DK172887B1 - Fremgangsmåde til fremstilling af mucopolysaccharider med høj antithrombotisk virkning - Google Patents
Fremgangsmåde til fremstilling af mucopolysaccharider med høj antithrombotisk virkning Download PDFInfo
- Publication number
- DK172887B1 DK172887B1 DK198504752A DK475285A DK172887B1 DK 172887 B1 DK172887 B1 DK 172887B1 DK 198504752 A DK198504752 A DK 198504752A DK 475285 A DK475285 A DK 475285A DK 172887 B1 DK172887 B1 DK 172887B1
- Authority
- DK
- Denmark
- Prior art keywords
- mps
- chains
- usp
- process according
- approx
- Prior art date
Links
- 229920002683 Glycosaminoglycan Polymers 0.000 title claims abstract description 38
- 230000002785 anti-thrombosis Effects 0.000 title claims abstract description 9
- 238000004519 manufacturing process Methods 0.000 title abstract description 4
- 239000003146 anticoagulant agent Substances 0.000 title description 3
- 239000000203 mixture Substances 0.000 claims abstract description 32
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229920000669 heparin Polymers 0.000 claims abstract description 22
- 229960002897 heparin Drugs 0.000 claims abstract description 22
- 238000005194 fractionation Methods 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
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- 235000011164 potassium chloride Nutrition 0.000 claims description 2
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- UDQPBAKZZSWNSE-MBMOQRBOSA-N (2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carboxylic acid Chemical group OC[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@@H]1O UDQPBAKZZSWNSE-MBMOQRBOSA-N 0.000 claims 1
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- 229940079593 drug Drugs 0.000 description 2
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- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
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- 229960004072 thrombin Drugs 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- ITRJWOMZKQRYTA-RFZYENFJSA-N Cortisone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)CC2=O ITRJWOMZKQRYTA-RFZYENFJSA-N 0.000 description 1
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- 238000012404 In vitro experiment Methods 0.000 description 1
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- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 235000005811 Viola adunca Nutrition 0.000 description 1
- 240000009038 Viola odorata Species 0.000 description 1
- 235000013487 Viola odorata Nutrition 0.000 description 1
- 235000002254 Viola papilionacea Nutrition 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
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- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000003527 anti-angiogenesis Effects 0.000 description 1
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- 239000012736 aqueous medium Substances 0.000 description 1
- 230000010455 autoregulation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 239000000969 carrier Substances 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical class [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
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- 229960000890 hydrocortisone Drugs 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
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- 229910052740 iodine Inorganic materials 0.000 description 1
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- 239000001923 methylcellulose Substances 0.000 description 1
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- 229920001542 oligosaccharide Polymers 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8415978 | 1984-10-18 | ||
| FR8415978A FR2572080B1 (fr) | 1984-10-18 | 1984-10-18 | Procede de preparation de compositions de mucopolysaccharides dotees d'une activite antithrombotique elevee, les compositions obtenues et leur application en tant que medicaments |
| FR8415979 | 1984-10-18 | ||
| FR8415979 | 1984-10-18 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK475285D0 DK475285D0 (da) | 1985-10-17 |
| DK475285A DK475285A (da) | 1986-04-19 |
| DK172887B1 true DK172887B1 (da) | 1999-09-06 |
Family
ID=26224209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198504752A DK172887B1 (da) | 1984-10-18 | 1985-10-17 | Fremgangsmåde til fremstilling af mucopolysaccharider med høj antithrombotisk virkning |
Country Status (11)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2755372B1 (fr) | 1996-11-07 | 1998-12-24 | Elf Aquitaine | Dispositif d'ionophorese comportant au moins un ensemble electrode a membrane, pour l'administration transcutanee de principes actifs a un sujet |
| RU2158907C1 (ru) * | 1999-09-07 | 2000-11-10 | Институт машиноведения и металлургии ДВО РАН | Способ автоматического уравновешивания ротативных систем |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2440376A1 (fr) * | 1978-11-06 | 1980-05-30 | Choay Sa | Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir |
| FR2478646A2 (fr) * | 1980-03-20 | 1981-09-25 | Choay Sa | Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir |
| US4500519A (en) * | 1978-11-06 | 1985-02-19 | Choay S.A. | Mucopolysaccharides having biological properties, preparation and method of use |
| SE449753B (sv) * | 1978-11-06 | 1987-05-18 | Choay Sa | Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav |
| FR2495935A1 (fr) * | 1980-12-15 | 1982-06-18 | Choay Sa | Fractions mucopolysaccharidiques possedant des proprietes biologiques, leur procede de preparation et leur application en tant que medicaments |
| FR2503714B1 (fr) * | 1981-04-10 | 1986-11-21 | Choay Sa | Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine |
| US4533549A (en) * | 1983-01-04 | 1985-08-06 | Lasker Sigmund E | Antithrombotic agent |
-
1985
- 1985-10-08 CA CA000492526A patent/CA1260461A/fr not_active Expired
- 1985-10-16 ES ES547916A patent/ES8604993A1/es not_active Expired
- 1985-10-17 DK DK198504752A patent/DK172887B1/da not_active IP Right Cessation
- 1985-10-18 EP EP85402027A patent/EP0181252B1/fr not_active Expired
- 1985-10-18 AU AU48860/85A patent/AU578750B2/en not_active Expired
- 1985-10-18 DE DE8585402027T patent/DE3573786D1/de not_active Expired
- 1985-10-18 GR GR852518A patent/GR852518B/el unknown
- 1985-10-18 AT AT85402027T patent/ATE47402T1/de not_active IP Right Cessation
- 1985-10-18 IE IE258885A patent/IE58619B1/en not_active IP Right Cessation
- 1985-10-18 PT PT81343A patent/PT81343B/pt unknown
-
1989
- 1989-12-08 SG SG786/89A patent/SG78689G/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE58619B1 (en) | 1993-10-20 |
| PT81343B (pt) | 1987-11-11 |
| PT81343A (fr) | 1985-11-01 |
| ES547916A0 (es) | 1986-03-16 |
| EP0181252A1 (fr) | 1986-05-14 |
| IE852588L (en) | 1986-04-18 |
| AU578750B2 (en) | 1988-11-03 |
| AU4886085A (en) | 1986-04-24 |
| DK475285D0 (da) | 1985-10-17 |
| EP0181252B1 (fr) | 1989-10-18 |
| GR852518B (enrdf_load_stackoverflow) | 1986-02-05 |
| DK475285A (da) | 1986-04-19 |
| DE3573786D1 (en) | 1989-11-23 |
| CA1260461A (fr) | 1989-09-26 |
| SG78689G (en) | 1990-07-13 |
| ATE47402T1 (de) | 1989-11-15 |
| ES8604993A1 (es) | 1986-03-16 |
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