DK160996C - Analogifremgangsmaade til fremstilling af et derivat af et in-vivo-fibrinolytisk enzym - Google Patents

Analogifremgangsmaade til fremstilling af et derivat af et in-vivo-fibrinolytisk enzym

Info

Publication number
DK160996C
DK160996C DK373479A DK373479A DK160996C DK 160996 C DK160996 C DK 160996C DK 373479 A DK373479 A DK 373479A DK 373479 A DK373479 A DK 373479A DK 160996 C DK160996 C DK 160996C
Authority
DK
Denmark
Prior art keywords
enzym
fibrinolytic
derivate
vivo
preparing
Prior art date
Application number
DK373479A
Other languages
Danish (da)
English (en)
Other versions
DK373479A (da
DK160996B (da
Inventor
Richard Anthony Godwin Smith
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of DK373479A publication Critical patent/DK373479A/da
Publication of DK160996B publication Critical patent/DK160996B/da
Application granted granted Critical
Publication of DK160996C publication Critical patent/DK160996C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK373479A 1978-09-07 1979-09-06 Analogifremgangsmaade til fremstilling af et derivat af et in-vivo-fibrinolytisk enzym DK160996C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7835960 1978-09-07
GB7835960 1978-09-07

Publications (3)

Publication Number Publication Date
DK373479A DK373479A (da) 1980-04-11
DK160996B DK160996B (da) 1991-05-13
DK160996C true DK160996C (da) 1991-10-28

Family

ID=10499512

Family Applications (1)

Application Number Title Priority Date Filing Date
DK373479A DK160996C (da) 1978-09-07 1979-09-06 Analogifremgangsmaade til fremstilling af et derivat af et in-vivo-fibrinolytisk enzym

Country Status (17)

Country Link
US (2) US4285932A (de)
EP (1) EP0009879B1 (de)
JP (3) JPS5537198A (de)
AR (1) AR220575A1 (de)
AU (1) AU524295B2 (de)
CA (1) CA1134295A (de)
DE (1) DE2966301D1 (de)
DK (1) DK160996C (de)
ES (1) ES483888A0 (de)
HK (1) HK65986A (de)
HU (1) HU182458B (de)
IE (1) IE48478B1 (de)
IL (1) IL58079A0 (de)
LU (1) LU88326I2 (de)
MY (1) MY8500995A (de)
NZ (1) NZ191320A (de)
ZA (1) ZA794294B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ191320A (en) * 1978-09-07 1982-09-14 Beecham Group Ltd In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions
JPS55167275A (en) * 1979-06-15 1980-12-26 Kowa Co Preparation of amidinophenyl ester derivative
DE3065190D1 (en) * 1979-11-05 1983-11-10 Beecham Group Plc Enzyme derivatives, and their preparation
GB2095239B (en) * 1981-02-27 1985-03-06 Torii & Co Ltd Novel amidine compounds
IT1170913B (it) * 1981-04-23 1987-06-03 Manetti & Roberts Italo Brit Procedimento per la produzione di un principio attivo fibrinolitico vasale prodotto enzimatico specifico angiochinasi cosi' ottenuto e sue applicazioni farmaceutiche
EP0091240B1 (de) * 1982-04-07 1985-12-27 Beecham Group Plc Enzymderivate, Verfahren zu ihrer Herstellung und dieselben enthaltende pharmazeutische Zusammensetzungen
WO1984001960A1 (en) * 1982-11-11 1984-05-24 Beecham Group Plc Pharmaceutically active compounds
EP0109653A3 (de) * 1982-11-17 1986-01-29 Otsuka Pharmaceutical Co., Ltd. Verfahren zur Herstellung eines Urokinasekomplexes
GB8319538D0 (en) * 1983-07-20 1983-08-24 Beecham Group Plc Compounds
JPS60136520A (ja) * 1983-12-23 1985-07-20 Otsuka Pharmaceut Co Ltd フイブリン吸着性ウロキナ−ゼ複合体
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives
US4880776A (en) * 1983-12-24 1989-11-14 Beecham Group P.L.C. Plasmin A-chain urokinase B-chain hybrid protein
GB8609948D0 (en) * 1986-04-23 1986-05-29 Beecham Group Plc Compounds
GB8400653D0 (en) * 1984-01-11 1984-02-15 Beecham Group Plc Conjugates
US5174994A (en) * 1985-11-11 1992-12-29 Leuven Research & Development Vzw Pharmaceutical composition having thrombolytic activity
EP0266032A1 (de) * 1986-08-29 1988-05-04 Beecham Group Plc Modifiziertes fibrinolytisches Enzym
GB8707369D0 (en) * 1987-03-27 1987-04-29 Beecham Group Plc Enzyme derivatives
US5009888A (en) * 1987-04-13 1991-04-23 Genzyme Corporation Therapeutic enzyme-antibody complexes
GB8715302D0 (en) * 1987-06-30 1987-08-05 Ordidge R J Nmr spectroscopy
US5302390A (en) * 1987-07-01 1994-04-12 Beecham Group Plc Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
NO882886L (no) * 1987-07-01 1989-01-02 Beecham Group Plc Nye forbindelser.
US5256642A (en) * 1988-04-01 1993-10-26 The Johns Hopkins University Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof
US6458360B1 (en) 1990-04-25 2002-10-01 The Johns Hopkins University Soluble complement regulatory molecules
GB9011861D0 (en) * 1990-05-26 1990-07-18 Beecham Group Plc Novel compounds
GB9013345D0 (en) * 1990-06-14 1990-08-08 Beecham Group Plc Novel compounds
US5597799A (en) * 1990-09-04 1997-01-28 Cor Therapeutics, Inc. Recombinant agents affecting thrombosis
US5583107A (en) * 1990-09-04 1996-12-10 Cor Therapeutics, Inc. Agents affecting thrombosis and hemostasis
US20040072757A1 (en) * 1990-09-04 2004-04-15 Cor Therapeutics, Inc. Agents affecting thrombosis and hemostasis
AU1873092A (en) * 1991-04-09 1992-11-17 Brigham And Women's Hospital Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques
GB9301289D0 (en) * 1993-01-22 1993-03-17 Smithkline Beecham Plc Novel composition
US5589571A (en) * 1994-10-28 1996-12-31 Cor Therapeutics, Inc. Process for production of inhibited forms of activated blood factors
US7544500B2 (en) 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
KR20110017903A (ko) 2008-06-04 2011-02-22 테일크리스 바이오쎄러퓨틱스 아이엔씨. 플라스민의 제조를 위한 조성물, 방법 및 키트
PL2403865T3 (pl) 2009-03-03 2016-01-29 Grifols Therapeutics Inc Sposoby wytwarzania plazminogenu
WO2011004011A1 (en) 2009-07-10 2011-01-13 Thrombogenics Nv Variants of plasminogen and plasmin
WO2011023805A1 (en) 2009-08-28 2011-03-03 Thrombogenics N.V. Use of plasmin for the treatment of filtration failure after trabeculectomy
KR20140015289A (ko) 2011-01-05 2014-02-06 쓰롬보제닉스 엔.브이. 플라스미노겐 및 플라스민 변이체
RU2604810C2 (ru) 2011-08-12 2016-12-10 Тромбодженикс Н.В. Варианты плазминогена и плазмина

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ191320A (en) * 1978-09-07 1982-09-14 Beecham Group Ltd In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions

Also Published As

Publication number Publication date
DE2966301D1 (en) 1983-11-17
ES8101385A1 (es) 1980-12-16
MY8500995A (en) 1985-12-31
EP0009879A1 (de) 1980-04-16
AU5004679A (en) 1980-03-13
DK373479A (da) 1980-04-11
US4285932A (en) 1981-08-25
ZA794294B (en) 1980-08-27
JPS5537198A (en) 1980-03-15
IL58079A0 (en) 1979-12-30
DK160996B (da) 1991-05-13
JPH02154687A (ja) 1990-06-14
JPH05304957A (ja) 1993-11-19
NZ191320A (en) 1982-09-14
HU182458B (en) 1984-01-30
CA1134295A (en) 1982-10-26
IE48478B1 (en) 1985-02-06
EP0009879B1 (de) 1983-10-12
AU524295B2 (en) 1982-09-09
AR220575A1 (es) 1980-11-14
ES483888A0 (es) 1980-12-16
LU88326I2 (fr) 1994-05-04
HK65986A (en) 1986-09-12
JPH0231952B2 (de) 1990-07-17
IE791696L (en) 1980-03-07
US4337244A (en) 1982-06-29

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PUP Patent expired