DK675489A - Anvendelse af tpa-varianter til fremstilling af et terapeutisk praeparat til behandling af vaskulaere sygdomme - Google Patents

Anvendelse af tpa-varianter til fremstilling af et terapeutisk praeparat til behandling af vaskulaere sygdomme Download PDF

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Publication number
DK675489A
DK675489A DK675489A DK675489A DK675489A DK 675489 A DK675489 A DK 675489A DK 675489 A DK675489 A DK 675489A DK 675489 A DK675489 A DK 675489A DK 675489 A DK675489 A DK 675489A
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DK
Denmark
Prior art keywords
preparation
tpa
variations
treatment
application
Prior art date
Application number
DK675489A
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English (en)
Other versions
DK675489D0 (da
DK175369B1 (da
Inventor
Deborah L Higgins
William E Holmes
Adair J Hotchkiss
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27371343&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK675489(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/188,237 external-priority patent/US4935237A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK675489D0 publication Critical patent/DK675489D0/da
Publication of DK675489A publication Critical patent/DK675489A/da
Application granted granted Critical
Publication of DK175369B1 publication Critical patent/DK175369B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK198906754A 1987-06-30 1989-12-29 Anvendelse af tPA-varianter til fremstilling af et terapeutisk præparat til behandling af vaskulæresygdomme DK175369B1 (da)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US6844887A 1987-06-30 1987-06-30
US6844887 1987-06-30
US17097088A 1988-03-21 1988-03-21
US17097088 1988-03-21
US07/188,237 US4935237A (en) 1988-03-21 1988-04-29 Processes for the preparation of t-PA mutants
US18823788 1988-04-29
US8802175 1988-06-27
PCT/US1988/002175 WO1989000197A1 (en) 1987-06-30 1988-06-27 Improved processes for the treatment of vascular disease

Publications (3)

Publication Number Publication Date
DK675489D0 DK675489D0 (da) 1989-12-29
DK675489A true DK675489A (da) 1990-02-28
DK175369B1 DK175369B1 (da) 2004-09-13

Family

ID=27371343

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198906754A DK175369B1 (da) 1987-06-30 1989-12-29 Anvendelse af tPA-varianter til fremstilling af et terapeutisk præparat til behandling af vaskulæresygdomme

Country Status (7)

Country Link
EP (1) EP0365597B2 (da)
JP (2) JPH02504102A (da)
CA (1) CA1340942C (da)
DE (1) DE3886755T3 (da)
DK (1) DK175369B1 (da)
NZ (1) NZ225200A (da)
WO (1) WO1989000197A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2534332B2 (ja) * 1987-10-29 1996-09-11 山之内製薬株式会社 ポリペプチド化合物
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
EP0462651A1 (en) * 1990-06-15 1991-12-27 Leuven Research & Development V.Z.W. Chimeric plasminogen activators
DE59204945D1 (de) * 1991-04-16 1996-02-15 Boehringer Mannheim Gmbh Pharmazeutische verpackungseinheit enthaltend plasminogenaktivatoren zur mehrfachbolusgabe
NZ253556A (en) * 1992-06-03 1995-11-27 Genentech Inc Tissue plasminogen activator (t-pa) variants (with extended circulatory half-life and/or potency); preparation, compositions, host cells, dna sequences, and expression vehicles thereof
DE69719265T2 (de) * 1996-09-06 2003-12-04 Chemo Sero Therapeut Res Inst Medizinische Zusammensetzung die Gewebeplasminogenaktivator und Nikotinamid enthält

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8508717D0 (en) * 1985-04-03 1985-05-09 Beecham Group Plc Composition
NZ215660A (en) * 1985-04-04 1990-03-27 Beecham Group Plc Tissue plasminogen activator modified in the growth factor domain
EP0199574B1 (en) * 1985-04-22 1991-10-23 Genentech, Inc. Human tissue plasminogen activator mutants, methods and intermediates therefor, and compositions using such mutants
NZ217331A (en) * 1985-08-26 1989-05-29 Lilly Co Eli Tissue plasminogen activator derivatives and genetically engineered product
EP0293394B2 (en) * 1986-01-31 2003-10-29 Genetics Institute, LLC Novel thrombolytic proteins

Also Published As

Publication number Publication date
DK675489D0 (da) 1989-12-29
EP0365597A1 (en) 1990-05-02
DK175369B1 (da) 2004-09-13
NZ225200A (en) 1991-03-26
DE3886755T3 (de) 2005-12-08
WO1989000197A1 (en) 1989-01-12
CA1340942C (en) 2000-04-04
DE3886755T2 (de) 1994-05-26
EP0365597B1 (en) 1993-12-29
JPH1080271A (ja) 1998-03-31
EP0365597B2 (en) 2005-02-09
JPH02504102A (ja) 1990-11-29
DE3886755D1 (de) 1994-02-10

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