DK157244C - Calciferolderivater, disse derivater til brug som farmaceutisk aktive stoffer, disse derivater til brug som antiproliferative og differentieringsinducerende aktive stoffer, samt laegemiddel indeholdende disse - Google Patents

Calciferolderivater, disse derivater til brug som farmaceutisk aktive stoffer, disse derivater til brug som antiproliferative og differentieringsinducerende aktive stoffer, samt laegemiddel indeholdende disse

Info

Publication number
DK157244C
DK157244C DK053785A DK53785A DK157244C DK 157244 C DK157244 C DK 157244C DK 053785 A DK053785 A DK 053785A DK 53785 A DK53785 A DK 53785A DK 157244 C DK157244 C DK 157244C
Authority
DK
Denmark
Prior art keywords
derivatives
active substances
differentient
calciferold
antiproliferative
Prior art date
Application number
DK053785A
Other languages
Danish (da)
English (en)
Other versions
DK53785D0 (da
DK53785A (da
DK157244B (da
Inventor
Enrico Guiseppe Baggiolini
Andrew David Batcho
Gary Arthur Truitt
Milan Radoje Uskokovic
Peter Michael Wovkulich
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK53785D0 publication Critical patent/DK53785D0/da
Publication of DK53785A publication Critical patent/DK53785A/da
Publication of DK157244B publication Critical patent/DK157244B/da
Application granted granted Critical
Publication of DK157244C publication Critical patent/DK157244C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20Free hydroxyl or mercaptan
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28Radicals substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK053785A 1984-02-08 1985-02-06 Calciferolderivater, disse derivater til brug som farmaceutisk aktive stoffer, disse derivater til brug som antiproliferative og differentieringsinducerende aktive stoffer, samt laegemiddel indeholdende disse DK157244C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US57816084A 1984-02-08 1984-02-08
US57816084 1984-02-08
US68212584A 1984-12-17 1984-12-17
US68212584 1984-12-17

Publications (4)

Publication Number Publication Date
DK53785D0 DK53785D0 (da) 1985-02-06
DK53785A DK53785A (da) 1985-08-09
DK157244B DK157244B (da) 1989-11-27
DK157244C true DK157244C (da) 1990-04-23

Family

ID=27077449

Family Applications (1)

Application Number Title Priority Date Filing Date
DK053785A DK157244C (da) 1984-02-08 1985-02-06 Calciferolderivater, disse derivater til brug som farmaceutisk aktive stoffer, disse derivater til brug som antiproliferative og differentieringsinducerende aktive stoffer, samt laegemiddel indeholdende disse

Country Status (10)

Country Link
EP (1) EP0154185B1 (de)
JP (1) JPH0735365B2 (de)
AU (1) AU575373B2 (de)
CA (1) CA1311501C (de)
DE (1) DE3565401D1 (de)
DK (1) DK157244C (de)
IE (1) IE57917B1 (de)
IL (1) IL74264A (de)
NZ (1) NZ211071A (de)
PH (1) PH19845A (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL77668A (en) * 1986-01-21 1989-03-31 Teva Pharma Production of cholecalciferol derivatives and novel intermediates used therefor
GB2229921B (en) * 1989-04-05 1992-12-16 Chugai Pharmaceutical Co Ltd Treatment for hyperparathyroidism with use of vitamin d derivatives
CA2062520C (en) * 1991-03-11 1998-08-11 Hector F. Deluca Synthesis of 1-alpha-hydroxy-secosterol compounds
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
US5300705A (en) * 1993-03-18 1994-04-05 Hoffmann-La Roche Inc. Process for the preparation of 1α,25,26-trihydroxy-22-ene-cholecalciferol
JP4752110B2 (ja) * 2000-12-25 2011-08-17 住友化学株式会社 トリフルオロプロペニル化合物の製造法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069321A (en) * 1975-10-14 1978-01-17 Merck & Co., Inc. Blocked cholecalciferol and dihydrotachysterol 3 derivatives
EP0086350A3 (de) * 1982-02-12 1984-11-28 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von Cholesterinderivaten
IL67881A0 (en) * 1982-02-12 1983-06-15 Sparamedica Ag Pharmaceutical compositions including certain cholecalciferol derivatives
JPS58210017A (ja) * 1982-05-31 1983-12-07 Kureha Chem Ind Co Ltd 抗腫瘍剤
ATE90564T1 (de) * 1982-06-30 1993-07-15 Gen Hospital Corp Vitamin d glycoside.
ATE34977T1 (de) * 1983-01-28 1988-06-15 Hoffmann La Roche Verfahren zur herstellung von cholecalciferolderivaten.

Also Published As

Publication number Publication date
IL74264A (en) 1988-08-31
IL74264A0 (en) 1985-05-31
DK53785D0 (da) 1985-02-06
PH19845A (en) 1986-07-22
NZ211071A (en) 1988-04-29
DK53785A (da) 1985-08-09
AU3846985A (en) 1985-08-15
EP0154185A1 (de) 1985-09-11
DE3565401D1 (de) 1988-11-10
EP0154185B1 (de) 1988-10-05
IE850298L (en) 1985-08-08
CA1311501C (en) 1992-12-15
JPH0735365B2 (ja) 1995-04-19
JPS60248664A (ja) 1985-12-09
IE57917B1 (en) 1993-05-19
DK157244B (da) 1989-11-27
AU575373B2 (en) 1988-07-28

Similar Documents

Publication Publication Date Title
DK457288A (da) Kapsel til farmaceutisk virksomme stoffer
DK328586A (da) Phenylethanolaminotetraliner og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende dem
DE3676248D1 (de) Ubidecarenon enthaltende arzneimittel.
DK164868C (da) Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK214090A (da) 5-aminosulfonylalkyl-indolderivater, fremgangsmaade og mellemprodukt til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
NL194239B (nl) Dialkoxyfosfinolmethylbenzamideverbindingen en farmaceutische preparaten, die deze bevatten.
DK605989D0 (da) Propenonoximethere og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende dem
NL8601838A (nl) Distamycinederivaten, werkwijze voor de bereiding ervan, alsmede farmaceutische preparaten, die deze derivaten bevatten.
DK431586A (da) Benzimidazolderivater, fremgangsmaade til fremstilling deraf og laegemiddel indeholdende disse
DK276189A (da) Polypeptidforbindelser, fremgangsmaader til fremstilling heraf farmaceutiske midler indeholdende disse
DE68911851D1 (de) Abgabe- und Behälterfördervorrichtung.
DK159652C (da) Cholecalciferolderivater, disse derivater til brug som terapeutisk aktive substanser, fremgangsmaade til fremstilling deraf samt farmaceutisk praeparat baseret paa disse cholecalciferolderivater
DK642588D0 (da) Indanderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
DK486789A (da) Benzoxazolinonderivater, fremgangsmaader til fremstilling deraf samt farmaceutiske midler indeholdende disse
DK157244C (da) Calciferolderivater, disse derivater til brug som farmaceutisk aktive stoffer, disse derivater til brug som antiproliferative og differentieringsinducerende aktive stoffer, samt laegemiddel indeholdende disse
DE3874390D1 (de) Carboxystyrol-derivate und arzneimittel, die sie als wirkstoff enthalten.
DE69018914D1 (de) Pharmakologisch aktive Präparate und sie enthaltende Arzneimittel.
DK191086D0 (da) Benzisoselenazolonylderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK617684D0 (da) 1,3-dioxolanylderivater, fremgangsmaade til deres fremstilling, deres anvendelse og laegemidler indeholdende disse forbindelser
NO306993B1 (no) Piperidinylmetyloksyzolidin-2-on-derivater, farmasoeytiske preparater som inneholder slike, samt anvendelse av forbindelsene til fremstilling av legemidler
DK552989D0 (da) Thiazolderivater, fremgangsmaade til fremstilling heraf samt farmaceutiske midler indeholdende dem
NO862917D0 (no) Dihydrokinolinon-derivater, fremgangsmaate til deres fremstilling, legemidler som inneholder disse og deres anvendelse, samt mellomprodukter til deres fremstilling.
DE3673801D1 (de) Bis-dioxopiperazinabkoemmlinge und arzneimittel daraus.
DK165789C (da) 4-oxo-4h-pyrimidooe2,1,aaaisoquinolinderivater, analogifremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse samt derivaterne til anvendelse som antiallergisk middel
DK39891A (da) N-(2-aminoethyl)-pyridin-2-carboxamid og farmaceutisk anvendelige syreadditionssalte deraf til anvendelse som terapeutisk virksomme stoffer samt laegemidler indeholdende disse forbindelser

Legal Events

Date Code Title Description
PBP Patent lapsed