DK1588707T3 - Stabilt fast medicinsk præparat til oral administration af ramosetron - Google Patents
Stabilt fast medicinsk præparat til oral administration af ramosetronInfo
- Publication number
- DK1588707T3 DK1588707T3 DK04706797T DK04706797T DK1588707T3 DK 1588707 T3 DK1588707 T3 DK 1588707T3 DK 04706797 T DK04706797 T DK 04706797T DK 04706797 T DK04706797 T DK 04706797T DK 1588707 T3 DK1588707 T3 DK 1588707T3
- Authority
- DK
- Denmark
- Prior art keywords
- ramosetron
- ester
- pharmaceutically acceptable
- solid drug
- acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003023500 | 2003-01-31 | ||
| PCT/JP2004/000896 WO2004066998A1 (ja) | 2003-01-31 | 2004-01-30 | 安定な経口用固形医薬組成物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1588707T3 true DK1588707T3 (da) | 2009-03-09 |
Family
ID=32820728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04706797T DK1588707T3 (da) | 2003-01-31 | 2004-01-30 | Stabilt fast medicinsk præparat til oral administration af ramosetron |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7794748B2 (ko) |
| EP (1) | EP1588707B1 (ko) |
| JP (1) | JP3689104B2 (ko) |
| KR (1) | KR100633836B1 (ko) |
| CN (1) | CN100379416C (ko) |
| AT (1) | ATE420638T1 (ko) |
| AU (1) | AU2004208617B2 (ko) |
| BR (1) | BRPI0405221A (ko) |
| CA (1) | CA2488422C (ko) |
| DE (1) | DE602004019049D1 (ko) |
| DK (1) | DK1588707T3 (ko) |
| ES (1) | ES2319292T3 (ko) |
| HK (1) | HK1084582A1 (ko) |
| IL (1) | IL165371A (ko) |
| MX (1) | MXPA04012462A (ko) |
| NO (1) | NO20045153L (ko) |
| NZ (1) | NZ537448A (ko) |
| PL (1) | PL375181A1 (ko) |
| PT (1) | PT1588707E (ko) |
| RU (1) | RU2284819C2 (ko) |
| WO (1) | WO2004066998A1 (ko) |
| ZA (2) | ZA200409537B (ko) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200409537B (en) | 2003-01-31 | 2006-10-25 | Yamanouchi Pharma Co Ltd | Stable solid medicinal composition for oral administration |
| US7358270B2 (en) * | 2004-01-30 | 2008-04-15 | Astellas Pharma Inc. | Treating agent for irritable bowel syndrome |
| GEP20125420B (en) * | 2006-08-10 | 2012-03-26 | Takeda Pharmaceutical | Solid pharmaceutical composition comprising benzimidazole compound |
| CA2662938A1 (en) | 2006-09-15 | 2008-03-20 | Astellas Pharma Inc. | Light-stable solid pharmaceutical composition of ramosetron |
| US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP3239170B1 (en) | 2008-06-04 | 2019-03-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| CN102811770B (zh) * | 2010-04-09 | 2014-07-09 | 荷兰联合利华有限公司 | 口腔护理组合物 |
| MX337364B (es) | 2010-12-16 | 2016-02-29 | Borje S Andersson | Formulaciones farmaceuticas de azol para la administracion parenteral y metodos para preparar y usar las mismas como tratamiento de las enfermedades sensibles a los compuestos de azol. |
| PL3238709T3 (pl) | 2011-04-28 | 2021-02-08 | Platform Brightworks Two, Ltd. | Ulepszone preparaty pozajelitowe lipofilowych środków farmaceutycznych oraz sposoby ich wytwarzania i stosowania |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| JP6630343B2 (ja) | 2015-03-19 | 2020-01-15 | 第一三共株式会社 | 抗酸化剤を含有する固形製剤 |
| WO2016148264A1 (ja) * | 2015-03-19 | 2016-09-22 | 第一三共株式会社 | 着色剤を含有する固形製剤 |
| CN106937946B (zh) * | 2016-01-05 | 2020-05-12 | 山东诚创医药技术开发有限公司 | 盐酸雷莫司琼泡腾片及其制备方法 |
| CN107224430A (zh) * | 2016-03-25 | 2017-10-03 | 江苏奥赛康药业股份有限公司 | 一种含盐酸雷莫司琼的药物组合物 |
| KR102349971B1 (ko) * | 2016-04-27 | 2022-01-12 | 주식회사 엘지생활건강 | 폴리다틴 또는 이의 약학적으로 허용 가능한 염의 광 안정화용 조성물 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB759081A (en) * | 1954-04-15 | 1956-10-10 | John Holroyd And Company Ltd | Improvements relating to machines for the production of coated tablets and the like |
| US4067974A (en) * | 1976-01-21 | 1978-01-10 | The Purdue Frederick Company | Stabilized solid form choline salicylate compositions |
| GB8629567D0 (en) | 1986-12-10 | 1987-01-21 | Boots Co Plc | Therapeutic agents |
| US5223508A (en) | 1988-12-27 | 1993-06-29 | Kirin Beer Kabushiki Kaisha | Pyridyl carboximidamide compounds useful in treating blood pressure |
| US5344927A (en) | 1989-02-02 | 1994-09-06 | Yamanouchi Pharmaceutical Co., Ltd. | Tetrahydrobenzimidazole derivatives and pharmaceutical compositions containing same |
| US5107887A (en) | 1990-12-03 | 1992-04-28 | The Aro Corporation | High pressure fluid regulator |
| JPH0565226A (ja) * | 1991-09-10 | 1993-03-19 | Taisho Pharmaceut Co Ltd | アミノアルキルピリジルオキシ誘導体の安定化組成物 |
| US6372755B2 (en) | 1997-07-11 | 2002-04-16 | Toray Industries, Inc. | Stable medicinal compositions containing 4,5-epoxymorphinan derivatives |
| GB9721139D0 (en) | 1997-10-07 | 1997-12-03 | Glaxo Group Ltd | Medicaments |
| KR100571613B1 (ko) | 1997-10-20 | 2006-04-17 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 안정화 의약 조성물 |
| JP3462490B2 (ja) * | 1999-08-04 | 2003-11-05 | 山之内製薬株式会社 | 安定な経口用医薬組成物 |
| EP1206266A2 (en) | 1999-08-09 | 2002-05-22 | Pharmacia Italia S.p.A. | Formulations for parenteral use of estramustine phosphate and albumin |
| DE19941997A1 (de) * | 1999-09-02 | 2001-03-08 | Gunther Meinhardt Voss | Verfahren und Vorrichtung zur Herstellung einer Tablette o. dgl. |
| AU7105501A (en) * | 2000-07-17 | 2002-01-30 | Yamanouchi Pharma Co Ltd | Pharmaceutical composition improved in peroral absorbability |
| US6566369B2 (en) | 2000-07-26 | 2003-05-20 | Solvay Pharmaceuticals Gmbh | Medicament containing cilansetron for the treatment of non-obstipative male irritable bowel syndrome patients |
| EP1413294B1 (en) * | 2001-07-27 | 2010-09-29 | Astellas Pharma Inc. | Composition comprising sustained-release fine particles for quick-disintegrating tablets in the buccal cavity |
| GB0119012D0 (en) * | 2001-08-03 | 2001-09-26 | Strakan Group Plc | Transdermal delivery of drugs |
| US20030143548A1 (en) | 2002-01-28 | 2003-07-31 | Camilleri Michael L. | Predicting patient responsiveness to serotonergic therapy |
| ZA200409537B (en) | 2003-01-31 | 2006-10-25 | Yamanouchi Pharma Co Ltd | Stable solid medicinal composition for oral administration |
| US7358270B2 (en) | 2004-01-30 | 2008-04-15 | Astellas Pharma Inc. | Treating agent for irritable bowel syndrome |
-
2004
- 2004-01-01 ZA ZA200409537A patent/ZA200409537B/en unknown
- 2004-01-30 RU RU2004136181/15A patent/RU2284819C2/ru not_active IP Right Cessation
- 2004-01-30 AU AU2004208617A patent/AU2004208617B2/en not_active Ceased
- 2004-01-30 EP EP04706797A patent/EP1588707B1/en not_active Expired - Lifetime
- 2004-01-30 DK DK04706797T patent/DK1588707T3/da active
- 2004-01-30 PT PT04706797T patent/PT1588707E/pt unknown
- 2004-01-30 AT AT04706797T patent/ATE420638T1/de active
- 2004-01-30 MX MXPA04012462A patent/MXPA04012462A/es active IP Right Grant
- 2004-01-30 CA CA002488422A patent/CA2488422C/en not_active Expired - Fee Related
- 2004-01-30 JP JP2004564051A patent/JP3689104B2/ja not_active Expired - Lifetime
- 2004-01-30 WO PCT/JP2004/000896 patent/WO2004066998A1/ja active Application Filing
- 2004-01-30 CN CNB2004800003517A patent/CN100379416C/zh not_active Expired - Fee Related
- 2004-01-30 KR KR1020047020096A patent/KR100633836B1/ko active Protection Beyond IP Right Term
- 2004-01-30 PL PL04375181A patent/PL375181A1/xx unknown
- 2004-01-30 DE DE602004019049T patent/DE602004019049D1/de not_active Expired - Lifetime
- 2004-01-30 NZ NZ537448A patent/NZ537448A/en not_active IP Right Cessation
- 2004-01-30 BR BR0405221-8A patent/BRPI0405221A/pt not_active IP Right Cessation
- 2004-01-30 ES ES04706797T patent/ES2319292T3/es not_active Expired - Lifetime
- 2004-08-27 US US10/928,464 patent/US7794748B2/en not_active Expired - Fee Related
- 2004-11-24 IL IL165371A patent/IL165371A/en not_active IP Right Cessation
- 2004-11-25 NO NO20045153A patent/NO20045153L/no not_active Application Discontinuation
-
2005
- 2005-08-15 ZA ZA200506503A patent/ZA200506503B/xx unknown
-
2006
- 2006-04-24 HK HK06104829A patent/HK1084582A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1084582A1 (en) | 2006-08-04 |
| AU2004208617A2 (en) | 2004-08-12 |
| RU2004136181A (ru) | 2005-08-10 |
| ATE420638T1 (de) | 2009-01-15 |
| WO2004066998A1 (ja) | 2004-08-12 |
| AU2004208617A1 (en) | 2004-08-12 |
| NO20045153L (no) | 2005-02-04 |
| CA2488422C (en) | 2008-08-19 |
| EP1588707B1 (en) | 2009-01-14 |
| CA2488422A1 (en) | 2004-08-12 |
| DE602004019049D1 (de) | 2009-03-05 |
| PL375181A1 (en) | 2005-11-28 |
| ZA200409537B (en) | 2006-10-25 |
| IL165371A0 (en) | 2006-01-15 |
| IL165371A (en) | 2009-08-03 |
| NZ537448A (en) | 2008-06-30 |
| AU2004208617B2 (en) | 2007-09-13 |
| ZA200506503B (en) | 2006-12-27 |
| JPWO2004066998A1 (ja) | 2006-05-18 |
| US20050026981A1 (en) | 2005-02-03 |
| CN1723021A (zh) | 2006-01-18 |
| PT1588707E (pt) | 2009-03-27 |
| KR20050044772A (ko) | 2005-05-12 |
| EP1588707A4 (en) | 2006-03-15 |
| JP3689104B2 (ja) | 2005-08-31 |
| MXPA04012462A (es) | 2005-02-24 |
| CN100379416C (zh) | 2008-04-09 |
| ES2319292T3 (es) | 2009-05-06 |
| EP1588707A1 (en) | 2005-10-26 |
| KR100633836B1 (ko) | 2006-10-13 |
| US7794748B2 (en) | 2010-09-14 |
| RU2284819C2 (ru) | 2006-10-10 |
| BRPI0405221A (pt) | 2005-03-15 |
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