DK1729848T3 - Forbedret apparat til elektrisk formidlet indgivelse af terapeutiske midler - Google Patents
Forbedret apparat til elektrisk formidlet indgivelse af terapeutiske midler Download PDFInfo
- Publication number
- DK1729848T3 DK1729848T3 DK05725237.1T DK05725237T DK1729848T3 DK 1729848 T3 DK1729848 T3 DK 1729848T3 DK 05725237 T DK05725237 T DK 05725237T DK 1729848 T3 DK1729848 T3 DK 1729848T3
- Authority
- DK
- Denmark
- Prior art keywords
- electrodes
- cartridge
- therapeutic agent
- tissue
- patient
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0502—Skin piercing electrodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/14—Leading-off electric charges, e.g. by earthing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
Claims (17)
1. Apparat (100, 200) til indgivelse af et elektrisk felt som letter den intracellulære indgivelse af et terapeutisk middel til et forudbestemt sted inde i vævet af en patient omfattende: a) en flerhed af penetrerende elektroder anbragt i et forudbestemt rumforhold, hver elektrode med et tværsnitareal som bidrager til det totale tværsnitareal afalle elektroder; b) strukturorgan som inkorporerer en ikke aktiv energikilde operativt forbundet til flerheden af elektroder for at indsætte elektroderne uden betydelig deformering, og hvor energikilden er tilstrækkelig til at overføre en kraft på mindst 0,7 kg/kvadratmillimeter (1000 pund pr. kvadrattomme) af det totale tværsnitareal af alle elektroder ved påbegyndelsen af indsættelsen af elektroderne, og en kraft på mindst 0,35 kg/kvadratmillimeter (500 pund pr. kvadrattomme) af det totale tværsnitareal af alle elektroder ved slutningen af indsættelsen af elektroderne således at elektroderne indsættes uden væsentlig deformering inde i vævet af en patient; og c) organ til at generere et elektrisk felt som letter den intracellulære indgivelse af et terapeutisk middel, hvilket organ er operativt forbundet til elektroderne i det mindste i deres anvendte tilstand.
2. Apparatet ifølge krav 1 endvidere omfattende: a) strukturorgan konfigureret til at acceptere en fluidbeholder til at indeholde et terapeutisk middel hvor beholderen er operativt forbundet til mindst en injektionsåbning; og b) aktiveringsorgan konfigureret til at sende det terapeutiske middel igennem åbningen til det forudbestemte sted inde i vævet af patienten.
3. Apparatet ifølge krav 1 endvidere omfattende: a) fluidbeholder til at indeholde et terapeutisk middel, beholderen operativt forbundet til mindst en injektionsåbning; b) aktiveringsorgan konfigureret til at sende det terapeutiske middel igennem åbningen til det forudbestemte sted inde i vævet af patienten; c) strukturorgan som inkorporerer virksomme forbindelser til de penetrerende elektroder, fluidbeholderen, og injektionsåbningen hvor strukturorganet er konfigureret til at tillade disposition af flerheden af elektroder og injektionsåbningen inde i vævet afen patient ifølge et forudbestemt rumforhold; og d) en ikke aktiv energikilde operativt forbundet til aktiveringsorganet hvor energikilden er konfigureret til at påføre en kraft på mindst 1,1 Newton (0,25 pund) igennem fluidbeholderen til det terapeutiske middel.
4. Apparatet ifølge et hvilket som helst af kravene 1 til 3, hvor energikilden til at indsætte elektroderne er mindst en fjeder.
5. Apparatet ifølge et hvilket som helst af kravene 1 til 3, hvor energikilden til at indsætte elektroderne er mindst en komprimeret gas.
6. Apparatet ifølge et hvilket som helst af kravene 1 til 3, hvor energikilden til at indsætte elektroderne er en lineær motor.
7. Apparatet ifølge et hvilket som helst af kravene 1 til 3, hvor elektroderne omfatter en underanordning som kan blive adskilt fra energikilden.
8. Apparatet ifølge krav 2 eller krav 3, hvor beholderen og åbningen omfatter en nål (300) og en sprøjte.
9. Apparatet ifølge krav 8, hvor sprøjten (300) er tilvejebragt forfyldt med det terapeutiske middel.
10. Apparatet ifølge krav 2 eller krav 3, hvor beholderen omfatter en glasampul.
11. Apparatet ifølge krav 2 eller krav 3, hvor beholderen og åbningen omfatter en underanordning som kan adskilles fra energikilden.
12. Apparatet ifølge krav 2 eller krav 3, hvor elektroderne, reservoir, og åbningen er huset inde i en enkelt underanordning som kan adskilles fra energikilden.
13. Apparatet ifølge krav 12, hvor beholderen er tilvejebragt forfyldt med det terapeutiske middel.
14. Apparatet ifølge et hvilket som helst af kravene 1 til 3, hvor elektroderne omfatter et ledende metal coatet med en ledende, elektrokemisk stabil forbindelse.
15. Apparatet ifølge et hvilket som helst af kravene 1 til 3, hvor den ledende, elektrokemisk stabile forbindelse er valgt fra gruppen bestående af titanium nitrit, platin, platinindiumlegeringer, og indiumoxid.
16. Apparatet ifølge et hvilket som helst af kravene 1 til 3, hvor organet til at generere et elektrisk felt er konfigureret til at inducere et elektrisk felt på fra omkring 50 til omkring 300 V/cm mellem mindst to af elektroderne.
17. Apparatet ifølge et hvilket som helst af kravene 1 til 3, hvor organet til at generere et elektrisk felt er konfigureret til at indgive feltet for en varighed på fra omkring 1 mikrosekund til omkring 100 millisekunder og ved en frekvens på fra omkring 0,1 hertz til omkring 1 megahertz til mindst to af elektroderne.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55167904P | 2004-03-08 | 2004-03-08 | |
| PCT/US2005/007936 WO2005087311A1 (en) | 2004-03-08 | 2005-03-08 | Improved apparatus for electrically mediated delivery of therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1729848T3 true DK1729848T3 (da) | 2015-07-20 |
Family
ID=34975354
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05725237.1T DK1729848T3 (da) | 2004-03-08 | 2005-03-08 | Forbedret apparat til elektrisk formidlet indgivelse af terapeutiske midler |
| DK15165174.2T DK2929909T3 (da) | 2004-03-08 | 2005-03-08 | Forbedret apparat til elektrisk-medieret levering af terapeutiske midler |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15165174.2T DK2929909T3 (da) | 2004-03-08 | 2005-03-08 | Forbedret apparat til elektrisk-medieret levering af terapeutiske midler |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9364664B2 (da) |
| EP (3) | EP2929909B1 (da) |
| JP (2) | JP5221127B2 (da) |
| KR (1) | KR101261642B1 (da) |
| CN (2) | CN1997423B (da) |
| AU (1) | AU2005221687A1 (da) |
| CA (1) | CA2559083C (da) |
| CY (1) | CY1116471T1 (da) |
| DK (2) | DK1729848T3 (da) |
| ES (2) | ES2695235T3 (da) |
| HK (1) | HK1216239A1 (da) |
| HU (1) | HUE025052T2 (da) |
| IL (2) | IL177942A (da) |
| NZ (2) | NZ585119A (da) |
| PL (1) | PL1729848T3 (da) |
| PT (1) | PT1729848E (da) |
| SG (1) | SG136133A1 (da) |
| SI (1) | SI1729848T1 (da) |
| WO (1) | WO2005087311A1 (da) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6912417B1 (en) | 2002-04-05 | 2005-06-28 | Ichor Medical Systmes, Inc. | Method and apparatus for delivery of therapeutic agents |
| NZ585119A (en) | 2004-03-08 | 2011-08-26 | Ichor Medical Systems Inc | Medical injector with surrounding electrical field generating penetrating electrodes |
| US7959598B2 (en) | 2008-08-20 | 2011-06-14 | Asante Solutions, Inc. | Infusion pump systems and methods |
| WO2013149186A1 (en) | 2012-03-30 | 2013-10-03 | Insulet Corporation | Fluid delivery device with transcutaneous access tool, insertion mechansim and blood glucose monitoring for use therewith |
| WO2015089142A1 (en) | 2013-12-11 | 2015-06-18 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Sub-micron laser patterning of graphene and 2d materials |
| GB2523989B (en) | 2014-01-30 | 2020-07-29 | Insulet Netherlands B V | Therapeutic product delivery system and method of pairing |
| JP2018505756A (ja) | 2015-02-18 | 2018-03-01 | インシュレット コーポレイション | 流体送達及び注入装置並びにその使用方法 |
| WO2017091584A1 (en) | 2015-11-25 | 2017-06-01 | Insulet Corporation | Wearable medication delivery device |
| US10275573B2 (en) | 2016-01-13 | 2019-04-30 | Bigfoot Biomedical, Inc. | User interface for diabetes management system |
| EP3374004B1 (en) | 2016-01-14 | 2023-06-28 | Bigfoot Biomedical, Inc. | Adjusting insulin delivery rates |
| US10363342B2 (en) | 2016-02-04 | 2019-07-30 | Insulet Corporation | Anti-inflammatory cannula |
| EA202191975A2 (ru) * | 2016-03-28 | 2022-03-31 | Айкор Медикэл Системс, Инк. | Устройство для доставки терапевтических средств |
| CA3020426A1 (en) | 2016-04-13 | 2017-10-19 | Synthetic Genomics, Inc. | Recombinant arterivirus replicon systems and uses thereof |
| US10561797B2 (en) | 2016-08-14 | 2020-02-18 | Insulet Corporation | Drug delivery device with indicator |
| US10765807B2 (en) | 2016-09-23 | 2020-09-08 | Insulet Corporation | Fluid delivery device with sensor |
| EP3522951A1 (en) | 2016-10-07 | 2019-08-14 | Insulet Corporation | Multi-stage delivery system |
| CN110073002A (zh) | 2016-10-17 | 2019-07-30 | 合成基因组公司 | 重组病毒复制子体系及其用途 |
| US10780217B2 (en) | 2016-11-10 | 2020-09-22 | Insulet Corporation | Ratchet drive for on body delivery system |
| KR102655641B1 (ko) | 2016-12-05 | 2024-04-05 | 얀센 파마슈티칼즈, 인코포레이티드 | 유전자 발현을 향상시키기 위한 조성물 및 방법 |
| EP3568859A1 (en) | 2017-01-13 | 2019-11-20 | Bigfoot Biomedical, Inc. | Insulin delivery methods, systems and devices |
| WO2018136699A1 (en) | 2017-01-19 | 2018-07-26 | Insulet Corporation | Cartridge hold-up volume reduction |
| US11045603B2 (en) | 2017-02-22 | 2021-06-29 | Insulet Corporation | Needle insertion mechanisms for drug containers |
| US10695485B2 (en) | 2017-03-07 | 2020-06-30 | Insulet Corporation | Very high volume user filled drug delivery device |
| US10773075B2 (en) * | 2017-03-22 | 2020-09-15 | Verily Life Sciences Llc | Neural electrode array attachment |
| US10973978B2 (en) | 2017-08-03 | 2021-04-13 | Insulet Corporation | Fluid flow regulation arrangements for drug delivery devices |
| WO2019028342A1 (en) | 2017-08-03 | 2019-02-07 | Insulet Corporation | MICRO PUMP WITH PISTON |
| US11786668B2 (en) | 2017-09-25 | 2023-10-17 | Insulet Corporation | Drug delivery devices, systems, and methods with force transfer elements |
| EP3687600B1 (en) | 2017-09-26 | 2022-04-27 | Insulet Corporation | Needle mechanism module for drug delivery device |
| US11147931B2 (en) | 2017-11-17 | 2021-10-19 | Insulet Corporation | Drug delivery device with air and backflow elimination |
| EA202091517A1 (ru) | 2017-12-19 | 2020-11-03 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Способы и устройство для доставки вакцин против вируса гепатита b (hbv) |
| MA51312A (fr) | 2017-12-19 | 2020-10-28 | Bavarian Nordic As | Méthodes et compositions permettant d'induire une réponse immunitaire contre le virus de l'hépatite b (vhb) |
| EA202091516A1 (ru) | 2017-12-19 | 2020-11-03 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Способы и композиции для индукции иммунного ответа против вируса гепатита b (hbv) |
| WO2019126120A1 (en) * | 2017-12-19 | 2019-06-27 | Janssen Sciences Ireland Unlimited Company | Methods and apparatus for the delivery of hepatitis b virus (hbv) vaccines |
| EA202091513A1 (ru) | 2017-12-19 | 2020-09-09 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Вакцины против вируса гепатита b (hbv) и их применение |
| MA51311A (fr) | 2017-12-19 | 2020-10-28 | Janssen Sciences Ireland Unlimited Co | Vaccins contre le virus de l'hépatite b (vhb) et utilisations associées |
| CN111902163B (zh) | 2018-01-19 | 2024-02-13 | 杨森制药公司 | 使用重组复制子系统诱导和增强免疫应答 |
| USD928199S1 (en) | 2018-04-02 | 2021-08-17 | Bigfoot Biomedical, Inc. | Medication delivery device with icons |
| JP7124120B2 (ja) | 2018-05-04 | 2022-08-23 | インスレット コーポレイション | 制御アルゴリズムベースの薬物送達システムのための安全制約 |
| US10874803B2 (en) | 2018-05-31 | 2020-12-29 | Insulet Corporation | Drug cartridge with drive system |
| US11229736B2 (en) | 2018-06-06 | 2022-01-25 | Insulet Corporation | Linear shuttle pump for drug delivery |
| CA3112209C (en) | 2018-09-28 | 2023-08-29 | Insulet Corporation | Activity mode for artificial pancreas system |
| WO2020077223A1 (en) | 2018-10-11 | 2020-04-16 | Insulet Corporation | Event detection for drug delivery system |
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| USD920343S1 (en) | 2019-01-09 | 2021-05-25 | Bigfoot Biomedical, Inc. | Display screen or portion thereof with graphical user interface associated with insulin delivery |
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| TWI772823B (zh) | 2019-06-18 | 2022-08-01 | 愛爾蘭商健生科學愛爾蘭無限公司 | B型肝炎病毒(hbv)疫苗與蛋白殼組裝調節劑之組合 |
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| AU2020297008A1 (en) | 2019-06-18 | 2022-02-17 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis B virus (HBV) vaccines and HBV-targeting RNAi |
| CA3140690A1 (en) | 2019-06-18 | 2020-12-24 | Helen Horton | Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators |
| CA3143634A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 antibody |
| WO2020254876A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Virus-like particle delivery of hepatitis b virus (hbv) vaccines |
| EP3986915A1 (en) | 2019-06-18 | 2022-04-27 | Janssen Sciences Ireland Unlimited Company | Recombinant interleukin 12 construct and uses thereof |
| WO2020255042A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and a pyrimidine derivative |
| WO2020255013A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being amide derivatives |
| WO2020255019A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and a quinazoline derivative |
| US20220305115A1 (en) | 2019-06-18 | 2022-09-29 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives |
| CA3140707A1 (en) | 2019-06-18 | 2020-12-24 | Helen Horton | Combination of hepatitis b virus (hbv) vaccines and quinazoline derivatives |
| WO2020255016A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators |
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| JP2022536850A (ja) | 2019-06-18 | 2022-08-19 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | Ｂ型肝炎ウイルス（ｈｂｖ）ワクチンおよび抗ｐｄ－１または抗ｐｄ－ｌ１抗体の組合せ |
| WO2020255035A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and pyrimidine derivatives |
| WO2020255018A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Hepatitis b virus (hbv) vaccines and uses thereof |
| CA3143627A1 (en) | 2019-06-20 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Carbohydrate nanocarrier delivery of hepatitis b virus (hbv) vaccines |
| CA3143631A1 (en) | 2019-06-20 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Lipid nanoparticle or liposome delivery of hepatitis b virus (hbv) vaccines |
| US11801344B2 (en) | 2019-09-13 | 2023-10-31 | Insulet Corporation | Blood glucose rate of change modulation of meal and correction insulin bolus quantity |
| US11935637B2 (en) | 2019-09-27 | 2024-03-19 | Insulet Corporation | Onboarding and total daily insulin adaptivity |
| US11369735B2 (en) | 2019-11-05 | 2022-06-28 | Insulet Corporation | Component positioning of a linear shuttle pump |
| EP4354455A2 (en) | 2019-12-06 | 2024-04-17 | Insulet Corporation | Techniques and devices providing adaptivity and personalization in diabetes treatment |
| US11833329B2 (en) | 2019-12-20 | 2023-12-05 | Insulet Corporation | Techniques for improved automatic drug delivery performance using delivery tendencies from past delivery history and use patterns |
| US11551802B2 (en) | 2020-02-11 | 2023-01-10 | Insulet Corporation | Early meal detection and calorie intake detection |
| US11547800B2 (en) | 2020-02-12 | 2023-01-10 | Insulet Corporation | User parameter dependent cost function for personalized reduction of hypoglycemia and/or hyperglycemia in a closed loop artificial pancreas system |
| US11324889B2 (en) | 2020-02-14 | 2022-05-10 | Insulet Corporation | Compensation for missing readings from a glucose monitor in an automated insulin delivery system |
| US11607493B2 (en) | 2020-04-06 | 2023-03-21 | Insulet Corporation | Initial total daily insulin setting for user onboarding |
| EP4178613A1 (en) | 2020-07-08 | 2023-05-17 | Janssen Sciences Ireland Unlimited Company | Rna replicon vaccines against hbv |
| US11684716B2 (en) | 2020-07-31 | 2023-06-27 | Insulet Corporation | Techniques to reduce risk of occlusions in drug delivery systems |
| WO2022133230A1 (en) | 2020-12-18 | 2022-06-23 | Janssen Pharmaceuticals, Inc. | Combination therapy for treating hepatitis b virus infection |
| JP2024501022A (ja) | 2020-12-28 | 2024-01-10 | アークトゥルス セラピューティクス， インコーポレイテッド | Ｈｂｖを標的とする転写活性化因子様エフェクターヌクレアーゼ（ｔａｌｅｎ） |
| US11904140B2 (en) | 2021-03-10 | 2024-02-20 | Insulet Corporation | Adaptable asymmetric medicament cost component in a control system for medicament delivery |
| US11738144B2 (en) | 2021-09-27 | 2023-08-29 | Insulet Corporation | Techniques enabling adaptation of parameters in aid systems by user input |
| US11439754B1 (en) | 2021-12-01 | 2022-09-13 | Insulet Corporation | Optimizing embedded formulations for drug delivery |
| WO2023141627A2 (en) * | 2022-01-21 | 2023-07-27 | Rx Bandz, Inc. | Systems, devices, and methods for fluidic throttle control of the delivery of therapies in needle-based delivery systems |
| WO2023233290A1 (en) | 2022-05-31 | 2023-12-07 | Janssen Sciences Ireland Unlimited Company | Rnai agents targeting pd-l1 |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2725877A (en) | 1950-12-22 | 1955-12-06 | Reiter David | Hypodermic syringe with feed control |
| US2860439A (en) | 1955-08-10 | 1958-11-18 | Arvey Corp | Foldable display piece |
| FR2348709A1 (fr) * | 1976-04-23 | 1977-11-18 | Pistor Michel | Procede de traitement mesotherapique et dispositif d'injection,formant micro-injecteur automatique,en comportant application |
| US4198975A (en) | 1978-10-06 | 1980-04-22 | Haller J Gilbert | Self-injecting hypodermic syringe device |
| US4394863A (en) | 1981-10-23 | 1983-07-26 | Survival Technology, Inc. | Automatic injector with cartridge having separate sequentially injectable medicaments |
| US4832682A (en) * | 1984-08-08 | 1989-05-23 | Survival Technology, Inc. | Injection method and apparatus with electrical blood absorbing stimulation |
| US4636197A (en) | 1985-02-15 | 1987-01-13 | Ping Chu | Intravenous fluid infusion device |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| JPH04244172A (ja) | 1991-01-30 | 1992-09-01 | Sony Corp | 低周波治療器による鎮痛方法及び鎮痛装置 |
| JPH04362767A (ja) | 1991-06-10 | 1992-12-15 | Agency Of Ind Science & Technol | マルチプロセッサ装置 |
| US5215089A (en) | 1991-10-21 | 1993-06-01 | Cyberonics, Inc. | Electrode assembly for nerve stimulation |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5273525A (en) | 1992-08-13 | 1993-12-28 | Btx Inc. | Injection and electroporation apparatus for drug and gene delivery |
| US5688233A (en) | 1992-08-17 | 1997-11-18 | Genetronics, Inc. | Electronincorporation enhanced transdermal delivery of molecules |
| US5318514A (en) * | 1992-08-17 | 1994-06-07 | Btx, Inc. | Applicator for the electroporation of drugs and genes into surface cells |
| US5306236A (en) | 1993-02-18 | 1994-04-26 | Vickers Plc | Needle electrode for use with hypodermic syringe attachment |
| US5993434A (en) | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
| US5702359A (en) | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
| US5425715A (en) * | 1993-08-05 | 1995-06-20 | Survival Technology, Inc. | Reloadable injector |
| US5478316A (en) * | 1994-02-02 | 1995-12-26 | Becton, Dickinson And Company | Automatic self-injection device |
| US5593429A (en) | 1994-06-28 | 1997-01-14 | Cadwell Industries, Inc. | Needle electrode with depth of penetration limiter |
| US6041252A (en) | 1995-06-07 | 2000-03-21 | Ichor Medical Systems Inc. | Drug delivery system and method |
| GB9612724D0 (en) | 1996-06-18 | 1996-08-21 | Owen Mumford Ltd | Improvements relating to injection devices |
| US5846225A (en) | 1997-02-19 | 1998-12-08 | Cornell Research Foundation, Inc. | Gene transfer therapy delivery device and method |
| US5851197A (en) * | 1997-02-05 | 1998-12-22 | Minimed Inc. | Injector for a subcutaneous infusion set |
| KR100427786B1 (ko) | 1997-04-03 | 2004-04-30 | 일렉트로우펙트 에이에스 | 약물과 핵산의 골격 근육 내 주입 장치 및 방법 |
| US5873849A (en) | 1997-04-24 | 1999-02-23 | Ichor Medical Systems, Inc. | Electrodes and electrode arrays for generating electroporation inducing electrical fields |
| US6558351B1 (en) | 1999-06-03 | 2003-05-06 | Medtronic Minimed, Inc. | Closed loop system for controlling insulin infusion |
| DE69812942T2 (de) | 1997-07-04 | 2004-01-29 | Reckitt Benckiser Uk Ltd | Verbessertes zielen von fliegenden insekten mit insektiziden und vorrichtung zum laden von flüssigkeiten |
| US6241701B1 (en) | 1997-08-01 | 2001-06-05 | Genetronics, Inc. | Apparatus for electroporation mediated delivery of drugs and genes |
| US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
| WO1999013719A1 (en) | 1997-09-18 | 1999-03-25 | Gene Therapy Systems, Inc. | Chemical modification of dna using peptide nucleic acid conjugates |
| TW368420B (en) | 1997-11-04 | 1999-09-01 | Genetronics Inc | Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum |
| US6356783B1 (en) | 1997-11-20 | 2002-03-12 | David R. Hubbard, Jr. | Multi-electrode and needle injection device for diagnosis and treatment of muscle injury and pain |
| US6918901B1 (en) | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
| US6120493A (en) | 1998-01-27 | 2000-09-19 | Genetronics, Inc. | Method for the introduction of therapeutic agents utilizing an electroporation apparatus |
| US6208893B1 (en) | 1998-01-27 | 2001-03-27 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
| ES2255155T3 (es) | 1998-02-05 | 2006-06-16 | Biosense Webster, Inc. | Dispositivo para la administracion intracardiaca de farmacos. |
| EP1064035B1 (en) | 1998-03-23 | 2003-11-26 | ELAN CORPORATION, Plc | Drug delivery device |
| GB9808408D0 (en) | 1998-04-18 | 1998-06-17 | Owen Mumford Ltd | Improvements relating to injection devices |
| BR9912747A (pt) | 1998-08-03 | 2001-05-15 | Univ North Carolina State | Uso de resfriamento por co2 no tratamento de ovos de aves domésticas |
| US6428528B2 (en) | 1998-08-11 | 2002-08-06 | Antares Pharma, Inc. | Needle assisted jet injector |
| GB9817662D0 (en) * | 1998-08-13 | 1998-10-07 | Crocker Peter J | Substance delivery |
| US6678558B1 (en) | 1999-03-25 | 2004-01-13 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
| EP1183068A4 (en) | 1999-05-10 | 2008-12-17 | Gentronics Inc | ENHANCED ACTIVE AGENT DELIVERY METHOD BY ELECTROPORATION |
| JP2000316991A (ja) | 1999-05-13 | 2000-11-21 | Hisamitsu Pharmaceut Co Inc | イオントフォレーシス装置の電極構造体及びその製造方法 |
| WO2001013975A2 (en) | 1999-08-20 | 2001-03-01 | Bioject, Inc. | Dna-based intramuscular injection system for humans |
| US6319224B1 (en) | 1999-08-20 | 2001-11-20 | Bioject Medical Technologies Inc. | Intradermal injection system for injecting DNA-based injectables into humans |
| AU2542001A (en) | 2000-01-21 | 2001-07-31 | Instrumentarium Corporation | Medical electrode |
| US7530964B2 (en) | 2000-06-30 | 2009-05-12 | Elan Pharma International Limited | Needle device and method thereof |
| CN1345607A (zh) * | 2000-09-30 | 2002-04-24 | 杭州泰士生物科技有限公司 | 带电极的肌内基因注射针装置 |
| ES2324461T3 (es) * | 2000-10-13 | 2009-08-07 | Alza Corporation | Aparato y procedimiento para perforar la piel con microprotuberancias. |
| US20020078161A1 (en) | 2000-12-19 | 2002-06-20 | Philips Electronics North America Corporation | UPnP enabling device for heterogeneous networks of slave devices |
| US6899699B2 (en) | 2001-01-05 | 2005-05-31 | Novo Nordisk A/S | Automatic injection device with reset feature |
| US6748266B2 (en) | 2001-04-06 | 2004-06-08 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
| GB2391480B (en) * | 2002-08-05 | 2007-02-28 | Caretek Medical Ltd | Drug delivery system |
| US7429258B2 (en) * | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
| CA2477872A1 (en) | 2002-03-07 | 2003-09-18 | Merck & Co., Inc. | Clinical syringe with electrical stimulation aspects |
| US6780171B2 (en) * | 2002-04-02 | 2004-08-24 | Becton, Dickinson And Company | Intradermal delivery device |
| US6912417B1 (en) | 2002-04-05 | 2005-06-28 | Ichor Medical Systmes, Inc. | Method and apparatus for delivery of therapeutic agents |
| US7328064B2 (en) * | 2002-07-04 | 2008-02-05 | Inovio As | Electroporation device and injection apparatus |
| JP2004041434A (ja) * | 2002-07-11 | 2004-02-12 | Kiyohito Ishida | エレクトロポレーション装置 |
| NZ585119A (en) | 2004-03-08 | 2011-08-26 | Ichor Medical Systems Inc | Medical injector with surrounding electrical field generating penetrating electrodes |
| EP2117607A4 (en) | 2007-01-11 | 2012-08-08 | Huntington Medical Res Inst | IMAGING AGENTS AND METHODS OF USE |
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