DK1713907T3 - Hybridproteiner af (aktivt site-serin)-ß-lactamase - Google Patents
Hybridproteiner af (aktivt site-serin)-ß-lactamaseInfo
- Publication number
- DK1713907T3 DK1713907T3 DK05726412.9T DK05726412T DK1713907T3 DK 1713907 T3 DK1713907 T3 DK 1713907T3 DK 05726412 T DK05726412 T DK 05726412T DK 1713907 T3 DK1713907 T3 DK 1713907T3
- Authority
- DK
- Denmark
- Prior art keywords
- lactamase
- beta
- active site
- alpha helix
- hybrid proteins
- Prior art date
Links
- 102000006635 beta-lactamase Human genes 0.000 title abstract 5
- 108090000204 Dipeptidase 1 Proteins 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 title 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 title 1
- 108010002833 beta-lactamase TEM-1 Proteins 0.000 abstract 2
- 108020004256 Beta-lactamase Proteins 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04075430A EP1564286A1 (en) | 2004-02-11 | 2004-02-11 | Hybrid proteins of beta-lactamase class A |
| PCT/EP2005/050174 WO2005078075A2 (en) | 2004-02-11 | 2005-01-17 | Hybrid proteins of active-site serine beta-lactamase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1713907T3 true DK1713907T3 (da) | 2012-04-23 |
Family
ID=34684717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05726412.9T DK1713907T3 (da) | 2004-02-11 | 2005-01-17 | Hybridproteiner af (aktivt site-serin)-ß-lactamase |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7745193B2 (da) |
| EP (2) | EP1564286A1 (da) |
| AT (1) | ATE548451T1 (da) |
| CA (1) | CA2555393C (da) |
| DK (1) | DK1713907T3 (da) |
| WO (1) | WO2005078075A2 (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1760092A1 (en) * | 2005-08-26 | 2007-03-07 | Applied Research Systems ARS Holding N.V. | System for screening cells for high expression of a protein of interest |
| FR2890859B1 (fr) | 2005-09-21 | 2012-12-21 | Oreal | Oligonucleotide d'arn double brin inhibant l'expression de la tyrosinase |
| KR100931027B1 (ko) * | 2006-06-27 | 2009-12-10 | 한국생명공학연구원 | Ｎ-말단에 시스테인 태그된 단백질 ｇ 변형체 |
| US8986997B2 (en) | 2007-08-31 | 2015-03-24 | The Regents Of The University Of Michigan | Methods and compositions for increasing biological molecule stability |
| US8592555B2 (en) | 2008-08-11 | 2013-11-26 | Emd Millipore Corporation | Immunoglobulin-binding proteins with improved specificity |
| EP2355846A4 (en) * | 2008-09-03 | 2013-06-19 | Univ Michigan State | THERMOSTABLE ENTEROXIN OF ESCHERICHIA COLI IMMUNOGENE |
| SG162687A1 (en) | 2008-12-24 | 2010-07-29 | Millipore Corp | Caustic stable chromatography ligands |
| AU2014201082B2 (en) * | 2010-05-24 | 2015-04-30 | Synthetic Biologics, Inc. | Modified beta-lactamases and methods and uses related thereto |
| FI20105572A0 (fi) * | 2010-05-24 | 2010-05-24 | Prevab R Lcc | Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt |
| EP2394670A1 (en) | 2010-06-04 | 2011-12-14 | Université de Liège | Chitosan-based biomimetic scaffolds and methods for preparing the same |
| SG10201604559TA (en) * | 2011-06-08 | 2016-07-28 | Emd Millipore Corp | Chromatography matrices including novel staphylococcus aureus protein a based ligands |
| EP2766735B1 (en) * | 2011-10-14 | 2017-02-01 | Université de Liège | Method for measuring beta-lactam antibiotics |
| RU2678124C2 (ru) | 2014-04-17 | 2019-01-23 | Синтесик Байолоджикс, Инк. | Бета-лактамазы с улучшенными свойствами для лечения |
| JP6803328B2 (ja) | 2014-08-28 | 2021-01-06 | シンセティック バイオロジクス，インコーポレイテッド | 大腸菌ベースでのベータラクタマーゼ生産 |
| US20170281737A1 (en) * | 2014-09-30 | 2017-10-05 | The Medical College Of Wisconsin, Inc. | Universal platform for targeting therapies to treat neurological diseases |
| CN107148473B (zh) | 2014-10-08 | 2021-08-06 | 合成生物制品有限公司 | β-内酰胺酶制剂及其用途 |
| US9744221B2 (en) | 2014-12-23 | 2017-08-29 | Synthetic Biologics, Inc. | Method and compositions for inhibiting or preventing adverse effects of oral antibiotics |
| US20160250304A1 (en) | 2015-02-23 | 2016-09-01 | Synthetic Biologics, Inc. | Carbapenemases for use with antibiotics for the protection of the intestinal microbiome |
| US10709773B2 (en) | 2015-03-06 | 2020-07-14 | Synthetic Biologics, Inc. | Safe and effective beta-lactamase dosing for microbiome protection |
| EP3333262A4 (en) * | 2015-08-04 | 2019-04-03 | Kaneka Corporation | IMMUNOGLOBULIN BINDING MODIFIED PROTEINS |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2687410A1 (fr) * | 1992-02-14 | 1993-08-20 | Pasteur Institut | Beta-lactamase recombinante, utilisable en tant que molecule porteuse pour la preparation de compositions immunogenes. |
| CA2397162A1 (en) * | 2000-01-13 | 2001-07-19 | Kalobios, Inc. | Circularly permutated, interaction-activated proteins |
| US20030104591A1 (en) * | 2000-12-14 | 2003-06-05 | Murray Christopher J. | Methods and compositions for grafting functional loops into a protein |
-
2004
- 2004-02-11 EP EP04075430A patent/EP1564286A1/en not_active Withdrawn
-
2005
- 2005-01-17 EP EP05726412A patent/EP1713907B1/en not_active Not-in-force
- 2005-01-17 AT AT05726412T patent/ATE548451T1/de active
- 2005-01-17 DK DK05726412.9T patent/DK1713907T3/da active
- 2005-01-17 CA CA2555393A patent/CA2555393C/en not_active Expired - Fee Related
- 2005-01-17 US US10/589,233 patent/US7745193B2/en not_active Expired - Fee Related
- 2005-01-17 WO PCT/EP2005/050174 patent/WO2005078075A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP1713907A2 (en) | 2006-10-25 |
| CA2555393C (en) | 2013-12-24 |
| US7745193B2 (en) | 2010-06-29 |
| ATE548451T1 (de) | 2012-03-15 |
| CA2555393A1 (en) | 2005-08-25 |
| WO2005078075A3 (en) | 2005-12-08 |
| EP1564286A1 (en) | 2005-08-17 |
| WO2005078075A2 (en) | 2005-08-25 |
| EP1713907B1 (en) | 2012-03-07 |
| US20070161040A1 (en) | 2007-07-12 |
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