DK173173B1 - Overfladeaktivt rekombinant-alveolarprotein, rekombinant -DNA-sekvens kodende herfor, værtscelle transformeret med dette DN - Google Patents

Overfladeaktivt rekombinant-alveolarprotein, rekombinant -DNA-sekvens kodende herfor, værtscelle transformeret med dette DN Download PDF

Info

Publication number
DK173173B1
DK173173B1 DK199201517A DK151792A DK173173B1 DK 173173 B1 DK173173 B1 DK 173173B1 DK 199201517 A DK199201517 A DK 199201517A DK 151792 A DK151792 A DK 151792A DK 173173 B1 DK173173 B1 DK 173173B1
Authority
DK
Denmark
Prior art keywords
protein
proteins
asp
human
dna
Prior art date
Application number
DK199201517A
Other languages
Danish (da)
English (en)
Other versions
DK151792A (da
Inventor
Bradley J Benson
Robert T White
Barbara Cordell
James W Schilling
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of DK151792A publication Critical patent/DK151792A/da
Application granted granted Critical
Publication of DK173173B1 publication Critical patent/DK173173B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
DK199201517A 1986-04-30 1992-12-17 Overfladeaktivt rekombinant-alveolarprotein, rekombinant -DNA-sekvens kodende herfor, værtscelle transformeret med dette DN DK173173B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85771586 1986-04-30
US06/857,715 US4933280A (en) 1984-12-11 1986-04-30 Recombinant DNA sequence encoding Alveolar Surfactant Protein
PCT/US1987/000978 WO1987006588A1 (en) 1986-04-30 1987-04-30 Recombinant alveolar surfactant protein
US8700978 1987-04-30

Publications (2)

Publication Number Publication Date
DK151792A DK151792A (da) 1992-12-17
DK173173B1 true DK173173B1 (da) 2000-02-28

Family

ID=25326586

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199201517A DK173173B1 (da) 1986-04-30 1992-12-17 Overfladeaktivt rekombinant-alveolarprotein, rekombinant -DNA-sekvens kodende herfor, værtscelle transformeret med dette DN

Country Status (14)

Country Link
US (1) US4933280A (de)
EP (1) EP0251449B1 (de)
JP (3) JPH0813839B2 (de)
KR (1) KR880701246A (de)
AT (1) ATE118035T1 (de)
AU (1) AU591566B2 (de)
CA (1) CA1340611C (de)
DE (1) DE3751033T2 (de)
DK (1) DK173173B1 (de)
ES (1) ES2072850T3 (de)
GR (1) GR3015913T3 (de)
HK (1) HK1005887A1 (de)
IL (1) IL82364A (de)
WO (1) WO1987006588A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3761394A (en) * 1969-12-31 1973-09-25 Texaco Inc Catalytic cracking of naphtha
US5840527A (en) * 1984-12-11 1998-11-24 Byk Gulden Lomberg Chemische Fabrik Gmbh Recombinant alveolar surfactant protein
WO1987002037A1 (en) * 1985-09-26 1987-04-09 Genetics Institute, Inc. Pulmonary surfactant proteins
US5013720A (en) * 1986-05-06 1991-05-07 Abbott Laboratories SAP-6-Val proteins and methods
JPH01501282A (ja) * 1986-12-08 1989-05-11 ホイツトセツト，ジエフリー　エイ． 肺胞疎水性界面活性物質関連タンパク質
US5164369A (en) * 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5260273A (en) * 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US6613734B2 (en) 1988-01-06 2003-09-02 The Scripps Research Institute Peptides-containing liposomal surfactants
JPH04501204A (ja) * 1988-08-11 1992-03-05 サイオス　ノバ　インコーポレイテッド 異種タンパク発現を安定させる方法およびそれに使用するベクター
SE8803713D0 (sv) * 1988-10-18 1988-10-18 Kabigen Ab Biologically active lipoprotein and its use
EP0458167B1 (de) * 1990-05-21 1997-04-23 Abbott Laboratories Fettsäure-Oberflächenaktives-Lungenprotein Konjate
GB9120005D0 (en) * 1991-09-19 1991-11-06 Wellcome Found Method of administering phospholipid dispersions
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
DE4418936A1 (de) * 1994-05-31 1996-02-08 Byk Gulden Lomberg Chem Fab Polypeptid
US6031075A (en) * 1996-02-05 2000-02-29 Children's Hospital Medical Center Mature alveolar SP-B and a process for producing the same
WO2001019392A1 (en) 1999-09-16 2001-03-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Combination of c1-inh and lung surfactant for the treatment of respiratory disorders
DE50214446D1 (de) 2001-10-11 2010-07-01 Nycomed Gmbh Neue verwendung von lungensurfactant
US8236750B2 (en) 2004-08-06 2012-08-07 Nycomed Gmbh Composition comprising a pulmonary surfactant and a TNF-derived peptide
US7951781B2 (en) 2006-11-02 2011-05-31 University Of Iowa Research Foundation Methods and compositions related to PLUNC surfactant polypeptides
CN102271666A (zh) 2008-12-10 2011-12-07 Paka肺部医药公司 用于向肺脏递送药物的方法和组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4312860A (en) * 1980-10-24 1982-01-26 Regents Of The University Of California Lung surfactant compositions
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4562003A (en) * 1984-10-26 1985-12-31 California Biotechnology, Inc. Monoclonal antibodies against alveolar surfactant protein
US4659805A (en) * 1984-12-11 1987-04-21 California Biotechnology, Inc. Recombinant alveolar surfactant protein
WO1987006943A1 (en) * 1986-05-06 1987-11-19 Children's Hospital Medical Center Pulmonary hydrophobic surfactant-associated protein of 6,000 daltons molecular weight and multimers thereof
JPH01501282A (ja) * 1986-12-08 1989-05-11 ホイツトセツト，ジエフリー　エイ． 肺胞疎水性界面活性物質関連タンパク質

Also Published As

Publication number Publication date
JPH0813839B2 (ja) 1996-02-14
JP2766806B2 (ja) 1998-06-18
JPH08188598A (ja) 1996-07-23
DE3751033T2 (de) 1995-08-10
WO1987006588A1 (en) 1987-11-05
IL82364A0 (en) 1987-10-30
AU591566B2 (en) 1989-12-07
IL82364A (en) 1993-08-18
US4933280A (en) 1990-06-12
JP2584962B2 (ja) 1997-02-26
JPH09117290A (ja) 1997-05-06
EP0251449A2 (de) 1988-01-07
HK1005887A1 (en) 1999-01-29
GR3015913T3 (en) 1995-07-31
ATE118035T1 (de) 1995-02-15
ES2072850T3 (es) 1995-08-01
DK151792A (da) 1992-12-17
AU7480287A (en) 1987-11-24
DE3751033D1 (de) 1995-03-16
JPH01500350A (ja) 1989-02-09
EP0251449B1 (de) 1995-02-01
KR880701246A (ko) 1988-07-26
EP0251449A3 (en) 1989-04-19
CA1340611C (en) 1999-06-29

Similar Documents

Publication Publication Date Title
DK173173B1 (da) Overfladeaktivt rekombinant-alveolarprotein, rekombinant -DNA-sekvens kodende herfor, værtscelle transformeret med dette DN
DK172227B1 (da) Overfladeaktivt pattedyr-alveolarprotein (pattedyr-ASP), rekombinant-DNA, der koder for et sådant ASP, overfladeaktivt lungeprotein, der kodes med et sådant DNA, rekombinant-ekspressionssystem, der indeholder et sådant DNA, rekombinant-værtscelle, der er transformeret med et sådant ekspressionssystem, fremgangsmåde til fremstilling af pattedyr-ASP'et under anvendelse af en sådan celle og ASP frems
US4912038A (en) Recombinant DNA sequence encoding alveolar surfactant protein
CA1340461C (en) Alveolar surfactant proteins
CA2083177C (en) Alveolar surfactant proteins
JP3644035B2 (ja) 新規な合成ペプチド，それを含有する肺サーファクタント及び呼吸窮迫症候群治療剤
US5840527A (en) Recombinant alveolar surfactant protein
DK173172B1 (da) Rekombinant overfladeaktivt alveolarprotein (ASP), rekombinant-DNA-sekvens kodende herfor, værtscelle transformeret med DNA
US5385840A (en) DNA encoding analogs of human alveolar surfactant protein SP-5
WO1988005820A1 (en) Recombinant alveolar surfactant protein
US5430020A (en) Recombinant alveolar surfactant protein
NO875477L (no) Rekombinant alveolaert overflateaktivt protein.
CA1340580C (en) Recombinant alveolar surfactant protein
NO177309B (no) Analogifremgangsmåte for fremstilling av et terapeutisk aktivt polypeptid

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

Country of ref document: DK