DK675489A - Anvendelse af tpa-varianter til fremstilling af et terapeutisk praeparat til behandling af vaskulaere sygdomme - Google Patents

Anvendelse af tpa-varianter til fremstilling af et terapeutisk praeparat til behandling af vaskulaere sygdomme Download PDF

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Publication number
DK675489A
DK675489A DK675489A DK675489A DK675489A DK 675489 A DK675489 A DK 675489A DK 675489 A DK675489 A DK 675489A DK 675489 A DK675489 A DK 675489A DK 675489 A DK675489 A DK 675489A
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DK
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Prior art keywords
preparation
tpa
variations
treatment
application
Prior art date
Application number
DK675489A
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English (en)
Other versions
DK175369B1 (da
DK675489D0 (da
Inventor
Deborah L Higgins
William E Holmes
Adair J Hotchkiss
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27371343&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK675489(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/188,237 external-priority patent/US4935237A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK675489D0 publication Critical patent/DK675489D0/da
Publication of DK675489A publication Critical patent/DK675489A/da
Application granted granted Critical
Publication of DK175369B1 publication Critical patent/DK175369B1/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK198906754A 1987-06-30 1989-12-29 Anvendelse af tPA-varianter til fremstilling af et terapeutisk præparat til behandling af vaskulæresygdomme DK175369B1 (da)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US6844887A 1987-06-30 1987-06-30
US6844887 1987-06-30
US17097088A 1988-03-21 1988-03-21
US17097088 1988-03-21
US07/188,237 US4935237A (en) 1988-03-21 1988-04-29 Processes for the preparation of t-PA mutants
US18823788 1988-04-29
PCT/US1988/002175 WO1989000197A1 (en) 1987-06-30 1988-06-27 Improved processes for the treatment of vascular disease
US8802175 1988-06-27

Publications (3)

Publication Number Publication Date
DK675489D0 DK675489D0 (da) 1989-12-29
DK675489A true DK675489A (da) 1990-02-28
DK175369B1 DK175369B1 (da) 2004-09-13

Family

ID=27371343

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198906754A DK175369B1 (da) 1987-06-30 1989-12-29 Anvendelse af tPA-varianter til fremstilling af et terapeutisk præparat til behandling af vaskulæresygdomme

Country Status (7)

Country Link
EP (1) EP0365597B2 (da)
JP (2) JPH02504102A (da)
CA (1) CA1340942C (da)
DE (1) DE3886755T3 (da)
DK (1) DK175369B1 (da)
NZ (1) NZ225200A (da)
WO (1) WO1989000197A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2534332B2 (ja) * 1987-10-29 1996-09-11 山之内製薬株式会社 ポリペプチド化合物
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
EP0462651A1 (en) * 1990-06-15 1991-12-27 Leuven Research & Development V.Z.W. Chimeric plasminogen activators
ES2082465T3 (es) * 1991-04-16 1996-03-16 Boehringer Mannheim Gmbh Unidad farmaceutica de envasado que contiene activadores de plasminogeno para la administracion multiple de bolos.
DK0643772T3 (da) * 1992-06-03 1998-02-02 Genentech Inc Glycosyleringsvarianter af vævsplasminogenaktivator med forbedrede terapeutiske egenskaber
DK0827751T3 (da) * 1996-09-06 2003-03-31 Chemo Sero Therapeut Res Inst Medicinsk præparat indeholdende vævsplasminogenaktivator og nicotinamid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8508717D0 (en) * 1985-04-03 1985-05-09 Beecham Group Plc Composition
GR860875B (en) * 1985-04-04 1986-07-29 Beecham Group Plc Novel compounds
HU206520B (en) * 1985-04-22 1992-11-30 Genentech Inc Process for producing new human tissue plasminogen activator /tpa/ mutants and pharmaceutical compositions containing them
NZ217331A (en) * 1985-08-26 1989-05-29 Lilly Co Eli Tissue plasminogen activator derivatives and genetically engineered product
EP0293394B2 (en) * 1986-01-31 2003-10-29 Genetics Institute, LLC Novel thrombolytic proteins

Also Published As

Publication number Publication date
NZ225200A (en) 1991-03-26
EP0365597B1 (en) 1993-12-29
DE3886755T2 (de) 1994-05-26
CA1340942C (en) 2000-04-04
DE3886755D1 (de) 1994-02-10
JPH02504102A (ja) 1990-11-29
WO1989000197A1 (en) 1989-01-12
DE3886755T3 (de) 2005-12-08
DK175369B1 (da) 2004-09-13
DK675489D0 (da) 1989-12-29
JPH1080271A (ja) 1998-03-31
EP0365597B2 (en) 2005-02-09
EP0365597A1 (en) 1990-05-02

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