DK1701946T3 - 1-piperazin- og 1-homopiperazincarboxylatderivater, deres fremstilling og deres terapeutiske anvendelse som inhibitorer af FAAH-enzymet - Google Patents

1-piperazin- og 1-homopiperazincarboxylatderivater, deres fremstilling og deres terapeutiske anvendelse som inhibitorer af FAAH-enzymet

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Publication number
DK1701946T3
DK1701946T3 DK04816424T DK04816424T DK1701946T3 DK 1701946 T3 DK1701946 T3 DK 1701946T3 DK 04816424 T DK04816424 T DK 04816424T DK 04816424 T DK04816424 T DK 04816424T DK 1701946 T3 DK1701946 T3 DK 1701946T3
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Prior art keywords
piperazine
inhibitors
preparation
therapeutic use
carboxylate derivatives
Prior art date
Application number
DK04816424T
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Danish (da)
English (en)
Inventor
Ahmed Abouabdellah
Garcia Antonio Almario
Christian Hoornaert
Adrien Tak Li
Original Assignee
Sanofi Aventis
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Publication date
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Publication of DK1701946T3 publication Critical patent/DK1701946T3/da

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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  • Organic Chemistry (AREA)
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  • Communicable Diseases (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK04816424T 2003-12-23 2004-12-17 1-piperazin- og 1-homopiperazincarboxylatderivater, deres fremstilling og deres terapeutiske anvendelse som inhibitorer af FAAH-enzymet DK1701946T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0315248A FR2864080B1 (fr) 2003-12-23 2003-12-23 Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique
PCT/FR2004/003289 WO2005070910A2 (fr) 2003-12-23 2004-12-17 Derives de 1 -piperazine- et 1-homopiperazine-carboxylates, leur preparation et leur application en tant qu’ inhibiteurs de l’enzyme faah

Publications (1)

Publication Number Publication Date
DK1701946T3 true DK1701946T3 (da) 2008-04-28

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DK04816424T DK1701946T3 (da) 2003-12-23 2004-12-17 1-piperazin- og 1-homopiperazincarboxylatderivater, deres fremstilling og deres terapeutiske anvendelse som inhibitorer af FAAH-enzymet

Country Status (29)

Country Link
US (2) US7687503B2 (xx)
EP (1) EP1701946B1 (xx)
JP (1) JP4833080B2 (xx)
KR (1) KR101276427B1 (xx)
CN (2) CN101538254B (xx)
AR (1) AR046982A1 (xx)
AT (1) ATE381552T1 (xx)
AU (1) AU2004314287B2 (xx)
BR (1) BRPI0418134A (xx)
CA (1) CA2550598C (xx)
CY (1) CY1107902T1 (xx)
DE (1) DE602004010848T2 (xx)
DK (1) DK1701946T3 (xx)
ES (1) ES2297533T3 (xx)
FR (1) FR2864080B1 (xx)
HK (2) HK1133009A1 (xx)
HR (1) HRP20080078T3 (xx)
IL (1) IL176478A (xx)
MA (1) MA28234A1 (xx)
NO (1) NO20063229L (xx)
NZ (1) NZ548194A (xx)
PL (1) PL1701946T3 (xx)
PT (1) PT1701946E (xx)
RS (1) RS50544B (xx)
RU (1) RU2356890C2 (xx)
SI (1) SI1701946T1 (xx)
TW (1) TWI339121B (xx)
WO (1) WO2005070910A2 (xx)
ZA (2) ZA200505522B (xx)

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FR2866888B1 (fr) * 2004-02-26 2006-05-05 Sanofi Synthelabo Derives de alkylpiperazine- et alkylhomopiperazine- carboxylates, leur preparation et leur application en therapeutique
US7269708B2 (en) * 2004-04-20 2007-09-11 Rambus Inc. Memory controller for non-homogenous memory system
TW200633990A (en) 2004-11-18 2006-10-01 Takeda Pharmaceuticals Co Amide compound
TWI385152B (zh) 2005-02-17 2013-02-11 Astellas Pharma Inc Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivatives (I)
PE20070099A1 (es) 2005-06-30 2007-02-06 Janssen Pharmaceutica Nv N-heteroarilpiperazinil ureas como moduladores de la amida hidrolasa del acido graso
ES2375929T3 (es) 2005-07-04 2012-03-07 High Point Pharmaceuticals, Llc Antagonistas del receptor histamina h3.
WO2007020888A1 (ja) * 2005-08-12 2007-02-22 Takeda Pharmaceutical Company Limited 脳・神経細胞保護剤および睡眠障害治療薬
GB0517184D0 (en) * 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
FR2892646B1 (fr) * 2005-10-28 2008-06-06 Novalyst Discovery Soc Par Act Systeme catalytique heterogene et son utilisation.
SG163547A1 (en) * 2006-05-29 2010-08-30 High Point Pharmaceuticals Llc 3- (1, 3-benz0di0x0l-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist
CA2665804A1 (en) * 2006-08-23 2008-02-28 Astellas Pharma Inc. Urea compound or salt thereof
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