DK159311C - Analogifremgangsmaade til fremstilling af 5,6-dialkoxy-4-alkyl-2(1h)quinazolinoner - Google Patents
Analogifremgangsmaade til fremstilling af 5,6-dialkoxy-4-alkyl-2(1h)quinazolinonerInfo
- Publication number
- DK159311C DK159311C DK449183A DK449183A DK159311C DK 159311 C DK159311 C DK 159311C DK 449183 A DK449183 A DK 449183A DK 449183 A DK449183 A DK 449183A DK 159311 C DK159311 C DK 159311C
- Authority
- DK
- Denmark
- Prior art keywords
- dialcoxy
- quinazolinones
- alkyl
- preparation
- analogy procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C265/00—Derivatives of isocyanic acid
- C07C265/12—Derivatives of isocyanic acid having isocyanate groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43055282 | 1982-09-30 | ||
| US06/430,552 US4490374A (en) | 1982-09-30 | 1982-09-30 | 5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use |
| JP59058527A JPS60204770A (ja) | 1982-09-30 | 1984-03-28 | ジヒドロキシ−２（１ｈ）キナゾリノン−１−アルカン酸類 |
| JP5852784 | 1984-03-28 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK449183D0 DK449183D0 (da) | 1983-09-29 |
| DK449183A DK449183A (da) | 1984-03-31 |
| DK159311B DK159311B (da) | 1990-10-01 |
| DK159311C true DK159311C (da) | 1991-03-11 |
Family
ID=26399581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK449183A DK159311C (da) | 1982-09-30 | 1983-09-29 | Analogifremgangsmaade til fremstilling af 5,6-dialkoxy-4-alkyl-2(1h)quinazolinoner |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4490374A (da) |
| EP (2) | EP0107398B1 (da) |
| JP (2) | JPS5982374A (da) |
| AU (1) | AU563958B2 (da) |
| CA (1) | CA1215712A (da) |
| DK (1) | DK159311C (da) |
| FI (1) | FI833523A (da) |
| GB (2) | GB2127823B (da) |
| GR (1) | GR79366B (da) |
| HK (2) | HK98787A (da) |
| IE (1) | IE56413B1 (da) |
| PT (1) | PT77422B (da) |
| SU (2) | SU1407398A3 (da) |
| ZA (1) | ZA837302B (da) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4656267A (en) * | 1983-09-29 | 1987-04-07 | Ortho Pharmaceutical Corporation | Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters |
| US4556739A (en) * | 1983-09-29 | 1985-12-03 | Ortho Pharmaceutical Corporation | 3,4-Dialkoxy-2-alkylcarbonyl analino compounds |
| US4617392A (en) * | 1983-09-29 | 1986-10-14 | Ortho Pharmaceutical Corporation | 4-alkyl-5,6-methylenedioxy-2-1[H]-quinazolinones useful as cardiotonic agents |
| US4731480A (en) | 1985-07-29 | 1988-03-15 | Ortho Pharmaceutical Corporation | Process for preparing 2-acyl-3,4-dialkoxyanilines |
| KR900003529B1 (ko) | 1985-07-29 | 1990-05-21 | 오르토 파마슈티컬 코포레이션 | 2-아실-3,4-디알콕시아닐린의 제조방법 |
| GB8524663D0 (en) * | 1985-10-07 | 1985-11-13 | Fujisawa Pharmaceutical Co | Quinazoline derivatives |
| US4975428A (en) * | 1988-05-31 | 1990-12-04 | Iolab Corporation | Treatment of glaucoma using phosphodiesterase inhibitors |
| IL102764A0 (en) * | 1991-08-16 | 1993-01-31 | Merck & Co Inc | Quinazoline derivatives,and pharmaceutical compositions containing them |
| WO1993004047A1 (en) * | 1991-08-16 | 1993-03-04 | Merck & Co., Inc. | Quinazoline derivatives as inhibitors of hiv reverse transcriptase |
| US7780628B1 (en) | 1999-01-11 | 2010-08-24 | Angiodynamics, Inc. | Apparatus and methods for treating congestive heart disease |
| US7329236B2 (en) | 1999-01-11 | 2008-02-12 | Flowmedica, Inc. | Intra-aortic renal drug delivery catheter |
| US7122019B1 (en) | 2000-11-28 | 2006-10-17 | Flowmedica Inc. | Intra-aortic renal drug delivery catheter |
| US7481803B2 (en) | 2000-11-28 | 2009-01-27 | Flowmedica, Inc. | Intra-aortic renal drug delivery catheter |
| US6749598B1 (en) | 1999-01-11 | 2004-06-15 | Flowmedica, Inc. | Apparatus and methods for treating congestive heart disease |
| US6982260B1 (en) | 1999-11-22 | 2006-01-03 | Warner-Lambert Company | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes |
| MXPA02003140A (es) * | 1999-11-22 | 2002-09-30 | Warner Lambert Co | Quinazolinas y su uso para la inhibicion de las enzimas cinasa dependientes del ciclin. |
| AU2003276903A1 (en) | 2002-09-20 | 2004-05-04 | Flowmedica, Inc. | Method and apparatus for selective material delivery via an intra-renal catheter |
| US20050197624A1 (en) | 2004-03-04 | 2005-09-08 | Flowmedica, Inc. | Sheath for use in peripheral interventions |
| EP1624909A2 (en) | 2002-09-20 | 2006-02-15 | FlowMedica, Inc. | Appartus and method for inserting an intra-aorta catheter trough a delivery sheath |
| US7063679B2 (en) | 2002-09-20 | 2006-06-20 | Flowmedica, Inc. | Intra-aortic renal delivery catheter |
| US7993325B2 (en) | 2002-09-20 | 2011-08-09 | Angio Dynamics, Inc. | Renal infusion systems and methods |
| EP1585572A4 (en) | 2002-09-20 | 2010-02-24 | Flowmedica Inc | METHOD AND APPARATUS FOR ADMINISTERING INTRA-AORTIC SUBSTANCE TO A BRANCHED VESSEL |
| JP2006526464A (ja) | 2003-06-05 | 2006-11-24 | フローメディカ，インコーポレイテッド | 分枝した身体管腔において両側介入または診断を行うためのシステムおよび方法 |
| JP2007537298A (ja) | 2004-05-14 | 2007-12-20 | フロウメディカ， インコーポレイテッド | うっ血性心不全の処置およびｂｎｐ療法のための両側性局所腎臓送達 |
| US7771401B2 (en) | 2006-06-08 | 2010-08-10 | Angiodynamics, Inc. | Selective renal cannulation and infusion systems and methods |
| KR101691954B1 (ko) | 2016-04-26 | 2017-01-02 | 고려대학교 산학협력단 | 신규 n-아실유레아 유도체 및 이를 함유하는 심혈관질환의 예방 또는 치료용 조성물 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1280551A (en) * | 1968-07-01 | 1972-07-05 | Sandoz Ltd | Quinazoline derivatives |
| DE2118315C3 (de) * | 1970-04-20 | 1975-04-03 | Sumitomo Chemical Co., Ltd., Osaka (Japan) | 2-(1H)-Chinazolinonderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US3950526A (en) * | 1970-04-20 | 1976-04-13 | Sumitomo Chemical Company, Limited | Quinazoline derivatives in pharmaceutical compositions for treating pain and inflammation |
| US3859237A (en) * | 1970-04-20 | 1975-01-07 | Sumitomo Chemical Co | Quinazoline derivatives |
| SE392616B (sv) * | 1971-06-29 | 1977-04-04 | Sumitomo Chemical Co | Forfarande for framstellning av kinazolinonforeningar |
| JPS4887012A (da) * | 1972-02-21 | 1973-11-16 | ||
| JPS5013271B2 (da) * | 1971-10-04 | 1975-05-19 | ||
| JPS4948957B2 (da) * | 1971-10-26 | 1974-12-24 | ||
| JPS555506B2 (da) * | 1972-09-07 | 1980-02-07 | ||
| JPS5217842A (en) * | 1975-07-31 | 1977-02-10 | Canon Inc | Device for fabricating sound hologram |
| ZA796623B (en) * | 1978-12-07 | 1981-07-29 | Ortho Pharma Corp | Substituted pyrrolo (1,2-c) quinazolines |
| AU533427B2 (en) * | 1978-12-07 | 1983-11-24 | Ortho Pharmaceutical Corporation | Substituted 2(1h) quinazolinones |
| GB2039895B (en) * | 1978-12-07 | 1983-03-02 | Ortho Pharma Corp | 4-substituted-2(1h)quinazolinones |
-
1982
- 1982-09-30 US US06/430,552 patent/US4490374A/en not_active Expired - Lifetime
-
1983
- 1983-09-29 FI FI833523A patent/FI833523A/fi not_active Application Discontinuation
- 1983-09-29 PT PT77422A patent/PT77422B/pt unknown
- 1983-09-29 EP EP83305895A patent/EP0107398B1/en not_active Expired
- 1983-09-29 SU SU833649765A patent/SU1407398A3/ru active
- 1983-09-29 GB GB08326030A patent/GB2127823B/en not_active Expired
- 1983-09-29 CA CA000437876A patent/CA1215712A/en not_active Expired
- 1983-09-29 DK DK449183A patent/DK159311C/da not_active IP Right Cessation
- 1983-09-29 IE IE2307/83A patent/IE56413B1/xx unknown
- 1983-09-29 EP EP86201912A patent/EP0220786B1/en not_active Expired - Lifetime
- 1983-09-29 ZA ZA837302A patent/ZA837302B/xx unknown
- 1983-09-30 AU AU19794/83A patent/AU563958B2/en not_active Ceased
- 1983-09-30 JP JP58180951A patent/JPS5982374A/ja active Pending
- 1983-09-30 GR GR72592A patent/GR79366B/el unknown
-
1984
- 1984-03-28 JP JP59058527A patent/JPS60204770A/ja active Pending
-
1985
- 1985-02-15 SU SU853856863A patent/SU1344246A3/ru active
- 1985-07-31 GB GB08519309A patent/GB2163426B/en not_active Expired
-
1987
- 1987-12-24 HK HK987/87A patent/HK98787A/xx unknown
- 1987-12-24 HK HK988/87A patent/HK98887A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR79366B (da) | 1984-10-22 |
| AU563958B2 (en) | 1987-07-30 |
| EP0220786A2 (en) | 1987-05-06 |
| HK98787A (en) | 1987-12-31 |
| JPS60204770A (ja) | 1985-10-16 |
| GB2163426B (en) | 1987-01-07 |
| EP0107398A1 (en) | 1984-05-02 |
| PT77422B (en) | 1986-09-10 |
| EP0107398B1 (en) | 1988-06-08 |
| SU1407398A3 (ru) | 1988-06-30 |
| HK98887A (en) | 1987-12-31 |
| IE56413B1 (en) | 1991-07-31 |
| CA1215712A (en) | 1986-12-23 |
| GB2127823A (en) | 1984-04-18 |
| GB2163426A (en) | 1986-02-26 |
| GB8326030D0 (en) | 1983-11-02 |
| DK449183D0 (da) | 1983-09-29 |
| GB2127823B (en) | 1987-01-07 |
| ZA837302B (en) | 1985-05-29 |
| GB8519309D0 (en) | 1985-09-04 |
| DK449183A (da) | 1984-03-31 |
| DK159311B (da) | 1990-10-01 |
| US4490374A (en) | 1984-12-25 |
| FI833523A (fi) | 1984-03-31 |
| SU1344246A3 (ru) | 1987-10-07 |
| AU1979483A (en) | 1984-04-05 |
| EP0220786B1 (en) | 1990-11-22 |
| IE832307L (en) | 1984-03-30 |
| FI833523A0 (fi) | 1983-09-29 |
| PT77422A (en) | 1983-10-01 |
| JPS5982374A (ja) | 1984-05-12 |
| EP0220786A3 (en) | 1988-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |