ATE546526T1 - Hybrid-interferenz-rna - Google Patents

Hybrid-interferenz-rna

Info

Publication number
ATE546526T1
ATE546526T1 AT06743972T AT06743972T ATE546526T1 AT E546526 T1 ATE546526 T1 AT E546526T1 AT 06743972 T AT06743972 T AT 06743972T AT 06743972 T AT06743972 T AT 06743972T AT E546526 T1 ATE546526 T1 AT E546526T1
Authority
AT
Austria
Prior art keywords
interference rna
hybrid interference
hybrid
rna
molecule
Prior art date
Application number
AT06743972T
Other languages
English (en)
Inventor
Josephine Anne Milner
Michael Gait
Ming Jiang
Andrei Arzumanov
Original Assignee
Univ York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0510612A external-priority patent/GB0510612D0/en
Priority claimed from GB0510617A external-priority patent/GB0510617D0/en
Priority claimed from GB0516191A external-priority patent/GB0516191D0/en
Priority claimed from GB0516193A external-priority patent/GB0516193D0/en
Application filed by Univ York filed Critical Univ York
Application granted granted Critical
Publication of ATE546526T1 publication Critical patent/ATE546526T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3519—Fusion with another nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT06743972T 2005-05-25 2006-05-24 Hybrid-interferenz-rna ATE546526T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0510612A GB0510612D0 (en) 2005-05-25 2005-05-25 Polymerase chain reaction
GB0510617A GB0510617D0 (en) 2005-05-25 2005-05-25 Hybrid interfering RNA
GB0516191A GB0516191D0 (en) 2005-08-06 2005-08-06 Polymerase chain reaction
GB0516193A GB0516193D0 (en) 2005-08-06 2005-08-06 Hybrid interfering rna
PCT/GB2006/001895 WO2006125977A2 (en) 2005-05-25 2006-05-24 Hybrid interfering rna

Publications (1)

Publication Number Publication Date
ATE546526T1 true ATE546526T1 (de) 2012-03-15

Family

ID=37420934

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06743972T ATE546526T1 (de) 2005-05-25 2006-05-24 Hybrid-interferenz-rna

Country Status (4)

Country Link
US (2) US8067572B2 (de)
EP (1) EP1891216B1 (de)
AT (1) ATE546526T1 (de)
WO (1) WO2006125977A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1304768B1 (it) * 1998-10-05 2001-03-29 Esaote Spa Lettino porta paziente o simili, e macchina, in particolare macchinaper il rilevamento d'immagini in risonanza magnetica nucleare in
ATE546526T1 (de) * 2005-05-25 2012-03-15 Univ York Hybrid-interferenz-rna
GB0716072D0 (en) * 2007-08-17 2007-09-26 Univ York Therapy
JP5583667B2 (ja) * 2008-08-08 2014-09-03 ジェニスフィア・エルエルシー 長時間作用型ｄｎａデンドリマーおよびその方法
CN102325534B (zh) * 2008-12-18 2016-02-17 戴瑟纳制药公司 延长的dicer酶底物和特异性抑制基因表达的方法
CN102481378A (zh) 2009-04-13 2012-05-30 法国健康和医学研究院 Hpv颗粒及其用途
EP2562257A4 (de) * 2010-04-19 2014-10-01 Riken Verfahren zur stabilisierung funktioneller nukleinsäuren
US20110306653A1 (en) 2010-05-14 2011-12-15 Tagcyx Biotechnologies Stabilization method of functional nucleic acid
WO2012014945A1 (ja) * 2010-07-28 2012-02-02 国立大学法人北海道大学 アジュバント活性を有する新規核酸およびその利用
WO2012016139A2 (en) * 2010-07-29 2012-02-02 Sirnaomics, Inc. Sirna compositions and methods for treatment of hpv and other infections
WO2012053741A2 (ko) 2010-10-22 2012-04-26 성균관대학교산학협력단 Rna 간섭을 유도하는 핵산 분자 및 그 용도
EP2770054A4 (de) * 2011-10-19 2015-09-02 Riken Aktivierung funktioneller nukleinsäuren durch spezifische modifikation
US9700639B2 (en) 2012-02-07 2017-07-11 Aura Biosciences, Inc. Virion-derived nanospheres for selective delivery of therapeutic and diagnostic agents to cancer cells
US10125362B2 (en) 2012-05-22 2018-11-13 Olix Pharmaceuticals, Inc. RNA-interference-inducing nucleic acid molecule able to penetrate into cells, and use therefor
JP6346265B2 (ja) 2013-03-21 2018-06-20 ジェニスフィア・エルエルシー Ｄｎａインターカレーティング剤の細胞送達
JP6444417B2 (ja) 2013-09-18 2018-12-26 オーラ バイオサイエンシーズ， インコーポレイテッド 腫瘍を診断および処置するためのウイルス様粒子結合体
CN108473950A (zh) 2015-10-30 2018-08-31 美国政府卫生与公众服务部 靶向癌症治疗
CN108699556B (zh) 2015-11-16 2023-02-17 奥利克斯医药有限公司 使用靶向myd88或tlr3的rna复合物治疗老年性黄斑变性
CN108779464B (zh) 2016-02-02 2022-05-17 奥利克斯医药有限公司 使用靶向angpt2和pdgfb的rna复合物治疗血管生成相关性疾病
CA3022874A1 (en) 2016-02-02 2017-08-10 Olix Pharmaceuticals, Inc. Treatment of atopic dermatitis and asthma using rna complexes that target il4ra, trpa1, or f2rl1
IL260983B (en) 2016-02-19 2022-07-01 Genisphere Llc Nucleic acid carriers and methods of medical use
CN109072238B (zh) 2016-04-11 2022-05-24 奥利克斯医药有限公司 使用靶向结缔组织生长因子的rna复合物治疗特发性肺纤维化
KR101916652B1 (ko) 2016-06-29 2018-11-08 올릭스 주식회사 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도
WO2018146557A2 (en) 2017-02-10 2018-08-16 Dong Ki Lee Long double-stranded rna for rna interference
CA3122930A1 (en) * 2018-12-12 2020-06-18 Dicerna Pharmaceuticals, Inc. Double-stranded nucleic acid inhibitor molecules containing a triloop
WO2021001646A2 (en) * 2019-07-02 2021-01-07 Argonaute RNA Limited Apolipoprotein b antagonist
CN110269014B (zh) * 2019-07-23 2021-01-12 中国海洋大学 一种单环刺螠幼虫的rna干扰方法
WO2021185765A1 (en) 2020-03-16 2021-09-23 Argonaute RNA Limited Antagonist of pcsk9
GB202020534D0 (en) * 2020-12-23 2021-02-03 Argonaute Rna Ltd Conjugate
EP4237561A1 (de) * 2020-12-23 2023-09-06 Argonaute Rna Limited Behandlung von herz-kreislauf-erkrankungen
EP4288542A4 (de) * 2021-02-08 2025-08-20 Ractigen Therapeutics Multivalentes oligonukleotidmittel und verfahren zur verwendung davon
JP2024531728A (ja) * 2021-09-14 2024-08-29 アルゴノート アールエヌエー リミテッド 心血管疾患の処置
GB2618915B (en) * 2022-05-18 2024-08-14 Argonaute Rna Ltd Treatment of cardiovascular disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030206887A1 (en) * 1992-05-14 2003-11-06 David Morrissey RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA)
CA2452653A1 (en) * 2001-07-17 2003-01-30 Anne Josephine Milner Silencing of gene expression by sirna
US20030194718A1 (en) * 2002-04-15 2003-10-16 Hitachi. Ltd. Probing sequence determination system for DNA arrays
EP1567662B1 (de) * 2002-11-18 2010-03-03 Panomics, Inc. Caged-sensoren, -regulatoren und-verbindungen sowie verwendungen davon
JP2004261002A (ja) * 2003-01-08 2004-09-24 Tsutomu Suzuki ｓｉＲＮＡの製造方法
WO2004065415A2 (en) * 2003-01-20 2004-08-05 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. L-amino acid oxidase with cytotoxic activity from aplysia punctata
EP1844147A2 (de) 2005-01-18 2007-10-17 Sirna Therpeutics, Inc. Durch rna-interferenz vermittelte inhibition von retinoblastina-genexpression unter verwendung von short-interfering-nukleinsäure
ATE546526T1 (de) * 2005-05-25 2012-03-15 Univ York Hybrid-interferenz-rna

Also Published As

Publication number Publication date
US20090012022A1 (en) 2009-01-08
WO2006125977A3 (en) 2007-01-25
EP1891216B1 (de) 2012-02-22
US8067572B2 (en) 2011-11-29
EP1891216A2 (de) 2008-02-27
WO2006125977A2 (en) 2006-11-30
US20120136040A1 (en) 2012-05-31

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