DK1690535T3 - Terapeutisk anvendelse af en nitrogenoxidforløber - Google Patents

Terapeutisk anvendelse af en nitrogenoxidforløber Download PDF

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Publication number
DK1690535T3
DK1690535T3 DK06005642.1T DK06005642T DK1690535T3 DK 1690535 T3 DK1690535 T3 DK 1690535T3 DK 06005642 T DK06005642 T DK 06005642T DK 1690535 T3 DK1690535 T3 DK 1690535T3
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Denmark
Prior art keywords
cpsi
leu
val
ala
gly
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DK06005642.1T
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English (en)
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Marshall L Summar
Brian W Christman
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Univ Vanderbilt
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23259343&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1690535(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
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Publication of DK1690535T3 publication Critical patent/DK1690535T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
    • C12Y603/04016—Carbamoyl-phosphate synthase (ammonia) (6.3.4.16)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/05—Carbon-nitrogen ligases with glutamine as amido-N-donor (6.3.5)
    • C12Y603/05005—Carbamoyl-phosphate synthase (glutamine-hydrolysing) (6.3.5.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Claims (5)

1. Citrullin til anvendelse i en fremgangsmåde til behandling eller forebyggelse af en tilstand eller lidelse i et subjekt, som får foretaget hjerteoperation, der er knyttet til en suboptimal funktion af urinstofcyklus.
2. Citrullin til anvendelse i en fremgangsmåde til behandling eller forebyggelse ifølge krav 1, kendetegnet ved, at citrullinet gives i en dosis, der ligger i området fra ca. 0,01 mg til ca. 1000 mg.
3. Citrullin til anvendelse i en fremgangsmåde til behandling eller forebyggelse ifølge krav 2, kendetegnet ved, at citrullinet gives i et dosisområde fra ca. 0,5 mg til ca. 500 mg.
4. Citrullin til anvendelse i en fremgangsmåde til behandling eller forebyggelse ifølge krav 2, kendetegnet ved, at citrullinet gives i et dosisområde fra ca. 1,0 mg til ca. 250 mg.
5. Citrullin til anvendelse i en fremgangsmåde til behandling eller forebyggelse ifølge ethvert af krav 1 til 4, hvori subjektet er et menneske.
DK06005642.1T 1999-06-01 2000-06-01 Terapeutisk anvendelse af en nitrogenoxidforløber DK1690535T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/323,472 US6346382B1 (en) 1999-06-01 1999-06-01 Human carbamyl phosphate synthetase I polymorphism and diagnostic methods related thereto
EP00939475A EP1187844A4 (en) 1999-06-01 2000-06-01 POLYMORPHISM OF HUMAN CARBAMYLPHOSPHATE SYNTHETASE I AND RELATED DIAGNOSTIC AND THERAPEUTIC METHODS

Publications (1)

Publication Number Publication Date
DK1690535T3 true DK1690535T3 (da) 2015-06-29

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ID=23259343

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06005642.1T DK1690535T3 (da) 1999-06-01 2000-06-01 Terapeutisk anvendelse af en nitrogenoxidforløber

Country Status (8)

Country Link
US (4) US6346382B1 (da)
EP (4) EP2335693A3 (da)
AU (1) AU5455600A (da)
DK (1) DK1690535T3 (da)
ES (1) ES2539272T3 (da)
HK (1) HK1097437A1 (da)
PT (1) PT1690535E (da)
WO (1) WO2000073322A1 (da)

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Also Published As

Publication number Publication date
EP2361621A1 (en) 2011-08-31
AU5455600A (en) 2000-12-18
EP1690535A2 (en) 2006-08-16
EP1690535A3 (en) 2007-07-18
US20080234379A1 (en) 2008-09-25
EP2335693A3 (en) 2011-09-28
US8536225B2 (en) 2013-09-17
US20120252895A1 (en) 2012-10-04
PT1690535E (pt) 2015-07-30
EP1690535B1 (en) 2015-04-29
EP2335693A2 (en) 2011-06-22
ES2539272T3 (es) 2015-06-29
EP1187844A1 (en) 2002-03-20
HK1097437A1 (en) 2007-06-29
US6743823B1 (en) 2004-06-01
US8188147B2 (en) 2012-05-29
EP2361621B1 (en) 2017-08-09
US6346382B1 (en) 2002-02-12
EP1187844A4 (en) 2003-09-03
WO2000073322A1 (en) 2000-12-07

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