DK175915B1 - 5-Amino- eller substituerede amino-1,2,3-triazoler anvendelige som antiproliferative midler - Google Patents

5-Amino- eller substituerede amino-1,2,3-triazoler anvendelige som antiproliferative midler Download PDF

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Publication number
DK175915B1
DK175915B1 DK198804654A DK465488A DK175915B1 DK 175915 B1 DK175915 B1 DK 175915B1 DK 198804654 A DK198804654 A DK 198804654A DK 465488 A DK465488 A DK 465488A DK 175915 B1 DK175915 B1 DK 175915B1
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DK
Denmark
Prior art keywords
compound
amino
cyano
cells
inhibition
Prior art date
Application number
DK198804654A
Other languages
Danish (da)
English (en)
Other versions
DK465488D0 (da
DK465488A (da
Inventor
Donald Hupe
Nancy Behrens
Lawrence Argenbright
Barbara Ann Azzolina
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK465488D0 publication Critical patent/DK465488D0/da
Publication of DK465488A publication Critical patent/DK465488A/da
Application granted granted Critical
Publication of DK175915B1 publication Critical patent/DK175915B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK198804654A 1987-08-20 1988-08-19 5-Amino- eller substituerede amino-1,2,3-triazoler anvendelige som antiproliferative midler DK175915B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8749487 1987-08-20
US07/087,494 US4847257A (en) 1987-08-20 1987-08-20 5-Amino or substituted amino 1,2,3,-triazoles useful as antiproliferative agents

Publications (3)

Publication Number Publication Date
DK465488D0 DK465488D0 (da) 1988-08-19
DK465488A DK465488A (da) 1989-03-15
DK175915B1 true DK175915B1 (da) 2005-06-27

Family

ID=22205528

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198804654A DK175915B1 (da) 1987-08-20 1988-08-19 5-Amino- eller substituerede amino-1,2,3-triazoler anvendelige som antiproliferative midler

Country Status (16)

Country Link
US (2) US4847257A (xx)
EP (1) EP0304221B1 (xx)
JP (1) JP2572115B2 (xx)
KR (1) KR960014871B1 (xx)
AT (1) ATE101513T1 (xx)
AU (1) AU612172B2 (xx)
CA (1) CA1325977C (xx)
CY (1) CY1954A (xx)
DE (1) DE3887793T2 (xx)
DK (1) DK175915B1 (xx)
HK (1) HK107596A (xx)
IE (1) IE61719B1 (xx)
IL (1) IL87421A (xx)
NZ (1) NZ225770A (xx)
PT (1) PT88275B (xx)
ZA (1) ZA886125B (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5880129A (en) * 1989-05-19 1999-03-09 The United States Of America As Represented By The Department Of Health And Human Services Methods of inhibiting invasion and metastasis of malignant solid tumors
US5498620A (en) * 1989-05-19 1996-03-12 The United States Of America As Represented By The Department Of Health And Human Services Signal transduction inhibitor 1,2,3-triazolo compounds
US5132315A (en) * 1989-05-19 1992-07-21 The United States Of America As Represented By The Department Of Health And Human Services Therapeutic application of an anti-invasive compound
US5359078A (en) * 1989-05-19 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Signal transduction inhibitor compounds
JP3095413B2 (ja) * 1990-12-28 2000-10-03 帝人株式会社 ベンゾオキサ縮合環化合物
US5602156A (en) * 1993-09-17 1997-02-11 The United States Of America As Represented By The Department Of Health And Human Services Method for inhibiting metalloproteinase expression
US5744492A (en) * 1993-09-17 1998-04-28 United States Of America Method for inhibiting angiogenesis
US5728707A (en) * 1995-07-21 1998-03-17 Constantia Gruppe Treatment and prevention of primary and metastatic neoplasms with salts of aminoimidazole carboxamide
EP0840608B1 (en) * 1995-07-21 2004-10-06 Savvipharm Inc. Orotate salts of 5-amino or substituted amino 1,2,3-triazoles for treatment of neoplasms
US8198334B2 (en) * 1997-10-27 2012-06-12 Pathologica Llc Methods for modulating macrophage proliferation in ocular disease using polyamine analogs
US7087648B1 (en) * 1997-10-27 2006-08-08 The Regents Of The University Of California Methods for modulating macrophage proliferation using polyamine analogs
US5886038A (en) * 1998-03-24 1999-03-23 Panda Pharmaceuticals, L.L.C. Composition and method for treatment of psoriasis
US5990100A (en) * 1998-03-24 1999-11-23 Panda Pharmaceuticals, L.L.C. Composition and method for treatment of psoriasis
US6702801B2 (en) * 1998-05-07 2004-03-09 Kimberly-Clark Worldwide, Inc. Absorbent garment with an extensible backsheet
EP1799200A1 (en) * 2004-10-04 2007-06-27 Cellgate, Inc. Polyamine analogs as therapeutic agents for ocular diseases
US7531560B2 (en) * 2004-11-10 2009-05-12 Boehringer Ingelheim Pharmaceuticals, Inc. Anti-cytokine heterocyclic compounds
CN101164538B (zh) * 2006-10-16 2011-12-14 中国医学科学院基础医学研究所 羧胺三唑类化合物及其盐在制备治疗疼痛性疾病和/或炎症性疾病的药物中的应用
CN104817507A (zh) * 2009-09-04 2015-08-05 巧妙疗法股份有限公司 用于制备5-氨基或取代的氨基1,2,3-三唑和三唑乳清酸盐制剂的新组合物和方法
CN112358451B (zh) * 2021-01-11 2021-04-13 广东银珠医药科技有限公司 羧胺三唑的合成方法
CN113620892B (zh) * 2021-10-12 2022-02-22 广东银珠医药科技有限公司 羧胺三唑单晶、制备方法及其组合物和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4590201A (en) * 1984-02-02 1986-05-20 Merck & Co., Inc. 5-amino or substituted amino 1,2,3-triazoles

Also Published As

Publication number Publication date
IL87421A0 (en) 1989-01-31
EP0304221A2 (en) 1989-02-22
CY1954A (en) 1997-05-16
US4847257A (en) 1989-07-11
EP0304221A3 (en) 1990-09-05
IE61719B1 (en) 1994-11-30
DE3887793D1 (de) 1994-03-24
KR890003385A (ko) 1989-04-14
JP2572115B2 (ja) 1997-01-16
CA1325977C (en) 1994-01-11
ATE101513T1 (de) 1994-03-15
AU612172B2 (en) 1991-07-04
US5045543A (en) 1991-09-03
NZ225770A (en) 1991-11-26
JPS6468321A (en) 1989-03-14
HK107596A (en) 1996-06-28
EP0304221B1 (en) 1994-02-16
DK465488D0 (da) 1988-08-19
KR960014871B1 (ko) 1996-10-21
PT88275B (pt) 1995-03-01
ZA886125B (en) 1989-04-26
IE882551L (en) 1989-02-20
DK465488A (da) 1989-03-15
DE3887793T2 (de) 1994-07-28
AU2115988A (en) 1989-03-16
IL87421A (en) 1992-12-01
PT88275A (pt) 1989-06-30

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