modified growth factor domains
WO2017072791A1 (en) A genetically modified yeast cell and improved process for production of clot-specific streptokinase
CA1339642C (en) Recombinant purified protease nexin
JP2518832B2 (ja) 変形された組織プラスミノ−ゲンアクチベ−タ−

Legal Events

Date Code Title Description
PUP Patent expired