DK1734997T3 - Natalizumab for use in the treatment of diseases requiring steroid treatment - Google Patents

Info

Publication number

DK1734997T3

DK1734997T3 DK05768245.2T DK05768245T DK1734997T3 DK 1734997 T3 DK1734997 T3 DK 1734997T3 DK 05768245 T DK05768245 T DK 05768245T DK 1734997 T3 DK1734997 T3 DK 1734997T3

Authority

DK

Denmark

Prior art keywords

disease

natalizumab

steroid

antibody

human subject

Prior art date

2004-04-01

Links

• Espacenet
• Global Dossier
• Discuss

• 150000003431 steroids Chemical class 0.000 title claims description 145
• 229960005027 natalizumab Drugs 0.000 title claims description 140
• 238000011282 treatment Methods 0.000 title claims description 122
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 109
• 201000010099 disease Diseases 0.000 title claims description 104
• 201000006417 multiple sclerosis Diseases 0.000 claims description 86
• 239000000203 mixture Substances 0.000 claims description 82
• 208000011231 Crohn disease Diseases 0.000 claims description 79
• 239000003814 drug Substances 0.000 claims description 72
• 239000003795 chemical substances by application Substances 0.000 claims description 71
• 239000012634 fragment Substances 0.000 claims description 67
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 57
• 206010039073 rheumatoid arthritis Diseases 0.000 claims description 57
• 208000024908 graft versus host disease Diseases 0.000 claims description 55
• 208000009329 Graft vs Host Disease Diseases 0.000 claims description 54
• 208000006673 asthma Diseases 0.000 claims description 38
• 208000006045 Spondylarthropathies Diseases 0.000 claims description 30
• 201000005671 spondyloarthropathy Diseases 0.000 claims description 30
• 238000002360 preparation method Methods 0.000 claims description 28
• 239000003018 immunosuppressive agent Substances 0.000 claims description 27
• 230000001684 chronic effect Effects 0.000 claims description 25
• KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 claims description 25
• 238000002560 therapeutic procedure Methods 0.000 claims description 23
• 229960004963 mesalazine Drugs 0.000 claims description 22
• 230000001419 dependent effect Effects 0.000 claims description 21
• 206010009900 Colitis ulcerative Diseases 0.000 claims description 20
• 201000006704 Ulcerative Colitis Diseases 0.000 claims description 19
• 229940125721 immunosuppressive agent Drugs 0.000 claims description 18
• 201000001263 Psoriatic Arthritis Diseases 0.000 claims description 16
• 208000036824 Psoriatic arthropathy Diseases 0.000 claims description 16
• 238000002648 combination therapy Methods 0.000 claims description 13
• 230000007423 decrease Effects 0.000 claims description 12
• 208000002574 reactive arthritis Diseases 0.000 claims description 12
• 206010002556 Ankylosing Spondylitis Diseases 0.000 claims description 11
• 208000033464 Reiter syndrome Diseases 0.000 claims description 11
• 229960003444 immunosuppressant agent Drugs 0.000 claims description 10
• 239000000890 drug combination Substances 0.000 claims description 8
• GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims description 8
• 210000004369 blood Anatomy 0.000 claims description 7
• 239000008280 blood Substances 0.000 claims description 7
• NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 claims description 7
• 229960000598 infliximab Drugs 0.000 claims description 6
• UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 claims description 5
• LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims description 5
• 229960002170 azathioprine Drugs 0.000 claims description 5
• 230000001861 immunosuppressant effect Effects 0.000 claims description 5
• 238000007911 parenteral administration Methods 0.000 claims description 5
• 229960001940 sulfasalazine Drugs 0.000 claims description 5
• NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 claims description 5
• 229960001428 mercaptopurine Drugs 0.000 claims description 4
• 201000002661 Spondylitis Diseases 0.000 claims description 3
• 208000023002 juvenile spondyloarthropathy Diseases 0.000 claims description 3
• 230000003442 weekly effect Effects 0.000 claims description 3
• 206010011224 Cough Diseases 0.000 claims description 2
• HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 claims description 2
• 229940014456 mycophenolate Drugs 0.000 claims description 2
• HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 claims description 2
• 108060003951 Immunoglobulin Proteins 0.000 description 102
• 102000018358 immunoglobulin Human genes 0.000 description 102
• 241000699666 Mus <mouse, genus> Species 0.000 description 93
• 108010044426 integrins Proteins 0.000 description 93
• 102000006495 integrins Human genes 0.000 description 93
• 235000001014 amino acid Nutrition 0.000 description 87
• 229940024606 amino acid Drugs 0.000 description 78
• 150000001413 amino acids Chemical class 0.000 description 77
• 230000027455 binding Effects 0.000 description 68
• 210000004027 cell Anatomy 0.000 description 66
• 238000000034 method Methods 0.000 description 65
• 108090000623 proteins and genes Proteins 0.000 description 62
• 206010061218 Inflammation Diseases 0.000 description 60
• 230000004054 inflammatory process Effects 0.000 description 60
• 229940079593 drug Drugs 0.000 description 58
• 235000018102 proteins Nutrition 0.000 description 52
• 102000004169 proteins and genes Human genes 0.000 description 52
• 230000004044 response Effects 0.000 description 50
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 46
• 239000000902 placebo Substances 0.000 description 44
• 229940068196 placebo Drugs 0.000 description 44
• 239000000427 antigen Substances 0.000 description 43
• 108091007433 antigens Proteins 0.000 description 41
• 102000036639 antigens Human genes 0.000 description 41
• 208000024891 symptom Diseases 0.000 description 41
• 238000001802 infusion Methods 0.000 description 40
• 108090000765 processed proteins & peptides Proteins 0.000 description 39
• 230000000694 effects Effects 0.000 description 38
• 125000003275 alpha amino acid group Chemical group 0.000 description 37
• 238000003556 assay Methods 0.000 description 37
• 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 description 35
• 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 description 35
• 238000006467 substitution reaction Methods 0.000 description 34
• 239000003446 ligand Substances 0.000 description 33
• 108010008212 Integrin alpha4beta1 Proteins 0.000 description 32
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 31
• 239000003153 chemical reaction reagent Substances 0.000 description 31
• 150000001875 compounds Chemical class 0.000 description 30
• 241001529936 Murinae Species 0.000 description 29
• 102000004196 processed proteins & peptides Human genes 0.000 description 29
• 241001465754 Metazoa Species 0.000 description 26
• 108020004414 DNA Proteins 0.000 description 24
• 229920001184 polypeptide Polymers 0.000 description 23
• 238000009472 formulation Methods 0.000 description 21
• 229940072221 immunoglobulins Drugs 0.000 description 21
• 108091033319 polynucleotide Proteins 0.000 description 21
• 102000040430 polynucleotide Human genes 0.000 description 21
• 239000002157 polynucleotide Substances 0.000 description 21
• 238000001990 intravenous administration Methods 0.000 description 20
• 239000000126 substance Substances 0.000 description 19
• 102100024952 Protein CBFA2T1 Human genes 0.000 description 18
• 210000004698 lymphocyte Anatomy 0.000 description 18
• 102000005962 receptors Human genes 0.000 description 18
• 108020003175 receptors Proteins 0.000 description 18
• 238000001727 in vivo Methods 0.000 description 17
• 230000003993 interaction Effects 0.000 description 17
• 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 16
• 238000006243 chemical reaction Methods 0.000 description 16
• 238000002483 medication Methods 0.000 description 16
• 241000894007 species Species 0.000 description 16
• 210000001519 tissue Anatomy 0.000 description 16
• 108091028043 Nucleic acid sequence Proteins 0.000 description 15
• 208000012997 experimental autoimmune encephalomyelitis Diseases 0.000 description 15
• 210000000987 immune system Anatomy 0.000 description 15
• 241001122767 Theaceae Species 0.000 description 14
• 125000000539 amino acid group Chemical group 0.000 description 14
• 206010003246 arthritis Diseases 0.000 description 14
• 230000008859 change Effects 0.000 description 14
• 108020001507 fusion proteins Proteins 0.000 description 14
• 102000037865 fusion proteins Human genes 0.000 description 14
• 210000000265 leukocyte Anatomy 0.000 description 14
• 230000001225 therapeutic effect Effects 0.000 description 14
• 230000037396 body weight Effects 0.000 description 13
• -1 inhalation Substances 0.000 description 13
• 210000001503 joint Anatomy 0.000 description 13
• 210000002966 serum Anatomy 0.000 description 13
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 12
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 12
• 230000001965 increasing effect Effects 0.000 description 12
• 208000015181 infectious disease Diseases 0.000 description 12
• 239000000047 product Substances 0.000 description 12
• 230000000750 progressive effect Effects 0.000 description 12
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 11
• 238000004458 analytical method Methods 0.000 description 11
• 230000004071 biological effect Effects 0.000 description 11
• 239000000539 dimer Substances 0.000 description 11
• 230000014509 gene expression Effects 0.000 description 11
• 239000008194 pharmaceutical composition Substances 0.000 description 11
• 108010074051 C-Reactive Protein Proteins 0.000 description 10
• 102100032752 C-reactive protein Human genes 0.000 description 10
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 10
• 229910052737 gold Inorganic materials 0.000 description 10
• 239000010931 gold Substances 0.000 description 10
• 210000000936 intestine Anatomy 0.000 description 10
• 239000012071 phase Substances 0.000 description 10
• 102000016359 Fibronectins Human genes 0.000 description 9
• 108010067306 Fibronectins Proteins 0.000 description 9
• 210000001744 T-lymphocyte Anatomy 0.000 description 9
• 108010086434 alanyl-seryl-glycine Proteins 0.000 description 9
• 238000005516 engineering process Methods 0.000 description 9
• 230000002757 inflammatory effect Effects 0.000 description 9
• 239000002773 nucleotide Substances 0.000 description 9
• 229920000642 polymer Polymers 0.000 description 9
• 239000004475 Arginine Substances 0.000 description 8
• 206010019233 Headaches Diseases 0.000 description 8
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 8
• 230000002411 adverse Effects 0.000 description 8
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 8
• 238000010276 construction Methods 0.000 description 8
• 238000013461 design Methods 0.000 description 8
• 210000001035 gastrointestinal tract Anatomy 0.000 description 8
• 231100000869 headache Toxicity 0.000 description 8
• 230000028993 immune response Effects 0.000 description 8
• 230000004968 inflammatory condition Effects 0.000 description 8
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 8
• 125000003729 nucleotide group Chemical group 0.000 description 8
• 230000001575 pathological effect Effects 0.000 description 8
• 239000000523 sample Substances 0.000 description 8
• 238000012360 testing method Methods 0.000 description 8
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 7
• KPSHWSWFPUDEGF-FXQIFTODSA-N Asp-Pro-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC(O)=O KPSHWSWFPUDEGF-FXQIFTODSA-N 0.000 description 7
• TVTZEOHWHUVYCG-KYNKHSRBSA-N Gly-Thr-Thr Chemical compound [H]NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O TVTZEOHWHUVYCG-KYNKHSRBSA-N 0.000 description 7
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 7
• KWUKZRFFKPLUPE-HJGDQZAQSA-N Lys-Asp-Thr Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O KWUKZRFFKPLUPE-HJGDQZAQSA-N 0.000 description 7
• 241000699670 Mus sp. Species 0.000 description 7
• ZVJGAXNBBKPYOE-HKUYNNGSSA-N Phe-Trp-Gly Chemical compound C([C@H](N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(O)=O)C1=CC=CC=C1 ZVJGAXNBBKPYOE-HKUYNNGSSA-N 0.000 description 7
• 206010037660 Pyrexia Diseases 0.000 description 7
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 7
• HTONZBWRYUKUKC-RCWTZXSCSA-N Val-Thr-Val Chemical compound CC(C)[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(O)=O HTONZBWRYUKUKC-RCWTZXSCSA-N 0.000 description 7
• 206010047700 Vomiting Diseases 0.000 description 7
• 230000001154 acute effect Effects 0.000 description 7
• 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 7
• 239000000872 buffer Substances 0.000 description 7
• 210000001072 colon Anatomy 0.000 description 7
• 239000000356 contaminant Substances 0.000 description 7
• 238000013270 controlled release Methods 0.000 description 7
• 210000002889 endothelial cell Anatomy 0.000 description 7
• 230000001900 immune effect Effects 0.000 description 7
• 238000000338 in vitro Methods 0.000 description 7
• 238000002347 injection Methods 0.000 description 7
• 239000007924 injection Substances 0.000 description 7
• 238000012423 maintenance Methods 0.000 description 7
• 230000001404 mediated effect Effects 0.000 description 7
• 230000004048 modification Effects 0.000 description 7
• 238000012986 modification Methods 0.000 description 7
• 150000007523 nucleic acids Chemical class 0.000 description 7
• 230000008569 process Effects 0.000 description 7
• 238000000746 purification Methods 0.000 description 7
• 210000003491 skin Anatomy 0.000 description 7
• 239000000243 solution Substances 0.000 description 7
• 238000001356 surgical procedure Methods 0.000 description 7
• 239000012730 sustained-release form Substances 0.000 description 7
• 231100000331 toxic Toxicity 0.000 description 7
• 230000002588 toxic effect Effects 0.000 description 7
• 102000003390 tumor necrosis factor Human genes 0.000 description 7
• 230000008673 vomiting Effects 0.000 description 7
• 208000004998 Abdominal Pain Diseases 0.000 description 6
• KIUYPHAMDKDICO-WHFBIAKZSA-N Ala-Asp-Gly Chemical compound C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(O)=O KIUYPHAMDKDICO-WHFBIAKZSA-N 0.000 description 6
• 206010012735 Diarrhoea Diseases 0.000 description 6
• RFTVTKBHDXCEEX-WDSKDSINSA-N Glu-Ser-Gly Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)NCC(O)=O RFTVTKBHDXCEEX-WDSKDSINSA-N 0.000 description 6
• MTBIKIMYHUWBRX-QWRGUYRKSA-N Gly-Phe-Asn Chemical compound C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)CN MTBIKIMYHUWBRX-QWRGUYRKSA-N 0.000 description 6
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 6
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 6
• 229940123038 Integrin antagonist Drugs 0.000 description 6
• UXJHNUBJSQQIOC-SZMVWBNQSA-N Met-Trp-Val Chemical compound [H]N[C@@H](CCSC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C(C)C)C(O)=O UXJHNUBJSQQIOC-SZMVWBNQSA-N 0.000 description 6
• 108010002311 N-glycylglutamic acid Proteins 0.000 description 6
• 208000002193 Pain Diseases 0.000 description 6
• SMFQZMGHCODUPQ-ULQDDVLXSA-N Pro-Lys-Phe Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O SMFQZMGHCODUPQ-ULQDDVLXSA-N 0.000 description 6
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
• MUARUIBTKQJKFY-WHFBIAKZSA-N Ser-Gly-Asp Chemical compound [H]N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O MUARUIBTKQJKFY-WHFBIAKZSA-N 0.000 description 6
• SRSPTFBENMJHMR-WHFBIAKZSA-N Ser-Ser-Gly Chemical compound OC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCC(O)=O SRSPTFBENMJHMR-WHFBIAKZSA-N 0.000 description 6
• PURRNJBBXDDWLX-ZDLURKLDSA-N Ser-Thr-Gly Chemical compound C[C@H]([C@@H](C(=O)NCC(=O)O)NC(=O)[C@H](CO)N)O PURRNJBBXDDWLX-ZDLURKLDSA-N 0.000 description 6
• SIEBDTCABMZCLF-XGEHTFHBSA-N Ser-Val-Thr Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O SIEBDTCABMZCLF-XGEHTFHBSA-N 0.000 description 6
• KKPOGALELPLJTL-MEYUZBJRSA-N Thr-Lys-Tyr Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 KKPOGALELPLJTL-MEYUZBJRSA-N 0.000 description 6
• XYNFFTNEQDWZNY-ULQDDVLXSA-N Tyr-Met-His Chemical compound CSCC[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)N XYNFFTNEQDWZNY-ULQDDVLXSA-N 0.000 description 6
• ANHVRCNNGJMJNG-BZSNNMDCSA-N Tyr-Tyr-Cys Chemical compound C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CS)C(=O)O)N)O ANHVRCNNGJMJNG-BZSNNMDCSA-N 0.000 description 6
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical compound CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 6
• 230000005856 abnormality Effects 0.000 description 6
• 238000007792 addition Methods 0.000 description 6
• 230000004075 alteration Effects 0.000 description 6
• 108010069205 aspartyl-phenylalanine Proteins 0.000 description 6
• 230000008901 benefit Effects 0.000 description 6
• 210000001185 bone marrow Anatomy 0.000 description 6
• 238000004422 calculation algorithm Methods 0.000 description 6
• 238000012217 deletion Methods 0.000 description 6
• 230000037430 deletion Effects 0.000 description 6
• 230000009266 disease activity Effects 0.000 description 6
• 239000002552 dosage form Substances 0.000 description 6
• 230000007613 environmental effect Effects 0.000 description 6
• 201000005884 exanthem Diseases 0.000 description 6
• XBGGUPMXALFZOT-UHFFFAOYSA-N glycyl-L-tyrosine hemihydrate Natural products NCC(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 XBGGUPMXALFZOT-UHFFFAOYSA-N 0.000 description 6
• 230000036541 health Effects 0.000 description 6
• 210000004408 hybridoma Anatomy 0.000 description 6
• 239000007943 implant Substances 0.000 description 6
• 208000027866 inflammatory disease Diseases 0.000 description 6
• 238000004519 manufacturing process Methods 0.000 description 6
• 210000000056 organ Anatomy 0.000 description 6
• 230000036961 partial effect Effects 0.000 description 6
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 6
• YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 6
• 230000000069 prophylactic effect Effects 0.000 description 6
• 206010037844 rash Diseases 0.000 description 6
• 238000011160 research Methods 0.000 description 6
• 238000007920 subcutaneous administration Methods 0.000 description 6
• 230000001629 suppression Effects 0.000 description 6
• 238000013268 sustained release Methods 0.000 description 6
• 230000009261 transgenic effect Effects 0.000 description 6
• 239000013598 vector Substances 0.000 description 6
• PPINMSZPTPRQQB-NHCYSSNCSA-N 2-[[(2s)-1-[(2s)-2-[[(2s)-2-amino-3-methylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]acetic acid Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O PPINMSZPTPRQQB-NHCYSSNCSA-N 0.000 description 5
• OQCWXQJLCDPRHV-UWVGGRQHSA-N Arg-Gly-Leu Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(O)=O OQCWXQJLCDPRHV-UWVGGRQHSA-N 0.000 description 5
• COXMUHNBYCVVRG-DCAQKATOSA-N Arg-Leu-Ser Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O COXMUHNBYCVVRG-DCAQKATOSA-N 0.000 description 5
• CZIVKMOEXPILDK-SRVKXCTJSA-N Asp-Tyr-Ser Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(O)=O CZIVKMOEXPILDK-SRVKXCTJSA-N 0.000 description 5
• 101100454807 Caenorhabditis elegans lgg-1 gene Proteins 0.000 description 5
• 206010009944 Colon cancer Diseases 0.000 description 5
• 208000010201 Exanthema Diseases 0.000 description 5
• 206010016717 Fistula Diseases 0.000 description 5
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 5
• 101000622304 Homo sapiens Vascular cell adhesion protein 1 Proteins 0.000 description 5
• 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 5
• 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 5
• LINKCQUOMUDLKN-KATARQTJSA-N Leu-Thr-Cys Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CS)C(=O)O)NC(=O)[C@H](CC(C)C)N)O LINKCQUOMUDLKN-KATARQTJSA-N 0.000 description 5
• FBNPMTNBFFAMMH-UHFFFAOYSA-N Leu-Val-Arg Natural products CC(C)CC(N)C(=O)NC(C(C)C)C(=O)NC(C(O)=O)CCCN=C(N)N FBNPMTNBFFAMMH-UHFFFAOYSA-N 0.000 description 5
• PDIDTSZKKFEDMB-UWVGGRQHSA-N Lys-Pro-Gly Chemical compound [H]N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O PDIDTSZKKFEDMB-UWVGGRQHSA-N 0.000 description 5
• 241000124008 Mammalia Species 0.000 description 5
• 229910021380 Manganese Chloride Inorganic materials 0.000 description 5
• GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 description 5
• KZNQNBZMBZJQJO-UHFFFAOYSA-N N-glycyl-L-proline Natural products NCC(=O)N1CCCC1C(O)=O KZNQNBZMBZJQJO-UHFFFAOYSA-N 0.000 description 5
• 206010028813 Nausea Diseases 0.000 description 5
• 108091005804 Peptidases Proteins 0.000 description 5
• 102000035195 Peptidases Human genes 0.000 description 5
• 239000002202 Polyethylene glycol Substances 0.000 description 5
• FKLSMYYLJHYPHH-UWVGGRQHSA-N Pro-Gly-Leu Chemical compound [H]N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(O)=O FKLSMYYLJHYPHH-UWVGGRQHSA-N 0.000 description 5
• 201000004681 Psoriasis Diseases 0.000 description 5
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
• YOOAQCZYZHGUAZ-KATARQTJSA-N Thr-Leu-Ser Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O YOOAQCZYZHGUAZ-KATARQTJSA-N 0.000 description 5
• ZOCJFNXUVSGBQI-HSHDSVGOSA-N Thr-Trp-Arg Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N)O ZOCJFNXUVSGBQI-HSHDSVGOSA-N 0.000 description 5
• TVOGEPLDNYTAHD-CQDKDKBSSA-N Tyr-Ala-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 TVOGEPLDNYTAHD-CQDKDKBSSA-N 0.000 description 5
• YQMILNREHKTFBS-IHRRRGAJSA-N Val-Phe-Cys Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CS)C(=O)O)N YQMILNREHKTFBS-IHRRRGAJSA-N 0.000 description 5
• 239000000443 aerosol Substances 0.000 description 5
• 210000003719 b-lymphocyte Anatomy 0.000 description 5
• 239000002585 base Substances 0.000 description 5
• 210000004556 brain Anatomy 0.000 description 5
• 238000010367 cloning Methods 0.000 description 5
• 238000005094 computer simulation Methods 0.000 description 5
• 229920001577 copolymer Polymers 0.000 description 5
• 239000003246 corticosteroid Substances 0.000 description 5
• 239000003937 drug carrier Substances 0.000 description 5
• 210000001508 eye Anatomy 0.000 description 5
• 230000003890 fistula Effects 0.000 description 5
• 108010077515 glycylproline Proteins 0.000 description 5
• 108010021315 integrin beta7 Proteins 0.000 description 5
• 238000007918 intramuscular administration Methods 0.000 description 5
• 230000007774 longterm Effects 0.000 description 5
• 239000011565 manganese chloride Substances 0.000 description 5
• 235000002867 manganese chloride Nutrition 0.000 description 5
• 239000000463 material Substances 0.000 description 5
• 239000011159 matrix material Substances 0.000 description 5
• 230000008693 nausea Effects 0.000 description 5
• 102000039446 nucleic acids Human genes 0.000 description 5
• 108020004707 nucleic acids Proteins 0.000 description 5
• 239000000546 pharmaceutical excipient Substances 0.000 description 5
• 229920001223 polyethylene glycol Polymers 0.000 description 5
• 150000003839 salts Chemical class 0.000 description 5
• 230000008961 swelling Effects 0.000 description 5
• 230000008685 targeting Effects 0.000 description 5
• 108010072644 valyl-alanyl-prolyl-glycine Proteins 0.000 description 5
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
• 229920000936 Agarose Polymers 0.000 description 4
• BTYTYHBSJKQBQA-GCJQMDKQSA-N Ala-Asp-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)N)O BTYTYHBSJKQBQA-GCJQMDKQSA-N 0.000 description 4
• CBCCCLMNOBLBSC-XVYDVKMFSA-N Ala-His-Ser Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(O)=O CBCCCLMNOBLBSC-XVYDVKMFSA-N 0.000 description 4
• ZDILXFDENZVOTL-BPNCWPANSA-N Ala-Val-Tyr Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O ZDILXFDENZVOTL-BPNCWPANSA-N 0.000 description 4
• XYBJLTKSGFBLCS-QXEWZRGKSA-N Asp-Arg-Val Chemical compound NC(N)=NCCC[C@@H](C(=O)N[C@@H](C(C)C)C(O)=O)NC(=O)[C@@H](N)CC(O)=O XYBJLTKSGFBLCS-QXEWZRGKSA-N 0.000 description 4
• VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 description 4
• 108091035707 Consensus sequence Proteins 0.000 description 4
• 102000004127 Cytokines Human genes 0.000 description 4
• 108090000695 Cytokines Proteins 0.000 description 4
• 206010013975 Dyspnoeas Diseases 0.000 description 4
• NVTPVQLIZCOJFK-FOHZUACHSA-N Gly-Thr-Asp Chemical compound [H]NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O NVTPVQLIZCOJFK-FOHZUACHSA-N 0.000 description 4
• XHVONGZZVUUORG-WEDXCCLWSA-N Gly-Thr-Lys Chemical compound NCC(=O)N[C@@H]([C@H](O)C)C(=O)N[C@H](C(O)=O)CCCCN XHVONGZZVUUORG-WEDXCCLWSA-N 0.000 description 4
• 241000282412 Homo Species 0.000 description 4
• 108700005091 Immunoglobulin Genes Proteins 0.000 description 4
• 102000013463 Immunoglobulin Light Chains Human genes 0.000 description 4
• 108010065825 Immunoglobulin Light Chains Proteins 0.000 description 4
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 4
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 4
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 4
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 4
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 4
• 241000880493 Leptailurus serval Species 0.000 description 4
• 239000004472 Lysine Substances 0.000 description 4
• 206010028980 Neoplasm Diseases 0.000 description 4
• 206010033799 Paralysis Diseases 0.000 description 4
• BPIMVBKDLSBKIJ-FCLVOEFKSA-N Phe-Thr-Phe Chemical compound C([C@H](N)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 BPIMVBKDLSBKIJ-FCLVOEFKSA-N 0.000 description 4
• LEIKGVHQTKHOLM-IUCAKERBSA-N Pro-Pro-Gly Chemical compound OC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H]1NCCC1 LEIKGVHQTKHOLM-IUCAKERBSA-N 0.000 description 4
• AFWBWPCXSWUCLB-WDSKDSINSA-N Pro-Ser Chemical compound OC[C@@H](C([O-])=O)NC(=O)[C@@H]1CCC[NH2+]1 AFWBWPCXSWUCLB-WDSKDSINSA-N 0.000 description 4
• OBXVZEAMXFSGPU-FXQIFTODSA-N Ser-Asn-Arg Chemical compound C(C[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)N)CN=C(N)N OBXVZEAMXFSGPU-FXQIFTODSA-N 0.000 description 4
• XGQKSRGHEZNWIS-IHRRRGAJSA-N Ser-Pro-Tyr Chemical compound N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O XGQKSRGHEZNWIS-IHRRRGAJSA-N 0.000 description 4
• WLJPJRGQRNCIQS-ZLUOBGJFSA-N Ser-Ser-Asn Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(O)=O WLJPJRGQRNCIQS-ZLUOBGJFSA-N 0.000 description 4
• GXUWHVZYDAHFSV-FLBSBUHZSA-N Thr-Ile-Thr Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(O)=O GXUWHVZYDAHFSV-FLBSBUHZSA-N 0.000 description 4
• BIBYEFRASCNLAA-CDMKHQONSA-N Thr-Phe-Gly Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@H](C(=O)NCC(O)=O)CC1=CC=CC=C1 BIBYEFRASCNLAA-CDMKHQONSA-N 0.000 description 4
• MNYNCKZAEIAONY-XGEHTFHBSA-N Thr-Val-Ser Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(O)=O MNYNCKZAEIAONY-XGEHTFHBSA-N 0.000 description 4
• MBLJBGZWLHTJBH-SZMVWBNQSA-N Trp-Val-Arg Chemical compound C1=CC=C2C(C[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O)=CNC2=C1 MBLJBGZWLHTJBH-SZMVWBNQSA-N 0.000 description 4
• 108090000631 Trypsin Proteins 0.000 description 4
• 102000004142 Trypsin Human genes 0.000 description 4
• ZZDYJFVIKVSUFA-WLTAIBSBSA-N Tyr-Thr-Gly Chemical compound [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(O)=O ZZDYJFVIKVSUFA-WLTAIBSBSA-N 0.000 description 4
• MWUYSCVVPVITMW-IGNZVWTISA-N Tyr-Tyr-Ala Chemical compound C([C@@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 MWUYSCVVPVITMW-IGNZVWTISA-N 0.000 description 4
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
• SLLKXDSRVAOREO-KZVJFYERSA-N Val-Ala-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)N)O SLLKXDSRVAOREO-KZVJFYERSA-N 0.000 description 4
• VJOWWOGRNXRQMF-UVBJJODRSA-N Val-Ala-Trp Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)C(C)C)C(O)=O)=CNC2=C1 VJOWWOGRNXRQMF-UVBJJODRSA-N 0.000 description 4
• OVLIFGQSBSNGHY-KKHAAJSZSA-N Val-Asp-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)N)O OVLIFGQSBSNGHY-KKHAAJSZSA-N 0.000 description 4
• 229920002877 acrylic styrene acrylonitrile Polymers 0.000 description 4
• 108010050025 alpha-glutamyltryptophan Proteins 0.000 description 4
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 4
• 239000005557 antagonist Substances 0.000 description 4
• 230000015572 biosynthetic process Effects 0.000 description 4
• 229960004436 budesonide Drugs 0.000 description 4
• 201000011510 cancer Diseases 0.000 description 4
• 239000000969 carrier Substances 0.000 description 4
• 210000003169 central nervous system Anatomy 0.000 description 4
• 206010009887 colitis Diseases 0.000 description 4
• 229960001334 corticosteroids Drugs 0.000 description 4
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 4
• 230000006378 damage Effects 0.000 description 4
• 238000003745 diagnosis Methods 0.000 description 4
• 230000029087 digestion Effects 0.000 description 4
• 208000035475 disorder Diseases 0.000 description 4
• 238000012377 drug delivery Methods 0.000 description 4
• 210000003989 endothelium vascular Anatomy 0.000 description 4
• 230000003628 erosive effect Effects 0.000 description 4
• 230000004927 fusion Effects 0.000 description 4
• 108010045126 glycyl-tyrosyl-glycine Proteins 0.000 description 4
• 238000000099 in vitro assay Methods 0.000 description 4
• 230000000968 intestinal effect Effects 0.000 description 4
• 238000007912 intraperitoneal administration Methods 0.000 description 4
• 238000007913 intrathecal administration Methods 0.000 description 4
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
• 230000033001 locomotion Effects 0.000 description 4
• 210000004072 lung Anatomy 0.000 description 4
• 210000004379 membrane Anatomy 0.000 description 4
• 239000012528 membrane Substances 0.000 description 4
• MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 4
• 229960000485 methotrexate Drugs 0.000 description 4
• 239000003094 microcapsule Substances 0.000 description 4
• 238000002703 mutagenesis Methods 0.000 description 4
• 231100000350 mutagenesis Toxicity 0.000 description 4
• 238000002823 phage display Methods 0.000 description 4
• 239000008363 phosphate buffer Substances 0.000 description 4
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 4
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 4
• 229920000053 polysorbate 80 Polymers 0.000 description 4
• 229940068968 polysorbate 80 Drugs 0.000 description 4
• 239000000843 powder Substances 0.000 description 4
• 229960005205 prednisolone Drugs 0.000 description 4
• OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 4
• 229960004618 prednisone Drugs 0.000 description 4
• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 4
• 108010087846 prolyl-prolyl-glycine Proteins 0.000 description 4
• 108010031719 prolyl-serine Proteins 0.000 description 4
• 230000002685 pulmonary effect Effects 0.000 description 4
• 230000009467 reduction Effects 0.000 description 4
• 150000003384 small molecules Chemical class 0.000 description 4
• 239000007787 solid Substances 0.000 description 4
• 230000009870 specific binding Effects 0.000 description 4
• 230000000699 topical effect Effects 0.000 description 4
• 239000012588 trypsin Substances 0.000 description 4
• 229960001322 trypsin Drugs 0.000 description 4
• 108010044292 tryptophyltyrosine Proteins 0.000 description 4
• WNHNMKOFKCHKKD-BFHQHQDPSA-N Ala-Thr-Gly Chemical compound [H]N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(O)=O WNHNMKOFKCHKKD-BFHQHQDPSA-N 0.000 description 3
• UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
• 241000283707 Capra Species 0.000 description 3
• 241000700198 Cavia Species 0.000 description 3
• 108010067225 Cell Adhesion Molecules Proteins 0.000 description 3
• 102000016289 Cell Adhesion Molecules Human genes 0.000 description 3
• OZHXXYOHPLLLMI-CIUDSAMLSA-N Cys-Lys-Ala Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O OZHXXYOHPLLLMI-CIUDSAMLSA-N 0.000 description 3
• 102000053602 DNA Human genes 0.000 description 3
• 102000004190 Enzymes Human genes 0.000 description 3
• 108090000790 Enzymes Proteins 0.000 description 3
• 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 3
• 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 3
• JVZLZVJTIXVIHK-SXNHZJKMSA-N Glu-Trp-Ile Chemical compound CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CCC(=O)O)N JVZLZVJTIXVIHK-SXNHZJKMSA-N 0.000 description 3
• JLXVRFDTDUGQEE-YFKPBYRVSA-N Gly-Arg Chemical compound NCC(=O)N[C@H](C(O)=O)CCCN=C(N)N JLXVRFDTDUGQEE-YFKPBYRVSA-N 0.000 description 3
• OCQUNKSFDYDXBG-QXEWZRGKSA-N Gly-Arg-Ile Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CCCN=C(N)N OCQUNKSFDYDXBG-QXEWZRGKSA-N 0.000 description 3
• 208000032843 Hemorrhage Diseases 0.000 description 3
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 3
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 3
• 102000012745 Immunoglobulin Subunits Human genes 0.000 description 3
• 108010079585 Immunoglobulin Subunits Proteins 0.000 description 3
• 108010041012 Integrin alpha4 Proteins 0.000 description 3
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 3
• IXHKPDJKKCUKHS-GARJFASQSA-N Lys-Ala-Pro Chemical compound C[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CCCCN)N IXHKPDJKKCUKHS-GARJFASQSA-N 0.000 description 3
• 101001018085 Lysobacter enzymogenes Lysyl endopeptidase Proteins 0.000 description 3
• 241000282567 Macaca fascicularis Species 0.000 description 3
• 108091034117 Oligonucleotide Proteins 0.000 description 3
• 108090000284 Pepsin A Proteins 0.000 description 3
• 102000057297 Pepsin A Human genes 0.000 description 3
• BPCLGWHVPVTTFM-QWRGUYRKSA-N Phe-Ser-Gly Chemical compound [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)NCC(O)=O BPCLGWHVPVTTFM-QWRGUYRKSA-N 0.000 description 3
• UNBFGVQVQGXXCK-KKUMJFAQSA-N Phe-Ser-Leu Chemical compound [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O UNBFGVQVQGXXCK-KKUMJFAQSA-N 0.000 description 3
• 206010035226 Plasma cell myeloma Diseases 0.000 description 3
• 241000288906 Primates Species 0.000 description 3
• MGDFPGCFVJFITQ-CIUDSAMLSA-N Pro-Glu-Asp Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O MGDFPGCFVJFITQ-CIUDSAMLSA-N 0.000 description 3
• 241000700159 Rattus Species 0.000 description 3
• 241000288960 Saguinus oedipus Species 0.000 description 3
• OQPNSDWGAMFJNU-QWRGUYRKSA-N Ser-Gly-Tyr Chemical compound OC[C@H](N)C(=O)NCC(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 OQPNSDWGAMFJNU-QWRGUYRKSA-N 0.000 description 3
• YUJLIIRMIAGMCQ-CIUDSAMLSA-N Ser-Leu-Ser Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O YUJLIIRMIAGMCQ-CIUDSAMLSA-N 0.000 description 3
• AZWNCEBQZXELEZ-FXQIFTODSA-N Ser-Pro-Ser Chemical compound OC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(O)=O AZWNCEBQZXELEZ-FXQIFTODSA-N 0.000 description 3
• ILVGMCVCQBJPSH-WDSKDSINSA-N Ser-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@@H](N)CO ILVGMCVCQBJPSH-WDSKDSINSA-N 0.000 description 3
• JZRYFUGREMECBH-XPUUQOCRSA-N Ser-Val-Gly Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)NCC(O)=O JZRYFUGREMECBH-XPUUQOCRSA-N 0.000 description 3
• YLXAMFZYJTZXFH-OLHMAJIHSA-N Thr-Asn-Asp Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)O)N)O YLXAMFZYJTZXFH-OLHMAJIHSA-N 0.000 description 3
• XNTVWRJTUIOGQO-RHYQMDGZSA-N Thr-Met-Leu Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(O)=O XNTVWRJTUIOGQO-RHYQMDGZSA-N 0.000 description 3
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 3
• 208000025865 Ulcer Diseases 0.000 description 3
• UBTBGUDNDFZLGP-SRVKXCTJSA-N Val-Arg-Val Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)O)N UBTBGUDNDFZLGP-SRVKXCTJSA-N 0.000 description 3
• HQYVQDRYODWONX-DCAQKATOSA-N Val-His-Ser Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CO)C(=O)O)N HQYVQDRYODWONX-DCAQKATOSA-N 0.000 description 3
• RWOGENDAOGMHLX-DCAQKATOSA-N Val-Lys-Ala Chemical compound C[C@@H](C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)N RWOGENDAOGMHLX-DCAQKATOSA-N 0.000 description 3
• ZXYPHBKIZLAQTL-QXEWZRGKSA-N Val-Pro-Asp Chemical compound CC(C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)O)N ZXYPHBKIZLAQTL-QXEWZRGKSA-N 0.000 description 3
• 206010047115 Vasculitis Diseases 0.000 description 3
• 206010000269 abscess Diseases 0.000 description 3
• 108010081404 acein-2 Proteins 0.000 description 3
• 239000002253 acid Substances 0.000 description 3
• 239000013543 active substance Substances 0.000 description 3
• 235000004279 alanine Nutrition 0.000 description 3
• 239000013566 allergen Substances 0.000 description 3
• 208000007502 anemia Diseases 0.000 description 3
• 238000000137 annealing Methods 0.000 description 3
• 239000003242 anti bacterial agent Substances 0.000 description 3
• 229940088710 antibiotic agent Drugs 0.000 description 3
• 208000034158 bleeding Diseases 0.000 description 3
• 230000000740 bleeding effect Effects 0.000 description 3
• 210000004899 c-terminal region Anatomy 0.000 description 3
• 238000004587 chromatography analysis Methods 0.000 description 3
• 208000037976 chronic inflammation Diseases 0.000 description 3
• 230000006020 chronic inflammation Effects 0.000 description 3
• 230000000295 complement effect Effects 0.000 description 3
• 239000002299 complementary DNA Substances 0.000 description 3
• 230000003247 decreasing effect Effects 0.000 description 3
• 238000011161 development Methods 0.000 description 3
• 230000018109 developmental process Effects 0.000 description 3
• 235000005911 diet Nutrition 0.000 description 3
• 239000003085 diluting agent Substances 0.000 description 3
• 238000010790 dilution Methods 0.000 description 3
• 239000012895 dilution Substances 0.000 description 3
• 231100000673 dose–response relationship Toxicity 0.000 description 3
• 239000012149 elution buffer Substances 0.000 description 3
• 229940088598 enzyme Drugs 0.000 description 3
• 210000003979 eosinophil Anatomy 0.000 description 3
• 238000002474 experimental method Methods 0.000 description 3
• 239000013604 expression vector Substances 0.000 description 3
• 239000012530 fluid Substances 0.000 description 3
• 238000001943 fluorescence-activated cell sorting Methods 0.000 description 3
• 108010015792 glycyllysine Proteins 0.000 description 3
• 230000012010 growth Effects 0.000 description 3
• 229960002885 histidine Drugs 0.000 description 3
• 230000007062 hydrolysis Effects 0.000 description 3
• 238000006460 hydrolysis reaction Methods 0.000 description 3
• 230000001976 improved effect Effects 0.000 description 3
• 230000006872 improvement Effects 0.000 description 3
• 230000002401 inhibitory effect Effects 0.000 description 3
• 238000003780 insertion Methods 0.000 description 3
• 230000037431 insertion Effects 0.000 description 3
• 238000001361 intraarterial administration Methods 0.000 description 3
• 239000002502 liposome Substances 0.000 description 3
• 208000019423 liver disease Diseases 0.000 description 3
• 239000012160 loading buffer Substances 0.000 description 3
• 108010017391 lysylvaline Proteins 0.000 description 3
• 238000007726 management method Methods 0.000 description 3
• 230000007246 mechanism Effects 0.000 description 3
• 239000002609 medium Substances 0.000 description 3
• 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 3
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
• 239000004005 microsphere Substances 0.000 description 3
• 230000005012 migration Effects 0.000 description 3
• 238000013508 migration Methods 0.000 description 3
• 239000000178 monomer Substances 0.000 description 3
• 210000004877 mucosa Anatomy 0.000 description 3
• 231100000219 mutagenic Toxicity 0.000 description 3
• 230000003505 mutagenic effect Effects 0.000 description 3
• 201000000050 myeloid neoplasm Diseases 0.000 description 3
• 231100000252 nontoxic Toxicity 0.000 description 3
• 230000003000 nontoxic effect Effects 0.000 description 3
• QQBDLJCYGRGAKP-FOCLMDBBSA-N olsalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=C(C(O)=CC=2)C(O)=O)=C1 QQBDLJCYGRGAKP-FOCLMDBBSA-N 0.000 description 3
• 229940111202 pepsin Drugs 0.000 description 3
• 206010034674 peritonitis Diseases 0.000 description 3
• 239000002953 phosphate buffered saline Substances 0.000 description 3
• 230000036470 plasma concentration Effects 0.000 description 3
• 210000004180 plasmocyte Anatomy 0.000 description 3
• 230000035935 pregnancy Effects 0.000 description 3
• 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 3
• 230000009257 reactivity Effects 0.000 description 3
• 238000010188 recombinant method Methods 0.000 description 3
• 238000011084 recovery Methods 0.000 description 3
• 210000000664 rectum Anatomy 0.000 description 3
• 230000002829 reductive effect Effects 0.000 description 3
• 210000000813 small intestine Anatomy 0.000 description 3
• 239000000779 smoke Substances 0.000 description 3
• 239000011780 sodium chloride Substances 0.000 description 3
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 3
• 230000006641 stabilisation Effects 0.000 description 3
• 238000011105 stabilization Methods 0.000 description 3
• 239000003381 stabilizer Substances 0.000 description 3
• 230000008093 supporting effect Effects 0.000 description 3
• 239000000829 suppository Substances 0.000 description 3
• 238000003786 synthesis reaction Methods 0.000 description 3
• 229940124597 therapeutic agent Drugs 0.000 description 3
• 230000001988 toxicity Effects 0.000 description 3
• 231100000419 toxicity Toxicity 0.000 description 3
• 231100000041 toxicology testing Toxicity 0.000 description 3
• 229960004441 tyrosine Drugs 0.000 description 3
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 3
• 229940079023 tysabri Drugs 0.000 description 3
• 210000003708 urethra Anatomy 0.000 description 3
• 108010073969 valyllysine Proteins 0.000 description 3
• 230000000007 visual effect Effects 0.000 description 3
• 230000004580 weight loss Effects 0.000 description 3
• LBYMZCVBOKYZNS-CIUDSAMLSA-N Ala-Leu-Asp Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O LBYMZCVBOKYZNS-CIUDSAMLSA-N 0.000 description 2
• CREYEAPXISDKSB-FQPOAREZSA-N Ala-Thr-Tyr Chemical compound [H]N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O CREYEAPXISDKSB-FQPOAREZSA-N 0.000 description 2
• IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 description 2
• HGKHPCFTRQDHCU-IUCAKERBSA-N Arg-Pro-Gly Chemical compound NC(N)=NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O HGKHPCFTRQDHCU-IUCAKERBSA-N 0.000 description 2
• 208000006820 Arthralgia Diseases 0.000 description 2
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
• BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
• 101100454808 Caenorhabditis elegans lgg-2 gene Proteins 0.000 description 2
• 108090000317 Chymotrypsin Proteins 0.000 description 2
• 150000008574 D-amino acids Chemical class 0.000 description 2
• 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 2
• 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 2
• 208000016192 Demyelinating disease Diseases 0.000 description 2
• 206010012305 Demyelination Diseases 0.000 description 2
• 201000004624 Dermatitis Diseases 0.000 description 2
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
• BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 2
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
• 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
• 208000010412 Glaucoma Diseases 0.000 description 2
• SBCYJMOOHUDWDA-NUMRIWBASA-N Glu-Asp-Thr Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O SBCYJMOOHUDWDA-NUMRIWBASA-N 0.000 description 2
• LLEUXCDZPQOJMY-AAEUAGOBSA-N Glu-Trp Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@H](CCC(O)=O)N)C(O)=O)=CNC2=C1 LLEUXCDZPQOJMY-AAEUAGOBSA-N 0.000 description 2
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
• 239000004471 Glycine Substances 0.000 description 2
• 229920002971 Heparan sulfate Polymers 0.000 description 2
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
• 101000935587 Homo sapiens Flavin reductase (NADPH) Proteins 0.000 description 2
• 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 description 2
• 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 description 2
• 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 description 2
• 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 description 2
• 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 description 2
• 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 description 2
• 101001002508 Homo sapiens Immunoglobulin-binding protein 1 Proteins 0.000 description 2
• 241000725303 Human immunodeficiency virus Species 0.000 description 2
• PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 2
• 206010020772 Hypertension Diseases 0.000 description 2
• IOVUXUSIGXCREV-DKIMLUQUSA-N Ile-Leu-Phe Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 IOVUXUSIGXCREV-DKIMLUQUSA-N 0.000 description 2
• 102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 2
• 108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 2
• 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 description 2
• 102100022949 Immunoglobulin kappa variable 2-29 Human genes 0.000 description 2
• 102100021042 Immunoglobulin-binding protein 1 Human genes 0.000 description 2
• 102000014150 Interferons Human genes 0.000 description 2
• 108010050904 Interferons Proteins 0.000 description 2
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 2
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 2
• 206010024264 Lethargy Diseases 0.000 description 2
• FAELBUXXFQLUAX-AJNGGQMLSA-N Leu-Leu-Ile Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C FAELBUXXFQLUAX-AJNGGQMLSA-N 0.000 description 2
• DRWMRVFCKKXHCH-BZSNNMDCSA-N Leu-Phe-Leu Chemical compound CC(C)C[C@H]([NH3+])C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C([O-])=O)CC1=CC=CC=C1 DRWMRVFCKKXHCH-BZSNNMDCSA-N 0.000 description 2
• 108010000817 Leuprolide Proteins 0.000 description 2
• NPBGTPKLVJEOBE-IUCAKERBSA-N Lys-Arg Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CCCNC(N)=N NPBGTPKLVJEOBE-IUCAKERBSA-N 0.000 description 2
• TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
• FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 description 2
• 208000008457 Neurologic Manifestations Diseases 0.000 description 2
• 208000001132 Osteoporosis Diseases 0.000 description 2
• 238000012408 PCR amplification Methods 0.000 description 2
• ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
• 206010038063 Rectal haemorrhage Diseases 0.000 description 2
• 208000009921 Rheumatoid Nodule Diseases 0.000 description 2
• INCNPLPRPOYTJI-JBDRJPRFSA-N Ser-Cys-Ile Chemical compound CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](CO)N INCNPLPRPOYTJI-JBDRJPRFSA-N 0.000 description 2
• UIGMAMGZOJVTDN-WHFBIAKZSA-N Ser-Gly-Ser Chemical compound OC[C@H](N)C(=O)NCC(=O)N[C@@H](CO)C(O)=O UIGMAMGZOJVTDN-WHFBIAKZSA-N 0.000 description 2
• NMZXJDSKEGFDLJ-DCAQKATOSA-N Ser-Pro-Lys Chemical compound C1C[C@H](N(C1)C(=O)[C@H](CO)N)C(=O)N[C@@H](CCCCN)C(=O)O NMZXJDSKEGFDLJ-DCAQKATOSA-N 0.000 description 2
• XZKQVQKUZMAADP-IMJSIDKUSA-N Ser-Ser Chemical compound OC[C@H](N)C(=O)N[C@@H](CO)C(O)=O XZKQVQKUZMAADP-IMJSIDKUSA-N 0.000 description 2
• 108010071390 Serum Albumin Proteins 0.000 description 2
• 102000007562 Serum Albumin Human genes 0.000 description 2
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
• NJEMRSFGDNECGF-GCJQMDKQSA-N Thr-Ala-Asp Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CC(O)=O NJEMRSFGDNECGF-GCJQMDKQSA-N 0.000 description 2
• FQPDRTDDEZXCEC-SVSWQMSJSA-N Thr-Ile-Ser Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(O)=O FQPDRTDDEZXCEC-SVSWQMSJSA-N 0.000 description 2
• WPSKTVVMQCXPRO-BWBBJGPYSA-N Thr-Ser-Ser Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(O)=O WPSKTVVMQCXPRO-BWBBJGPYSA-N 0.000 description 2
• 108700019146 Transgenes Proteins 0.000 description 2
• UOXPLPBMEPLZBW-WDSOQIARSA-N Trp-Val-Lys Chemical compound C1=CC=C2C(C[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O)=CNC2=C1 UOXPLPBMEPLZBW-WDSOQIARSA-N 0.000 description 2
• QPPZEDOTPZOSEC-RCWTZXSCSA-N Val-Met-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](C(C)C)N)O QPPZEDOTPZOSEC-RCWTZXSCSA-N 0.000 description 2
• 229960001138 acetylsalicylic acid Drugs 0.000 description 2
• 239000004480 active ingredient Substances 0.000 description 2
• 230000009798 acute exacerbation Effects 0.000 description 2
• 239000000654 additive Substances 0.000 description 2
• 238000001042 affinity chromatography Methods 0.000 description 2
• 230000002776 aggregation Effects 0.000 description 2
• 238000004220 aggregation Methods 0.000 description 2
• 125000001931 aliphatic group Chemical group 0.000 description 2
• VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 2
• 230000003110 anti-inflammatory effect Effects 0.000 description 2
• 230000002788 anti-peptide Effects 0.000 description 2
• 230000000890 antigenic effect Effects 0.000 description 2
• 238000013459 approach Methods 0.000 description 2
• 125000003118 aryl group Chemical group 0.000 description 2
• 239000012911 assay medium Substances 0.000 description 2
• 230000003376 axonal effect Effects 0.000 description 2
• 229940064856 azulfidine Drugs 0.000 description 2
• 229920001222 biopolymer Polymers 0.000 description 2
• 230000000903 blocking effect Effects 0.000 description 2
• 230000008499 blood brain barrier function Effects 0.000 description 2
• 210000001218 blood-brain barrier Anatomy 0.000 description 2
• DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 2
• 239000004202 carbamide Substances 0.000 description 2
• 230000020411 cell activation Effects 0.000 description 2
• 230000021164 cell adhesion Effects 0.000 description 2
• 238000005119 centrifugation Methods 0.000 description 2
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
• 229960002376 chymotrypsin Drugs 0.000 description 2
• 208000029742 colonic neoplasm Diseases 0.000 description 2
• 230000001472 cytotoxic effect Effects 0.000 description 2
• 230000007850 degeneration Effects 0.000 description 2
• 238000012938 design process Methods 0.000 description 2
• 238000001514 detection method Methods 0.000 description 2
• 229960003957 dexamethasone Drugs 0.000 description 2
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 2
• 206010012601 diabetes mellitus Diseases 0.000 description 2
• 230000037213 diet Effects 0.000 description 2
• 229940104799 dipentum Drugs 0.000 description 2
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
• PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 2
• 206010014599 encephalitis Diseases 0.000 description 2
• 239000005038 ethylene vinyl acetate Substances 0.000 description 2
• 210000002744 extracellular matrix Anatomy 0.000 description 2
• 230000002349 favourable effect Effects 0.000 description 2
• 239000012091 fetal bovine serum Substances 0.000 description 2
• 210000002683 foot Anatomy 0.000 description 2
• 230000006870 function Effects 0.000 description 2
• 230000002068 genetic effect Effects 0.000 description 2
• 238000010353 genetic engineering Methods 0.000 description 2
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
• VPZXBVLAVMBEQI-UHFFFAOYSA-N glycyl-DL-alpha-alanine Natural products OC(=O)C(C)NC(=O)CN VPZXBVLAVMBEQI-UHFFFAOYSA-N 0.000 description 2
• XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Natural products NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 description 2
• 208000006454 hepatitis Diseases 0.000 description 2
• 210000003630 histaminocyte Anatomy 0.000 description 2
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
• JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
• 239000000017 hydrogel Substances 0.000 description 2
• 230000002209 hydrophobic effect Effects 0.000 description 2
• 229960002591 hydroxyproline Drugs 0.000 description 2
• 208000008384 ileus Diseases 0.000 description 2
• 210000002865 immune cell Anatomy 0.000 description 2
• 238000010874 in vitro model Methods 0.000 description 2
• 238000011534 incubation Methods 0.000 description 2
• 230000006698 induction Effects 0.000 description 2
• 230000001939 inductive effect Effects 0.000 description 2
• 230000008595 infiltration Effects 0.000 description 2
• 238000001764 infiltration Methods 0.000 description 2
• 230000028709 inflammatory response Effects 0.000 description 2
• 239000003112 inhibitor Substances 0.000 description 2
• 230000005764 inhibitory process Effects 0.000 description 2
• 208000014674 injury Diseases 0.000 description 2
• 230000007794 irritation Effects 0.000 description 2
• 238000002955 isolation Methods 0.000 description 2
• 208000018937 joint inflammation Diseases 0.000 description 2
• 235000014655 lactic acid Nutrition 0.000 description 2
• 239000004310 lactic acid Substances 0.000 description 2
• 206010024378 leukocytosis Diseases 0.000 description 2
• RGLRXNKKBLIBQS-XNHQSDQCSA-N leuprolide acetate Chemical compound CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 RGLRXNKKBLIBQS-XNHQSDQCSA-N 0.000 description 2
• 230000000670 limiting effect Effects 0.000 description 2
• 239000007788 liquid Substances 0.000 description 2
• 210000004185 liver Anatomy 0.000 description 2
• 108010038320 lysylphenylalanine Proteins 0.000 description 2
• 210000002540 macrophage Anatomy 0.000 description 2
• 230000014759 maintenance of location Effects 0.000 description 2
• 206010025482 malaise Diseases 0.000 description 2
• 210000004962 mammalian cell Anatomy 0.000 description 2
• 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 description 2
• 229960004584 methylprednisolone Drugs 0.000 description 2
• 210000001616 monocyte Anatomy 0.000 description 2
• 229940126619 mouse monoclonal antibody Drugs 0.000 description 2
• 230000035772 mutation Effects 0.000 description 2
• 239000003921 oil Substances 0.000 description 2
• 235000019198 oils Nutrition 0.000 description 2
• 229940124624 oral corticosteroid Drugs 0.000 description 2
• 230000003204 osmotic effect Effects 0.000 description 2
• 238000012856 packing Methods 0.000 description 2
• 230000008506 pathogenesis Effects 0.000 description 2
• 229940072223 pentasa Drugs 0.000 description 2
• 230000002093 peripheral effect Effects 0.000 description 2
• 210000001322 periplasm Anatomy 0.000 description 2
• 230000002085 persistent effect Effects 0.000 description 2
• 210000001986 peyer's patch Anatomy 0.000 description 2
• 230000000144 pharmacologic effect Effects 0.000 description 2
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
• 108010070409 phenylalanyl-glycyl-glycine Proteins 0.000 description 2
• 230000035790 physiological processes and functions Effects 0.000 description 2
• 239000013612 plasmid Substances 0.000 description 2
• 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
• 230000002035 prolonged effect Effects 0.000 description 2
• 238000000159 protein binding assay Methods 0.000 description 2
• 230000002285 radioactive effect Effects 0.000 description 2
• 230000007115 recruitment Effects 0.000 description 2
• 229940116176 remicade Drugs 0.000 description 2
• 231100000101 reproductive and developmental toxicity testing Toxicity 0.000 description 2
• 229920005989 resin Polymers 0.000 description 2
• 239000011347 resin Substances 0.000 description 2
• 108091008146 restriction endonucleases Proteins 0.000 description 2
• 150000003873 salicylate salts Chemical class 0.000 description 2
• 238000013207 serial dilution Methods 0.000 description 2
• 238000001542 size-exclusion chromatography Methods 0.000 description 2
• 239000002904 solvent Substances 0.000 description 2
• 238000011301 standard therapy Methods 0.000 description 2
• 239000007858 starting material Substances 0.000 description 2
• 238000003860 storage Methods 0.000 description 2
• UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
• 239000000758 substrate Substances 0.000 description 2
• 229940124530 sulfonamide Drugs 0.000 description 2
• 150000003456 sulfonamides Chemical class 0.000 description 2
• 238000011477 surgical intervention Methods 0.000 description 2
• 239000000725 suspension Substances 0.000 description 2
• 210000005222 synovial tissue Anatomy 0.000 description 2
• 108010061238 threonyl-glycine Proteins 0.000 description 2
• 238000012546 transfer Methods 0.000 description 2
• 238000011269 treatment regimen Methods 0.000 description 2
• 108010080629 tryptophan-leucine Proteins 0.000 description 2
• 239000002451 tumor necrosis factor inhibitor Substances 0.000 description 2
• 108010003137 tyrosyltyrosine Proteins 0.000 description 2
• 238000000108 ultra-filtration Methods 0.000 description 2
• 235000013311 vegetables Nutrition 0.000 description 2
• 239000003981 vehicle Substances 0.000 description 2
• 230000003313 weakening effect Effects 0.000 description 2
• 208000016261 weight loss Diseases 0.000 description 2
• XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 1
• GJLXVWOMRRWCIB-MERZOTPQSA-N (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanamide Chemical compound C([C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CC=C(O)C=C1 GJLXVWOMRRWCIB-MERZOTPQSA-N 0.000 description 1
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
• XMQUEQJCYRFIQS-YFKPBYRVSA-N (2s)-2-amino-5-ethoxy-5-oxopentanoic acid Chemical compound CCOC(=O)CC[C@H](N)C(O)=O XMQUEQJCYRFIQS-YFKPBYRVSA-N 0.000 description 1
• LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 description 1
• OOIBFPKQHULHSQ-UHFFFAOYSA-N (3-hydroxy-1-adamantyl) 2-methylprop-2-enoate Chemical compound C1C(C2)CC3CC2(O)CC1(OC(=O)C(=C)C)C3 OOIBFPKQHULHSQ-UHFFFAOYSA-N 0.000 description 1
• NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
• KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 description 1
• MNRDNGRAKFSUSO-KHEUVVEUSA-N 2-aminoacetic acid;(2s)-2-amino-3-phenylpropanoic acid;(2s)-2,4-diamino-4-oxobutanoic acid Chemical group NCC(O)=O.OC(=O)[C@@H](N)CC(N)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 MNRDNGRAKFSUSO-KHEUVVEUSA-N 0.000 description 1
• XBBVURRQGJPTHH-UHFFFAOYSA-N 2-hydroxyacetic acid;2-hydroxypropanoic acid Chemical compound OCC(O)=O.CC(O)C(O)=O XBBVURRQGJPTHH-UHFFFAOYSA-N 0.000 description 1
• BRMWTNUJHUMWMS-UHFFFAOYSA-N 3-Methylhistidine Natural products CN1C=NC(CC(N)C(O)=O)=C1 BRMWTNUJHUMWMS-UHFFFAOYSA-N 0.000 description 1
• QFVHZQCOUORWEI-UHFFFAOYSA-N 4-[(4-anilino-5-sulfonaphthalen-1-yl)diazenyl]-5-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C=12C(O)=CC(S(O)(=O)=O)=CC2=CC(S(O)(=O)=O)=CC=1N=NC(C1=CC=CC(=C11)S(O)(=O)=O)=CC=C1NC1=CC=CC=C1 QFVHZQCOUORWEI-UHFFFAOYSA-N 0.000 description 1
• 229940117976 5-hydroxylysine Drugs 0.000 description 1
• 206010052489 Abdominal rebound tenderness Diseases 0.000 description 1
• 206010000234 Abortion spontaneous Diseases 0.000 description 1
• 208000002874 Acne Vulgaris Diseases 0.000 description 1
• 239000000275 Adrenocorticotropic Hormone Substances 0.000 description 1
• WDIYWDJLXOCGRW-ACZMJKKPSA-N Ala-Asp-Glu Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O WDIYWDJLXOCGRW-ACZMJKKPSA-N 0.000 description 1
• KXEVYGKATAMXJJ-ACZMJKKPSA-N Ala-Glu-Asp Chemical compound C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O KXEVYGKATAMXJJ-ACZMJKKPSA-N 0.000 description 1
• OMMDTNGURYRDAC-NRPADANISA-N Ala-Glu-Val Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(O)=O OMMDTNGURYRDAC-NRPADANISA-N 0.000 description 1
• RTZCUEHYUQZIDE-WHFBIAKZSA-N Ala-Ser-Gly Chemical compound C[C@H](N)C(=O)N[C@@H](CO)C(=O)NCC(O)=O RTZCUEHYUQZIDE-WHFBIAKZSA-N 0.000 description 1
• QDGMZAOSMNGBLP-MRFFXTKBSA-N Ala-Trp-Tyr Chemical compound C[C@@H](C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)O)N QDGMZAOSMNGBLP-MRFFXTKBSA-N 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 102000009027 Albumins Human genes 0.000 description 1
• 208000004881 Amebiasis Diseases 0.000 description 1
• 206010001980 Amoebiasis Diseases 0.000 description 1
• 208000037259 Amyloid Plaque Diseases 0.000 description 1
• 241000024188 Andala Species 0.000 description 1
• 208000008822 Ankylosis Diseases 0.000 description 1
• PRLPSDIHSRITSF-UNQGMJICSA-N Arg-Phe-Thr Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(O)=O PRLPSDIHSRITSF-UNQGMJICSA-N 0.000 description 1
• LQJAALCCPOTJGB-YUMQZZPRSA-N Arg-Pro Chemical compound NC(N)=NCCC[C@H](N)C(=O)N1CCC[C@H]1C(O)=O LQJAALCCPOTJGB-YUMQZZPRSA-N 0.000 description 1
• ISJWBVIYRBAXEB-CIUDSAMLSA-N Arg-Ser-Glu Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(O)=O ISJWBVIYRBAXEB-CIUDSAMLSA-N 0.000 description 1
• QLSRIZIDQXDQHK-RCWTZXSCSA-N Arg-Val-Thr Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O QLSRIZIDQXDQHK-RCWTZXSCSA-N 0.000 description 1
• 206010003267 Arthritis reactive Diseases 0.000 description 1
• DNYRZPOWBTYFAF-IHRRRGAJSA-N Asn-Arg-Tyr Chemical compound C1=CC(=CC=C1C[C@@H](C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)N)N)O DNYRZPOWBTYFAF-IHRRRGAJSA-N 0.000 description 1
• IYVSIZAXNLOKFQ-BYULHYEWSA-N Asn-Asp-Val Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(O)=O IYVSIZAXNLOKFQ-BYULHYEWSA-N 0.000 description 1
• YQNBILXAUIAUCF-CIUDSAMLSA-N Asn-Cys-Lys Chemical compound C(CCN)C[C@@H](C(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)N)N YQNBILXAUIAUCF-CIUDSAMLSA-N 0.000 description 1
• WLVLIYYBPPONRJ-GCJQMDKQSA-N Asn-Thr-Ala Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(O)=O WLVLIYYBPPONRJ-GCJQMDKQSA-N 0.000 description 1
• RQYMKRMRZWJGHC-BQBZGAKWSA-N Asp-Gly-Met Chemical compound CSCC[C@@H](C(=O)O)NC(=O)CNC(=O)[C@H](CC(=O)O)N RQYMKRMRZWJGHC-BQBZGAKWSA-N 0.000 description 1
• UAXIKORUDGGIGA-DCAQKATOSA-N Asp-Pro-Lys Chemical compound C1C[C@H](N(C1)C(=O)[C@H](CC(=O)O)N)C(=O)N[C@@H](CCCCN)C(=O)O UAXIKORUDGGIGA-DCAQKATOSA-N 0.000 description 1
• MNQMTYSEKZHIDF-GCJQMDKQSA-N Asp-Thr-Ala Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(O)=O MNQMTYSEKZHIDF-GCJQMDKQSA-N 0.000 description 1
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
• 206010003591 Ataxia Diseases 0.000 description 1
• XHVAWZZCDCWGBK-WYRLRVFGSA-M Aurothioglucose Chemical compound OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O XHVAWZZCDCWGBK-WYRLRVFGSA-M 0.000 description 1
• 206010003827 Autoimmune hepatitis Diseases 0.000 description 1
• 208000004429 Bacillary Dysentery Diseases 0.000 description 1
• 241000894006 Bacteria Species 0.000 description 1
• 206010004053 Bacterial toxaemia Diseases 0.000 description 1
• 102100036597 Basement membrane-specific heparan sulfate proteoglycan core protein Human genes 0.000 description 1
• 108700004676 Bence Jones Proteins 0.000 description 1
• 201000004569 Blindness Diseases 0.000 description 1
• 206010065687 Bone loss Diseases 0.000 description 1
• 241000283690 Bos taurus Species 0.000 description 1
• 101100339496 Caenorhabditis elegans hop-1 gene Proteins 0.000 description 1
• 101100217502 Caenorhabditis elegans lgg-3 gene Proteins 0.000 description 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
• 241000589876 Campylobacter Species 0.000 description 1
• 208000002177 Cataract Diseases 0.000 description 1
• 241000700199 Cavia porcellus Species 0.000 description 1
• 102000000844 Cell Surface Receptors Human genes 0.000 description 1
• 108010001857 Cell Surface Receptors Proteins 0.000 description 1
• 229920002284 Cellulose triacetate Polymers 0.000 description 1
• 206010051290 Central nervous system lesion Diseases 0.000 description 1
• 229930186147 Cephalosporin Natural products 0.000 description 1
• 241000282693 Cercopithecidae Species 0.000 description 1
• 206010008479 Chest Pain Diseases 0.000 description 1
• 206010008469 Chest discomfort Diseases 0.000 description 1
• 206010008531 Chills Diseases 0.000 description 1
• 241000606153 Chlamydia trachomatis Species 0.000 description 1
• 206010008609 Cholangitis sclerosing Diseases 0.000 description 1
• 229920001287 Chondroitin sulfate Polymers 0.000 description 1
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
• 108020004635 Complementary DNA Proteins 0.000 description 1
• 206010010741 Conjunctivitis Diseases 0.000 description 1
• 208000034656 Contusions Diseases 0.000 description 1
• 208000006069 Corneal Opacity Diseases 0.000 description 1
• 102400000739 Corticotropin Human genes 0.000 description 1
• 101800000414 Corticotropin Proteins 0.000 description 1
• 241000699800 Cricetinae Species 0.000 description 1
• 241000699802 Cricetulus griseus Species 0.000 description 1
• 206010011469 Crying Diseases 0.000 description 1
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
• 108010036949 Cyclosporine Proteins 0.000 description 1
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
• 102100033072 DNA replication ATP-dependent helicase DNA2 Human genes 0.000 description 1
• 238000001712 DNA sequencing Methods 0.000 description 1
• 230000006820 DNA synthesis Effects 0.000 description 1
• 206010012455 Dermatitis exfoliative Diseases 0.000 description 1
• 239000004375 Dextrin Substances 0.000 description 1
• 229920001353 Dextrin Polymers 0.000 description 1
• 206010012741 Diarrhoea haemorrhagic Diseases 0.000 description 1
• 239000004338 Dichlorodifluoromethane Substances 0.000 description 1
• 208000003164 Diplopia Diseases 0.000 description 1
• 206010013710 Drug interaction Diseases 0.000 description 1
• 208000000059 Dyspnea Diseases 0.000 description 1
• 238000012286 ELISA Assay Methods 0.000 description 1
• 208000009701 Embryo Loss Diseases 0.000 description 1
• 108010042407 Endonucleases Proteins 0.000 description 1
• 102000004533 Endonucleases Human genes 0.000 description 1
• 208000004232 Enteritis Diseases 0.000 description 1
• 206010015084 Episcleritis Diseases 0.000 description 1
• 108010008655 Epstein-Barr Virus Nuclear Antigens Proteins 0.000 description 1
• 206010015150 Erythema Diseases 0.000 description 1
• 206010015226 Erythema nodosum Diseases 0.000 description 1
• 108700024394 Exon Proteins 0.000 description 1
• 206010015943 Eye inflammation Diseases 0.000 description 1
• 208000004930 Fatty Liver Diseases 0.000 description 1
• 208000028387 Felty syndrome Diseases 0.000 description 1
• 108010088842 Fibrinolysin Proteins 0.000 description 1
• 206010016654 Fibrosis Diseases 0.000 description 1
• 208000007882 Gastritis Diseases 0.000 description 1
• 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• 108010072051 Glatiramer Acetate Proteins 0.000 description 1
• 206010018341 Gliosis Diseases 0.000 description 1
• JVSBYEDSSRZQGV-GUBZILKMSA-N Glu-Asp-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CCC(O)=O JVSBYEDSSRZQGV-GUBZILKMSA-N 0.000 description 1
• GJBUAAAIZSRCDC-GVXVVHGQSA-N Glu-Leu-Val Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(O)=O GJBUAAAIZSRCDC-GVXVVHGQSA-N 0.000 description 1
• PMNHJLASAAWELO-FOHZUACHSA-N Gly-Asp-Thr Chemical compound [H]NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O PMNHJLASAAWELO-FOHZUACHSA-N 0.000 description 1
• UQJNXZSSGQIPIQ-FBCQKBJTSA-N Gly-Gly-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)CNC(=O)CN UQJNXZSSGQIPIQ-FBCQKBJTSA-N 0.000 description 1
• DKEXFJVMVGETOO-LURJTMIESA-N Gly-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)CN DKEXFJVMVGETOO-LURJTMIESA-N 0.000 description 1
• ULZCYBYDTUMHNF-IUCAKERBSA-N Gly-Leu-Glu Chemical compound NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(O)=O ULZCYBYDTUMHNF-IUCAKERBSA-N 0.000 description 1
• HQSKKSLNLSTONK-JTQLQIEISA-N Gly-Tyr-Gly Chemical compound OC(=O)CNC(=O)[C@@H](NC(=O)CN)CC1=CC=C(O)C=C1 HQSKKSLNLSTONK-JTQLQIEISA-N 0.000 description 1
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical group OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 1
• 102000003886 Glycoproteins Human genes 0.000 description 1
• 108090000288 Glycoproteins Proteins 0.000 description 1
• 229920002683 Glycosaminoglycan Polymers 0.000 description 1
• 244000060234 Gmelina philippensis Species 0.000 description 1
• 208000024869 Goodpasture syndrome Diseases 0.000 description 1
• JBCLFWXMTIKCCB-UHFFFAOYSA-N H-Gly-Phe-OH Natural products NCC(=O)NC(C(O)=O)CC1=CC=CC=C1 JBCLFWXMTIKCCB-UHFFFAOYSA-N 0.000 description 1
• 102000006354 HLA-DR Antigens Human genes 0.000 description 1
• 108010058597 HLA-DR Antigens Proteins 0.000 description 1
• 239000012981 Hank's balanced salt solution Substances 0.000 description 1
• 206010019708 Hepatic steatosis Diseases 0.000 description 1
• 206010020112 Hirsutism Diseases 0.000 description 1
• 208000017604 Hodgkin disease Diseases 0.000 description 1
• 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
• 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
• 101000927313 Homo sapiens DNA replication ATP-dependent helicase DNA2 Proteins 0.000 description 1
• 101001021527 Homo sapiens Huntingtin-interacting protein 1 Proteins 0.000 description 1
• 241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
• 102100035957 Huntingtin-interacting protein 1 Human genes 0.000 description 1
• 206010020649 Hyperkeratosis Diseases 0.000 description 1
• 208000003623 Hypoalbuminemia Diseases 0.000 description 1
• 206010021079 Hypopnoea Diseases 0.000 description 1
• HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
• CYHYBSGMHMHKOA-CIQUZCHMSA-N Ile-Ala-Thr Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)N CYHYBSGMHMHKOA-CIQUZCHMSA-N 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 206010065042 Immune reconstitution inflammatory syndrome Diseases 0.000 description 1
• 238000012404 In vitro experiment Methods 0.000 description 1
• 238000012695 Interfacial polymerization Methods 0.000 description 1
• 206010022941 Iridocyclitis Diseases 0.000 description 1
• 206010023198 Joint ankylosis Diseases 0.000 description 1
• 206010023203 Joint destruction Diseases 0.000 description 1
• 206010023230 Joint stiffness Diseases 0.000 description 1
• 206010023232 Joint swelling Diseases 0.000 description 1
• 229920000288 Keratan sulfate Polymers 0.000 description 1
• 208000001126 Keratosis Diseases 0.000 description 1
• 208000000913 Kidney Calculi Diseases 0.000 description 1
• 206010023509 Kyphosis Diseases 0.000 description 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 description 1
• RNKSNIBMTUYWSH-YFKPBYRVSA-N L-prolylglycine Chemical compound [O-]C(=O)CNC(=O)[C@@H]1CCC[NH2+]1 RNKSNIBMTUYWSH-YFKPBYRVSA-N 0.000 description 1
• 125000000510 L-tryptophano group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C(C([H])([H])[C@@]([H])(C(O[H])=O)N([H])[*])C2=C1[H] 0.000 description 1
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
• 108010060630 Lactoglobulins Proteins 0.000 description 1
• 102000008192 Lactoglobulins Human genes 0.000 description 1
• 208000005230 Leg Ulcer Diseases 0.000 description 1
• QVFGXCVIXXBFHO-AVGNSLFASA-N Leu-Glu-Leu Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O QVFGXCVIXXBFHO-AVGNSLFASA-N 0.000 description 1
• KGCLIYGPQXUNLO-IUCAKERBSA-N Leu-Gly-Glu Chemical compound CC(C)C[C@H](N)C(=O)NCC(=O)N[C@H](C(O)=O)CCC(O)=O KGCLIYGPQXUNLO-IUCAKERBSA-N 0.000 description 1
• NRFGTHFONZYFNY-MGHWNKPDSA-N Leu-Ile-Tyr Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 NRFGTHFONZYFNY-MGHWNKPDSA-N 0.000 description 1
• KIZIOFNVSOSKJI-CIUDSAMLSA-N Leu-Ser-Cys Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)O)N KIZIOFNVSOSKJI-CIUDSAMLSA-N 0.000 description 1
• BRTVHXHCUSXYRI-CIUDSAMLSA-N Leu-Ser-Ser Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(O)=O BRTVHXHCUSXYRI-CIUDSAMLSA-N 0.000 description 1
• LRKCBIUDWAXNEG-CSMHCCOUSA-N Leu-Thr Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O LRKCBIUDWAXNEG-CSMHCCOUSA-N 0.000 description 1
• ILDSIMPXNFWKLH-KATARQTJSA-N Leu-Thr-Ser Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(O)=O ILDSIMPXNFWKLH-KATARQTJSA-N 0.000 description 1
• 108010055685 Leukocyte-Adhesion Receptors Proteins 0.000 description 1
• 206010050551 Lupus-like syndrome Diseases 0.000 description 1
• 208000008771 Lymphadenopathy Diseases 0.000 description 1
• 206010025323 Lymphomas Diseases 0.000 description 1
• UWKNTTJNVSYXPC-CIUDSAMLSA-N Lys-Ala-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCCN UWKNTTJNVSYXPC-CIUDSAMLSA-N 0.000 description 1
• SKRGVGLIRUGANF-AVGNSLFASA-N Lys-Leu-Glu Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(O)=O SKRGVGLIRUGANF-AVGNSLFASA-N 0.000 description 1
• RMKJOQSYLQQRFN-KKUMJFAQSA-N Lys-Tyr-Asp Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(O)=O)C(O)=O RMKJOQSYLQQRFN-KKUMJFAQSA-N 0.000 description 1
• 239000007987 MES buffer Substances 0.000 description 1
• 239000004907 Macro-emulsion Substances 0.000 description 1
• 208000002720 Malnutrition Diseases 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• GZENKSODFLBBHQ-ILSZZQPISA-N Medrysone Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@H](C(C)=O)CC[C@H]21 GZENKSODFLBBHQ-ILSZZQPISA-N 0.000 description 1
• 102000012750 Membrane Glycoproteins Human genes 0.000 description 1
• 108010090054 Membrane Glycoproteins Proteins 0.000 description 1
• ABHVWYPPHDYFNY-WDSOQIARSA-N Met-His-Trp Chemical compound C([C@H](NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)C1=CN=CN1 ABHVWYPPHDYFNY-WDSOQIARSA-N 0.000 description 1
• KAKJTZWHIUWTTD-VQVTYTSYSA-N Met-Thr Chemical compound CSCC[C@H]([NH3+])C(=O)N[C@@H]([C@@H](C)O)C([O-])=O KAKJTZWHIUWTTD-VQVTYTSYSA-N 0.000 description 1
• 206010027918 Mononeuropathy multiplex Diseases 0.000 description 1
• 206010027951 Mood swings Diseases 0.000 description 1
• 206010028124 Mucosal ulceration Diseases 0.000 description 1
• 241000699660 Mus musculus Species 0.000 description 1
• 101100174574 Mus musculus Pikfyve gene Proteins 0.000 description 1
• 208000010428 Muscle Weakness Diseases 0.000 description 1
• 208000021642 Muscular disease Diseases 0.000 description 1
• 206010028372 Muscular weakness Diseases 0.000 description 1
• 206010052904 Musculoskeletal stiffness Diseases 0.000 description 1
• 102000006386 Myelin Proteins Human genes 0.000 description 1
• 108010083674 Myelin Proteins Proteins 0.000 description 1
• 102000055324 Myelin Proteolipid Human genes 0.000 description 1
• 101710094913 Myelin proteolipid protein Proteins 0.000 description 1
• 201000009623 Myopathy Diseases 0.000 description 1
• DTERQYGMUDWYAZ-ZETCQYMHSA-N N(6)-acetyl-L-lysine Chemical compound CC(=O)NCCCC[C@H]([NH3+])C([O-])=O DTERQYGMUDWYAZ-ZETCQYMHSA-N 0.000 description 1
• NTNWOCRCBQPEKQ-YFKPBYRVSA-N N(omega)-methyl-L-arginine Chemical compound CN=C(N)NCCC[C@H](N)C(O)=O NTNWOCRCBQPEKQ-YFKPBYRVSA-N 0.000 description 1
• JDHILDINMRGULE-LURJTMIESA-N N(pros)-methyl-L-histidine Chemical compound CN1C=NC=C1C[C@H](N)C(O)=O JDHILDINMRGULE-LURJTMIESA-N 0.000 description 1
• WUGMRIBZSVSJNP-UHFFFAOYSA-N N-L-alanyl-L-tryptophan Natural products C1=CC=C2C(CC(NC(=O)C(N)C)C(O)=O)=CNC2=C1 WUGMRIBZSVSJNP-UHFFFAOYSA-N 0.000 description 1
• MDSUKZSLOATHMH-UHFFFAOYSA-N N-L-leucyl-L-valine Natural products CC(C)CC(N)C(=O)NC(C(C)C)C(O)=O MDSUKZSLOATHMH-UHFFFAOYSA-N 0.000 description 1
• JJIHLJJYMXLCOY-BYPYZUCNSA-N N-acetyl-L-serine Chemical compound CC(=O)N[C@@H](CO)C(O)=O JJIHLJJYMXLCOY-BYPYZUCNSA-N 0.000 description 1
• PYUSHNKNPOHWEZ-YFKPBYRVSA-N N-formyl-L-methionine Chemical compound CSCC[C@@H](C(O)=O)NC=O PYUSHNKNPOHWEZ-YFKPBYRVSA-N 0.000 description 1
• 108010079364 N-glycylalanine Proteins 0.000 description 1
• 108091007491 NSP3 Papain-like protease domains Proteins 0.000 description 1
• 206010028851 Necrosis Diseases 0.000 description 1
• 206010029148 Nephrolithiasis Diseases 0.000 description 1
• 206010029164 Nephrotic syndrome Diseases 0.000 description 1
• 208000012902 Nervous system disease Diseases 0.000 description 1
• 206010029260 Neuroblastoma Diseases 0.000 description 1
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
• 208000003435 Optic Neuritis Diseases 0.000 description 1
• 208000007117 Oral Ulcer Diseases 0.000 description 1
• 206010068319 Oropharyngeal pain Diseases 0.000 description 1
• 206010031264 Osteonecrosis Diseases 0.000 description 1
• 102000004264 Osteopontin Human genes 0.000 description 1
• 108010081689 Osteopontin Proteins 0.000 description 1
• 208000012868 Overgrowth Diseases 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 206010033645 Pancreatitis Diseases 0.000 description 1
• 108090000526 Papain Proteins 0.000 description 1
• 206010033892 Paraplegia Diseases 0.000 description 1
• 208000031481 Pathologic Constriction Diseases 0.000 description 1
• 235000019483 Peanut oil Nutrition 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 241000721454 Pemphigus Species 0.000 description 1
• 229930182555 Penicillin Natural products 0.000 description 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
• 208000008469 Peptic Ulcer Diseases 0.000 description 1
• 208000005228 Pericardial Effusion Diseases 0.000 description 1
• 201000007100 Pharyngitis Diseases 0.000 description 1
• KIEPQOIQHFKQLK-PCBIJLKTSA-N Phe-Asn-Ile Chemical compound [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O KIEPQOIQHFKQLK-PCBIJLKTSA-N 0.000 description 1
• PSBJZLMFFTULDX-IXOXFDKPSA-N Phe-Cys-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](CC1=CC=CC=C1)N)O PSBJZLMFFTULDX-IXOXFDKPSA-N 0.000 description 1
• NAXPHWZXEXNDIW-JTQLQIEISA-N Phe-Gly-Gly Chemical compound OC(=O)CNC(=O)CNC(=O)[C@@H](N)CC1=CC=CC=C1 NAXPHWZXEXNDIW-JTQLQIEISA-N 0.000 description 1
• YTILBRIUASDGBL-BZSNNMDCSA-N Phe-Leu-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC1=CC=CC=C1 YTILBRIUASDGBL-BZSNNMDCSA-N 0.000 description 1
• ROHDXJUFQVRDAV-UWVGGRQHSA-N Phe-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=CC=C1 ROHDXJUFQVRDAV-UWVGGRQHSA-N 0.000 description 1
• 108010004729 Phycoerythrin Proteins 0.000 description 1
• 208000002151 Pleural effusion Diseases 0.000 description 1
• 206010035664 Pneumonia Diseases 0.000 description 1
• 206010035742 Pneumonitis Diseases 0.000 description 1
• 206010036030 Polyarthritis Diseases 0.000 description 1
• 229920000805 Polyaspartic acid Polymers 0.000 description 1
• 239000004698 Polyethylene Substances 0.000 description 1
• JARJPEMLQAWNBR-GUBZILKMSA-N Pro-Asp-Arg Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O JARJPEMLQAWNBR-GUBZILKMSA-N 0.000 description 1
• DXTOOBDIIAJZBJ-BQBZGAKWSA-N Pro-Gly-Ser Chemical compound [H]N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CO)C(O)=O DXTOOBDIIAJZBJ-BQBZGAKWSA-N 0.000 description 1
• QKWYXRPICJEQAJ-KJEVXHAQSA-N Pro-Tyr-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@@H]2CCCN2)O QKWYXRPICJEQAJ-KJEVXHAQSA-N 0.000 description 1
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
• 239000004365 Protease Substances 0.000 description 1
• 229940124158 Protease/peptidase inhibitor Drugs 0.000 description 1
• 208000003251 Pruritus Diseases 0.000 description 1
• 208000028017 Psychotic disease Diseases 0.000 description 1
• 206010037714 Quadriplegia Diseases 0.000 description 1
• 239000012980 RPMI-1640 medium Substances 0.000 description 1
• 108010025216 RVF peptide Proteins 0.000 description 1
• 241000700157 Rattus norvegicus Species 0.000 description 1
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
• 208000021329 Refractory celiac disease Diseases 0.000 description 1
• 208000007400 Relapsing-Remitting Multiple Sclerosis Diseases 0.000 description 1
• 208000037656 Respiratory Sounds Diseases 0.000 description 1
• 108010081750 Reticulin Proteins 0.000 description 1
• 201000007737 Retinal degeneration Diseases 0.000 description 1
• 108091028664 Ribonucleotide Proteins 0.000 description 1
• 241000283984 Rodentia Species 0.000 description 1
• 206010039361 Sacroiliitis Diseases 0.000 description 1
• 206010039705 Scleritis Diseases 0.000 description 1
• 206010040026 Sensory disturbance Diseases 0.000 description 1
• 229920002684 Sepharose Polymers 0.000 description 1
• 206010040047 Sepsis Diseases 0.000 description 1
• UQFYNFTYDHUIMI-WHFBIAKZSA-N Ser-Gly-Ala Chemical compound OC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](N)CO UQFYNFTYDHUIMI-WHFBIAKZSA-N 0.000 description 1
• FUMGHWDRRFCKEP-CIUDSAMLSA-N Ser-Leu-Ala Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(O)=O FUMGHWDRRFCKEP-CIUDSAMLSA-N 0.000 description 1
• PJIQEIFXZPCWOJ-FXQIFTODSA-N Ser-Pro-Asp Chemical compound [H]N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(O)=O PJIQEIFXZPCWOJ-FXQIFTODSA-N 0.000 description 1
• BMKNXTJLHFIAAH-CIUDSAMLSA-N Ser-Ser-Leu Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O BMKNXTJLHFIAAH-CIUDSAMLSA-N 0.000 description 1
• VGQVAVQWKJLIRM-FXQIFTODSA-N Ser-Ser-Val Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(O)=O VGQVAVQWKJLIRM-FXQIFTODSA-N 0.000 description 1
• SNXUIBACCONSOH-BWBBJGPYSA-N Ser-Thr-Ser Chemical compound OC[C@H](N)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CO)C(O)=O SNXUIBACCONSOH-BWBBJGPYSA-N 0.000 description 1
• LGIMRDKGABDMBN-DCAQKATOSA-N Ser-Val-Lys Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CO)N LGIMRDKGABDMBN-DCAQKATOSA-N 0.000 description 1
• GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 description 1
• XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
• BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
• 108020004682 Single-Stranded DNA Proteins 0.000 description 1
• 208000021386 Sjogren Syndrome Diseases 0.000 description 1
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
• 208000007107 Stomach Ulcer Diseases 0.000 description 1
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
• 206010043275 Teratogenicity Diseases 0.000 description 1
• 239000004098 Tetracycline Substances 0.000 description 1
• DWYAUVCQDTZIJI-VZFHVOOUSA-N Thr-Ala-Ser Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(O)=O DWYAUVCQDTZIJI-VZFHVOOUSA-N 0.000 description 1
• NFMPFBCXABPALN-OWLDWWDNSA-N Thr-Ala-Trp Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)O)N)O NFMPFBCXABPALN-OWLDWWDNSA-N 0.000 description 1
• DGDCHPCRMWEOJR-FQPOAREZSA-N Thr-Ala-Tyr Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 DGDCHPCRMWEOJR-FQPOAREZSA-N 0.000 description 1
• KRPKYGOFYUNIGM-XVSYOHENSA-N Thr-Asp-Phe Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O)N)O KRPKYGOFYUNIGM-XVSYOHENSA-N 0.000 description 1
• YAAPRMFURSENOZ-KATARQTJSA-N Thr-Cys-Lys Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)O)N)O YAAPRMFURSENOZ-KATARQTJSA-N 0.000 description 1
• BIYXEUAFGLTAEM-WUJLRWPWSA-N Thr-Gly Chemical compound C[C@@H](O)[C@H](N)C(=O)NCC(O)=O BIYXEUAFGLTAEM-WUJLRWPWSA-N 0.000 description 1
• JQAWYCUUFIMTHE-WLTAIBSBSA-N Thr-Gly-Tyr Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O JQAWYCUUFIMTHE-WLTAIBSBSA-N 0.000 description 1
• JKGGPMOUIAAJAA-YEPSODPASA-N Thr-Gly-Val Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C(C)C)C(O)=O JKGGPMOUIAAJAA-YEPSODPASA-N 0.000 description 1
• MXNAOGFNFNKUPD-JHYOHUSXSA-N Thr-Phe-Thr Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(O)=O MXNAOGFNFNKUPD-JHYOHUSXSA-N 0.000 description 1
• GFRIEEKFXOVPIR-RHYQMDGZSA-N Thr-Pro-Lys Chemical compound C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(O)=O GFRIEEKFXOVPIR-RHYQMDGZSA-N 0.000 description 1
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
• 239000004473 Threonine Substances 0.000 description 1
• 108090000190 Thrombin Proteins 0.000 description 1
• 208000013222 Toxemia Diseases 0.000 description 1
• 206010070863 Toxicity to various agents Diseases 0.000 description 1
• 101710120037 Toxin CcdB Proteins 0.000 description 1
• 206010066901 Treatment failure Diseases 0.000 description 1
• 108091061763 Triple-stranded DNA Proteins 0.000 description 1
• BABINGWMZBWXIX-BPUTZDHNSA-N Trp-Val-Ser Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)N BABINGWMZBWXIX-BPUTZDHNSA-N 0.000 description 1
• 206010054094 Tumour necrosis Diseases 0.000 description 1
• LGEYOIQBBIPHQN-UWJYBYFXSA-N Tyr-Ala-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 LGEYOIQBBIPHQN-UWJYBYFXSA-N 0.000 description 1
• SMLCYZYQFRTLCO-UWJYBYFXSA-N Tyr-Cys-Ala Chemical compound [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(O)=O SMLCYZYQFRTLCO-UWJYBYFXSA-N 0.000 description 1
• 241000202921 Ureaplasma urealyticum Species 0.000 description 1
• CVUDMNSZAIZFAE-TUAOUCFPSA-N Val-Arg-Pro Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)O)N CVUDMNSZAIZFAE-TUAOUCFPSA-N 0.000 description 1
• VCAWFLIWYNMHQP-UKJIMTQDSA-N Val-Glu-Ile Chemical compound CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C(C)C)N VCAWFLIWYNMHQP-UKJIMTQDSA-N 0.000 description 1
• ZRSZTKTVPNSUNA-IHRRRGAJSA-N Val-Lys-Leu Chemical compound CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)C(C)C)C(O)=O ZRSZTKTVPNSUNA-IHRRRGAJSA-N 0.000 description 1
• SSYBNWFXCFNRFN-GUBZILKMSA-N Val-Pro-Ser Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(O)=O SSYBNWFXCFNRFN-GUBZILKMSA-N 0.000 description 1
• DEGUERSKQBRZMZ-FXQIFTODSA-N Val-Ser-Ala Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(O)=O DEGUERSKQBRZMZ-FXQIFTODSA-N 0.000 description 1
• OFTXTCGQJXTNQS-XGEHTFHBSA-N Val-Thr-Ser Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](C(C)C)N)O OFTXTCGQJXTNQS-XGEHTFHBSA-N 0.000 description 1
• 241000700605 Viruses Species 0.000 description 1
• 229930003316 Vitamin D Natural products 0.000 description 1
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
• 208000021017 Weight Gain Diseases 0.000 description 1
• 206010047924 Wheezing Diseases 0.000 description 1
• 208000027418 Wounds and injury Diseases 0.000 description 1
• NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 description 1
• 230000002159 abnormal effect Effects 0.000 description 1
• 239000004015 abortifacient agent Substances 0.000 description 1
• 231100000641 abortifacient agent Toxicity 0.000 description 1
• 206010000210 abortion Diseases 0.000 description 1
• 231100000176 abortion Toxicity 0.000 description 1
• 238000009825 accumulation Methods 0.000 description 1
• 239000003929 acidic solution Substances 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• 150000007513 acids Chemical class 0.000 description 1
• 206010000496 acne Diseases 0.000 description 1
• 238000003915 air pollution Methods 0.000 description 1
• 108010008685 alanyl-glutamyl-aspartic acid Proteins 0.000 description 1
• 108010047495 alanylglycine Proteins 0.000 description 1
• NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
• 125000000217 alkyl group Chemical group 0.000 description 1
• 230000029936 alkylation Effects 0.000 description 1
• 238000005804 alkylation reaction Methods 0.000 description 1
• 230000000172 allergic effect Effects 0.000 description 1
• 230000000735 allogeneic effect Effects 0.000 description 1
• BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
• 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
• 238000012870 ammonium sulfate precipitation Methods 0.000 description 1
• 235000011130 ammonium sulphate Nutrition 0.000 description 1
• AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
• 229960000723 ampicillin Drugs 0.000 description 1
• 238000010171 animal model Methods 0.000 description 1
• 239000003957 anion exchange resin Substances 0.000 description 1
• 150000001450 anions Chemical class 0.000 description 1
• 210000003423 ankle Anatomy 0.000 description 1
• 208000022531 anorexia Diseases 0.000 description 1
• 201000004612 anterior uveitis Diseases 0.000 description 1
• 230000001142 anti-diarrhea Effects 0.000 description 1
• 229940121363 anti-inflammatory agent Drugs 0.000 description 1
• 239000002260 anti-inflammatory agent Substances 0.000 description 1
• 229940124599 anti-inflammatory drug Drugs 0.000 description 1
• 230000003460 anti-nuclear Effects 0.000 description 1
• 230000000692 anti-sense effect Effects 0.000 description 1
• 230000000259 anti-tumor effect Effects 0.000 description 1
• 230000009830 antibody antigen interaction Effects 0.000 description 1
• 238000011091 antibody purification Methods 0.000 description 1
• 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 description 1
• 239000003963 antioxidant agent Substances 0.000 description 1
• 235000006708 antioxidants Nutrition 0.000 description 1
• 239000012062 aqueous buffer Substances 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
• 108010060035 arginylproline Proteins 0.000 description 1
• 238000000149 argon plasma sintering Methods 0.000 description 1
• 229960005070 ascorbic acid Drugs 0.000 description 1
• 235000010323 ascorbic acid Nutrition 0.000 description 1
• 239000011668 ascorbic acid Substances 0.000 description 1
• 229960001230 asparagine Drugs 0.000 description 1
• 235000009582 asparagine Nutrition 0.000 description 1
• 108010093581 aspartyl-proline Proteins 0.000 description 1
• 239000012131 assay buffer Substances 0.000 description 1
• 238000002820 assay format Methods 0.000 description 1
• 210000001130 astrocyte Anatomy 0.000 description 1
• 208000010668 atopic eczema Diseases 0.000 description 1
• 238000000376 autoradiography Methods 0.000 description 1
• 230000001580 bacterial effect Effects 0.000 description 1
• 239000003637 basic solution Substances 0.000 description 1
• 210000003651 basophil Anatomy 0.000 description 1
• 230000006399 behavior Effects 0.000 description 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
• 229960002537 betamethasone Drugs 0.000 description 1
• UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 description 1
• 230000001588 bifunctional effect Effects 0.000 description 1
• 210000003445 biliary tract Anatomy 0.000 description 1
• 208000027119 bilirubin metabolic disease Diseases 0.000 description 1
• 229920002988 biodegradable polymer Polymers 0.000 description 1
• 239000004621 biodegradable polymer Substances 0.000 description 1
• 239000012472 biological sample Substances 0.000 description 1
• 230000036765 blood level Effects 0.000 description 1
• 210000004204 blood vessel Anatomy 0.000 description 1
• 238000006664 bond formation reaction Methods 0.000 description 1
• 210000004958 brain cell Anatomy 0.000 description 1
• 208000025698 brain inflammatory disease Diseases 0.000 description 1
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• 239000001110 calcium chloride Substances 0.000 description 1
• 229910001628 calcium chloride Inorganic materials 0.000 description 1
• 239000002775 capsule Substances 0.000 description 1
• 150000001720 carbohydrates Chemical class 0.000 description 1
• 235000014633 carbohydrates Nutrition 0.000 description 1
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
• JLQUFIHWVLZVTJ-UHFFFAOYSA-N carbosulfan Chemical compound CCCCN(CCCC)SN(C)C(=O)OC1=CC=CC2=C1OC(C)(C)C2 JLQUFIHWVLZVTJ-UHFFFAOYSA-N 0.000 description 1
• 239000005018 casein Substances 0.000 description 1
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
• 235000021240 caseins Nutrition 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 239000003729 cation exchange resin Substances 0.000 description 1
• 210000004534 cecum Anatomy 0.000 description 1
• 238000003352 cell adhesion assay Methods 0.000 description 1
• 239000013592 cell lysate Substances 0.000 description 1
• 230000012292 cell migration Effects 0.000 description 1
• 229940124587 cephalosporin Drugs 0.000 description 1
• 150000001780 cephalosporins Chemical class 0.000 description 1
• 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
• 239000002738 chelating agent Substances 0.000 description 1
• 239000005081 chemiluminescent agent Substances 0.000 description 1
• 229940038705 chlamydia trachomatis Drugs 0.000 description 1
• 201000001883 cholelithiasis Diseases 0.000 description 1
• 235000012000 cholesterol Nutrition 0.000 description 1
• 239000000812 cholinergic antagonist Substances 0.000 description 1
• 229940094517 chondroitin 4-sulfate Drugs 0.000 description 1
• KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 1
• 238000011098 chromatofocusing Methods 0.000 description 1
• 229960001265 ciclosporin Drugs 0.000 description 1
• 235000019504 cigarettes Nutrition 0.000 description 1
• 230000007882 cirrhosis Effects 0.000 description 1
• 208000019425 cirrhosis of liver Diseases 0.000 description 1
• 238000003776 cleavage reaction Methods 0.000 description 1
• 238000005354 coacervation Methods 0.000 description 1
• 238000012321 colectomy Methods 0.000 description 1
• 230000000112 colonic effect Effects 0.000 description 1
• 238000012875 competitive assay Methods 0.000 description 1
• 239000002131 composite material Substances 0.000 description 1
• 229940124301 concurrent medication Drugs 0.000 description 1
• 238000012790 confirmation Methods 0.000 description 1
• 230000021615 conjugation Effects 0.000 description 1
• 239000005289 controlled pore glass Substances 0.000 description 1
• 230000001276 controlling effect Effects 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 229940038717 copaxone Drugs 0.000 description 1
• 231100000269 corneal opacity Toxicity 0.000 description 1
• 229960000258 corticotropin Drugs 0.000 description 1
• IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 1
• 229940111134 coxibs Drugs 0.000 description 1
• 238000004132 cross linking Methods 0.000 description 1
• 230000009260 cross reactivity Effects 0.000 description 1
• 238000011461 current therapy Methods 0.000 description 1
• ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
• 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 description 1
• 229930182912 cyclosporin Natural products 0.000 description 1
• 230000006240 deamidation Effects 0.000 description 1
• 206010061428 decreased appetite Diseases 0.000 description 1
• 230000007812 deficiency Effects 0.000 description 1
• 239000003405 delayed action preparation Substances 0.000 description 1
• 230000003111 delayed effect Effects 0.000 description 1
• YSMODUONRAFBET-UHFFFAOYSA-N delta-DL-hydroxylysine Natural products NCC(O)CCC(N)C(O)=O YSMODUONRAFBET-UHFFFAOYSA-N 0.000 description 1
• 238000004925 denaturation Methods 0.000 description 1
• 230000036425 denaturation Effects 0.000 description 1
• 239000005547 deoxyribonucleotide Substances 0.000 description 1
• 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
• 230000000994 depressogenic effect Effects 0.000 description 1
• 229940019765 dermatin Drugs 0.000 description 1
• 230000001066 destructive effect Effects 0.000 description 1
• 239000003599 detergent Substances 0.000 description 1
• 235000019425 dextrin Nutrition 0.000 description 1
• 238000000502 dialysis Methods 0.000 description 1
• PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
• 235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
• 230000000378 dietary effect Effects 0.000 description 1
• 235000015872 dietary supplement Nutrition 0.000 description 1
• 230000010339 dilation Effects 0.000 description 1
• 229960001051 dimercaprol Drugs 0.000 description 1
• WQABCVAJNWAXTE-UHFFFAOYSA-N dimercaprol Chemical compound OCC(S)CS WQABCVAJNWAXTE-UHFFFAOYSA-N 0.000 description 1
• 150000002016 disaccharides Chemical class 0.000 description 1
• 208000028659 discharge Diseases 0.000 description 1
• 239000012153 distilled water Substances 0.000 description 1
• 230000006334 disulfide bridging Effects 0.000 description 1
• 125000002228 disulfide group Chemical group 0.000 description 1
• 208000002173 dizziness Diseases 0.000 description 1
• 231100000371 dose-limiting toxicity Toxicity 0.000 description 1
• 238000001647 drug administration Methods 0.000 description 1
• 201000006549 dyspepsia Diseases 0.000 description 1
• 206010013990 dysuria Diseases 0.000 description 1
• 239000012636 effector Substances 0.000 description 1
• 230000009881 electrostatic interaction Effects 0.000 description 1
• 230000008030 elimination Effects 0.000 description 1
• 238000003379 elimination reaction Methods 0.000 description 1
• 230000008451 emotion Effects 0.000 description 1
• 239000003995 emulsifying agent Substances 0.000 description 1
• 230000001804 emulsifying effect Effects 0.000 description 1
• 230000003511 endothelial effect Effects 0.000 description 1
• 239000003623 enhancer Substances 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• 210000000981 epithelium Anatomy 0.000 description 1
• YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical compound NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 description 1
• 150000002148 esters Chemical class 0.000 description 1
• 238000012869 ethanol precipitation Methods 0.000 description 1
• 238000011156 evaluation Methods 0.000 description 1
• 230000005713 exacerbation Effects 0.000 description 1
• 238000009207 exercise therapy Methods 0.000 description 1
• 208000004526 exfoliative dermatitis Diseases 0.000 description 1
• 238000013265 extended release Methods 0.000 description 1
• 210000003414 extremity Anatomy 0.000 description 1
• 206010016256 fatigue Diseases 0.000 description 1
• 208000010706 fatty liver disease Diseases 0.000 description 1
• 210000004700 fetal blood Anatomy 0.000 description 1
• 230000008175 fetal development Effects 0.000 description 1
• 210000002950 fibroblast Anatomy 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• 210000003811 finger Anatomy 0.000 description 1
• 210000004905 finger nail Anatomy 0.000 description 1
• FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 description 1
• 229960001048 fluorometholone Drugs 0.000 description 1
• FAOZLTXFLGPHNG-KNAQIMQKSA-N fluorometholone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@]2(F)[C@@H](O)C[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 FAOZLTXFLGPHNG-KNAQIMQKSA-N 0.000 description 1
• 229960002714 fluticasone Drugs 0.000 description 1
• MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 description 1
• 239000006260 foam Substances 0.000 description 1
• 229960002848 formoterol Drugs 0.000 description 1
• BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 description 1
• 238000005194 fractionation Methods 0.000 description 1
• 238000004108 freeze drying Methods 0.000 description 1
• 238000007710 freezing Methods 0.000 description 1
• 230000008014 freezing Effects 0.000 description 1
• 208000001130 gallstones Diseases 0.000 description 1
• 108010063718 gamma-glutamylaspartic acid Proteins 0.000 description 1
• 230000002496 gastric effect Effects 0.000 description 1
• 238000001502 gel electrophoresis Methods 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• 230000007387 gliosis Effects 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 229960002989 glutamic acid Drugs 0.000 description 1
• 229960002743 glutamine Drugs 0.000 description 1
• 108010057083 glutamyl-aspartyl-leucine Proteins 0.000 description 1
• 125000005456 glyceride group Chemical group 0.000 description 1
• 150000002334 glycols Chemical class 0.000 description 1
• 230000013595 glycosylation Effects 0.000 description 1
• 238000006206 glycosylation reaction Methods 0.000 description 1
• 108010050848 glycylleucine Proteins 0.000 description 1
• 150000002344 gold compounds Chemical class 0.000 description 1
• 229940015045 gold sodium thiomalate Drugs 0.000 description 1
• 208000037824 growth disorder Diseases 0.000 description 1
• 229940093915 gynecological organic acid Drugs 0.000 description 1
• 230000009067 heart development Effects 0.000 description 1
• 210000003709 heart valve Anatomy 0.000 description 1
• 208000024798 heartburn Diseases 0.000 description 1
• 210000002443 helper t lymphocyte Anatomy 0.000 description 1
• 230000002489 hematologic effect Effects 0.000 description 1
• 229920000669 heparin Polymers 0.000 description 1
• 229960002897 heparin Drugs 0.000 description 1
• 231100000283 hepatitis Toxicity 0.000 description 1
• 208000021760 high fever Diseases 0.000 description 1
• 210000001624 hip Anatomy 0.000 description 1
• 239000012510 hollow fiber Substances 0.000 description 1
• 229940088597 hormone Drugs 0.000 description 1
• 239000005556 hormone Substances 0.000 description 1
• 230000005745 host immune response Effects 0.000 description 1
• 210000005260 human cell Anatomy 0.000 description 1
• 229920002674 hyaluronan Polymers 0.000 description 1
• 229960003160 hyaluronic acid Drugs 0.000 description 1
• 210000004754 hybrid cell Anatomy 0.000 description 1
• 238000009396 hybridization Methods 0.000 description 1
• 229960000890 hydrocortisone Drugs 0.000 description 1
• 229920001477 hydrophilic polymer Polymers 0.000 description 1
• 229920001600 hydrophobic polymer Polymers 0.000 description 1
• XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 description 1
• 229960004171 hydroxychloroquine Drugs 0.000 description 1
• 238000012872 hydroxylapatite chromatography Methods 0.000 description 1
• 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
• 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
• 208000036796 hyperbilirubinemia Diseases 0.000 description 1
• 229960001680 ibuprofen Drugs 0.000 description 1
• 208000009326 ileitis Diseases 0.000 description 1
• 238000003384 imaging method Methods 0.000 description 1
• 125000001841 imino group Chemical group [H]N=* 0.000 description 1
• 230000008105 immune reaction Effects 0.000 description 1
• 230000008629 immune suppression Effects 0.000 description 1
• 230000000899 immune system response Effects 0.000 description 1
• 238000003018 immunoassay Methods 0.000 description 1
• 230000002163 immunogen Effects 0.000 description 1
• 230000005847 immunogenicity Effects 0.000 description 1
• 230000016784 immunoglobulin production Effects 0.000 description 1
• 238000009177 immunoglobulin therapy Methods 0.000 description 1
• 229940088592 immunologic factor Drugs 0.000 description 1
• 239000000367 immunologic factor Substances 0.000 description 1
• 229940124589 immunosuppressive drug Drugs 0.000 description 1
• 239000012535 impurity Substances 0.000 description 1
• 238000005462 in vivo assay Methods 0.000 description 1
• 238000011065 in-situ storage Methods 0.000 description 1
• 239000012678 infectious agent Substances 0.000 description 1
• 230000002458 infectious effect Effects 0.000 description 1
• 210000004969 inflammatory cell Anatomy 0.000 description 1
• 206010022000 influenza Diseases 0.000 description 1
• 229940125369 inhaled corticosteroids Drugs 0.000 description 1
• 238000007689 inspection Methods 0.000 description 1
• 229940079322 interferon Drugs 0.000 description 1
• 229960003161 interferon beta-1b Drugs 0.000 description 1
• 229940047124 interferons Drugs 0.000 description 1
• 230000008944 intestinal immunity Effects 0.000 description 1
• 239000007928 intraperitoneal injection Substances 0.000 description 1
• 238000011835 investigation Methods 0.000 description 1
• 238000005342 ion exchange Methods 0.000 description 1
• 238000004255 ion exchange chromatography Methods 0.000 description 1
• 239000003456 ion exchange resin Substances 0.000 description 1
• 229920003303 ion-exchange polymer Polymers 0.000 description 1
• OEXHQOGQTVQTAT-JRNQLAHRSA-N ipratropium Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-JRNQLAHRSA-N 0.000 description 1
• 229960001888 ipratropium Drugs 0.000 description 1
• 201000004614 iritis Diseases 0.000 description 1
• 230000001788 irregular Effects 0.000 description 1
• 230000002427 irreversible effect Effects 0.000 description 1
• 229960000310 isoleucine Drugs 0.000 description 1
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
• 239000007951 isotonicity adjuster Substances 0.000 description 1
• KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 description 1
• 210000000629 knee joint Anatomy 0.000 description 1
• 238000002372 labelling Methods 0.000 description 1
• 230000002045 lasting effect Effects 0.000 description 1
• 230000003902 lesion Effects 0.000 description 1
• 208000032839 leukemia Diseases 0.000 description 1
• 229960004338 leuprorelin Drugs 0.000 description 1
• 210000003041 ligament Anatomy 0.000 description 1
• 150000002632 lipids Chemical class 0.000 description 1
• 230000005976 liver dysfunction Effects 0.000 description 1
• 208000018191 liver inflammation Diseases 0.000 description 1
• 230000004807 localization Effects 0.000 description 1
• 229940127212 long-acting beta 2 agonist Drugs 0.000 description 1
• 230000005923 long-lasting effect Effects 0.000 description 1
• 239000007937 lozenge Substances 0.000 description 1
• 229940087857 lupron Drugs 0.000 description 1
• 208000018555 lymphatic system disease Diseases 0.000 description 1
• 210000003563 lymphoid tissue Anatomy 0.000 description 1
• 239000006166 lysate Substances 0.000 description 1
• 229910001629 magnesium chloride Inorganic materials 0.000 description 1
• 201000004792 malaria Diseases 0.000 description 1
• 230000036210 malignancy Effects 0.000 description 1
• 210000005075 mammary gland Anatomy 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 230000035800 maturation Effects 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 238000013160 medical therapy Methods 0.000 description 1
• 229960001011 medrysone Drugs 0.000 description 1
• 210000001809 melena Anatomy 0.000 description 1
• 210000003071 memory t lymphocyte Anatomy 0.000 description 1
• 230000004060 metabolic process Effects 0.000 description 1
• 108010034507 methionyltryptophan Proteins 0.000 description 1
• VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
• 229960000282 metronidazole Drugs 0.000 description 1
• 239000004530 micro-emulsion Substances 0.000 description 1
• 238000010232 migration assay Methods 0.000 description 1
• 235000013336 milk Nutrition 0.000 description 1
• 239000008267 milk Substances 0.000 description 1
• 210000004080 milk Anatomy 0.000 description 1
• 239000002480 mineral oil Substances 0.000 description 1
• 235000010446 mineral oil Nutrition 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 239000003607 modifier Substances 0.000 description 1
• 230000007193 modulation by symbiont of host erythrocyte aggregation Effects 0.000 description 1
• 238000000302 molecular modelling Methods 0.000 description 1
• 201000002003 mononeuritis multiplex Diseases 0.000 description 1
• 201000005518 mononeuropathy Diseases 0.000 description 1
• 150000002772 monosaccharides Chemical class 0.000 description 1
• 210000004400 mucous membrane Anatomy 0.000 description 1
• 210000003205 muscle Anatomy 0.000 description 1
• 230000003387 muscular Effects 0.000 description 1
• 231100000299 mutagenicity Toxicity 0.000 description 1
• 230000007886 mutagenicity Effects 0.000 description 1
• 206010028417 myasthenia gravis Diseases 0.000 description 1
• 210000004165 myocardium Anatomy 0.000 description 1
• 210000000282 nail Anatomy 0.000 description 1
• 239000002088 nanocapsule Substances 0.000 description 1
• 239000002105 nanoparticle Substances 0.000 description 1
• 230000017074 necrotic cell death Effects 0.000 description 1
• 230000023578 negative regulation of cell adhesion Effects 0.000 description 1
• 208000009928 nephrosis Diseases 0.000 description 1
• 231100001027 nephrosis Toxicity 0.000 description 1
• 210000005036 nerve Anatomy 0.000 description 1
• 208000015122 neurodegenerative disease Diseases 0.000 description 1
• 230000009251 neurologic dysfunction Effects 0.000 description 1
• 230000007971 neurological deficit Effects 0.000 description 1
• 230000007935 neutral effect Effects 0.000 description 1
• 210000000440 neutrophil Anatomy 0.000 description 1
• 229910052757 nitrogen Inorganic materials 0.000 description 1
• 239000002736 nonionic surfactant Substances 0.000 description 1
• 235000018343 nutrient deficiency Nutrition 0.000 description 1
• 235000016709 nutrition Nutrition 0.000 description 1
• 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 229960004110 olsalazine Drugs 0.000 description 1
• 238000011275 oncology therapy Methods 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• 229940043515 other immunoglobulins in atc Drugs 0.000 description 1
• 210000001672 ovary Anatomy 0.000 description 1
• 239000005022 packaging material Substances 0.000 description 1
• 229940124583 pain medication Drugs 0.000 description 1
• 229940055729 papain Drugs 0.000 description 1
• 235000019834 papain Nutrition 0.000 description 1
• 230000036285 pathological change Effects 0.000 description 1
• 239000000312 peanut oil Substances 0.000 description 1
• 229960001639 penicillamine Drugs 0.000 description 1
• 229940049954 penicillin Drugs 0.000 description 1
• 208000011906 peptic ulcer disease Diseases 0.000 description 1
• 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
• 239000000816 peptidomimetic Substances 0.000 description 1
• 210000005259 peripheral blood Anatomy 0.000 description 1
• 239000011886 peripheral blood Substances 0.000 description 1
• 108010049224 perlecan Proteins 0.000 description 1
• 239000003208 petroleum Substances 0.000 description 1
• 230000003285 pharmacodynamic effect Effects 0.000 description 1
• 108010051242 phenylalanylserine Proteins 0.000 description 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
• 238000000053 physical method Methods 0.000 description 1
• 238000000554 physical therapy Methods 0.000 description 1
• 230000001766 physiological effect Effects 0.000 description 1
• 230000006461 physiological response Effects 0.000 description 1
• 239000002504 physiological saline solution Substances 0.000 description 1
• 239000006187 pill Substances 0.000 description 1
• 230000028742 placenta development Effects 0.000 description 1
• 229940012957 plasmin Drugs 0.000 description 1
• 229920003023 plastic Polymers 0.000 description 1
• 239000004033 plastic Substances 0.000 description 1
• 229920001983 poloxamer Polymers 0.000 description 1
• 229920000747 poly(lactic acid) Polymers 0.000 description 1
• 229920001515 polyalkylene glycol Polymers 0.000 description 1
• 108010064470 polyaspartate Proteins 0.000 description 1
• 229920000728 polyester Polymers 0.000 description 1
• 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
• 208000005987 polymyositis Diseases 0.000 description 1
• 229920000136 polysorbate Polymers 0.000 description 1
• 229920002451 polyvinyl alcohol Polymers 0.000 description 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
• 238000010837 poor prognosis Methods 0.000 description 1
• 230000008092 positive effect Effects 0.000 description 1
• 230000003334 potential effect Effects 0.000 description 1
• 230000003389 potentiating effect Effects 0.000 description 1
• 238000001556 precipitation Methods 0.000 description 1
• 238000009597 pregnancy test Methods 0.000 description 1
• 239000003755 preservative agent Substances 0.000 description 1
• 230000002265 prevention Effects 0.000 description 1
• 201000000742 primary sclerosing cholangitis Diseases 0.000 description 1
• 238000012545 processing Methods 0.000 description 1
• 238000010880 proctocolectomy Methods 0.000 description 1
• 238000004393 prognosis Methods 0.000 description 1
• 230000000770 proinflammatory effect Effects 0.000 description 1
• 108010029020 prolylglycine Proteins 0.000 description 1
• 239000001294 propane Substances 0.000 description 1
• 239000003380 propellant Substances 0.000 description 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 235000019833 protease Nutrition 0.000 description 1
• 238000001742 protein purification Methods 0.000 description 1
• 238000003521 protein stability assay Methods 0.000 description 1
• 201000001474 proteinuria Diseases 0.000 description 1
• 230000017854 proteolysis Effects 0.000 description 1
• 230000002797 proteolythic effect Effects 0.000 description 1
• 230000005180 public health Effects 0.000 description 1
• 239000000700 radioactive tracer Substances 0.000 description 1
• 238000003259 recombinant expression Methods 0.000 description 1
• 230000000306 recurrent effect Effects 0.000 description 1
• 238000007670 refining Methods 0.000 description 1
• 230000001105 regulatory effect Effects 0.000 description 1
• 229940127558 rescue medication Drugs 0.000 description 1
• 210000002345 respiratory system Anatomy 0.000 description 1
• 230000000717 retained effect Effects 0.000 description 1
• 230000004258 retinal degeneration Effects 0.000 description 1
• 238000004007 reversed phase HPLC Methods 0.000 description 1
• 230000002441 reversible effect Effects 0.000 description 1
• 238000012552 review Methods 0.000 description 1
• 239000002336 ribonucleotide Substances 0.000 description 1
• 125000002652 ribonucleotide group Chemical group 0.000 description 1
• 229960001487 rimexolone Drugs 0.000 description 1
• QTTRZHGPGKRAFB-OOKHYKNYSA-N rimexolone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CC)(C)[C@@]1(C)C[C@@H]2O QTTRZHGPGKRAFB-OOKHYKNYSA-N 0.000 description 1
• 229940063148 rowasa Drugs 0.000 description 1
• VGGUKFAVHPGNBF-UHFFFAOYSA-N s-ethyl 2,2,2-trifluoroethanethioate Chemical compound CCSC(=O)C(F)(F)F VGGUKFAVHPGNBF-UHFFFAOYSA-N 0.000 description 1
• 229960002052 salbutamol Drugs 0.000 description 1
• 229960004017 salmeterol Drugs 0.000 description 1
• 238000009118 salvage therapy Methods 0.000 description 1
• 238000003118 sandwich ELISA Methods 0.000 description 1
• 210000004761 scalp Anatomy 0.000 description 1
• 231100000241 scar Toxicity 0.000 description 1
• 230000037390 scarring Effects 0.000 description 1
• 230000007017 scission Effects 0.000 description 1
• 208000010157 sclerosing cholangitis Diseases 0.000 description 1
• 238000012216 screening Methods 0.000 description 1
• 239000006152 selective media Substances 0.000 description 1
• 230000035945 sensitivity Effects 0.000 description 1
• 238000010206 sensitivity analysis Methods 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• 208000013223 septicemia Diseases 0.000 description 1
• 238000012163 sequencing technique Methods 0.000 description 1
• 238000012882 sequential analysis Methods 0.000 description 1
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
• 238000010008 shearing Methods 0.000 description 1
• 201000005113 shigellosis Diseases 0.000 description 1
• 229940127211 short-acting beta 2 agonist Drugs 0.000 description 1
• 208000013220 shortness of breath Diseases 0.000 description 1
• 229910052710 silicon Inorganic materials 0.000 description 1
• 239000010703 silicon Substances 0.000 description 1
• 239000000377 silicon dioxide Substances 0.000 description 1
• 229910052709 silver Inorganic materials 0.000 description 1
• 239000004332 silver Substances 0.000 description 1
• 238000002741 site-directed mutagenesis Methods 0.000 description 1
• 230000005808 skin problem Effects 0.000 description 1
• 231100000046 skin rash Toxicity 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 239000001632 sodium acetate Substances 0.000 description 1
• 235000017281 sodium acetate Nutrition 0.000 description 1
• AGHLUVOCTHWMJV-UHFFFAOYSA-J sodium;gold(3+);2-sulfanylbutanedioate Chemical compound [Na+].[Au+3].[O-]C(=O)CC(S)C([O-])=O.[O-]C(=O)CC(S)C([O-])=O AGHLUVOCTHWMJV-UHFFFAOYSA-J 0.000 description 1
• 239000007790 solid phase Substances 0.000 description 1
• 239000000600 sorbitol Substances 0.000 description 1
• 238000001179 sorption measurement Methods 0.000 description 1
• 239000003549 soybean oil Substances 0.000 description 1
• 235000012424 soybean oil Nutrition 0.000 description 1
• 208000020431 spinal cord injury Diseases 0.000 description 1
• 238000009987 spinning Methods 0.000 description 1
• 210000004989 spleen cell Anatomy 0.000 description 1
• 210000004988 splenocyte Anatomy 0.000 description 1
• 208000000995 spontaneous abortion Diseases 0.000 description 1
• 230000000087 stabilizing effect Effects 0.000 description 1
• 238000007619 statistical method Methods 0.000 description 1
• 231100000240 steatosis hepatitis Toxicity 0.000 description 1
• 210000000130 stem cell Anatomy 0.000 description 1
• 238000011146 sterile filtration Methods 0.000 description 1
• 238000013517 stratification Methods 0.000 description 1
• 229960005322 streptomycin Drugs 0.000 description 1
• 230000036435 stunted growth Effects 0.000 description 1
• 231100000064 subacute toxicity study Toxicity 0.000 description 1
• 238000010254 subcutaneous injection Methods 0.000 description 1
• 239000007929 subcutaneous injection Substances 0.000 description 1
• 150000005846 sugar alcohols Chemical class 0.000 description 1
• 239000006228 supernatant Substances 0.000 description 1
• 239000013589 supplement Substances 0.000 description 1
• 239000004094 surface-active agent Substances 0.000 description 1
• 230000004083 survival effect Effects 0.000 description 1
• 239000000375 suspending agent Substances 0.000 description 1
• 230000002459 sustained effect Effects 0.000 description 1
• 208000011580 syndromic disease Diseases 0.000 description 1
• 201000004595 synovitis Diseases 0.000 description 1
• 230000009885 systemic effect Effects 0.000 description 1
• 238000009121 systemic therapy Methods 0.000 description 1
• 239000003826 tablet Substances 0.000 description 1
• 231100000211 teratogenicity Toxicity 0.000 description 1
• 229960000195 terbutaline Drugs 0.000 description 1
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 229960002180 tetracycline Drugs 0.000 description 1
• 229930101283 tetracycline Natural products 0.000 description 1
• 235000019364 tetracycline Nutrition 0.000 description 1
• 150000003522 tetracyclines Chemical class 0.000 description 1
• 238000010257 thawing Methods 0.000 description 1
• 230000004797 therapeutic response Effects 0.000 description 1
• 230000008719 thickening Effects 0.000 description 1
• 125000003396 thiol group Chemical group [H]S* 0.000 description 1
• 210000000779 thoracic wall Anatomy 0.000 description 1
• 229960004072 thrombin Drugs 0.000 description 1
• 238000001269 time-of-flight mass spectrometry Methods 0.000 description 1
• 230000009258 tissue cross reactivity Effects 0.000 description 1
• 230000000451 tissue damage Effects 0.000 description 1
• 231100000827 tissue damage Toxicity 0.000 description 1
• 208000037816 tissue injury Diseases 0.000 description 1
• 230000017423 tissue regeneration Effects 0.000 description 1
• 210000003371 toe Anatomy 0.000 description 1
• 210000004906 toe nail Anatomy 0.000 description 1
• 229940125379 topical corticosteroid Drugs 0.000 description 1
• 201000002516 toxic megacolon Diseases 0.000 description 1
• 238000013518 transcription Methods 0.000 description 1
• 230000035897 transcription Effects 0.000 description 1
• 238000011830 transgenic mouse model Methods 0.000 description 1
• 238000013519 translation Methods 0.000 description 1
• 238000002054 transplantation Methods 0.000 description 1
• 230000032258 transport Effects 0.000 description 1
• 210000003384 transverse colon Anatomy 0.000 description 1
• 230000008733 trauma Effects 0.000 description 1
• 229960005294 triamcinolone Drugs 0.000 description 1
• GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
• 231100000397 ulcer Toxicity 0.000 description 1
• 230000036269 ulceration Effects 0.000 description 1
• 230000003827 upregulation Effects 0.000 description 1
• 238000011144 upstream manufacturing Methods 0.000 description 1
• 238000002562 urinalysis Methods 0.000 description 1
• 210000003932 urinary bladder Anatomy 0.000 description 1
• 210000002700 urine Anatomy 0.000 description 1
• 210000001215 vagina Anatomy 0.000 description 1
• 239000004474 valine Substances 0.000 description 1
• 210000000264 venule Anatomy 0.000 description 1
• 210000001835 viscera Anatomy 0.000 description 1
• 230000009278 visceral effect Effects 0.000 description 1
• 239000011782 vitamin Substances 0.000 description 1
• 235000013343 vitamin Nutrition 0.000 description 1
• 229940088594 vitamin Drugs 0.000 description 1
• 229930003231 vitamin Natural products 0.000 description 1
• 235000019166 vitamin D Nutrition 0.000 description 1
• 239000011710 vitamin D Substances 0.000 description 1
• 150000003710 vitamin D derivatives Chemical class 0.000 description 1
• 229940046008 vitamin d Drugs 0.000 description 1
• 230000004584 weight gain Effects 0.000 description 1
• 235000019786 weight gain Nutrition 0.000 description 1