DK159397C - Fremgangsmaade til fremstilling af cholesterolsyntese-inhiberende derivater af forbindelserne ml-236b lacton og ml-236b carboxylsyre - Google Patents

Fremgangsmaade til fremstilling af cholesterolsyntese-inhiberende derivater af forbindelserne ml-236b lacton og ml-236b carboxylsyre

Info

Publication number
DK159397C
DK159397C DK325782A DK325782A DK159397C DK 159397 C DK159397 C DK 159397C DK 325782 A DK325782 A DK 325782A DK 325782 A DK325782 A DK 325782A DK 159397 C DK159397 C DK 159397C
Authority
DK
Denmark
Prior art keywords
carboxylic acid
compounds
lacton
inhibitive
derivatives
Prior art date
Application number
DK325782A
Other languages
Danish (da)
English (en)
Other versions
DK159397B (da
DK325782A (da
Inventor
Akira Terahara
Minoru Tanaka
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of DK325782A publication Critical patent/DK325782A/da
Publication of DK159397B publication Critical patent/DK159397B/da
Application granted granted Critical
Publication of DK159397C publication Critical patent/DK159397C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transplanting Machines (AREA)
  • Steering-Linkage Mechanisms And Four-Wheel Steering (AREA)
  • Switches With Compound Operations (AREA)
DK325782A 1981-07-21 1982-07-20 Fremgangsmaade til fremstilling af cholesterolsyntese-inhiberende derivater af forbindelserne ml-236b lacton og ml-236b carboxylsyre DK159397C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11403881 1981-07-21
JP56114038A JPS5815968A (ja) 1981-07-21 1981-07-21 Ｍｌ−２３６ｂ誘導体およびその製法

Publications (3)

Publication Number Publication Date
DK325782A DK325782A (da) 1983-01-22
DK159397B DK159397B (da) 1990-10-08
DK159397C true DK159397C (da) 1991-03-25

Family

ID=14627469

Family Applications (1)

Application Number Title Priority Date Filing Date
DK325782A DK159397C (da) 1981-07-21 1982-07-20 Fremgangsmaade til fremstilling af cholesterolsyntese-inhiberende derivater af forbindelserne ml-236b lacton og ml-236b carboxylsyre

Country Status (12)

Country Link
US (1) US4447626A (ja)
EP (1) EP0070649B1 (ja)
JP (1) JPS5815968A (ja)
KR (1) KR880001354B1 (ja)
AT (1) ATE39487T1 (ja)
AU (1) AU547968B2 (ja)
CA (1) CA1185199A (ja)
DE (1) DE3279304D1 (ja)
DK (1) DK159397C (ja)
ES (1) ES514185A0 (ja)
FI (1) FI75186C (ja)
IE (1) IE54747B1 (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE33033E (en) * 1985-07-05 1989-08-22 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors intermediates
US4611081A (en) * 1985-07-05 1986-09-09 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors intermediates
US4841074A (en) * 1987-12-11 1989-06-20 Merck & Co., Inc. Intermediates and processes for 6-carboxy HMG-CoA reductase inhibitors
JP2792600B2 (ja) * 1989-04-14 1998-09-03 旭電化工業株式会社 メバロン酸生産菌
EP0409399B1 (en) * 1989-06-09 1996-03-13 Merck & Co. Inc. 3-keto HMG-COA reductase inhibitors
KR100186758B1 (ko) 1996-08-09 1999-04-01 영진약품공업 주식회사 프라바스타틴(pravastatin)전구체의제조방법
IN191580B (ja) * 1999-12-17 2003-12-06 Ranbaxy Lab Ltd

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (ja) * 1974-06-07 1981-03-18
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre

Also Published As

Publication number Publication date
IE821738L (en) 1983-01-21
JPS5815968A (ja) 1983-01-29
FI822567L (fi) 1983-01-22
ATE39487T1 (de) 1989-01-15
KR840000519A (ko) 1984-02-25
DK159397B (da) 1990-10-08
EP0070649A2 (en) 1983-01-26
EP0070649B1 (en) 1988-12-28
DK325782A (da) 1983-01-22
FI822567A0 (fi) 1982-07-20
IE54747B1 (en) 1990-01-31
US4447626A (en) 1984-05-08
ES8308358A1 (es) 1983-08-16
AU8592682A (en) 1983-01-27
EP0070649A3 (en) 1984-04-04
FI75186C (fi) 1988-05-09
DE3279304D1 (en) 1989-02-02
FI75186B (fi) 1988-01-29
CA1185199A (en) 1985-04-09
JPS6355502B2 (ja) 1988-11-02
KR880001354B1 (ko) 1988-07-28
AU547968B2 (en) 1985-11-14
ES514185A0 (es) 1983-08-16

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PUP Patent expired