DK1718660T3 - Oligonukleotider forbundet med lipidmembranbindinger - Google Patents

Oligonukleotider forbundet med lipidmembranbindinger

Info

Publication number
DK1718660T3
DK1718660T3 DK05711148.6T DK05711148T DK1718660T3 DK 1718660 T3 DK1718660 T3 DK 1718660T3 DK 05711148 T DK05711148 T DK 05711148T DK 1718660 T3 DK1718660 T3 DK 1718660T3
Authority
DK
Denmark
Prior art keywords
strand
lipid membrane
oligonucleotide
moieties
hydrophobic anchoring
Prior art date
Application number
DK05711148.6T
Other languages
English (en)
Inventor
Indriati Pfeiffer
Fredrik Hoeoek
Original Assignee
Layerlab Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Layerlab Aktiebolag filed Critical Layerlab Aktiebolag
Application granted granted Critical
Publication of DK1718660T3 publication Critical patent/DK1718660T3/da

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK05711148.6T 2004-02-26 2005-02-28 Oligonukleotider forbundet med lipidmembranbindinger DK1718660T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54814904P 2004-02-26 2004-02-26
PCT/SE2005/000288 WO2005082922A1 (en) 2004-02-26 2005-02-28 Oligonucleotides related to lipid membrane attachments

Publications (1)

Publication Number Publication Date
DK1718660T3 true DK1718660T3 (da) 2011-03-21

Family

ID=34910990

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05711148.6T DK1718660T3 (da) 2004-02-26 2005-02-28 Oligonukleotider forbundet med lipidmembranbindinger

Country Status (10)

Country Link
US (2) US8389707B2 (da)
EP (1) EP1718660B1 (da)
JP (2) JP2007525500A (da)
AT (1) ATE490260T1 (da)
AU (1) AU2005217347A1 (da)
CA (1) CA2558256C (da)
DE (1) DE602005025087D1 (da)
DK (1) DK1718660T3 (da)
NZ (1) NZ549643A (da)
WO (1) WO2005082922A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706474B1 (en) 2000-06-27 2004-03-16 Board Of Trustees Of The University Of Illinois Nucleic acid enzyme biosensors for ions
US6890719B2 (en) 2002-05-10 2005-05-10 The Board Of Trustess Of The University Of Illinois Fluorescence based biosensor
EP1718660B1 (en) * 2004-02-26 2010-12-01 Layerlab Aktiebolag Oligonucleotides related to lipid membrane attachments
US7892734B2 (en) 2005-08-11 2011-02-22 The Board Of Trustees Of The University Of Illinois Aptamer based colorimetric sensor systems
WO2007109500A1 (en) 2006-03-16 2007-09-27 The Board Of Trustees Of The University Of Illinois Lateral flow devices
US8415461B2 (en) * 2007-01-19 2013-04-09 The Board Of Trustees Of The University Of Illinois Amphiphilic substances and functionalized lipid vesicles including the same
EP2111218B1 (en) * 2007-01-24 2014-07-02 Syddansk Universitet Dna controlled assembly of lipid membranes
US8058415B2 (en) 2007-04-24 2011-11-15 The Board Of Trustees Of The University Of Illinois Aptamer- and nucleic acid enzyme-based systems for simultaneous detection of multiple analytes
WO2010032945A2 (ko) * 2008-09-16 2010-03-25 포항공과대학교 산학협력단 콜레스테롤을 이용한 생분자의 고정화
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
JP5863670B2 (ja) 2010-01-19 2016-02-17 ノースウェスタン ユニバーシティ 核酸および／または他の構成要素を含有している合成ナノ構造体
US9650407B2 (en) 2011-11-02 2017-05-16 The Regents Of The University Of California Reprogramming of cellular adhesion
KR20140037716A (ko) * 2012-09-19 2014-03-27 삼성전자주식회사 소포를 분리하기 위한 조성물, 키트 및 이를 이용하여 소포를 분리하는 방법
AU2014270410B2 (en) * 2013-05-24 2020-07-16 Illumina Cambridge Limited Pyrophosphorolytic sequencing
AU2014292926B2 (en) 2013-07-25 2020-03-05 Exicure Operating Company Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
US10568898B2 (en) 2013-08-13 2020-02-25 Northwestern University Lipophilic nanoparticles for drug delivery
JP6527516B2 (ja) 2013-12-03 2019-06-05 ノースウェスタン ユニバーシティ リポソーム粒子、前述のものを作製する方法及びその使用
JP6581604B2 (ja) 2014-06-04 2019-09-25 イグジキュア, インコーポレーテッドExicure, Inc. 予防的または治療的適用のためのリポソーム球状核酸による免疫調節物質の多価送達
CA2968531A1 (en) 2014-11-21 2016-05-26 Northwestern University The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
US10967072B2 (en) 2016-04-27 2021-04-06 Northwestern University Short interfering RNA templated lipoprotein particles (siRNA-TLP)
US11364304B2 (en) 2016-08-25 2022-06-21 Northwestern University Crosslinked micellar spherical nucleic acids
US11696954B2 (en) 2017-04-28 2023-07-11 Exicure Operating Company Synthesis of spherical nucleic acids using lipophilic moieties
AU2018314159A1 (en) 2017-07-13 2020-01-30 Northwestern University General and direct method for preparing oligonucleotide-functionalized metal-organic framework nanoparticles
AU2019274469A1 (en) * 2018-05-21 2020-11-26 The Regents Of The University Of California Single cell mapping and transcriptome analysis
CN112654699A (zh) * 2018-07-06 2021-04-13 加利福尼亚大学董事会 脂质修饰的寡核苷酸及其使用方法
US11504425B2 (en) 2019-02-26 2022-11-22 Wayne State University Amphiphilic oligodeoxynucleotide conjugates as adjuvant enhancers
JP7365022B2 (ja) * 2019-10-28 2023-10-19 日本電信電話株式会社 生体分子の支持体とその製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60132670T2 (de) * 2000-10-12 2009-02-05 The University Of Medicine And Dentistry Of New Jersey Oligonukleotid-unterstützte koaleszenz
WO2002081739A2 (en) 2001-04-09 2002-10-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Non-enzymatic liposome-linked closely spaced array electrodes assay (nel-ela) for detecting and quantifying nucleic acids
WO2002081738A2 (en) 2001-04-09 2002-10-17 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. System and method for detecting and quantifying nucleic acids using covalent binding
WO2005030259A2 (en) * 2003-09-25 2005-04-07 Coley Pharmaceutical Group, Inc. Nucleic acid-lipophilic conjugates
EP1718660B1 (en) * 2004-02-26 2010-12-01 Layerlab Aktiebolag Oligonucleotides related to lipid membrane attachments

Also Published As

Publication number Publication date
CA2558256A1 (en) 2005-09-09
ATE490260T1 (de) 2010-12-15
EP1718660B1 (en) 2010-12-01
US20130252852A1 (en) 2013-09-26
AU2005217347A1 (en) 2005-09-09
JP2013055939A (ja) 2013-03-28
US8901046B2 (en) 2014-12-02
WO2005082922A1 (en) 2005-09-09
EP1718660A1 (en) 2006-11-08
JP2007525500A (ja) 2007-09-06
DE602005025087D1 (de) 2011-01-13
NZ549643A (en) 2009-07-31
US8389707B2 (en) 2013-03-05
CA2558256C (en) 2014-05-13
US20070275047A1 (en) 2007-11-29

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