DK1572087T3 - Antistoffer med cancerantigen TMEFF2 og anvendelser deraf - Google Patents

Antistoffer med cancerantigen TMEFF2 og anvendelser deraf

Info

Publication number
DK1572087T3
DK1572087T3 DK03744243T DK03744243T DK1572087T3 DK 1572087 T3 DK1572087 T3 DK 1572087T3 DK 03744243 T DK03744243 T DK 03744243T DK 03744243 T DK03744243 T DK 03744243T DK 1572087 T3 DK1572087 T3 DK 1572087T3
Authority
DK
Denmark
Prior art keywords
antibodies
applications
cancer antigen
tmeff2
antigen tmeff2
Prior art date
Application number
DK03744243T
Other languages
Danish (da)
English (en)
Inventor
La Calle Agustin De
Ingrid Caras
Vinay Bhaskar
Debbie Law
Vanitha Ramakrishnan
Richard Murray
Daniel Afar
David Powers
Original Assignee
Pdl Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pdl Biopharma Inc filed Critical Pdl Biopharma Inc
Application granted granted Critical
Publication of DK1572087T3 publication Critical patent/DK1572087T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK03744243T 2002-03-08 2003-03-07 Antistoffer med cancerantigen TMEFF2 og anvendelser deraf DK1572087T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36283702P 2002-03-08 2002-03-08
US43681202P 2002-12-27 2002-12-27
PCT/US2003/007209 WO2003075855A2 (fr) 2002-03-08 2003-03-07 Anticorps diriges contre l'antigene cancereux tmeff2 et utilisations de ceux-ci

Publications (1)

Publication Number Publication Date
DK1572087T3 true DK1572087T3 (da) 2008-08-25

Family

ID=27807977

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03744243T DK1572087T3 (da) 2002-03-08 2003-03-07 Antistoffer med cancerantigen TMEFF2 og anvendelser deraf

Country Status (15)

Country Link
US (5) US7288248B2 (fr)
EP (1) EP1572087B1 (fr)
JP (2) JP2006502092A (fr)
KR (1) KR101104655B1 (fr)
AT (1) ATE395082T1 (fr)
AU (1) AU2003252830B2 (fr)
CA (1) CA2478683C (fr)
DE (1) DE60321041D1 (fr)
DK (1) DK1572087T3 (fr)
ES (1) ES2305481T3 (fr)
IL (1) IL163902A0 (fr)
PT (1) PT1572087E (fr)
SI (1) SI1572087T1 (fr)
WO (1) WO2003075855A2 (fr)
ZA (1) ZA200407733B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996036709A1 (fr) * 1995-05-19 1996-11-21 Human Genome Sciences, Inc. Facteur de croissance transformant alpha hii
US20040141983A1 (en) * 1999-03-15 2004-07-22 Protein Design Labs, Inc. Compositions against cancer antigen LIV-1 and uses thereof
ES2305481T3 (es) * 2002-03-08 2008-11-01 Pdl Biopharma, Inc. Anticuerpos contra el antigeno cancerigeno tmeff2 y usos de los mismos.
US20030180348A1 (en) * 2002-03-22 2003-09-25 Levinson R. Saul Transcellular drug delivery system
HUE027549T2 (hu) * 2002-07-31 2016-10-28 Seattle Genetics Inc Hatóanyagot tartalmazó konjugátumok és alkalmazásuk rák, autoimmun betegség vagy fertõzéses betegség kezelésére
WO2004067564A2 (fr) 2003-01-29 2004-08-12 Protein Design Labs, Inc. Compositions contre l'antgene cancereux liv-1 et leurs utilisations
DK2489364T3 (en) 2003-11-06 2015-03-02 Seattle Genetics Inc Monomethylvaline compounds conjugated to antibodies
US20050175619A1 (en) * 2004-02-05 2005-08-11 Robert Duffy Methods of producing antibody conjugates
AU2005249490B2 (en) * 2004-06-01 2010-07-29 Genentech, Inc. Antibody drug conjugates and methods
JP5372500B2 (ja) 2005-06-17 2013-12-18 トレラクス リクイデーティング トラスト Ｉｌｔ３結合分子およびその使用
US20060292074A1 (en) * 2005-06-28 2006-12-28 Schering Aktiengesellschaft Tomoregulin antibodies and uses thereof
WO2008094176A2 (fr) * 2006-06-19 2008-08-07 Tolerx, Inc. Molécules se liant à l'ilt3 et leurs utilisations
CN101605918B (zh) * 2007-02-05 2012-03-21 六号元素（产品）（控股）公司 多晶金刚石(pcd)材料
EP2474557B1 (fr) 2007-07-16 2014-08-20 Genentech, Inc. Anticorps anti-CD79b, immuno-conjugués et procédés d'utilisation
PE20140625A1 (es) 2007-07-16 2014-05-29 Genentech Inc ANTICUERPOS ANTI-CD79b E INMUNOCONJUGADOS HUMANIZADOS
JP5606916B2 (ja) * 2007-10-19 2014-10-15 ジェネンテック， インコーポレイテッド システイン操作抗ｔｅｎｂ２抗体および抗体薬物結合体
RU2553566C2 (ru) 2008-01-31 2015-06-20 Дженентек, Инк. АНТИ-CD79b АНТИТЕЛА И ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
EP3470534B1 (fr) * 2009-01-07 2024-03-20 Arcedi Biotech ApS Enrichissement et identification de cellules foetales dans le sang maternel et ligands pour une telle utilisation
US20110159588A1 (en) * 2009-12-30 2011-06-30 Kui Lin Methods for Modulating a PDGF-AA Mediated Biological Response
USRE48959E1 (en) 2010-12-06 2022-03-08 Seagen Inc. Humanized antibodies to LIV-1 and use of same to treat cancer
US20150030602A1 (en) * 2011-12-23 2015-01-29 Phenoquest Ag Antibodies for the treatment and diagnosis of affective and anxiety disorders
WO2016049214A1 (fr) 2014-09-23 2016-03-31 Genentech, Inc. Procédé d'utilisation d'immunoconjugués anti-cd79b
MA45324A (fr) 2016-03-15 2019-01-23 Seattle Genetics Inc Polythérapie utilisant un adc-liv1 et un agent chimiothérapeutique
SG11202011268VA (en) 2018-05-24 2020-12-30 Janssen Biotech Inc Monospecific and multispecific anti-tmeff2 antibodies and there uses
AU2020289708B2 (en) 2019-06-07 2024-07-25 Arcedi Biotech Aps Isolation of fetal cells using FACS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2305481T3 (es) * 2002-03-08 2008-11-01 Pdl Biopharma, Inc. Anticuerpos contra el antigeno cancerigeno tmeff2 y usos de los mismos.

Also Published As

Publication number Publication date
US7674883B2 (en) 2010-03-09
AU2003252830A1 (en) 2003-09-22
US20080160012A1 (en) 2008-07-03
US20080175846A1 (en) 2008-07-24
WO2003075855A3 (fr) 2006-03-23
DE60321041D1 (de) 2008-06-26
JP2011121950A (ja) 2011-06-23
WO2003075855A2 (fr) 2003-09-18
US20080044840A1 (en) 2008-02-21
US7288248B2 (en) 2007-10-30
US7824678B2 (en) 2010-11-02
US7785816B2 (en) 2010-08-31
US8257708B2 (en) 2012-09-04
PT1572087E (pt) 2008-07-11
KR101104655B1 (ko) 2012-01-13
JP2006502092A (ja) 2006-01-19
ZA200407733B (en) 2005-10-26
EP1572087A2 (fr) 2005-09-14
ATE395082T1 (de) 2008-05-15
US20110038864A1 (en) 2011-02-17
ES2305481T3 (es) 2008-11-01
JP5192537B2 (ja) 2013-05-08
EP1572087B1 (fr) 2008-05-14
EP1572087A4 (fr) 2006-11-02
KR20050002848A (ko) 2005-01-10
AU2003252830B2 (en) 2008-10-09
US20040096392A1 (en) 2004-05-20
SI1572087T1 (sl) 2008-10-31
IL163902A0 (en) 2005-12-18
CA2478683C (fr) 2016-01-26
CA2478683A1 (fr) 2003-09-18

Similar Documents

Publication Publication Date Title
DK1572087T3 (da) Antistoffer med cancerantigen TMEFF2 og anvendelser deraf
CY1123400T1 (el) Ανθρωπινα anti-il-23 αντισωματα, συνθεσεις, μεθοδοι και χρησεις
CY1119291T1 (el) Πολυσθενη αντισωματα και χρησεις για αυτα
IL200404A (en) Couplings of 191p4d12 (b) protein-binding antibodies and their use in the treatment of cancer
CY1112862T1 (el) Θραυσματα μονοσθενους αντισωματος χρησιμα ως θεραπευτικα
NO20071740L (no) Humaniserte anti-beta7-antagonister og anvendelser derav
TW200510459A (en) RG1 antibodies and uses thereof
DK1383785T3 (da) Rekombinant tumorspecifikt antistof og anvendelse deraf
ATE526987T1 (de) Dr5-antikörper und deren verwendung
HK1109636A1 (en) Human antibodies and proteins
HK1074670A1 (en) Sets of digital antibodies directed against short epitopes, and methods using same
NZ605429A (en) Therapeutic human anti-il-1r1 monoclonal antibody
CY1110759T1 (el) Παραλλαγες ανοσοσφαιρινων και χρησεις αυτων
BR0011838A (pt) Elementos misturadores estáticos empilhados
MY150400A (en) Antibodies that bind human protein tyrosine phosphatase beta (hptpbeta) and uses thereof
NO20055018D0 (no) Anti-amyolide antistoffer, sammensetninger, fremgangsmater og anvendelser
MX2009009926A (es) Anticuerpo tumor-especifico humano monoclonal.
MXPA04006517A (es) Conjugados que comprenden un anticuerpo especifico para el dominio ed-b de fibronectina y sus usos para la deteccion y tratamiento de tumores.
DE602004027992D1 (de) In metastatischen menschlichen tumorzellen exprimiertes glycoproteinantigen sima135
ATE490785T1 (de) Parathormon-antikörper und damit zusammenhängende verfahren
HK1076055A1 (en) Covalent conjugates between artemisinin-related endoperoxides and iron- carrying proteins and methods of use
WO2004067564A3 (fr) Compositions contre l'antgene cancereux liv-1 et leurs utilisations
CY1106200T1 (el) Αντισωματα εναντια σε κασπαση-8, παρασκευη και χρηση τους
ATE525401T1 (de) Vom tumorantigen 5t4 abgeleitete mhc-klasse-i- und ii-peptidantigene
DE60231971D1 (de) Ndet, und seine verwendung zur behandlung von krebs