DK1673391T3 - Modificeret cDNA til höje ekspressionsniveauer af faktor VIII og dens derivater - Google Patents

Modificeret cDNA til höje ekspressionsniveauer af faktor VIII og dens derivater

Info

Publication number
DK1673391T3
DK1673391T3 DK04790326T DK04790326T DK1673391T3 DK 1673391 T3 DK1673391 T3 DK 1673391T3 DK 04790326 T DK04790326 T DK 04790326T DK 04790326 T DK04790326 T DK 04790326T DK 1673391 T3 DK1673391 T3 DK 1673391T3
Authority
DK
Denmark
Prior art keywords
derivatives
factor viii
dna sequences
expression vectors
expression levels
Prior art date
Application number
DK04790326T
Other languages
English (en)
Inventor
Claude Negrier
Hans-Peter Hauser
Jean-Luc Plantier
Cecille Ducasse
Original Assignee
Claude Negrier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Claude Negrier filed Critical Claude Negrier
Application granted granted Critical
Publication of DK1673391T3 publication Critical patent/DK1673391T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK04790326T 2003-10-16 2004-10-13 Modificeret cDNA til höje ekspressionsniveauer af faktor VIII og dens derivater DK1673391T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03023637 2003-10-16
PCT/EP2004/011445 WO2005040213A1 (en) 2003-10-16 2004-10-13 MODIFIED cDNA FOR HIGH EXPRESSION LEVELS OF FACTOR VIII AND ITS DERIVATIVES

Publications (1)

Publication Number Publication Date
DK1673391T3 true DK1673391T3 (da) 2009-04-06

Family

ID=34486073

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04790326T DK1673391T3 (da) 2003-10-16 2004-10-13 Modificeret cDNA til höje ekspressionsniveauer af faktor VIII og dens derivater

Country Status (15)

Country Link
US (1) US20080312143A1 (da)
EP (1) EP1673391B1 (da)
JP (1) JP4804356B2 (da)
AT (1) ATE417066T1 (da)
AU (1) AU2004283833A1 (da)
BR (1) BRPI0415296A (da)
CA (1) CA2541280A1 (da)
DE (1) DE602004018349D1 (da)
DK (1) DK1673391T3 (da)
ES (1) ES2319198T3 (da)
IL (1) IL174645A0 (da)
PL (1) PL1673391T3 (da)
PT (1) PT1673391E (da)
SI (1) SI1673391T1 (da)
WO (1) WO2005040213A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2651478C (en) * 2006-05-17 2015-02-03 Josef Endl Polypeptide producing cells
FR2913020B1 (fr) 2007-02-23 2012-11-23 Biomethodes Nouveaux facteurs viii pour le traitement des hemophiles de type a
CN109562191A (zh) 2016-04-15 2019-04-02 宾夕法尼亚州大学信托人 用于治疗血友病a的基因疗法
JP6818134B2 (ja) 2016-09-29 2021-01-20 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ポリペプチド産生細胞を選択するための改善された方法
CN109507435A (zh) * 2018-11-23 2019-03-22 重庆医科大学 Grp78蛋白双抗夹心elisa法检测试剂盒及其检测方法
GB202108855D0 (en) * 2021-06-21 2021-08-04 Cambridge Entpr Ltd Methods of eukaryotic gene expression

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK175363B1 (da) * 1986-09-12 2004-09-13 Genentech Inc Fremgangsmåde til kontinuert produktion af et önsket heterologt protein i en eukaryotisk værtcelle, vektor, som tilförer denne evne, og celler transformeret med vektoren
EP0629700A3 (en) * 1993-06-10 1995-02-15 Miles Inc Vector and mammalian cell line having improved productivity.
EP1048726B1 (en) * 1999-04-27 2006-07-26 Négrier, Claude Modified factor VIII cDNA
EP1038959A1 (en) * 1999-03-17 2000-09-27 Aventis Behring Gesellschaft mit beschränkter Haftung Factor VIII without B-domain, comprising one or more insertions of a truncated intron I of factor IX
EP1233064A1 (en) * 2001-02-09 2002-08-21 Aventis Behring Gesellschaft mit beschränkter Haftung Modified factor VIII cDNA and its use for the production of factor VIII
EP1284290A1 (en) * 2001-08-08 2003-02-19 Aventis Behring GmbH Increase of the expression levels of factor VIII by insertion of spliceable nucleotide sequences into factor VIII cDNA
EP1283263A1 (en) * 2001-08-08 2003-02-12 Aventis Behring GmbH Modified cDNA for high expression levels of factor VIII and its derivatives

Also Published As

Publication number Publication date
EP1673391B1 (en) 2008-12-10
ES2319198T3 (es) 2009-05-05
AU2004283833A1 (en) 2005-05-06
ATE417066T1 (de) 2008-12-15
IL174645A0 (en) 2006-08-20
US20080312143A1 (en) 2008-12-18
JP2007537713A (ja) 2007-12-27
CA2541280A1 (en) 2005-05-06
DE602004018349D1 (de) 2009-01-22
WO2005040213A1 (en) 2005-05-06
JP4804356B2 (ja) 2011-11-02
PT1673391E (pt) 2009-03-18
SI1673391T1 (sl) 2009-06-30
EP1673391A1 (en) 2006-06-28
PL1673391T3 (pl) 2009-06-30
BRPI0415296A (pt) 2006-12-26

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