YU45645B - Postupak za dobivanje dihidropiridinskih derivata - Google Patents
Postupak za dobivanje dihidropiridinskih derivataInfo
- Publication number
- YU45645B YU45645B YU140084A YU140084A YU45645B YU 45645 B YU45645 B YU 45645B YU 140084 A YU140084 A YU 140084A YU 140084 A YU140084 A YU 140084A YU 45645 B YU45645 B YU 45645B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- procedure
- preparation
- dihydropyridine derivatives
- dihydropyridine
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Particle Accelerators (AREA)
- Confectionery (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
POSTUPAK ZA DOBIVANJE DIHIDROPIRIDINSKIH DERIVATA, koji imaju opštu formulu izabranu od: u kojima se R bira iz grupe koja sadrži C1-6 alkil, C1-4 haloalkil, C1-4 alkoksialkil, C1-2 hidroksialkil, C1-2 alkilkarboniloks-C1-2 a lkil i cikloalkanil-C1-2 alkil i heterociklične radikale takve kao što su furil, piridil i tienil; svaki R1 se nezavisno bira od C1-4 nižih alkil radikala a R2 je fluorovani metil radikal, naznačen time, što reaguje niži alkil 3- ketoestrar formule: gde su R1 i R2 kao što je definisano napred, sa aledehidom opšte formule: RCHO gde je R kao što je definisano napred u tetrahidrofuranu, metilenhloridu ili toluolu kao rastvaraču na temperaturi u opsegu od 40 C do refluks temperature reakcione smeše i u prisustvu 0,1 do 1,0 mas,% piperidina kao katalizatora, tako da se dobiva tetrahidropiranski derivat opšte formule: u kojoj su R, R1 i R2 kao što je definisano napred, koji se onda tretira u tečnoj fazi sa amonijum hidroksidom ili gasovitim amonijakom na sobnoj temperaturi do temperature refluksa, obično na 40 C-100 C, tako da se dobiva dihidroksi-piperadinski derivat opšte formule: u kojoj su R, R1 i R2 kao što je definisano napred, koji se onda dehidratiše u tečnoj fazi dehidratacionim sredstvom izabranim iz grupe koja obuhvata sumpornu kiselinu, toluol-sulfonsku kiselinu i anhidrid trifluorosirćetne kiseline na temperaturi 0 C do refluks temperature.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52228183A | 1983-08-11 | 1983-08-11 | |
| US60202284A | 1984-04-24 | 1984-04-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU140084A YU140084A (sh) | 1987-10-31 |
| YU45645B true YU45645B (sh) | 1992-07-20 |
Family
ID=27060765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU140084A YU45645B (sh) | 1983-08-11 | 1984-08-10 | Postupak za dobivanje dihidropiridinskih derivata |
Country Status (33)
| Country | Link |
|---|---|
| EP (1) | EP0135491B1 (sh) |
| KR (2) | KR870001233B1 (sh) |
| AT (1) | ATE40262T1 (sh) |
| AU (1) | AU566077B2 (sh) |
| BG (1) | BG42832A3 (sh) |
| BR (1) | BR8404010A (sh) |
| CA (1) | CA1269383A (sh) |
| CS (1) | CS261875B2 (sh) |
| CY (1) | CY1425A (sh) |
| DD (1) | DD228247A5 (sh) |
| DE (1) | DE3476319D1 (sh) |
| DK (1) | DK167732B1 (sh) |
| ES (1) | ES535012A0 (sh) |
| FI (1) | FI82037C (sh) |
| GB (1) | GB2145085B (sh) |
| HK (1) | HK30988A (sh) |
| HU (1) | HU197172B (sh) |
| IL (1) | IL72640A (sh) |
| IN (1) | IN160125B (sh) |
| KE (1) | KE3794A (sh) |
| MA (1) | MA20199A1 (sh) |
| MX (1) | MX160550A (sh) |
| NO (1) | NO166752C (sh) |
| NZ (1) | NZ209179A (sh) |
| OA (1) | OA07790A (sh) |
| PL (1) | PL142320B1 (sh) |
| PT (1) | PT79062B (sh) |
| RO (2) | RO93219B (sh) |
| SG (1) | SG5088G (sh) |
| SU (1) | SU1565339A3 (sh) |
| TR (1) | TR22217A (sh) |
| YU (1) | YU45645B (sh) |
| ZW (1) | ZW12984A1 (sh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4771057A (en) * | 1986-02-03 | 1988-09-13 | University Of Alberta | Reduced pyridyl derivatives with cardiovascular regulating properties |
| US4908057A (en) * | 1988-08-01 | 1990-03-13 | Monsanto Company | Substituted 2,6-substituted 1,2- or 1,6-dihydro pyridine compounds |
| US5099024A (en) * | 1990-03-19 | 1992-03-24 | Monsanto Company | Process for preparation of fluoromethyl-substituted pyridine carbodithioates |
| US5070204A (en) * | 1990-03-19 | 1991-12-03 | Monsanto Company | Process for preparation of fluoromethyl-substituted pyridine dicarboxylates |
| US5099023A (en) * | 1990-03-19 | 1992-03-24 | Monsanto Company | Process for preparation of fluoromethyl-substituted pyridine carbodithioates |
| HU209737B (en) * | 1990-03-19 | 1994-10-28 | Monsanto Co | Process for preparation of 4-alkyl-2,6 bis (fluoromethyl)-3,4-dihydro-pyridine- dicarboxylic acid-oxyesters and thioesters |
| US5116991A (en) * | 1990-03-19 | 1992-05-26 | Monsanto Company | Process for preparation of fluoromethyl-substituted dihydropyridine carbodithioates |
| US5206369A (en) * | 1992-01-21 | 1993-04-27 | Monsanto Company | Process for the dehydration of dihydroxypiperidinedicarboxylates |
| US6605624B1 (en) | 1998-02-13 | 2003-08-12 | Pharmacia Corporation | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity |
-
1984
- 1984-08-09 ES ES535012A patent/ES535012A0/es active Granted
- 1984-08-10 PL PL1984249141A patent/PL142320B1/pl unknown
- 1984-08-10 GB GB08420323A patent/GB2145085B/en not_active Expired
- 1984-08-10 PT PT79062A patent/PT79062B/pt not_active IP Right Cessation
- 1984-08-10 NO NO843204A patent/NO166752C/no unknown
- 1984-08-10 DE DE8484870118T patent/DE3476319D1/de not_active Expired
- 1984-08-10 IL IL72640A patent/IL72640A/xx not_active IP Right Cessation
- 1984-08-10 RO RO122930A patent/RO93219B/ro unknown
- 1984-08-10 AT AT84870118T patent/ATE40262T1/de not_active IP Right Cessation
- 1984-08-10 TR TR22217A patent/TR22217A/xx unknown
- 1984-08-10 KR KR8404808A patent/KR870001233B1/ko not_active IP Right Cessation
- 1984-08-10 AU AU31810/84A patent/AU566077B2/en not_active Ceased
- 1984-08-10 MX MX5969A patent/MX160550A/es unknown
- 1984-08-10 MA MA20423A patent/MA20199A1/fr unknown
- 1984-08-10 YU YU140084A patent/YU45645B/sh unknown
- 1984-08-10 FI FI843168A patent/FI82037C/fi not_active IP Right Cessation
- 1984-08-10 OA OA58364A patent/OA07790A/xx unknown
- 1984-08-10 SU SU843783502A patent/SU1565339A3/ru active
- 1984-08-10 NZ NZ209179A patent/NZ209179A/xx unknown
- 1984-08-10 CA CA000460730A patent/CA1269383A/en not_active Expired - Lifetime
- 1984-08-10 EP EP84870118A patent/EP0135491B1/en not_active Expired
- 1984-08-10 IN IN597/MAS/84A patent/IN160125B/en unknown
- 1984-08-10 BG BG066569A patent/BG42832A3/xx unknown
- 1984-08-10 RO RO84115469A patent/RO89127A/ro unknown
- 1984-08-10 DD DD84275353A patent/DD228247A5/de not_active IP Right Cessation
- 1984-08-10 DK DK385784A patent/DK167732B1/da not_active IP Right Cessation
- 1984-08-10 CS CS846101A patent/CS261875B2/cs unknown
- 1984-08-10 BR BR8404010A patent/BR8404010A/pt unknown
- 1984-08-10 HU HU843062A patent/HU197172B/hu not_active IP Right Cessation
- 1984-08-10 ZW ZW129/84A patent/ZW12984A1/xx unknown
- 1984-08-10 KR KR1019840004808D patent/KR890000481B1/ko active
-
1988
- 1988-01-14 SG SG50/88A patent/SG5088G/en unknown
- 1988-01-25 KE KE3794A patent/KE3794A/xx unknown
- 1988-04-28 HK HK309/88A patent/HK30988A/xx not_active IP Right Cessation
- 1988-09-02 CY CY1425A patent/CY1425A/xx unknown
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