DK158678C - Fremgangsmaade til fremstilling af et hepatitis b kerneantigen og anvendelse af dette antigen til fremstilling af diagnostiske praeparater og vacciner. - Google Patents

Fremgangsmaade til fremstilling af et hepatitis b kerneantigen og anvendelse af dette antigen til fremstilling af diagnostiske praeparater og vacciner.

Info

Publication number
DK158678C
DK158678C DK171178A DK171178A DK158678C DK 158678 C DK158678 C DK 158678C DK 171178 A DK171178 A DK 171178A DK 171178 A DK171178 A DK 171178A DK 158678 C DK158678 C DK 158678C
Authority
DK
Denmark
Prior art keywords
antigen
vaccines
hepatitis
procedure
preparation
Prior art date
Application number
DK171178A
Other languages
Danish (da)
English (en)
Other versions
DK158678B (da
DK171178A (da
Inventor
William Joseph Mcaleer
William John Miller
Edward Henry Wasmuth
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK171178A publication Critical patent/DK171178A/da
Publication of DK158678B publication Critical patent/DK158678B/da
Application granted granted Critical
Publication of DK158678C publication Critical patent/DK158678C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5761Hepatitis B
    • G01N33/5762Hepatitis B core antigen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00Reverse transcribing DNA viruses
    • C12N2730/00011Details
    • C12N2730/10011Hepadnaviridae
    • C12N2730/10111Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/961Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK171178A 1977-04-20 1978-04-19 Fremgangsmaade til fremstilling af et hepatitis b kerneantigen og anvendelse af dette antigen til fremstilling af diagnostiske praeparater og vacciner. DK158678C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78903377 1977-04-20
US05/789,033 US4102996A (en) 1977-04-20 1977-04-20 Method of preparing hepatitis B core antigen

Publications (3)

Publication Number Publication Date
DK171178A DK171178A (da) 1978-10-21
DK158678B DK158678B (da) 1990-07-02
DK158678C true DK158678C (da) 1990-12-31

Family

ID=25146371

Family Applications (1)

Application Number Title Priority Date Filing Date
DK171178A DK158678C (da) 1977-04-20 1978-04-19 Fremgangsmaade til fremstilling af et hepatitis b kerneantigen og anvendelse af dette antigen til fremstilling af diagnostiske praeparater og vacciner.

Country Status (14)

Country Link
US (1) US4102996A (ko)
JP (4) JPS53133628A (ko)
BE (1) BE866096A (ko)
CA (1) CA1106279A (ko)
DE (1) DE2816864C2 (ko)
DK (1) DK158678C (ko)
FR (1) FR2387656A1 (ko)
GB (3) GB1596591A (ko)
HK (3) HK67584A (ko)
IE (1) IE46793B1 (ko)
IT (1) IT1102573B (ko)
LU (1) LU79477A1 (ko)
NL (1) NL7803625A (ko)
SG (1) SG41884G (ko)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2750045A1 (de) * 1977-11-09 1979-05-10 Behringwerke Ag Verfahren zur entfernung von detergentien aus virusantigensuspensionen
US4204989A (en) * 1978-12-13 1980-05-27 Merck & Co., Inc. Isolation of hepatitis B e antigen
US4241175A (en) * 1978-12-18 1980-12-23 Merck & Co., Inc. Assay for hepatitis B core antibody
ES487106A0 (es) * 1978-12-22 1981-05-16 Biogen Nv Un metodo para producir al menos un polipeptido que muestra antigenicidad de hbv
US6297355B1 (en) 1978-12-22 2001-10-02 Biogen, Inc. Polypeptides displaying HBV antigenicity or hbv antigen specificity
US4395395A (en) * 1979-05-21 1983-07-26 The United States Of America As Represented By The Department Of Health And Human Services Detection of non-A, non-B hepatitis associated antigen
CA1148859A (en) * 1979-06-14 1983-06-28 Lacy R. Overby Simultaneous assay of two hepatitis viruses using a solid phase
FR2470795A1 (fr) * 1979-12-07 1981-06-12 Pasteur Institut Procede de purification de particules d'origine biologique, notamment de l'antigene de surface du virus de l'hepatite b (aghbs) et les produits obtenus
JPH0625069B2 (ja) * 1981-01-29 1994-04-06 ブリティッシュ・テクノロジー・グループ・リミテッド B型肝炎ワクチン製造方法
AU8746582A (en) * 1981-09-02 1983-03-10 Biogen N.V. Hepatitis b virus e type antigen
US4721675A (en) * 1982-02-01 1988-01-26 Abbott Laboratories Production of hepatitis A virus in vitro utilizing a persistently virus infected cell culture system
EP0121303B1 (en) * 1983-03-04 1989-07-26 Noctech Limited Diagnostic agent, a process for its preparation and its use in diagnostic methods
US4547367A (en) * 1983-12-20 1985-10-15 The United States Of America As Represented By The Department Of Health And Human Services Hepatitis B core antigen vaccine
US4547368A (en) * 1983-12-20 1985-10-15 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Hepatitis B core antigen vaccine made by recombinant DNA
JPS60197629A (ja) * 1984-03-16 1985-10-07 Chemo Sero Therapeut Res Inst HBs抗原の精製方法
JPS60258127A (ja) * 1984-06-04 1985-12-20 Green Cross Corp:The B型肝炎ワクチンの製造方法
US4683294A (en) * 1985-04-03 1987-07-28 Smith Kline Rit, S.A. Process for the extraction and purification of proteins from culture media producing them
US4649192A (en) * 1985-05-30 1987-03-10 Smith Kline-Rit Method for the isolation and purification of hepatitis B surface antigen using polysorbate
DE3604947A1 (de) * 1986-02-17 1987-08-20 Biotest Pharma Gmbh Verfahren zur herstellung eines immunglobulinhaltigen praeparates und dessen verwendung zur prophylaxe und therapie von aids
DE68907996T2 (de) * 1988-05-11 1994-01-05 Abbott Lab Verfahren zur Erhöhung der Spezifizität in kompetitiven Immuntests.
BR0205774A (pt) * 2002-02-27 2004-04-20 Fundacao De Amparo A Pesquisa Sistema adjuvante para produção de anticorpos, vacina e uso

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3636191A (en) * 1969-10-08 1972-01-18 Cancer Res Inst Vaccine against viral hepatitis and process
SE437329B (sv) * 1975-03-14 1985-02-25 Community Blood Council Sett att ur blodserum framstella vaccin mot virushepatit
GB1518582A (en) * 1975-11-17 1978-07-19 Community Blood Council Viral hepatitis vaccine
DE2611723C3 (de) * 1976-03-19 1978-09-21 The Green Cross Corp., Osaka (Japan) Verfahren zur Herstellung von einheitlichen kugelförmigen HBsAg-Teilchen
NL7711378A (nl) * 1976-11-02 1978-05-05 Merck & Co Inc Werkwijze voor het bereiden van preparaten die dane-deeltjes bevatten.

Also Published As

Publication number Publication date
CA1106279A (en) 1981-08-04
DE2816864C2 (de) 1985-08-14
DE2816864A1 (de) 1978-10-26
HK67784A (en) 1984-09-07
GB1596591A (en) 1981-08-26
GB1596593A (en) 1981-08-26
DK158678B (da) 1990-07-02
NL7803625A (nl) 1978-10-24
IT1102573B (it) 1985-10-07
JPS58180430A (ja) 1983-10-21
HK67584A (en) 1984-09-07
SG41884G (en) 1985-03-08
JPS57201854A (en) 1982-12-10
BE866096A (fr) 1978-10-18
FR2387656B1 (ko) 1982-02-19
GB1596592A (en) 1981-08-26
JPS6141897B2 (ko) 1986-09-18
JPS53133628A (en) 1978-11-21
LU79477A1 (fr) 1978-11-28
IE46793B1 (en) 1983-09-21
JPS57203016A (en) 1982-12-13
IT7848873A0 (it) 1978-04-12
HK67684A (en) 1984-09-07
IE780716L (en) 1978-10-20
FR2387656A1 (fr) 1978-11-17
US4102996A (en) 1978-07-25
DK171178A (da) 1978-10-21

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)