DK1691184T3 - Manifoldanordning - Google Patents

Manifoldanordning Download PDF

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Publication number
DK1691184T3
DK1691184T3 DK06101495.7T DK06101495T DK1691184T3 DK 1691184 T3 DK1691184 T3 DK 1691184T3 DK 06101495 T DK06101495 T DK 06101495T DK 1691184 T3 DK1691184 T3 DK 1691184T3
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Denmark
Prior art keywords
manifold
fluid
supply
tray
bottle
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DK06101495.7T
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English (en)
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Xuan S Bui
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Sakura Finetek Usa Inc
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N35/1097Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31Apparatus therefor
    • G01N1/312Apparatus therefor for samples mounted on planar substrates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/52Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/02Devices for withdrawing samples
    • G01N1/10Devices for withdrawing samples in the liquid or fluent state
    • G01N1/18Devices for withdrawing samples in the liquid or fluent state with provision for splitting samples into portions
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125Digestion or removing interfering materials
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575Volumetric liquid transfer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Claims (24)

1. Manifoldanordning (500) til et automatiseret vævsbehandlingssystem omfattende: en manifold (520) omfattende et mønster af fluidledninger der strækker sig derigennem; og en plade (510) fastgjort til manifolden (520), pladen omfattende en flerhed af prøvemodtagende dele, hvor hver prøvemodtagende del er tilpasset til at modtage en glidetilbageholdelsesbakke (550) og omfatter et indløb (600) og et udløb (610), hvor indløbet (600) og udløbet (610) er dannet gennem separate dele af pladen der definerer den respektive prøvemodtagende del, og indløbet (600) er i fluid kontakt med mindst en fluidledning (730) af manifolden (520) og udløbet (610) er i fluid kontakt med mindst en fluidledning (740) af manifolden (520), maniholdanordningen er kendetegnet ved at manifolden (520) er et plant element konstrueret fra flere pladekomponenter hvor fluidledningerne er ætsede direkte ind i hver manifoldkomponent.
2. Manifolden ifølge krav 1, hvor manifolden er dannet fra to separate stykker materiale.
3. Manifold ifølge krav 2, hvor de to separate stykker materiale er mekanisk ætset for at danne komplementære passager og koblet således at de komplementære passager danner mønstret af fluidledningerne.
4. Manifolden ifølge krav 2, hvor materialet er en polymer.
5. Manifolden ifølge krav 2, hvor de to stykker materiale er mekanisk fastgjort sammen.
6. Manifolden ifølge krav 1, hvor manifolden er i fluid kontakt med mindst en forsyningsflaske (180; 900) og mindst en spildflaske (1000).
7. Manifolden ifølge krav 6, yderligere omfattende en trykpumpe (940) i fluid kontakt med den mindst ene forsyningsflaske (900).
8. Manifolden ifølge krav 6 yderligere omfattende en vakuumpumpe (1040) i fluid kontakt med mindst en spildflaske (1000).
9. Manifolden ifølge krav 1 yderligere omfattende en indløbsport (600) på en proksimal ende af pladen og en tømningsport (610) på en distal ende af pladen.
10. Manifolden ifølge krav 1 yderligere omfattende en flerhed af ventiler (640) konfigureret til at styre fluidstrøm gennem fluidledningerne.
11. Manifolden ifølge krav 10 yderligere omfattende en ventilkontroller (1350) koblet til manifold.
12. Manifolden ifølge krav 11 yderligere omfattende en drypramme (650) koblet til manifolden mellem manifolden og kontrolleren.
13. Manifolden ifølge krav 6 yderligere omfattende en fluidniveausensor (1160) til at overvåge fluidniveauet af den mindst ene forsyningsflaske.
14. Manifolden ifølge krav 13, hvor fluidniveausensoren er en første fluidniveausensor og manifolden et yderligere omfatter en anden fluidniveausensor til at overvåge fluidniveauet af den mindst ene spildflaske.
15. Manifolden ifølge krav 14, hvor fluidniveausensorerne er koblet til en fælles sensorbærer (1170).
16. Manifolden ifølge krav 15, hvor sensorbæreren er konfigureret til forskydning parallelt med en vertikal akse af forsyningsflasken.
17. Manifolden ifølge krav 1 yderligere omfattende mindst en varmeenhed (560) koblet til mindst en af de prøvemodtagende dele.
18. Manifolden ifølge krav 1 yderligere omfattende en flerhed af varmeenheder koblet til pladen hvor hver af flerheden af varmenheder er uafhængigt drevet.
19. Fremgangsmåde til drift af en manifold af en automatiseret vævsprocessor ifølge et hvilket som helst af kravene 1 til 18, hvilken fremgangsmåde omfatter: modtage instruktioner angående et program at udføre; positionere en flerhed af ventiler omfattet i manifolden der støtter en vævsprøve til at danne en fluidbane mellem en forsyningskilde og et indløb afen prøvemodtagelsesbakke, hvor manifolden omfatter en manifold der definerer en flerhed af fluidbaner der strækker sig derigennem; og tilføre et reagens til en vævsprøve gennem fluidbanen og indløbet af den prøvemodtagende bakke.
20. Manifoldsystem til anvendelse i et vævsbehandlingssystem, omfattende: en fordeleranordning/manifold ifølge et hvilket som helst af kravene 1 til 18; en flerhed af stormængde-fluidflasker i fluid kontakt med manifolden; en flerhed af fluidniveausensorer, hver fluidniveausensor er anbragt tilgrænsende til en respektiv stormængde-fluidflaske; en sensorbærer der er konfigureret til at blive forskudt i en retning parallelt med en vertikal akse af forsyningsflasken, hvor flerheden af fluidniveausensorer er koblet til sensorbæreren, og en processor omfattende instruktionslogik til at udføre fremgangsmåden ifølge krav 19.
21. Manifoldsystemet ifølge krav 20 yderligere omfattende en trykpumpe omfattende en tryksat fluidudgang der er fluidt koblet til mindst en stormængde-fluidflaske.
22. Manifoldsystemet ifølge krav 21 yderligere omfattende en vakuumpumpe omfattende et fluidindløb der er fluidt koblet til mindst en stormængde-fluidflaske.
23. Manifoldsystemet ifølge krav 20, hvor manifolden omfatter et manifold omfattende et mønster af fluidledninger der strækker sig derigennem.
24. Manifoldsystemet ifølge krav 23, hvor manifolden er dannet af to separate stykker materiale.
DK06101495.7T 2005-02-11 2006-02-09 Manifoldanordning DK1691184T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65244005P 2005-02-11 2005-02-11
US11/349,325 US7744817B2 (en) 2003-08-11 2006-02-06 Manifold assembly

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DK1691184T3 true DK1691184T3 (da) 2016-10-03

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US (1) US7744817B2 (da)
EP (1) EP1691184B1 (da)
JP (2) JP4493605B2 (da)
AU (2) AU2006200549C1 (da)
BR (1) BRPI0600373B1 (da)
DK (1) DK1691184T3 (da)
ES (1) ES2589782T3 (da)

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EP1691184A3 (en) 2007-01-17
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AU2006200549B8 (en) 2008-07-31
BRPI0600373A (pt) 2006-10-03
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AU2006200549B2 (en) 2008-07-03
ES2589782T3 (es) 2016-11-16
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US20060169719A1 (en) 2006-08-03
AU2006200549C1 (en) 2011-03-31
US7744817B2 (en) 2010-06-29
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EP1691184A2 (en) 2006-08-16
EP1691184B1 (en) 2016-08-03

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