ATE101513T1 - 5-amino- oder substituierte amino-1,2,3-triazole, verwendbar als antiproliferativa. - Google Patents

5-amino- oder substituierte amino-1,2,3-triazole, verwendbar als antiproliferativa.

Info

Publication number
ATE101513T1
ATE101513T1 AT88307418T AT88307418T ATE101513T1 AT E101513 T1 ATE101513 T1 AT E101513T1 AT 88307418 T AT88307418 T AT 88307418T AT 88307418 T AT88307418 T AT 88307418T AT E101513 T1 ATE101513 T1 AT E101513T1
Authority
AT
Austria
Prior art keywords
amino
antiproliferants
triazole
usable
substituted amino
Prior art date
Application number
AT88307418T
Other languages
English (en)
Inventor
Donald Hupe
Barbara A Azzolina
Lawrence Argenbright
Nancy Behrens
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE101513T1 publication Critical patent/ATE101513T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT88307418T 1987-08-20 1988-08-11 5-amino- oder substituierte amino-1,2,3-triazole, verwendbar als antiproliferativa. ATE101513T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/087,494 US4847257A (en) 1987-08-20 1987-08-20 5-Amino or substituted amino 1,2,3,-triazoles useful as antiproliferative agents
EP88307418A EP0304221B1 (de) 1987-08-20 1988-08-11 5-Amino- oder substituierte Amino-1,2,3-Triazole, verwendbar als Antiproliferativa

Publications (1)

Publication Number Publication Date
ATE101513T1 true ATE101513T1 (de) 1994-03-15

Family

ID=22205528

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88307418T ATE101513T1 (de) 1987-08-20 1988-08-11 5-amino- oder substituierte amino-1,2,3-triazole, verwendbar als antiproliferativa.

Country Status (16)

Country Link
US (2) US4847257A (de)
EP (1) EP0304221B1 (de)
JP (1) JP2572115B2 (de)
KR (1) KR960014871B1 (de)
AT (1) ATE101513T1 (de)
AU (1) AU612172B2 (de)
CA (1) CA1325977C (de)
CY (1) CY1954A (de)
DE (1) DE3887793T2 (de)
DK (1) DK175915B1 (de)
HK (1) HK107596A (de)
IE (1) IE61719B1 (de)
IL (1) IL87421A (de)
NZ (1) NZ225770A (de)
PT (1) PT88275B (de)
ZA (1) ZA886125B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5359078A (en) * 1989-05-19 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Signal transduction inhibitor compounds
US5132315A (en) * 1989-05-19 1992-07-21 The United States Of America As Represented By The Department Of Health And Human Services Therapeutic application of an anti-invasive compound
US5880129A (en) * 1989-05-19 1999-03-09 The United States Of America As Represented By The Department Of Health And Human Services Methods of inhibiting invasion and metastasis of malignant solid tumors
US5498620A (en) * 1989-05-19 1996-03-12 The United States Of America As Represented By The Department Of Health And Human Services Signal transduction inhibitor 1,2,3-triazolo compounds
ES2145743T3 (es) * 1990-12-28 2000-07-16 Teijin Ltd Compuesto de anillo condensado benzoxa, su produccion y composicion farmaceutica que lo contiene.
US5602156A (en) * 1993-09-17 1997-02-11 The United States Of America As Represented By The Department Of Health And Human Services Method for inhibiting metalloproteinase expression
US5744492A (en) * 1993-09-17 1998-04-28 United States Of America Method for inhibiting angiogenesis
ATE278399T1 (de) * 1995-07-21 2004-10-15 Savvipharm Inc Orotatsalze von 5-amino- oder substituierten amino-1,2,3-triazolen zur behandlung von neoplasmen
US5728707A (en) * 1995-07-21 1998-03-17 Constantia Gruppe Treatment and prevention of primary and metastatic neoplasms with salts of aminoimidazole carboxamide
US8198334B2 (en) * 1997-10-27 2012-06-12 Pathologica Llc Methods for modulating macrophage proliferation in ocular disease using polyamine analogs
US7087648B1 (en) 1997-10-27 2006-08-08 The Regents Of The University Of California Methods for modulating macrophage proliferation using polyamine analogs
US5990100A (en) * 1998-03-24 1999-11-23 Panda Pharmaceuticals, L.L.C. Composition and method for treatment of psoriasis
US5886038A (en) * 1998-03-24 1999-03-23 Panda Pharmaceuticals, L.L.C. Composition and method for treatment of psoriasis
US6702801B2 (en) * 1998-05-07 2004-03-09 Kimberly-Clark Worldwide, Inc. Absorbent garment with an extensible backsheet
WO2006041805A1 (en) * 2004-10-04 2006-04-20 Cellgate, Inc. Polyamine analogs as therapeutic agents for ocular diseases
US7531560B2 (en) * 2004-11-10 2009-05-12 Boehringer Ingelheim Pharmaceuticals, Inc. Anti-cytokine heterocyclic compounds
CN101164538B (zh) * 2006-10-16 2011-12-14 中国医学科学院基础医学研究所 羧胺三唑类化合物及其盐在制备治疗疼痛性疾病和/或炎症性疾病的药物中的应用
RU2594155C2 (ru) * 2009-09-04 2016-08-10 Тэктикал Терапеутикс, Инк Новые композиции и способы получения 5-амино- или замещенных амино-1,2,3-триазолов и триазол-оротатных композиций
CN112358451B (zh) * 2021-01-11 2021-04-13 广东银珠医药科技有限公司 羧胺三唑的合成方法
CN113620892B (zh) * 2021-10-12 2022-02-22 广东银珠医药科技有限公司 羧胺三唑单晶、制备方法及其组合物和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4590201A (en) * 1984-02-02 1986-05-20 Merck & Co., Inc. 5-amino or substituted amino 1,2,3-triazoles

Also Published As

Publication number Publication date
JPS6468321A (en) 1989-03-14
IL87421A0 (en) 1989-01-31
AU2115988A (en) 1989-03-16
KR960014871B1 (ko) 1996-10-21
IE882551L (en) 1989-02-20
US4847257A (en) 1989-07-11
EP0304221B1 (de) 1994-02-16
HK107596A (en) 1996-06-28
KR890003385A (ko) 1989-04-14
DK465488A (da) 1989-03-15
EP0304221A2 (de) 1989-02-22
IE61719B1 (en) 1994-11-30
CY1954A (en) 1997-05-16
DK175915B1 (da) 2005-06-27
JP2572115B2 (ja) 1997-01-16
US5045543A (en) 1991-09-03
NZ225770A (en) 1991-11-26
ZA886125B (en) 1989-04-26
PT88275B (pt) 1995-03-01
AU612172B2 (en) 1991-07-04
PT88275A (pt) 1989-06-30
DE3887793D1 (de) 1994-03-24
CA1325977C (en) 1994-01-11
IL87421A (en) 1992-12-01
EP0304221A3 (en) 1990-09-05
DE3887793T2 (de) 1994-07-28
DK465488D0 (da) 1988-08-19

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time