DK165687A - Modificeret fibrinolytisk enzym - Google Patents

Modificeret fibrinolytisk enzym

Info

Publication number
DK165687A
DK165687A DK165687A DK165687A DK165687A DK 165687 A DK165687 A DK 165687A DK 165687 A DK165687 A DK 165687A DK 165687 A DK165687 A DK 165687A DK 165687 A DK165687 A DK 165687A
Authority
DK
Denmark
Prior art keywords
enzym
fibrinolytic
modified
modified fibrinolytic
fibrinolytic enzym
Prior art date
Application number
DK165687A
Other languages
Danish (da)
English (en)
Other versions
DK165687D0 (da
Inventor
Michael Joseph Browne
Jeffery Hugh Robinson
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868608019A external-priority patent/GB8608019D0/en
Priority claimed from GB878704078A external-priority patent/GB8704078D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of DK165687D0 publication Critical patent/DK165687D0/da
Publication of DK165687A publication Critical patent/DK165687A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
DK165687A 1986-04-02 1987-04-01 Modificeret fibrinolytisk enzym DK165687A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868608019A GB8608019D0 (en) 1986-04-02 1986-04-02 Compounds
GB878704078A GB8704078D0 (en) 1987-02-21 1987-02-21 Compounds

Publications (2)

Publication Number Publication Date
DK165687D0 DK165687D0 (da) 1987-04-01
DK165687A true DK165687A (da) 1987-10-03

Family

ID=26290572

Family Applications (1)

Application Number Title Priority Date Filing Date
DK165687A DK165687A (da) 1986-04-02 1987-04-01 Modificeret fibrinolytisk enzym

Country Status (3)

Country Link
EP (1) EP0241209A1 (de)
DK (1) DK165687A (de)
PT (1) PT84589B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756093A (en) * 1985-04-22 1998-05-26 Genentech, Inc. Tissue plasminogen activator variants
US5736134A (en) * 1985-04-22 1998-04-07 Genentech, In.C Tissue plasminogen activator variants
US5714372A (en) * 1985-04-22 1998-02-03 Genentech, Inc. Tissue plasminogen activator variants
WO1993012225A1 (en) * 1991-12-16 1993-06-24 Genentech, Inc. Novel tissue plasminogen activator variants
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
GB8701811D0 (en) * 1987-01-28 1987-03-04 Beecham Group Plc Compounds
US5376547A (en) * 1987-01-30 1994-12-27 American Home Products Corporation Des-epidermal growth factor plasminogen activators
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
GB8815135D0 (en) * 1988-06-24 1988-08-03 British Bio Technology Proteins & nucleic acids
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5258180A (en) * 1988-09-02 1993-11-02 Genetech, Inc. Tissue plasminogen activator having fibrin specific properties and deletion of amino acids 466-970, compositions and methods of treatment
SE462829B (sv) * 1989-01-10 1990-09-10 Kabigen Ab Trombolytiskt aktiva kompositioner innehaallande en modifierad plasminogenaktivator av vaevnadstyp samt en normal human t-pa, streptokinas eller humant urokinas
US5190756A (en) * 1989-12-01 1993-03-02 Genentech, Inc. Methods and materials for expression of human plasminogen variant
US5087572A (en) * 1989-12-01 1992-02-11 Genentech, Inc. Dna encoding human plasminogen modified at the cleavage site
DE69333127T2 (de) * 1992-06-03 2004-05-06 Genentech, Inc., South San Francisco Varianten des Gewebeplasminogenaktivators mit verbesserter therapeutischer Wirkung
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79202B (de) * 1982-05-05 1984-10-22 Genentech Inc
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
EP0201153A3 (de) * 1985-02-09 1987-10-07 Beecham Group Plc Modifiziertes Enzym und Verfahren zu dessen Herstellung
EP0207589A1 (de) * 1985-04-03 1987-01-07 Beecham Group Plc Modifiziertes fibrinolytisches Enzym
IL78571A (en) * 1985-04-22 1991-06-30 Genentech Inc Human tissue plasminogen activator mutants resistant to enzymatic cleavage resulting in two-chain form

Also Published As

Publication number Publication date
PT84589A (en) 1987-04-01
PT84589B (en) 1989-05-09
EP0241209A1 (de) 1987-10-14
DK165687D0 (da) 1987-04-01

Similar Documents

Publication Publication Date Title
DK62586A (da) Fibrinolytisk enzym
NO176920C (no) Enzymelektrode
DK43387A (da) Fibrinolytisk enzym
IT1205010B (it) Tetraidronaftalin-derivati e indan-derivati
DK149786A (da) Proteolytisk enzym
KR890700227A (ko) 효소 센서
DE3662057D1 (de) Enzyme immobilisation
DK165687A (da) Modificeret fibrinolytisk enzym
DK165787A (da) Modificeret fibrinolytisk enzym
DK85987A (da) Klaebemiddel
DK275788A (da) Fibrinolytiske proteiner
DK324387A (da) Aza-bicycliske forbindelser
ES2014442B3 (es) Rodamiento
DK165987A (da) Modificeret fibrinolytisk enzym
FI88825C (fi) Aktivt pansar
KR890003510U (ko) 축받이 장치
DK359888A (da) Fibrinolytisk enzym
DK165887A (da) Modificeret fibrinolytisk enzym
BR8706134A (pt) Mancal
DK708988A (da) Enzym
IT8620081A1 (it) Cianoacetoammido-derivati ad azione antifungina
DK328089D0 (da) Enzym
DK656087D0 (da) Enzym
DK476088D0 (da) Enzym
DK205488D0 (da) Enzym

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment
PUP Patent expired