ES2072850T3 - Proteina recombinante surfactante alveolar. - Google Patents

Proteina recombinante surfactante alveolar.

Info

Publication number
ES2072850T3
ES2072850T3 ES87303919T ES87303919T ES2072850T3 ES 2072850 T3 ES2072850 T3 ES 2072850T3 ES 87303919 T ES87303919 T ES 87303919T ES 87303919 T ES87303919 T ES 87303919T ES 2072850 T3 ES2072850 T3 ES 2072850T3
Authority
ES
Spain
Prior art keywords
proteins
alveolar surfactant
recombinant protein
disclosed
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87303919T
Other languages
English (en)
Inventor
James W Schilling
Robert T White
Barbara Cordell
Bradley J Benson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scios LLC
Original Assignee
Scios Nova Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scios Nova Inc filed Critical Scios Nova Inc
Application granted granted Critical
Publication of ES2072850T3 publication Critical patent/ES2072850T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

SE PRESENTAN LAS SECUENCIAS CODIFICADORAS COMPLETAS Y LAS SECUENCIAS DE AMINOACIDOS PARA PROTEINAS ALVEOLARES TENSIOACTIVAS (PAS) 10K CANINAS Y HUMANAS; TAMBIEN CLONES QUE CODIFICAN VARIANTES DE LAS FORMAS SP-18 Y SP-5 DE PROTEINA HUMANA. TAMBIEN SE DESCRIBEN METODOS Y VECTORES PARA OBTENER ESTAS PROTEINAS EN FORMA RECOMBINANTE. UN METODO PERFECCIONADO PARA LA PURIFICACION DE LA PROTEINA 32K APROVECHA SU AFINIDAD A LOS HIDRATOS DE CARBONO. COMPOSICIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE SINDROMES DE DEFICIENCIA RESPIRATORIA UTILIZAN LAS PROTEINAS 10K CON O SIN LA FORMA 32K.
ES87303919T 1986-04-30 1987-04-30 Proteina recombinante surfactante alveolar. Expired - Lifetime ES2072850T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/857,715 US4933280A (en) 1984-12-11 1986-04-30 Recombinant DNA sequence encoding Alveolar Surfactant Protein

Publications (1)

Publication Number Publication Date
ES2072850T3 true ES2072850T3 (es) 1995-08-01

Family

ID=25326586

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87303919T Expired - Lifetime ES2072850T3 (es) 1986-04-30 1987-04-30 Proteina recombinante surfactante alveolar.

Country Status (14)

Country Link
US (1) US4933280A (es)
EP (1) EP0251449B1 (es)
JP (3) JPH0813839B2 (es)
KR (1) KR880701246A (es)
AT (1) ATE118035T1 (es)
AU (1) AU591566B2 (es)
CA (1) CA1340611C (es)
DE (1) DE3751033T2 (es)
DK (1) DK173173B1 (es)
ES (1) ES2072850T3 (es)
GR (1) GR3015913T3 (es)
HK (1) HK1005887A1 (es)
IL (1) IL82364A (es)
WO (1) WO1987006588A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3761394A (en) * 1969-12-31 1973-09-25 Texaco Inc Catalytic cracking of naphtha
US5840527A (en) * 1984-12-11 1998-11-24 Byk Gulden Lomberg Chemische Fabrik Gmbh Recombinant alveolar surfactant protein
WO1987002037A1 (en) * 1985-09-26 1987-04-09 Genetics Institute, Inc. Pulmonary surfactant proteins
US5013720A (en) * 1986-05-06 1991-05-07 Abbott Laboratories SAP-6-Val proteins and methods
JPH01501282A (ja) * 1986-12-08 1989-05-11 ホイツトセツト，ジエフリー　エイ． 肺胞疎水性界面活性物質関連タンパク質
US6613734B2 (en) 1988-01-06 2003-09-02 The Scripps Research Institute Peptides-containing liposomal surfactants
US5164369A (en) * 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5260273A (en) * 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
CA1320162C (en) * 1988-08-11 1993-07-13 California Biotechnology Inc. Method for stabilizing heterologous protein expression and vectors for use therein
SE8803713D0 (sv) * 1988-10-18 1988-10-18 Kabigen Ab Biologically active lipoprotein and its use
EP0458167B1 (en) * 1990-05-21 1997-04-23 Abbott Laboratories Fatty acid-pulmonary surfactant conjugates
GB9120005D0 (en) * 1991-09-19 1991-11-06 Wellcome Found Method of administering phospholipid dispersions
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
DE4418936A1 (de) * 1994-05-31 1996-02-08 Byk Gulden Lomberg Chem Fab Polypeptid
US6031075A (en) * 1996-02-05 2000-02-29 Children's Hospital Medical Center Mature alveolar SP-B and a process for producing the same
EP1216052A1 (en) 1999-09-16 2002-06-26 Byk Gulden Lomberg Chemische Fabrik GmbH Combination of c1-inh and lung surfactant for the treatment of respiratory disorders
AU2002338882B2 (en) 2001-10-11 2008-04-03 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Novel use of pulmonary surfactant
WO2006013183A1 (en) 2004-08-06 2006-02-09 Altana Pharma Ag Composition comprising a pulmonary surfactant and a tnf-derived peptide
US7951781B2 (en) 2006-11-02 2011-05-31 University Of Iowa Research Foundation Methods and compositions related to PLUNC surfactant polypeptides
US9289388B2 (en) 2008-12-10 2016-03-22 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4312860A (en) * 1980-10-24 1982-01-26 Regents Of The University Of California Lung surfactant compositions
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4562003A (en) * 1984-10-26 1985-12-31 California Biotechnology, Inc. Monoclonal antibodies against alveolar surfactant protein
US4659805A (en) * 1984-12-11 1987-04-21 California Biotechnology, Inc. Recombinant alveolar surfactant protein
WO1987006943A1 (en) * 1986-05-06 1987-11-19 Children's Hospital Medical Center Pulmonary hydrophobic surfactant-associated protein of 6,000 daltons molecular weight and multimers thereof
JPH01501282A (ja) * 1986-12-08 1989-05-11 ホイツトセツト，ジエフリー　エイ． 肺胞疎水性界面活性物質関連タンパク質

Also Published As

Publication number Publication date
ATE118035T1 (de) 1995-02-15
AU7480287A (en) 1987-11-24
IL82364A0 (en) 1987-10-30
JPH01500350A (ja) 1989-02-09
JPH0813839B2 (ja) 1996-02-14
DK173173B1 (da) 2000-02-28
DK151792A (da) 1992-12-17
JP2766806B2 (ja) 1998-06-18
WO1987006588A1 (en) 1987-11-05
AU591566B2 (en) 1989-12-07
HK1005887A1 (en) 1999-01-29
CA1340611C (en) 1999-06-29
DE3751033T2 (de) 1995-08-10
JPH09117290A (ja) 1997-05-06
EP0251449B1 (en) 1995-02-01
EP0251449A2 (en) 1988-01-07
US4933280A (en) 1990-06-12
DE3751033D1 (de) 1995-03-16
EP0251449A3 (en) 1989-04-19
KR880701246A (ko) 1988-07-26
IL82364A (en) 1993-08-18
JPH08188598A (ja) 1996-07-23
JP2584962B2 (ja) 1997-02-26
GR3015913T3 (en) 1995-07-31

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