DK159397C - Fremgangsmaade til fremstilling af cholesterolsyntese-inhiberende derivater af forbindelserne ml-236b lacton og ml-236b carboxylsyre - Google Patents
Fremgangsmaade til fremstilling af cholesterolsyntese-inhiberende derivater af forbindelserne ml-236b lacton og ml-236b carboxylsyreInfo
- Publication number
- DK159397C DK159397C DK325782A DK325782A DK159397C DK 159397 C DK159397 C DK 159397C DK 325782 A DK325782 A DK 325782A DK 325782 A DK325782 A DK 325782A DK 159397 C DK159397 C DK 159397C
- Authority
- DK
- Denmark
- Prior art keywords
- carboxylic acid
- compounds
- lacton
- inhibitive
- derivatives
- Prior art date
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 235000012000 cholesterol Nutrition 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- -1 ML-236B CARBOXYLIC ACID Chemical class 0.000 title 1
- AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 2
- 150000002596 lactones Chemical class 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 241000235389 Absidia Species 0.000 abstract 1
- 241000293029 Absidia caerulea Species 0.000 abstract 1
- 241000235555 Cunninghamella Species 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 241000736854 Syncephalastrum Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000012059 conventional drug carrier Substances 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Seasonings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steering-Linkage Mechanisms And Four-Wheel Steering (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11403881 | 1981-07-21 | ||
| JP56114038A JPS5815968A (ja) | 1981-07-21 | 1981-07-21 | Ｍｌ−２３６ｂ誘導体およびその製法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK325782A DK325782A (da) | 1983-01-22 |
| DK159397B DK159397B (da) | 1990-10-08 |
| DK159397C true DK159397C (da) | 1991-03-25 |
Family
ID=14627469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK325782A DK159397C (da) | 1981-07-21 | 1982-07-20 | Fremgangsmaade til fremstilling af cholesterolsyntese-inhiberende derivater af forbindelserne ml-236b lacton og ml-236b carboxylsyre |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4447626A (cs) |
| EP (1) | EP0070649B1 (cs) |
| JP (1) | JPS5815968A (cs) |
| KR (1) | KR880001354B1 (cs) |
| AT (1) | ATE39487T1 (cs) |
| AU (1) | AU547968B2 (cs) |
| CA (1) | CA1185199A (cs) |
| DE (1) | DE3279304D1 (cs) |
| DK (1) | DK159397C (cs) |
| ES (1) | ES514185A0 (cs) |
| FI (1) | FI75186C (cs) |
| IE (1) | IE54747B1 (cs) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE33033E (en) * | 1985-07-05 | 1989-08-22 | Merck & Co., Inc. | Process for the preparation of HMG-CoA reductase inhibitors intermediates |
| US4611081A (en) * | 1985-07-05 | 1986-09-09 | Merck & Co., Inc. | Process for the preparation of HMG-CoA reductase inhibitors intermediates |
| US4841074A (en) * | 1987-12-11 | 1989-06-20 | Merck & Co., Inc. | Intermediates and processes for 6-carboxy HMG-CoA reductase inhibitors |
| JP2792600B2 (ja) * | 1989-04-14 | 1998-09-03 | 旭電化工業株式会社 | メバロン酸生産菌 |
| EP0409399B1 (en) * | 1989-06-09 | 1996-03-13 | Merck & Co. Inc. | 3-keto HMG-COA reductase inhibitors |
| KR100186758B1 (ko) | 1996-08-09 | 1999-04-01 | 영진약품공업 주식회사 | 프라바스타틴(pravastatin)전구체의제조방법 |
| IN191580B (cs) | 1999-12-17 | 2003-12-06 | Ranbaxy Lab Ltd |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612114B2 (cs) * | 1974-06-07 | 1981-03-18 | ||
| MX7065E (es) * | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
-
1981
- 1981-07-21 JP JP56114038A patent/JPS5815968A/ja active Granted
-
1982
- 1982-07-07 US US06/395,968 patent/US4447626A/en not_active Expired - Lifetime
- 1982-07-08 AT AT82303576T patent/ATE39487T1/de not_active IP Right Cessation
- 1982-07-08 DE DE8282303576T patent/DE3279304D1/de not_active Expired
- 1982-07-08 EP EP82303576A patent/EP0070649B1/en not_active Expired
- 1982-07-09 CA CA000406984A patent/CA1185199A/en not_active Expired
- 1982-07-12 AU AU85926/82A patent/AU547968B2/en not_active Expired
- 1982-07-20 DK DK325782A patent/DK159397C/da not_active IP Right Cessation
- 1982-07-20 FI FI822567A patent/FI75186C/fi not_active IP Right Cessation
- 1982-07-20 IE IE1738/82A patent/IE54747B1/en not_active IP Right Cessation
- 1982-07-20 ES ES514185A patent/ES514185A0/es active Granted
- 1982-07-21 KR KR8203252A patent/KR880001354B1/ko not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5815968A (ja) | 1983-01-29 |
| EP0070649A2 (en) | 1983-01-26 |
| FI75186C (fi) | 1988-05-09 |
| KR840000519A (ko) | 1984-02-25 |
| FI75186B (fi) | 1988-01-29 |
| IE821738L (en) | 1983-01-21 |
| FI822567A0 (fi) | 1982-07-20 |
| KR880001354B1 (ko) | 1988-07-28 |
| DK325782A (da) | 1983-01-22 |
| US4447626A (en) | 1984-05-08 |
| DK159397B (da) | 1990-10-08 |
| CA1185199A (en) | 1985-04-09 |
| EP0070649A3 (en) | 1984-04-04 |
| AU547968B2 (en) | 1985-11-14 |
| ES8308358A1 (es) | 1983-08-16 |
| IE54747B1 (en) | 1990-01-31 |
| AU8592682A (en) | 1983-01-27 |
| ES514185A0 (es) | 1983-08-16 |
| JPS6355502B2 (cs) | 1988-11-02 |
| DE3279304D1 (en) | 1989-02-02 |
| EP0070649B1 (en) | 1988-12-28 |
| FI822567L (fi) | 1983-01-22 |
| ATE39487T1 (de) | 1989-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |