DK157013C - Analogifremgangsmaade til fremstilling af fluorholdige 1,4-dihydropyridiner eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents
Analogifremgangsmaade til fremstilling af fluorholdige 1,4-dihydropyridiner eller farmaceutisk acceptable syreadditionssalte derafInfo
- Publication number
- DK157013C DK157013C DK399079A DK399079A DK157013C DK 157013 C DK157013 C DK 157013C DK 399079 A DK399079 A DK 399079A DK 399079 A DK399079 A DK 399079A DK 157013 C DK157013 C DK 157013C
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- fluorous
- dihydropyridines
- analogue
- acid addition
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 abstract 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2841667 | 1978-09-25 | ||
| DE19782841667 DE2841667A1 (de) | 1978-09-25 | 1978-09-25 | Fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK399079A DK399079A (da) | 1980-03-26 |
| DK157013B DK157013B (da) | 1989-10-30 |
| DK157013C true DK157013C (da) | 1990-03-26 |
Family
ID=6050376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK399079A DK157013C (da) | 1978-09-25 | 1979-09-24 | Analogifremgangsmaade til fremstilling af fluorholdige 1,4-dihydropyridiner eller farmaceutisk acceptable syreadditionssalte deraf |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4256749A (ja) |
| EP (1) | EP0009206B1 (ja) |
| JP (2) | JPS6016934B2 (ja) |
| AT (1) | ATE290T1 (ja) |
| CA (1) | CA1130291A (ja) |
| DE (2) | DE2841667A1 (ja) |
| DK (1) | DK157013C (ja) |
| ES (1) | ES484397A1 (ja) |
| FI (1) | FI70887C (ja) |
| GR (1) | GR74127B (ja) |
| HK (1) | HK15184A (ja) |
| HU (1) | HU178449B (ja) |
| IE (1) | IE49462B1 (ja) |
| IL (1) | IL58299A (ja) |
| SG (1) | SG38783G (ja) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2508446B1 (fr) * | 1981-06-25 | 1986-05-02 | Rhone Poulenc Agrochimie | Herbicides a fonctions amide et ester derives de la pyridine ainsi que leur procede de preparation et leur application |
| DE3130041A1 (de) * | 1981-07-30 | 1983-02-17 | Bayer Ag, 5090 Leverkusen | Dihydropyridine mit positiv inotroper wirkung, neue verbindungen, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung |
| JPS5897333U (ja) * | 1981-12-24 | 1983-07-02 | 株式会社昭和製作所 | 油圧緩衝器の減衰力調整機構 |
| JPS5897332U (ja) * | 1981-12-24 | 1983-07-02 | 株式会社昭和製作所 | 油圧緩衝器の減衰力調整機構 |
| DE3312283A1 (de) * | 1983-04-05 | 1984-10-18 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von unsymmetrischen 1,4-dihydropyridincarbonsaeureestern |
| DE3316510A1 (de) * | 1983-05-06 | 1984-11-08 | Bayer Ag | Parenterale formulierung von nimodipin, ein verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung von erkrankungen |
| US4677101A (en) * | 1983-09-26 | 1987-06-30 | Merck & Co., Inc. | Substituted dihydroazepines useful as calcium channel blockers |
| IE57810B1 (en) * | 1984-03-27 | 1993-04-21 | Delagrange Lab | 1,4-dihydropyridine derivatives,their preparation and their use |
| EP0169009A3 (en) * | 1984-07-17 | 1988-08-31 | FISONS plc | Novel dihydropyridine derivatives and their production, formulation and use as pharmaceuticals |
| DE3544211A1 (de) * | 1985-12-13 | 1987-06-19 | Bayer Ag | Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| JPS62292757A (ja) * | 1986-06-12 | 1987-12-19 | Taisho Pharmaceut Co Ltd | １，４−ジヒドロピリジン誘導体 |
| US4868181A (en) * | 1986-08-04 | 1989-09-19 | E. I. Du Pont De Nemours And Company | 1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity |
| JPS63160458U (ja) * | 1987-04-09 | 1988-10-20 | ||
| US5177211A (en) * | 1988-01-21 | 1993-01-05 | Alter, S.A. | 4-alkyl-1,4-dihydropyridines with PAF-antagonist activity |
| US5216172A (en) * | 1988-02-24 | 1993-06-01 | Ajinomoto Co., Inc. | 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells |
| EP0330470A3 (en) * | 1988-02-24 | 1992-01-02 | Ajinomoto Co., Inc. | 1,4-dihydropyridine derivatives useful against tumour cells |
| DE3833893A1 (de) * | 1988-10-05 | 1990-04-12 | Bayer Ag | Verwendung von basischen nitro-phenyl-dihydropyridin-amiden als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung ueber neue zwischenprodukte |
| JP3040364U (ja) * | 1996-07-23 | 1997-08-19 | 清秀 中川 | 芳香含有物質の詰め替え可能な枕 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2117571C3 (de) * | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| DE2117573C3 (de) * | 1971-04-10 | 1978-07-27 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel |
| GB1409865A (en) * | 1973-02-13 | 1975-10-15 | Science Union & Cie | Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them |
| DE2508181A1 (de) * | 1975-02-26 | 1976-09-09 | Bayer Ag | 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
-
1978
- 1978-09-25 DE DE19782841667 patent/DE2841667A1/de not_active Withdrawn
-
1979
- 1979-09-10 US US06/074,048 patent/US4256749A/en not_active Expired - Lifetime
- 1979-09-12 AT AT79103411T patent/ATE290T1/de active
- 1979-09-12 DE DE7979103411T patent/DE2961012D1/de not_active Expired
- 1979-09-12 EP EP79103411A patent/EP0009206B1/de not_active Expired
- 1979-09-21 IL IL58299A patent/IL58299A/xx unknown
- 1979-09-21 FI FI792939A patent/FI70887C/fi not_active IP Right Cessation
- 1979-09-21 CA CA336,100A patent/CA1130291A/en not_active Expired
- 1979-09-21 JP JP54120911A patent/JPS6016934B2/ja not_active Expired
- 1979-09-24 IE IE1802/79A patent/IE49462B1/en unknown
- 1979-09-24 ES ES484397A patent/ES484397A1/es not_active Expired
- 1979-09-24 DK DK399079A patent/DK157013C/da not_active IP Right Cessation
- 1979-09-24 HU HU79BA3852A patent/HU178449B/hu not_active IP Right Cessation
- 1979-09-24 GR GR60102A patent/GR74127B/el unknown
-
1983
- 1983-07-02 SG SG387/83A patent/SG38783G/en unknown
-
1984
- 1984-02-23 HK HK151/84A patent/HK15184A/xx unknown
- 1984-07-27 JP JP59155722A patent/JPS6069018A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| IE49462B1 (en) | 1985-10-16 |
| DE2961012D1 (en) | 1981-12-24 |
| FI70887B (fi) | 1986-07-18 |
| HK15184A (en) | 1984-03-02 |
| FI792939A (fi) | 1980-03-26 |
| IE791802L (en) | 1980-03-25 |
| CA1130291A (en) | 1982-08-24 |
| DK399079A (da) | 1980-03-26 |
| ES484397A1 (es) | 1980-05-16 |
| US4256749A (en) | 1981-03-17 |
| ATE290T1 (de) | 1981-10-15 |
| EP0009206A3 (en) | 1980-04-16 |
| GR74127B (ja) | 1984-06-06 |
| JPS6016934B2 (ja) | 1985-04-30 |
| IL58299A (en) | 1983-03-31 |
| JPS6069018A (ja) | 1985-04-19 |
| DK157013B (da) | 1989-10-30 |
| JPS6217972B2 (ja) | 1987-04-21 |
| FI70887C (fi) | 1986-10-27 |
| EP0009206A2 (de) | 1980-04-02 |
| SG38783G (en) | 1984-07-27 |
| JPS5547657A (en) | 1980-04-04 |
| EP0009206B1 (de) | 1981-10-14 |
| DE2841667A1 (de) | 1980-04-10 |
| HU178449B (en) | 1982-05-28 |
| IL58299A0 (en) | 1979-12-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK157013C (da) | Analogifremgangsmaade til fremstilling af fluorholdige 1,4-dihydropyridiner eller farmaceutisk acceptable syreadditionssalte deraf | |
| DE2963183D1 (en) | 1,4-dihydropyridine compounds, their preparation, pharmaceutical compositions containing said compounds and preparation of these compositions | |
| DK147362C (da) | Analogifremgangsmaade til fremstilling af ergolen- eller ergolin-derivater eller syreadditionssalte deraf | |
| DK462380A (da) | Analogifremgangsmaade til fremstilling af 2,4-diaminoquinazolin-forbindelser eller syreadditionssalte deraf | |
| DK164545C (da) | Analogifremgangsmaade til fremstilling af sulfonylamino- eller sulfonylaminoalkylphenoxyalkylcarbonsyrederivater eller fysiologisk uskadelige salte deraf | |
| DK151623C (da) | Analogifremgangsmaade til fremstilling af n-substituerede moranolinderivater eller farmaceutisk acceptable syreadditionssalte deraf | |
| DK499579A (da) | Fremgangsmaade til fremstilling af hydroxyethyl-azoler | |
| DK148477C (da) | Analogifremgangsmaade til fremstilling af tetrahydropyridinylindolderivater eller additionssalte deraf | |
| DK1284D0 (da) | Substituerede 4-aminomethylen-chromaner eller -chromener eller syreadditionssalte deraf, deres fremstilling og anvendelse | |
| DK149630C (da) | Analogifremgangsmaade til fremstilling af tripeptidamider eller -estere eller fysiologisk acceptable syreadditionssalte deraf | |
| DK499679A (da) | Fremgangsmaade til fremstilling af hydroxypropyl-triazoler | |
| DK151017C (da) | Analogifremgangsmaade til fremstilling af substituerede n-(4-indolyl-piperidino-alkyl)-benzimidazoloner eller fysiologisk acceptable syreadditionssalte deraf | |
| DK154950C (da) | Analogifremgangsmaade til fremstilling af 1-(benzazolylalkyl)-piperidinderivater eller de farmaceutisk acceptable syreadditionssalte deraf | |
| DK142544C (da) | Analogifremgangsmaade til fremstilling af 2-(n-propargyl-n-phenylamino)-imidazolin-(2)-derivater eller fysiologisk acceptable syreadditionssalte heraf | |
| DK146066C (da) | Analogifremgangsmaade til fremstilling af substituerede 2-phenylimino- imidazolidiner eller syreadditionssalte deraf | |
| DK149946C (da) | Analogifremgangsmaade til fremstilling af piperidin-derivater af 1,2- eller 1,3-(di-o-n-alkyl)propandiol eller farmaceutisk acceptable syreadditionssalte deraf | |
| DK165005C (da) | Analogifremgangsmaade til fremstilling af 4,5-dihydro-4-oxofuran-2-carboxylsyrederivater eller terapeutisk acceptable salte deraf | |
| DK152427C (da) | Analogifremgangsmaade til fremstilling af 4-thiomethylpyridinforbindelser eller farmaceutisk acceptable syreadditionssalte deraf | |
| YU45645B (sh) | Postupak za dobivanje dihidropiridinskih derivata | |
| DK152211C (da) | Analogifremgangsmaade til fremstilling af n-phenyl-n-(4-piperidinyl)-amider eller farmaceutisk acceptable syreadditionssalte deraf. | |
| DK148036C (da) | Analogifremgangsmaade til fremstilling af epimere 4''-amino-erythromycin-forbindelser eller syreadditionssalte deraf | |
| DK455980A (da) | Analogifremgangsmaade til fremstilling af spiroimidazolonforbindelser eller syreaddiionssalte deraf | |
| DK160874C (da) | Analogifremgangsmaade til fremstilling af ergol-8-en- eller ergolinforbindelser eller farmaceutisk acceptable syreadditionssalte deraf | |
| DK149750C (da) | Analogifremgangsmaade til fremstilling af n-alkenylmoranolin-derivater eller farmaceutiske acceptable syreadditionssalte deraf | |
| DK150158C (da) | Analogifremgangsmaade til fremstilling af 4-phenylthieno-(2,3-c)piperidiner eller fysiologisk acceptable syreadditionssalte deraf |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |