DK160287B - LIQUID DEODORANT - Google Patents

Description

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DK 160287 B

The present invention relates to liquid deodorant agents comprising a mixture of water and propylene glycol as the only active deodorant principle. More particularly, the invention relates to liquid deodorant agents containing a mixture of propylene = glycol and water in a non-aqueous solvent, preferably comprising ethanol or isopropanol suitable for delivery in the form of an aerosol spray liquid, a pump spray liquid or a roll-on liquid. liquid.

In general, liquid deodorant agents comprise an active deodorant principle, a moisture-binding agent such as propylene glycol or glycerine, and a carrier liquid such as water, ethanol, etc. These agents generally fall into one of three types or classes based on the active agent. deodorant principle. X the first class are the popular antiperspirant agents containing astringent, inorganic salts of aluminum, zinc and zirconium as the active antiperspirant deodorant principle. The second class of deodorant agents contain germicides or antibacterial agents such as cetyl = trimethylammonium bromide, trichlorosalicylanilide, hexachlorophen, chlorhexidine, trichlorohydroxydiphenyl ether and the like. This class of deodorants works by inhibiting the growth of bacteria and other microorganisms, which appear to give rise to body odor in decomposing skin debris and into the transpiration itself. The third class of deodorant agents are based on various other non-astringent compounds, such as sodium bicarbonate, zinc castinoleate, etc., as active deodorant principle.

One of the major shortcomings of using antiperspirants based on astringent metal salts is that discoloration and rotting can occur on the clothing in contact with the surface to which the agent is used. Eg. For example, these salts can sometimes cause a white or colored deposit on clothing, which deposit is not removed when the laundry is washed in the normal manner. Furthermore, these deposits on the clothing have led to decay

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the clothes themselves. Other disadvantages of using astringent salts are that they can cause an unpleasant stinging sensation in some users and chemically interfere with the natural sweat-producing body process for regulating body temperature. Deodorants based on germicides also tend to discolor clothing, thereby exhibiting one of the same disadvantages as deodorants based on astringent salts. Finally, deodorants based on sodium bicarbonate or zincricin oleate tend to exhibit stability problems.

10 In light of the foregoing, research continues in the hope of finding an active deodorant principle, which is an effective deodorant, does not discolour, is compatible with other components common in deodorant agents, and can be combined to form products which are stable, i.e. not 15 undergoes separation or precipitation. This research has led to the discovery that mixtures of water and propylene glycol in certain proportions are effective deodorants.

This finding is surprising in view of the fact that propylene = glycol is commonly used in antiperspirants 20 and deodorant agents. Eg. For example, 3% to 10% by weight of propylene glycol has been used as a moisture-binding agent in antiperspirant and / or deodorant sticks, liquids and creams. U.S. Patents Nos. 2,890,087, 3,943,242, and 4,137,306 also disclose anti-perspiration or deodorant pins containing 35-85% by weight of aqueous propylene glycol. Finally, Russian Patent No. 507,323 describes a mixture of a greater amount of propylene = glycol with smaller amounts (1-2%) of urotropin and polyvinylpyrrolidone as an active anti-perspiration or deodorant principle. However, to date, the prior art has not recognized that aqueous propylene glycol alone is an effective deodorant.

It has now been found that it is possible to regulate body odor with a liquid deodorant for topical application to the skin, which is characterized in that the only active deodorant principle is an effective amount of a mixture of 47% 3.

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to 87% by weight propylene glycol and water. The optimum deodorant efficiency is noted when an aqueous mixture containing 64% to 82% by weight of propylene glycol is used as the only active deodorant principle.

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The liquid deodorant of the invention comprises, in a preferred embodiment, 10 to 100 parts by weight of an aqueous propylene glycol containing 47% to 87% by weight of propylene glycol and 0 to 90 parts by weight of a compatible non-aqueous, non-toxic, volatile, 2Q organic liquid carrier, preferably comprising an alcohol which is ethanol or isopropanol. These agents are generally single phase liquids which are stable and safe to use.

Preferred agents are liquids suitable for use in the form of a pressurized spray liquid, a pump spray liquid or a roll-on consisting essentially of 47 to 87% aqueous propylene glycol as the only active deodorant principle and either ethanol or isopropanol, the weight ratio of the alcohol to aqueous propylene glycol is from 1: 3 to 3: 1. More particularly, the active principle will represent 30-75 parts by weight of a pump spray liquid, 23-75 parts by weight of the roll-on liquid and 11-44 parts by weight of a pressurized spray liquid. The pressurized spray liquid will also contain a liquid, normally gaseous propellant.

In the most preferred agents, the active deodorant principle will be a 64% to 82% aqueous propylene glycol.

As mentioned above, the invention is based on the finding that aqueous mixtures of propylene glycol in the range of 47% to 88% by weight of propylene glycol are effective in preventing human sweat odor when used as the sole active deodorant principle. Optimal deodorant action is achieved with aqueous propylene glycol having a concentration of 64% to 82% by weight of propylene glycol.

Propylene glycol (1,2-propanediol) has the formula CH 2 CH (OH) CE 2 OH

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and is commonly used to scan a moisture-binding agent or solvent in cosmetics. It is a colorless, odorless liquid that has a slightly sweet taste and is completely miscible with water and most organic solvents.

Propylene glycol is industrially prepared by the hydration of propylene oxide obtained through the intermediate propylene chloride = hydrine.

The internal propylene glycol mixtures are readily obtained by mixing the required amounts of water and propylene glycol. These solutions 10 can be prepared at room temperature either by adding propylene glycol to water or by adding water to propylene glycol.

Generally, the liquid deodorant will comprise from 10 to 100 parts by weight of the mixture of propylene glycol and water containing 47% to 87% by weight of propylene glycol as the only active deodorant principle. In the most preferred agents, the mixture of propylene glycol and water will contain 64% to 82% by weight of propylene glycol.

The second high component of the deodorant is a volatile organic liquid carrier in which the mixture of water and propylene glycol is either soluble or insoluble, with the soluble 2Q equal carriers being preferred. This organic liquid carrier must also be both chemically unreasonable with the aqueous propylene glycol and non-toxic to humans.

Examples of volatile compounds which may act as carriers include both polar and nonpolar compounds. Suitable polar compounds are ethanol, n-propanol, isopropanol and tertiary butanol, with ethanol and isopropanol being preferred. Satisfactory non-polar compounds include C5-C10 paraffinic hydrocarbons having a boiling point in the range of 35-175 ° C, cyclic dimethylsiloxanes of formula 30 [(CH2) 2SiO] χ / where x is a number from 3-6, low molecular weight poly = dimethylsiloxanes of the formula (CH2) ^ SiQ (CH3) 2Si °) ySi (CH2) 3I1

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where y is a number from 0 to 4, and liquid, usually gaseous, hydrocarbon propellants and halohydrocarbon propellants. Examples of suitable hydrocarbons are n-hexane, heptane, octane and mixtures thereof. Examples of droplet, normally gaseous propellants are dimethyl ether, C 1 -C 4 hydrocarbons, e.g. propane, n-butane and isobutane and mixtures thereof, and halohydrocarbons, e.g. dichlorodifluoromethane; monochlor = difluoromethane; Dimethyl ether is a preferred propellant in pressurized sprayers because it forms single-phase liquids in the presence of water. On the other hand, hydrocarbon propellants and halohydrocarbon propellants can be used where the pressurized agent is in the form of a water-in-oil emulsion.

Generally, the amount of the liquid organic volatile carrier is in the range of 0 to 90 parts by weight of the deodorant, wherein aqueous propylene glycol is the only active deodorant principle. However, the preferred amount of volatile carrier varies with the shape of the final product as described below, and the form of the final product may be a pressurized spray liquid, a pump spray liquid or a roll-on liquid.

Irrespective of the form of the final liquid product, the carrier in the preferred agents comprises either ethanol or isopropanol in a weight amount relative to the aqueous propylene glycol mixture in the range of about 10%. 1: 3 to 3: 1.

In the liquid roll-on agent, the amount of the mixture 30 of water and propylene glycol is usually from 23-75 parts by weight and preferably from 50-65 parts by weight, provided that the amount of water in the agent does not exceed a maximum of approx. 40 parts by weight of the final product. The remainder of the agent will be the volatile carrier comprising ca. 25-77 parts by weight, preferably 3G-45 parts by weight

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6 ethanol and / or isopropanol in a weight ratio of ethanol or isopropanol to aqueous propylene glycol in the range of 1: 3 to 3: 1.

In the liquid pump sprayers, the mixture of water 5 and propylene glycol usually ranges from approx. 30-75 parts by weight, preferably from 30-60 parts by weight, provided again that the amount of water does not exceed approx. 40% by weight of the final product. The remainder of the agent is again the volatile carrier comprising preferably 25-65 parts by weight of ethanol and / or isopropanol in an amount by weight of the mixture of water and propylene glycol in the range of 1: 3 to 1.7: 1.

The pump sprayers and liquid roll-on agents can be prepared in the form of clear or opaque liquids, but the clear liquids are preferred because stability problems are reduced. Furthermore, small amounts of known thickening agents can be added to increase the viscosity of the liquids. Eg. For example, thickening can be achieved by adding from 0.5 to 5% by weight of a carboxyvinyl polymer, e.g. Carbopol 934 and 941, hydroxypro = pylcellulose, methylcellulose, carboxymethylcellulose, etc.

In pressurized spray liquids, the amount of the mixture of yand and propylene glycol is usually from 12 to 43 parts, preferably 20 to 30 parts by weight, provided that the amount of water does not exceed a maximum of approx. 20 parts by weight. The remainder of the agent will be the volatile carrier which comprises 8-43 parts by weight of ethanol or 25 isopropanol and 45-80 parts by weight of a droplet, usually airy, propellant. Again, the weight ratio of ethanol or isopropanol to the mixture of water and propylene glycol will be from 1: 3 to 3: 1. Further, when the propellant is other than dimethyl ether, the pressurized liquid will generally be in the form of a yand-in-oil emulsion which requires the presence of 0.5-5.0%, preferably 0.75 to 4% by weight of the a water-in-oil emulsifier such as propylene glycol stearate, glyceryl monostearate, sorbitam pyrolaurate, sorbitan monooleate, poly

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7 glycerin oleate, sorbitan sesquioleate and mixtures thereof, of which sorbitan sesquioleate is preferred.

In addition to the foregoing essential components of the present agent, from 0.1 to 2% by weight of components such as perfumes, dyes and the like may be added to improve the aesthetic value and consumer acceptance thereof.

Means according to the invention are used in the usual way using containers of normal construction which dispense the usual amounts of product.

Where the product which is a pressurized spray liquid is in the form of a water-in-oil emulsion, the water-in-oil emulsifier will generally be dissolved in the constituents comprising the liquid oil phase with the exception of the propellant, and the mixture of water and propylene glycol will being slowly added thereto with stirring to form a water-in-oil emulsion which is then mixed with the propellant in known manner.

The liquid agents of the invention cause less discoloration of substances in contact therewith compared to deodorant agents containing low concentrations of either a 2Q astringent salt such as aluminum chloride hydroxide or an antibacterial compound containing a quaternary ammonium group in the molecular structure such as chlorhexidine and cetylpyridium chloride. Also, less substance degradation or substance degradation is observed when the agents of the invention are used in comparison with some known compositions. Furthermore, the compositions of the invention containing ethanol or isopropanol form a film on the skin which is not annoyingly wet despite the presence of water and which provides a desirable cooling effect at the first contact due to the balanced amounts of water and monovalent alcohol. . Furthermore, the agents of the invention are mild to the skin due to the absence of the irritating astringent salts and antibacterial agents.

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The following examples serve to illustrate the invention.

In the examples and in the description, all parts and percentages are by weight.

EXAMPLE 1 The bacteriostatic effect of various concentrations of propylene glycol on the skin was determined using the in vivo skin occlusion test of Harpies and Kligman, described in TGA Cosmetics Journal, 26, 1969. Eleven products were used in the sample as described below, dsv.

10 ten concentrations of aqueous propylene glycol (PG1 and pure water.

1. yand 2. 10% propylene glycol 3. 20% propylene glycol 4.30% propylene glycol 5. 40% propylene glycol 6. 50% propylene glycol 7. 60% propylene glycol 8. 7Q% propylene glycol · 20 9. 80S propylene glycol 1Q. 90% propylene glycol 11. 1QQ% propylene glycol

In this test, 39 people in a panel were divided into three groups of 13 and the trial funds were randomly assigned. Every 25 people in the panel had the test product applied in four places on the left and right forearms. Each test product was thus tested in 13 different locations.

The program followed by the skin occlusion test was as follows: 30 1. The corners in four 5 cm squares were marked on sub 9

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the arms of each of the 13 people.

2. Three of the sites were then given products, while the fourth remained an untreated control site.

3. After 0.1 ml of the test product was spread over each 5 cm square with a pipette and allowed to dry, all four sites were sealed with 5 cm square polyethylene foils.

4. The polyethylene films were removed after 48 hours and samples were taken of the sites on Letheen agar plates.

5, The plates were then incubated aerobically for 24 hours at 37 ° C before being assessed for bacterial growth on the following scale: 0 = less than 30 colonies 1 = 3Q-30Q colonies 2 = more than 300 colonies where the colonies were clearly 15 separated 3 = some but not all colonies merged 4 = growth not completely confluent 5 = confluent growth.

The test results are given in Table 1 below.

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T a b e 1 I

Bacterial rating for each product site

Yand Propylene Glyco1 (1 Water) 10% 20% 30% '4Ό% 5O%' £ 0% 7Ό% 80% 9O% ^ 100¾ 5 4 5430000050 5 1 1 4 3 0 3 3 20 3 3 5234100005 5 2 3 4 1 0 0 2 2 4 2 4 5304241021 10 2 512544300 0 5 3 4 Q 0 Q 0 2 0 0 4 3 40350Q1040 4 345 0 340251 5 1550 0 4140 4 15 5 404530014 0 5 50Q0110002 5 3 3 0 0 2 0 0 0 0 0

Total rating: 55 46 30 · 33 27 16 20 13 11 24 22 20 Average rating: 4.2 3.5 2.3 2.5 2.1 1.2 1.5 1.0 0.8 1.8 1 , 7

From Table I, it will be seen that inside concentrations of propylene glycol in the range of 50-80% exhibit considerable bacteriostatic effect, with the maximum activity being in the range of 70-80% propylene glycol.

Example 2

The skin occlusion test according to Marples and Kligman, described in Example 1) was repeated using 13 panelists to compare the following test products: 11

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(A) water, (B) 60% propylene glycol aqueous solution and (C) an antiseptic aqueous alcoholic agent containing 0.15 wt% cetyltrimethylammonium bromide and 0.25 wt% 1,6-di-p-chloro = phenylbiguanidohexane (chlorhexidine). The results are shown in Table II below.

Table II Propylene Glycol

Water (60%) _ Antiseptic 5 13 10 5 2 2 4 0 0 5 4 2 5 11 4 11 15 4 1 0 5 2 0 4 Q 0 5 0 4 110 20 3 Q 0 5 5 1

Total rating: 55 18 14

Average rating: 25 4.2 1.4 1/1

Example 3

The deodorant efficacy of the following agents was evaluated clinically by panelists under actual conditions of use: A. water 3Q B. 60% propylene glycol and 40% water (60% PG) 12

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C - 30% propylene glycol, 20% water and 50% ethanol (30% PG / 50% E) D. 50% aluminum chlorine hydroxide and 50% water (50% ACH).

In this test for deodorant efficiency, a panel of 5 56 people was divided into four groups. In the first week, the panel participants were given a placebo soap and allowed to wash under their arms as often as they wished, but no antiperspirant or deodorant product was used. Starting with the second week, each panelist visited the assessment site in the morning, with the odor of each of the left and right armpits self-rated using an odor rating scale from 1 (very weak) to 9 (very strong).

After the odor assessment, the panelist applied four metered cans of the test product, nozzle. 0.6 ml of product on each arm-15 hollow. The panelists returned 5 hours later to assess the odor level. This routine was continued for the next two weeks.

The mean ratings were determined for each product based on 15 days of use and are shown in Table XXI.

Table III

Yand · 60% P.G. 30% P.G./5Q%'-E 50% „ACH

5 hours 4.55 3.25 3.49 3.16 24 hours 3.47 2.85 3.45 3.16

Combined (5 + 24 25 hour rating 4.01 3, Q5 3.45 3.16

The foregoing results show that a pump spray deodorant containing 60% propylene glycol solution gives the same deodorant efficiency as a pump spray containing 50% aluminum chloride hydroxide, for example, the most common active component of antiperspirants, and- 13

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saw an effective deodorant, but its effectiveness was not as great as the other pump spray liquids, presumably because the use concentration of the active principle, ie. 60% propylene = glycol, in fact only half of the concentration was 5 of the 60% PG product. Undoubtedly, equivalent efficiencies for the 30% PG / 50% E product could be obtained by applying 1.2 ml of the product to each armpit, such that the concentration of endogenous propylene glycol would be the same for the 60% PG product.

As indicated, the compositions of the invention may be in the form of liquids with a propellant for delivery from an aerosol container or as propellant-free liquids or emulsions or lotions or gels either for spraying by a finger operated pump or for dispensing from a roller ball in a roll-on body directly on the skin.

The following means serve to illustrate the various product forms of the invention. These examples are given by way of illustration and do not limit the invention.

Example 4 A satisfactory aerosol spray product of the following composition is prepared and packaged in a pressurized aerosol container: Weight%

Propylene Glycol 10 25 Deionized Water 10

Ethanol 10

Perfume 1

Dimethyl ether. 69 100

This agent is prepared by mixing the propylene glycol, water, ethanol and perfume to form a single phase c 14

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liquid. This liquid is transferred to a container closed with a valve designed to dispense approx. 0.6 ml per and the dimethyl ether is added through the valve and the associated dip tube to form a homogeneous liquid after shaking.

When the amounts of propylene glycol, water, ethanol and dimethyl ether are changed to 20%, 5%, 12.5% and 61.5% respectively in the agent of Example 4, an aerosol spray product having optimum deodorant effect is obtained. Due to the improved efficiency 10, a valve designed to deliver 0.45 ml per liter can be used. SEC.

Example 5

A satisfactory product for dispensing from a finger operated pump spray container had the following composition: 15% by weight

Propylene Glycol 29.3

Deionized water 20.0

Ethanol 50.0

Hydrogenated ethoxylated castor oil 0.2

Color solution (1% FD&C Yellow No. 5) 0.3

Perfume. . . .0., 2 100.0

It is packed in a container equipped with a finger operated pump · 25 · 25 which provides approx. 1 ml / sec.

Example 6

A satisfactory liquid product suitable for dispensing from a container equipped with a rolling ball is prepared 15

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having the following composition: Weight%

Propylene Glycol 36

Deionized water 22.9 5 Ethanol 40

Carbopol 941 * 0.3

Triethanolamine 0.3

Color solution (1% FD&C Yellow No. 5) 0.3 10 Perfume 0.2 100.0 I *

A polymer of a monomeric mixture of acrylic acid, allylsucrose and acrylamide.

This product is prepared by dispersing Carbopol 941 in 15 water followed by the addition of ethanol and propylene glycol. Then the triethanolamine is added with stirring followed by the color solution and perfume. The resulting product is a homogeneous yellow liquid with a viscosity of approx. 600 cps. measured with a Brookfield RVT viscometer with a No. 3 spindle, 20 rotating at 30 rpm. This liquid is packaged in a glass container with a closure of a rolling ball arranged to deliver an appropriate amount per armpit when used in the normal way.

Example 7 A satisfactory mother-of-pearl liquid product suitable for roll-on is obtained from the following composition:

Claims (8)

Liquid deodorant for topical application to the skin, 15 containing propylene glycol and water, characterized in that the only active deodorant principle is an effective amount of a mixture of 47-87 weight propylene glycol and water. Liquid deodorant according to claim 1, known g. 20 nets comprising 10-100 parts by weight of the propylene glycol-water mixture and 0-90 parts by weight of a compatible non-aqueous non-toxic, volatile organic liquid carrier. Liquid deodorant agent according to claim 2, characterized in that the carrier comprises an alcohol which is ethanol or isopropanol, and the weight ratio of ethanol or isopropanol to the mixture is in the range of approx. 1: 3 to approx. 3: 1. Liquid deodorant according to claim 2, characterized in that the mixture of propylene glycol and water contains 64-82 weight propylene glycol. DK 160287 B 17 Liquid deodorant according to claim 3, characterized in that it is suitable for delivery in the form of a pump spray tea liquid and consists essentially of 30-75 parts by weight of the mixture of propylene glycol and water and 2 to 5 parts by weight of the alcohol, the weight ratio of the alcohol to the mixture being from 1: 3 to 3: 1. Liquid deodorant according to claim 3, keno + eq "net in that it is suitable for desiccation in the form of -n 10" on and consists essentially of 23-75 parts by weight of the mixture of propylene glycol and water and 25- 7 "by weight of the alcohol, the weight ratio of the alcohol to the mixture being from about 1: 3 to 3: 1. Liquid deodorant according to claim 3, characterized in that it is suitable for delivery in the form of is. brittle liquid under pressure and consisting essentially of 11 to 44 parts by weight of the propylene glycol and water mixture, 9-43 parts by weight of the alcohol, the weight ratio of the alcohol to the mixture being from about 1: 3 to 3: 1, and 45-80 parts by weight of dimethyl ether, which is a single phase liquid. Liquid deodorant according to claim 2, characterized in that it is suitable for dispensing in the form of a pressurized liquid liquid and consists essentially of 11 to 14 W parts of the mixture of propylene glycol and water. 5-5 wt.% of a water-in-oil emulsifier and 51-88.5 parts by weight ac of the non-aqueous carrier, which is driven by a dry droplet, usually gaseous hydrocarbon or halohydrocarbon as the propellant. , which form a stable oil-in-water emulsion of the aqueous propylene glycol in the islet non-aqueous solvent. 35