AU4886085A - A process for preparing mucopolysaccharidic compositions having a high antithrombotic activity - Google Patents

A process for preparing mucopolysaccharidic compositions having a high antithrombotic activity

Info

Publication number
AU4886085A
AU4886085A AU48860/85A AU4886085A AU4886085A AU 4886085 A AU4886085 A AU 4886085A AU 48860/85 A AU48860/85 A AU 48860/85A AU 4886085 A AU4886085 A AU 4886085A AU 4886085 A AU4886085 A AU 4886085A
Authority
AU
Australia
Prior art keywords
compositions
preparing
chains
antithrombotic activity
usp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU48860/85A
Other versions
AU578750B2 (en
Inventor
Jean Choay
Jean-Claude Lormeau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8415978A external-priority patent/FR2572080B1/en
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Publication of AU4886085A publication Critical patent/AU4886085A/en
Application granted granted Critical
Publication of AU578750B2 publication Critical patent/AU578750B2/en
Assigned to SANOFI-SYNTHELABO reassignment SANOFI-SYNTHELABO Request to Amend Deed and Register Assignors: CHOAY S.A.
Assigned to SANOFI-AVENTIS reassignment SANOFI-AVENTIS Request to Amend Deed and Register Assignors: SANOFI-SYNTHELABO
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1. Process for preparing mucopolysaccharides or MPS possessing high antithrombotic activity, characterized by the fact that compositions formed form a majority of MPS chains having a molecular weight of about 1800 to 8000 daltons, a YW titer and a ratio of the YW/USP titers higher than those of heparin to at least one fractionation step, in order to selectively separate from said compositions at least the major part of chains having MW lower than about 2000 and those having a higher MW but a sulfate content lower than the sulfate average contents of the mixture chain and that the fractions devoid from said chains are recovered, said fractions having a lower ratio of YW/USP titers than the starting compositions but higher than the one of heparin with USP titer higher than the one of the starting compositions.
AU48860/85A 1984-10-18 1985-10-18 A process for preparing mucopolysaccharidic compositions having a high antithrombotic activity Expired AU578750B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8415978A FR2572080B1 (en) 1984-10-18 1984-10-18 PROCESS FOR THE PREPARATION OF MUCOPOLYSACCHARIDE COMPOSITIONS WITH HIGH ANTITHROMBOTIC ACTIVITY, THE COMPOSITIONS OBTAINED AND THEIR APPLICATION AS MEDICAMENTS
FR8415978 1984-10-18
FR8415979 1984-10-18
FR8415979 1984-10-18

Publications (2)

Publication Number Publication Date
AU4886085A true AU4886085A (en) 1986-04-24
AU578750B2 AU578750B2 (en) 1988-11-03

Family

ID=26224209

Family Applications (1)

Application Number Title Priority Date Filing Date
AU48860/85A Expired AU578750B2 (en) 1984-10-18 1985-10-18 A process for preparing mucopolysaccharidic compositions having a high antithrombotic activity

Country Status (11)

Country Link
EP (1) EP0181252B1 (en)
AT (1) ATE47402T1 (en)
AU (1) AU578750B2 (en)
CA (1) CA1260461A (en)
DE (1) DE3573786D1 (en)
DK (1) DK172887B1 (en)
ES (1) ES8604993A1 (en)
GR (1) GR852518B (en)
IE (1) IE58619B1 (en)
PT (1) PT81343B (en)
SG (1) SG78689G (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2755372B1 (en) 1996-11-07 1998-12-24 Elf Aquitaine IONOPHORESIS DEVICE COMPRISING AT LEAST ONE MEMBRANE ELECTRODE ASSEMBLY FOR THE TRANSCUTANEOUS ADMINISTRATION OF ACTIVE PRINCIPLES TO A SUBJECT

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2478646A2 (en) * 1980-03-20 1981-09-25 Choay Sa MUCOPOLYSACCHARIDIC COMPOSITION HAVING A COAGULATION REGULATING ACTIVITY, MEDICAMENT CONTAINING THE SAME, AND METHOD FOR OBTAINING THE SAME
US4500519A (en) * 1978-11-06 1985-02-19 Choay S.A. Mucopolysaccharides having biological properties, preparation and method of use
FR2440376A1 (en) * 1978-11-06 1980-05-30 Choay Sa MUCOPOLYSACCHARIDIC COMPOSITION HAVING REGULATORY COAGULATION ACTIVITY, MEDICAMENT CONTAINING SAME AND METHOD FOR OBTAINING SAME
SE449753B (en) * 1978-11-06 1987-05-18 Choay Sa MUCOPOLYSACCARIDE COMPOSITION WITH REGULATORY EFFECTS ON COAGULATION, MEDICINAL CONTAINING ITS SAME AND PROCEDURE FOR PREPARING THEREOF
FR2495935A1 (en) * 1980-12-15 1982-06-18 Choay Sa Muco:polysaccharide fractions derived from heparin - with selective inhibitory action against factor Xa but low anticoagulant activity
FR2503714B1 (en) * 1981-04-10 1986-11-21 Choay Sa PROCESS FOR OBTAINING BIOLOGICALLY ACTIVE MUCOPOLYSACCHARIDES, OF HIGH PURITY, BY DEPOLYMERIZATION OF HEPARIN
US4533549A (en) * 1983-01-04 1985-08-06 Lasker Sigmund E Antithrombotic agent

Also Published As

Publication number Publication date
EP0181252A1 (en) 1986-05-14
CA1260461A (en) 1989-09-26
EP0181252B1 (en) 1989-10-18
PT81343A (en) 1985-11-01
ES8604993A1 (en) 1986-03-16
SG78689G (en) 1990-07-13
DK475285D0 (en) 1985-10-17
DK172887B1 (en) 1999-09-06
IE58619B1 (en) 1993-10-20
IE852588L (en) 1986-04-18
AU578750B2 (en) 1988-11-03
ES547916A0 (en) 1986-03-16
ATE47402T1 (en) 1989-11-15
DE3573786D1 (en) 1989-11-23
GR852518B (en) 1986-02-05
PT81343B (en) 1987-11-11
DK475285A (en) 1986-04-19

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