DK175369B1 - Anvendelse af tPA-varianter til fremstilling af et terapeutisk præparat til behandling af vaskulæresygdomme - Google Patents

Anvendelse af tPA-varianter til fremstilling af et terapeutisk præparat til behandling af vaskulæresygdomme Download PDF

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Publication number
DK175369B1
DK175369B1 DK198906754A DK675489A DK175369B1 DK 175369 B1 DK175369 B1 DK 175369B1 DK 198906754 A DK198906754 A DK 198906754A DK 675489 A DK675489 A DK 675489A DK 175369 B1 DK175369 B1 DK 175369B1
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Denmark
Prior art keywords
variant
natural
life
approx
protein
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Application number
DK198906754A
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Danish (da)
English (en)
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DK675489A (da
DK675489D0 (da
Inventor
Deborah L Higgins
Adair J Hotchkiss
William E Holmes
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority claimed from US07/188,237 external-priority patent/US4935237A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK675489D0 publication Critical patent/DK675489D0/da
Publication of DK675489A publication Critical patent/DK675489A/da
Application granted granted Critical
Publication of DK175369B1 publication Critical patent/DK175369B1/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK198906754A 1987-06-30 1989-12-29 Anvendelse af tPA-varianter til fremstilling af et terapeutisk præparat til behandling af vaskulæresygdomme DK175369B1 (da)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US6844887A 1987-06-30 1987-06-30
US6844887 1987-06-30
US17097088A 1988-03-21 1988-03-21
US17097088 1988-03-21
US07/188,237 US4935237A (en) 1988-03-21 1988-04-29 Processes for the preparation of t-PA mutants
US18823788 1988-04-29
PCT/US1988/002175 WO1989000197A1 (en) 1987-06-30 1988-06-27 Improved processes for the treatment of vascular disease
US8802175 1988-06-27

Publications (3)

Publication Number Publication Date
DK675489D0 DK675489D0 (da) 1989-12-29
DK675489A DK675489A (da) 1990-02-28
DK175369B1 true DK175369B1 (da) 2004-09-13

Family

ID=27371343

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198906754A DK175369B1 (da) 1987-06-30 1989-12-29 Anvendelse af tPA-varianter til fremstilling af et terapeutisk præparat til behandling af vaskulæresygdomme

Country Status (7)

Country Link
EP (1) EP0365597B2 (de)
JP (2) JPH02504102A (de)
CA (1) CA1340942C (de)
DE (1) DE3886755T3 (de)
DK (1) DK175369B1 (de)
NZ (1) NZ225200A (de)
WO (1) WO1989000197A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2534332B2 (ja) * 1987-10-29 1996-09-11 山之内製薬株式会社 ポリペプチド化合物
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
EP0462651A1 (de) * 1990-06-15 1991-12-27 Leuven Research & Development V.Z.W. Chimäre Plasminogenaktivatoren
ES2082465T3 (es) * 1991-04-16 1996-03-16 Boehringer Mannheim Gmbh Unidad farmaceutica de envasado que contiene activadores de plasminogeno para la administracion multiple de bolos.
AU664469B2 (en) * 1992-06-03 1995-11-16 Genentech Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties
US6139838A (en) * 1996-09-06 2000-10-31 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Tissue plasminogen activator medicinal composition

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8508717D0 (en) * 1985-04-03 1985-05-09 Beecham Group Plc Composition
NZ215660A (en) * 1985-04-04 1990-03-27 Beecham Group Plc Tissue plasminogen activator modified in the growth factor domain
IL78571A (en) * 1985-04-22 1991-06-30 Genentech Inc Human tissue plasminogen activator mutants resistant to enzymatic cleavage resulting in two-chain form
NZ217331A (en) * 1985-08-26 1989-05-29 Lilly Co Eli Tissue plasminogen activator derivatives and genetically engineered product
WO1987004722A1 (en) * 1986-01-31 1987-08-13 Genetics Institute, Inc. Novel thrombolytic proteins

Also Published As

Publication number Publication date
EP0365597B1 (de) 1993-12-29
NZ225200A (en) 1991-03-26
DK675489A (da) 1990-02-28
DK675489D0 (da) 1989-12-29
CA1340942C (en) 2000-04-04
WO1989000197A1 (en) 1989-01-12
DE3886755D1 (de) 1994-02-10
EP0365597B2 (de) 2005-02-09
JPH1080271A (ja) 1998-03-31
DE3886755T2 (de) 1994-05-26
DE3886755T3 (de) 2005-12-08
EP0365597A1 (de) 1990-05-02
JPH02504102A (ja) 1990-11-29

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