DK173375B1 - LHRH-Antagonister, deres fremstilling og lægemidler der indeholder dem - Google Patents

LHRH-Antagonister, deres fremstilling og lægemidler der indeholder dem Download PDF

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Publication number
DK173375B1
DK173375B1 DK198803956A DK395688A DK173375B1 DK 173375 B1 DK173375 B1 DK 173375B1 DK 198803956 A DK198803956 A DK 198803956A DK 395688 A DK395688 A DK 395688A DK 173375 B1 DK173375 B1 DK 173375B1
Authority
DK
Denmark
Prior art keywords
phe
peptide
nal
pro
group
Prior art date
Application number
DK198803956A
Other languages
Danish (da)
English (en)
Other versions
DK395688A (da
DK395688D0 (da
Inventor
Andrew V Schally
Sandor Bajusz
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of DK395688D0 publication Critical patent/DK395688D0/da
Publication of DK395688A publication Critical patent/DK395688A/da
Application granted granted Critical
Publication of DK173375B1 publication Critical patent/DK173375B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/11—Gonadotropin; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK198803956A 1987-07-17 1988-07-15 LHRH-Antagonister, deres fremstilling og lægemidler der indeholder dem DK173375B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/074,126 US4800191A (en) 1987-07-17 1987-07-17 LHRH antagonists
US7412687 1987-07-17

Publications (3)

Publication Number Publication Date
DK395688D0 DK395688D0 (da) 1988-07-15
DK395688A DK395688A (da) 1989-01-18
DK173375B1 true DK173375B1 (da) 2000-09-11

Family

ID=22117877

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198803956A DK173375B1 (da) 1987-07-17 1988-07-15 LHRH-Antagonister, deres fremstilling og lægemidler der indeholder dem

Country Status (18)

Country Link
US (2) US4800191A (fr)
EP (1) EP0299402B1 (fr)
JP (1) JP2944669B2 (fr)
AT (1) ATE90362T1 (fr)
BR (1) BR1100478A (fr)
CA (1) CA1339623C (fr)
DE (3) DE19975052I2 (fr)
DK (1) DK173375B1 (fr)
ES (1) ES2054741T3 (fr)
FI (1) FI91075C (fr)
HK (1) HK21194A (fr)
HU (1) HU206376B (fr)
IE (1) IE62744B1 (fr)
LU (1) LU90425I2 (fr)
LV (1) LV5795B4 (fr)
NL (1) NL990029I2 (fr)
PT (1) PT87998B (fr)
ZA (1) ZA885147B (fr)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
US5171835A (en) * 1988-10-21 1992-12-15 The Administrators Of The Tulane Educational Fund LHRH antagonists
US5169932A (en) * 1989-10-30 1992-12-08 The Salk Institute For Biological Studies Gnrh analogs
US5064939A (en) * 1990-02-06 1991-11-12 The Salk Institute For Biological Studies Cyclic gnrh antagonists
DE69102659T2 (de) * 1990-02-20 1995-02-23 Syntex Inc Synthese von LH-RH-Analogen unter Anwendung eines zeitlich begrenzten minimalen Schutzes.
JP2719233B2 (ja) * 1991-04-25 1998-02-25 デゲンギ，ロマノ 黄体形成ホルモン放出ホルモン拮抗ペプチド
DE4117507A1 (de) * 1991-05-24 1992-11-26 Schering Ag Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
WO1993003752A1 (fr) * 1991-08-19 1993-03-04 The Arizona Board Of Regents On Behalf Of The University Of Arizona Decapeptide possedant une efficacite de stimulation de la dopamine
US6468959B1 (en) * 1991-12-05 2002-10-22 Alfatec-Pharm Gmbh Peroral dosage form for peptide containing medicaments, in particular insulin
BE1005720A3 (fr) * 1992-03-20 1993-12-28 Solvay Procede de synthese peptidique et nouveaux intermediaires de synthese.
US6828415B2 (en) * 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
DE4305225A1 (de) * 1993-02-19 1994-08-25 Asta Medica Ag Neues Herstellverfahren für Cetrorelix Lyophilisat
BE1007183A3 (fr) * 1993-06-18 1995-04-18 Solvay Ureines derivees d'alpha, omega-diaminoacides et procede pour leur preparation.
DE4320201A1 (de) * 1993-06-18 1995-01-12 Asta Medica Ag Verwendung von Cetrorelix und weiteren Nona- und Dekapeptiden zur Herstellung eines Arzneimittels zur Bekämpfung von Aids und zur Wachstumsstimulation
US5502035A (en) * 1993-08-06 1996-03-26 Tap Holdings Inc. N-terminus modified analogs of LHRH
US5413990A (en) * 1993-08-06 1995-05-09 Tap Pharmaceuticals Inc. N-terminus modified analogs of LHRH
JP3662926B2 (ja) * 1993-08-06 2005-06-22 タツプ・ホールデイングス・インコーポレイテツド Ｌｈｒｈのｎ末端改変類似体
US5643605A (en) * 1993-10-25 1997-07-01 Genentech, Inc. Methods and compositions for microencapsulation of adjuvants
US6913767B1 (en) 1993-10-25 2005-07-05 Genentech, Inc. Compositions for microencapsulation of antigens for use as vaccines
US6080429A (en) * 1993-10-25 2000-06-27 Genentech, Inc. Method for drying microspheres
CA2178592C (fr) * 1993-12-09 2009-07-28 Jurgen Engel Suspensions pour injection a action prolongee et procede de preparation
DE4342091A1 (de) * 1993-12-09 1995-06-14 Asta Medica Ag Erzeugnisse zur Anwendung von initial hohen Dosen von Cetrorelix und Herstellung einer Kombinationspackung zur Verwendung bei Therapie von Krankheiten
US5550212A (en) * 1993-12-17 1996-08-27 The Administrators Of The Tulane Educational Fund Analogues of hGH-RH(1-29)NH2 having antagonistic activity
US5843901A (en) * 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
US5932547A (en) * 1996-07-03 1999-08-03 Alza Corporation Non-aqueous polar aprotic peptide formulations
US5916582A (en) * 1996-07-03 1999-06-29 Alza Corporation Aqueous formulations of peptides
US5981489A (en) * 1996-07-18 1999-11-09 Alza Corporation Non-aqueous protic peptide formulations
DE19644994A1 (de) * 1996-10-30 1998-05-07 Asta Medica Ag Diagnostisches Mittel
US5821230A (en) * 1997-04-11 1998-10-13 Ferring Bv GnRH antagonist decapeptides
US5925730A (en) 1997-04-11 1999-07-20 Ferring Bv GnRH antagonists
US6407205B1 (en) * 1997-06-04 2002-06-18 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College FSH-releasing peptides
DE19728737C1 (de) * 1997-07-04 1999-02-11 Johannes Christian Groeninghen Verfahren zur Erkennung und Bestimmung von GnRH-Rezeptoren und die Verwendung von GnRH-Agonisten und GnRH-Antagonisten zur Behandlung eines Tumors ausgehend vom Hirn und/oder Nervensystem und/oder den Hirnhäuten
US5941844A (en) * 1997-11-17 1999-08-24 Alza Corporation Method and device for controlling mammalian reproductive cycle
US6191115B1 (en) * 1998-08-12 2001-02-20 Abbott Laboratories C-terminus modified heptapeptide LHRH analogs
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
DE19911771B4 (de) * 1999-03-17 2006-03-30 Zentaris Gmbh LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung
DE10024451A1 (de) * 2000-05-18 2001-11-29 Asta Medica Ag Pharmazeutische Darreichungsform für Peptide, Verfahren zu deren Herstellung und Verwendung
DE10040700A1 (de) * 2000-08-17 2002-02-28 Asta Medica Ag Salze von biologisch aktiven Peptiden, ihre Herstellung und Verwendung
EP1349459A4 (fr) 2000-12-15 2006-09-13 Wrigley W M Jun Co Melanges d'acides encapsules et produits renfermant ceux-ci
DE10157628A1 (de) * 2001-11-26 2003-06-12 Zentaris Ag Injektionslösung eines LHRH-Antagonisten
US7214662B2 (en) 2001-11-27 2007-05-08 Zentaris Gmbh Injectable solution of an LHRH antagonist
CN101647772A (zh) * 2008-08-12 2010-02-17 中国人民解放军军事医学科学院毒物药物研究所 Lhrh拮抗剂类物质的注射用缓释制剂及其制备
WO2010085145A1 (fr) 2009-01-22 2010-07-29 Maatschap Interne Geneeskunde Rijnstate Méthode de traitement prophylactique ou thérapeutique des bouffées vasomotrices
CN101863960B (zh) * 2009-04-15 2013-03-06 无锡市凯利药业有限公司 西曲瑞克的制备方法
EP2266567A1 (fr) 2009-05-26 2010-12-29 Æterna Zentaris GmbH Composition pharmaceutique comprenant de Cetrorelix e d'inhibiteurs de PDE V pour le traitement des étas dépendants de l'hormone sexuel
US20130303464A1 (en) 2010-12-06 2013-11-14 Astron Research Limited Stable ready-to-use cetrorelix injection
CA3143663A1 (fr) 2019-06-17 2020-12-24 Intas Pharmaceuticals Ltd. Formulation stable de cetrorelix
CN111875673B (zh) * 2020-07-31 2022-03-11 江苏莱森生物科技研究院有限公司 一种具有抗肿瘤活性的多肽及其用途
CN112175043A (zh) * 2020-10-12 2021-01-05 湖南津安生物科技有限公司 一种改进的鲑鱼促性腺激素释放激素的固相合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3250759A (en) * 1961-08-18 1966-05-10 Olin Mathieson Citrulline containing peptides
AU9102582A (en) * 1981-12-10 1983-06-16 David Howard Coy Lh-rh antagonists
FI832053L (fi) * 1982-06-10 1983-12-11 Syntex Inc Nonapeptid- och dekapeptidanaloger av lhrh anvaendbara som lhrh-antagonister samt deras framstaellningsfoerfarande
DE3467173D1 (en) * 1983-08-16 1987-12-10 Akzo Nv Lh- rh antagonists
US4565804A (en) * 1984-09-07 1986-01-21 The Salk Institute For Biological Studies GnRH Antagonists VI
US4690916A (en) * 1984-11-13 1987-09-01 Syntex (U.S.A.) Inc. Nona and decapeptide analogs of LHRH useful as LHRH antagonists
US4677193A (en) * 1985-02-22 1987-06-30 The Salk Institute For Biological Studies Peptides containing an aliphatic-aromatic ketone side chain
AU5638886A (en) * 1985-04-19 1986-10-23 Syntex (U.S.A.) Inc. Contraceptive methods for dogs using the decapeptide lhrh
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists

Also Published As

Publication number Publication date
ES2054741T3 (es) 1994-08-16
US4800191A (en) 1989-01-24
HUT47311A (en) 1989-02-28
EP0299402A2 (fr) 1989-01-18
NL990029I1 (nl) 1999-12-01
DK395688A (da) 1989-01-18
DE3881592D1 (de) 1993-07-15
ATE90362T1 (de) 1993-06-15
HK21194A (en) 1994-03-18
LV5795B4 (lv) 1997-08-20
IE62744B1 (en) 1995-02-22
FI883388A (fi) 1989-01-18
LV5795A4 (lv) 1997-02-20
JP2944669B2 (ja) 1999-09-06
NL990029I2 (nl) 2000-03-01
DK395688D0 (da) 1988-07-15
US5198533A (en) 1993-03-30
DE3823590A1 (de) 1989-01-26
FI91075B (fi) 1994-01-31
HU206376B (en) 1992-10-28
BR1100478A (pt) 2000-03-14
LU90425I2 (fr) 1999-10-04
CA1339623C (fr) 1998-01-06
FI91075C (fi) 1994-05-10
EP0299402A3 (en) 1990-06-06
DE19975052I2 (de) 2009-01-02
PT87998A (pt) 1989-06-30
IE882185L (en) 1989-01-17
PT87998B (pt) 1995-03-01
EP0299402B1 (fr) 1993-06-09
ZA885147B (en) 1989-04-26
FI883388A0 (fi) 1988-07-15
JPS6434997A (en) 1989-02-06

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Legal Events

Date Code Title Description
CTFG Supplementary protection certificate (spc) issued

Free format text: PRODUCT NAME: CETRORELIX ACETAT

Spc suppl protection certif: CA 2000 00017

Filing date: 20000926

PUP Patent expired