EP1187844A4 - Human carbamyl phosphate synthetase i polymorphism and diagnostic and therapeutic methods relating thereto - Google Patents

Human carbamyl phosphate synthetase i polymorphism and diagnostic and therapeutic methods relating thereto

Info

Publication number
EP1187844A4
EP1187844A4 EP00939475A EP00939475A EP1187844A4 EP 1187844 A4 EP1187844 A4 EP 1187844A4 EP 00939475 A EP00939475 A EP 00939475A EP 00939475 A EP00939475 A EP 00939475A EP 1187844 A4 EP1187844 A4 EP 1187844A4
Authority
EP
European Patent Office
Prior art keywords
polymorphism
diagnostic
therapeutic methods
methods relating
phosphate synthetase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00939475A
Other languages
German (de)
French (fr)
Other versions
EP1187844A1 (en
Inventor
Marshall L Summar
Brian W Christman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanderbilt University
Original Assignee
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23259343&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1187844(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vanderbilt University filed Critical Vanderbilt University
Priority to DK06005642.1T priority Critical patent/DK1690535T3/en
Priority to EP10185406.5A priority patent/EP2361621B1/en
Priority to EP10185438A priority patent/EP2335693A3/en
Priority to EP20060005642 priority patent/EP1690535B1/en
Publication of EP1187844A1 publication Critical patent/EP1187844A1/en
Publication of EP1187844A4 publication Critical patent/EP1187844A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
    • C12Y603/04016—Carbamoyl-phosphate synthase (ammonia) (6.3.4.16)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/05—Carbon-nitrogen ligases with glutamine as amido-N-donor (6.3.5)
    • C12Y603/05005—Carbamoyl-phosphate synthase (glutamine-hydrolysing) (6.3.5.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
EP00939475A 1999-06-01 2000-06-01 Human carbamyl phosphate synthetase i polymorphism and diagnostic and therapeutic methods relating thereto Withdrawn EP1187844A4 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DK06005642.1T DK1690535T3 (en) 1999-06-01 2000-06-01 Therapeutic use of a nitric oxide precursor
EP10185406.5A EP2361621B1 (en) 1999-06-01 2000-06-01 Human carbamyl phosphate synthetase I polymorphism and diagnostic and therapeutic methods relating thereto
EP10185438A EP2335693A3 (en) 1999-06-01 2000-06-01 Therapeutic use of nitric oxide precursor
EP20060005642 EP1690535B1 (en) 1999-06-01 2000-06-01 Therapeutic use of nitric oxide precursor

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/323,472 US6346382B1 (en) 1999-06-01 1999-06-01 Human carbamyl phosphate synthetase I polymorphism and diagnostic methods related thereto
US323472 1999-06-01
PCT/US2000/015079 WO2000073322A1 (en) 1999-06-01 2000-06-01 Human carbamyl phosphate synthetase i polymorphism and diagnostic and therapeutic methods relating thereto

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP20060005642 Division EP1690535B1 (en) 1999-06-01 2000-06-01 Therapeutic use of nitric oxide precursor
EP10185406.5A Division EP2361621B1 (en) 1999-06-01 2000-06-01 Human carbamyl phosphate synthetase I polymorphism and diagnostic and therapeutic methods relating thereto

Publications (2)

Publication Number Publication Date
EP1187844A1 EP1187844A1 (en) 2002-03-20
EP1187844A4 true EP1187844A4 (en) 2003-09-03

Family

ID=23259343

Family Applications (4)

Application Number Title Priority Date Filing Date
EP10185438A Ceased EP2335693A3 (en) 1999-06-01 2000-06-01 Therapeutic use of nitric oxide precursor
EP10185406.5A Expired - Lifetime EP2361621B1 (en) 1999-06-01 2000-06-01 Human carbamyl phosphate synthetase I polymorphism and diagnostic and therapeutic methods relating thereto
EP20060005642 Expired - Lifetime EP1690535B1 (en) 1999-06-01 2000-06-01 Therapeutic use of nitric oxide precursor
EP00939475A Withdrawn EP1187844A4 (en) 1999-06-01 2000-06-01 Human carbamyl phosphate synthetase i polymorphism and diagnostic and therapeutic methods relating thereto

Family Applications Before (3)

Application Number Title Priority Date Filing Date
EP10185438A Ceased EP2335693A3 (en) 1999-06-01 2000-06-01 Therapeutic use of nitric oxide precursor
EP10185406.5A Expired - Lifetime EP2361621B1 (en) 1999-06-01 2000-06-01 Human carbamyl phosphate synthetase I polymorphism and diagnostic and therapeutic methods relating thereto
EP20060005642 Expired - Lifetime EP1690535B1 (en) 1999-06-01 2000-06-01 Therapeutic use of nitric oxide precursor

Country Status (8)

Country Link
US (4) US6346382B1 (en)
EP (4) EP2335693A3 (en)
AU (1) AU5455600A (en)
DK (1) DK1690535T3 (en)
ES (1) ES2539272T3 (en)
HK (1) HK1097437A1 (en)
PT (1) PT1690535E (en)
WO (1) WO2000073322A1 (en)

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PT2247297T (en) * 2008-01-31 2019-04-24 Univ Vanderbilt Therapeutic treatment for lung conditions
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See also references of WO0073322A1 *
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Also Published As

Publication number Publication date
US8188147B2 (en) 2012-05-29
ES2539272T3 (en) 2015-06-29
EP1690535A3 (en) 2007-07-18
US6743823B1 (en) 2004-06-01
US6346382B1 (en) 2002-02-12
EP2361621A1 (en) 2011-08-31
US20080234379A1 (en) 2008-09-25
WO2000073322A1 (en) 2000-12-07
US20120252895A1 (en) 2012-10-04
EP1690535A2 (en) 2006-08-16
AU5455600A (en) 2000-12-18
PT1690535E (en) 2015-07-30
EP1690535B1 (en) 2015-04-29
EP2335693A3 (en) 2011-09-28
DK1690535T3 (en) 2015-06-29
US8536225B2 (en) 2013-09-17
EP2335693A2 (en) 2011-06-22
EP2361621B1 (en) 2017-08-09
EP1187844A1 (en) 2002-03-20
HK1097437A1 (en) 2007-06-29

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