DK172444B1 - Kimære monoklonale antistoffer og derivater deraf, fremgangsmåde til deres fremstilling, rekombinant DNA og fremgangsmåde t - Google Patents

Kimære monoklonale antistoffer og derivater deraf, fremgangsmåde til deres fremstilling, rekombinant DNA og fremgangsmåde t Download PDF

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Publication number
DK172444B1
DK172444B1 DK198900021A DK2189A DK172444B1 DK 172444 B1 DK172444 B1 DK 172444B1 DK 198900021 A DK198900021 A DK 198900021A DK 2189 A DK2189 A DK 2189A DK 172444 B1 DK172444 B1 DK 172444B1
Authority
DK
Denmark
Prior art keywords
ser
chimeric monoclonal
gly
formula
chimeric
Prior art date
Application number
DK198900021A
Other languages
Danish (da)
English (en)
Other versions
DK2189A (da
DK2189D0 (da
Inventor
Norman Hardman
Laura Lee Gill
Ronald F J De Winter
Kathrin Wagner
Christoph Heusser
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888800077A external-priority patent/GB8800077D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of DK2189D0 publication Critical patent/DK2189D0/da
Publication of DK2189A publication Critical patent/DK2189A/da
Application granted granted Critical
Publication of DK172444B1 publication Critical patent/DK172444B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK198900021A 1988-01-05 1989-01-04 Kimære monoklonale antistoffer og derivater deraf, fremgangsmåde til deres fremstilling, rekombinant DNA og fremgangsmåde t DK172444B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8800077 1988-01-05
GB888800077A GB8800077D0 (en) 1988-01-05 1988-01-05 Novel chimeric antibodies
GB888820099A GB8820099D0 (en) 1988-01-05 1988-08-24 Novel chimeric antibodies
GB8820099 1988-08-24

Publications (3)

Publication Number Publication Date
DK2189D0 DK2189D0 (da) 1989-01-04
DK2189A DK2189A (da) 1989-07-06
DK172444B1 true DK172444B1 (da) 1998-07-27

Family

ID=26293262

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198900021A DK172444B1 (da) 1988-01-05 1989-01-04 Kimære monoklonale antistoffer og derivater deraf, fremgangsmåde til deres fremstilling, rekombinant DNA og fremgangsmåde t

Country Status (10)

Country Link
EP (1) EP0323806B1 (el)
JP (1) JPH02154696A (el)
AU (1) AU625613B2 (el)
DE (1) DE3879452T2 (el)
DK (1) DK172444B1 (el)
ES (1) ES2053810T3 (el)
GR (1) GR3007853T3 (el)
HK (1) HK156695A (el)
IE (1) IE62440B1 (el)
PT (1) PT89384B (el)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0617127A1 (en) * 1987-12-31 1994-09-28 Tanox Biosystems, Inc. Antigenic epitopes on B cell-bound IgE Immunoglobulins
IL89491A0 (en) * 1988-11-17 1989-09-10 Hybritech Inc Bifunctional chimeric antibodies
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE3900534A1 (de) * 1989-01-10 1990-07-12 Boehringer Mannheim Gmbh Diagnostischer nachweis unter verwendung von chimaeren antikoerpern
US5081235A (en) * 1989-07-26 1992-01-14 City Of Hope Chimeric anti-cea antibody
US5580774A (en) * 1989-07-31 1996-12-03 Eli Lilly And Company Chimeric antibodies directed against a human glycoprotein antigen
AU632843B2 (en) * 1989-08-10 1993-01-14 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Cat-mouse heterohybridoma and gene fragment coding for constant region of feline immunoglobulin
JPH03206886A (ja) * 1989-11-13 1991-09-10 Green Cross Corp:The ヒト腫瘍細胞抗原に対し特異性を持つマウス―ヒトキメラａ１０抗体
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
AU654811B2 (en) * 1990-03-20 1994-11-24 Trustees Of Columbia University In The City Of New York, The Chimeric antibodies with receptor binding ligands in place of their constant region
GB2276169A (en) * 1990-07-05 1994-09-21 Celltech Ltd Antibodies specific for carcinoembryonic antigen
GB9014932D0 (en) * 1990-07-05 1990-08-22 Celltech Ltd Recombinant dna product and method
GB9020282D0 (en) 1990-09-17 1990-10-31 Gorman Scott D Altered antibodies and their preparation
US5612034A (en) * 1990-10-03 1997-03-18 Redcell, Inc. Super-globuling for in vivo extended lifetimes
GB9109645D0 (en) * 1991-05-03 1991-06-26 Celltech Ltd Recombinant antibodies
US6797492B2 (en) 1991-05-17 2004-09-28 Merck & Co., Inc. Method for reducing the immunogenicity of antibody variable domains
US6800738B1 (en) 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
US6407213B1 (en) 1991-06-14 2002-06-18 Genentech, Inc. Method for making humanized antibodies
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
GB9317423D0 (en) * 1993-08-21 1993-10-06 Imp Cancer Res Tech Monoclonal antibodies
GB2301366B (en) * 1994-03-29 1998-07-29 Celltech Therapeutics Ltd Antibodies against E-selectin
CU22615A1 (es) 1994-06-30 2000-02-10 Centro Inmunologia Molecular Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos
US5874540A (en) 1994-10-05 1999-02-23 Immunomedics, Inc. CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies
AU4373197A (en) * 1996-09-19 1998-04-14 Diagnocure Inc. Recombinant single chain antibodies directed against the gp54 cancer marker, composition comprising same and use thereof
DE19911329A1 (de) * 1998-03-27 2000-09-21 Benes Ivan Friedrich Humantherapeutisch anwendbares Radioimmunkonjugat und Verfahren zu seiner Herstellung
EP1598671A1 (en) * 1999-10-28 2005-11-23 Agensys, Inc. Diagnosis and therapy of cancer using SGP28-related molecules
JP4790413B2 (ja) 2002-10-08 2011-10-12 イミューノメディクス、インコーポレイテッド 抗体療法
EP2210903A1 (en) * 2009-01-21 2010-07-28 Monoclonal Antibodies Therapeutics Anti-CD160 monoclonal antibodies and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations

Also Published As

Publication number Publication date
HK156695A (en) 1995-10-13
JPH02154696A (ja) 1990-06-14
EP0323806B1 (en) 1993-03-17
IE62440B1 (en) 1995-02-08
GR3007853T3 (el) 1993-08-31
IE890019L (en) 1989-07-05
DE3879452D1 (de) 1993-04-22
PT89384A (pt) 1990-02-08
AU2759588A (en) 1989-07-06
ES2053810T3 (es) 1994-08-01
DK2189A (da) 1989-07-06
EP0323806A1 (en) 1989-07-12
PT89384B (pt) 1993-09-30
AU625613B2 (en) 1992-07-16
DK2189D0 (da) 1989-01-04
DE3879452T2 (de) 1993-07-15

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed