DK1554250T3 - Hidtil ukendt lactamer og anvendelser deraf - Google Patents
Hidtil ukendt lactamer og anvendelser derafInfo
- Publication number
- DK1554250T3 DK1554250T3 DK03799234T DK03799234T DK1554250T3 DK 1554250 T3 DK1554250 T3 DK 1554250T3 DK 03799234 T DK03799234 T DK 03799234T DK 03799234 T DK03799234 T DK 03799234T DK 1554250 T3 DK1554250 T3 DK 1554250T3
- Authority
- DK
- Denmark
- Prior art keywords
- lactams
- hitherto unknown
- hitherto
- unknown
- unknown lactams
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/06—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0202929A SE0202929D0 (sv) | 2002-10-03 | 2002-10-03 | Novel benzothiazepines and uses thereof |
| SE0203829A SE0203829D0 (sv) | 2002-12-18 | 2002-12-18 | Novel lactams and uses thereof |
| PCT/SE2003/001534 WO2004031154A1 (fr) | 2002-10-03 | 2003-10-02 | Nouvelles lactames et utilisations de ces dernieres |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1554250T3 true DK1554250T3 (da) | 2007-12-17 |
Family
ID=32072595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03799234T DK1554250T3 (da) | 2002-10-03 | 2003-10-02 | Hidtil ukendt lactamer og anvendelser deraf |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7294622B2 (fr) |
| EP (2) | EP1845089A1 (fr) |
| JP (2) | JP4637584B2 (fr) |
| AR (1) | AR041440A1 (fr) |
| AT (1) | ATE374187T1 (fr) |
| AU (1) | AU2003265202A1 (fr) |
| DE (1) | DE60316588T2 (fr) |
| DK (1) | DK1554250T3 (fr) |
| ES (1) | ES2291743T3 (fr) |
| PT (1) | PT1554250E (fr) |
| TW (1) | TW200502221A (fr) |
| WO (1) | WO2004031154A1 (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1636196A1 (fr) | 2003-03-14 | 2006-03-22 | AstraZeneca AB | Nouveaux lactames et leurs utilisations |
| US7211573B2 (en) * | 2004-12-08 | 2007-05-01 | Hoffmann-La Roche Inc. | Malonamide derivatives |
| EP1831187A1 (fr) * | 2004-12-14 | 2007-09-12 | AstraZeneca AB | Nouvelles sondes moleculaires |
| GB2423085C (en) | 2005-02-11 | 2011-11-09 | Cambridge Entpr Ltd | Ligands for G-protein coupled receptors |
| EP2597087B1 (fr) | 2005-10-25 | 2016-03-30 | Shionogi&Co., Ltd. | Dérivés dihydrooxazine et tétrahydropyrimidine comme inhibiteurs de BACE 1 |
| WO2007104933A1 (fr) * | 2006-03-10 | 2007-09-20 | Astrazeneca Ab | Composés chimiques |
| AU2007229550B2 (en) * | 2006-03-27 | 2012-03-08 | F. Hoffmann-La Roche Ag | Malonamide derivatives as gamma secretase inhibitors |
| EP2032539A4 (fr) * | 2006-06-09 | 2011-03-16 | Merck Sharp & Dohme | Benzazépinones en tant que bloqueurs des canaux sodiques |
| US7919490B2 (en) * | 2006-10-04 | 2011-04-05 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| JP5383483B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
| EP2147914B1 (fr) | 2007-04-24 | 2014-06-04 | Shionogi&Co., Ltd. | Dérivés d'aminodihydrothiazine substitués par des groupes cycliques |
| WO2009023453A1 (fr) * | 2007-08-14 | 2009-02-19 | Eli Lilly And Company | Dérivés d'azépine en tant qu'inhibiteurs de gamma-sécrétase |
| CA2727859C (fr) | 2008-06-13 | 2016-11-01 | Shionogi & Co., Ltd. | DERIVE HETEROCYCLIQUE CONTENANT DU SOUFRE AYANT UNE ACTIVITE INHIBANT LA ß-SECRETASE |
| JPWO2010047372A1 (ja) | 2008-10-22 | 2012-03-22 | 塩野義製薬株式会社 | Ｂａｃｅ１阻害活性を有する２−アミノピリミジン−４−オンおよび２−アミノピリジン誘導体 |
| CN101735211B (zh) * | 2008-11-04 | 2012-11-14 | 复旦大学 | 2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途 |
| US9023767B2 (en) * | 2009-05-07 | 2015-05-05 | Memorial Sloan-Kettering Cancer Center | γ-Secretase substrates and methods of use |
| UY32799A (es) * | 2009-07-24 | 2011-02-28 | Novartis Ag | Derivados de oxazina y su uso en el tratamiento de trastornos neurológicos |
| ES2590038T5 (es) | 2009-12-11 | 2021-10-19 | Shionogi & Co | Derivado de oxazina |
| WO2012033831A2 (fr) | 2010-09-07 | 2012-03-15 | Memorial Sloan-Kettering Cancer Center | Procédés et compositions pour un dosage de gamma-secrétase |
| JP2014001142A (ja) * | 2010-10-05 | 2014-01-09 | Astellas Pharma Inc | シクロアルカン化合物 |
| PE20140239A1 (es) * | 2010-10-07 | 2014-03-07 | Takeda Pharmaceutical | Derivados de 1,4-oxazepano |
| AU2011321427A1 (en) | 2010-10-29 | 2013-05-02 | Shionogi & Co., Ltd. | Naphthyridine derivative |
| JP5766198B2 (ja) | 2010-10-29 | 2015-08-19 | 塩野義製薬株式会社 | 縮合アミノジヒドロピリミジン誘導体 |
| TW201247635A (en) | 2011-04-26 | 2012-12-01 | Shionogi & Co | Oxazine derivatives and a pharmaceutical composition for inhibiting BAC1 containing them |
| CA2877048A1 (fr) * | 2012-08-09 | 2014-02-13 | F. Hoffmann-La Roche Ag | Hetero-azepinones substituees |
| US9540359B2 (en) | 2012-10-24 | 2017-01-10 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04503073A (ja) | 1989-01-31 | 1992-06-04 | アボツト・ラボラトリーズ | アナフィラトキシン受容体リガンド |
| US5936065A (en) | 1993-12-06 | 1999-08-10 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
| US6136834A (en) | 1995-12-27 | 2000-10-24 | Ono Pharmaceutical Co., Ltd. | Tetrazole compounds and pharmaceutical agents containing such derivative |
| GB9621836D0 (en) | 1996-10-19 | 1996-12-11 | Zeneca Ltd | Peptide compounds |
| WO1998028268A2 (fr) * | 1996-12-23 | 1998-07-02 | Elan Pharmaceuticals, Inc. | CYCLOALKYLE, LACTAME ET COMPOSES ASSOCIES, COMPOSITIONS PHARMACEUTIQUES CONTENANT CES COMPOSES, ET PROCEDES D'INHIBITION DE LA LIBERATION DU PEPTIDE β-AMYLOIDE ET/OU DE SA SYNTHESE AU MOYEN DE TELS COMPOSES |
| CA2325388A1 (fr) * | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Composes permettant d'inhiber la liberation et/ou la synthese de peptide beta-amyloide |
| WO1999067219A1 (fr) | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Composes destines a inhiber la liberation et/ou la synthese du peptide beta-amyloide |
| WO1999067221A1 (fr) | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | COMPOSES D'INHIBITION DE LA LIBERATION DU PEPTIDE β-AMYLOIDE ET/OU DE SA SYNTHESE |
| WO2000002903A1 (fr) | 1998-07-10 | 2000-01-20 | Cytel Corporation | Peptidomimetique de cs-1, compositions et leurs procedes d'utilisation |
| HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
| EP1131634A2 (fr) | 1998-09-30 | 2001-09-12 | Elan Pharmaceuticals, Inc. | Reactifs biologiques et procedes servant a determiner le mecanisme implique dans la generation du peptide beta-amyloide |
| WO2000038618A2 (fr) * | 1998-12-24 | 2000-07-06 | Du Pont Pharmaceuticals Company | BENZODIAZEPINES SUCCINOYLAMINO UTILISEES COMME INHIBITEURS DE LA PRODUCTION DE PROTEINE A$g(b) |
| JP2001030342A (ja) | 1999-07-23 | 2001-02-06 | Japan Polychem Corp | ポリオレフィン製延伸ブロー成形用インモールドラベル及びそのラベルを熱融着させた成形体 |
| MXPA02001813A (es) * | 1999-09-13 | 2004-03-19 | Bristol Myers Squibb Pharma Co | Hidroxialcanoilaminolactamas y estructuras relacionas como inhibidores de la produccion de la proteina abeta. |
| WO2001068655A2 (fr) | 2000-03-10 | 2001-09-20 | Ariad Pharmaceuticals, Inc. | Derives de caprolactam et leurs utilisations |
| EP1267906A1 (fr) * | 2000-03-28 | 2003-01-02 | Bristol-Myers Squibb Pharma Company | Lactames en tant qu'inhibiteurs de production de proteines a-beta |
| EP1636196A1 (fr) | 2003-03-14 | 2006-03-22 | AstraZeneca AB | Nouveaux lactames et leurs utilisations |
| US7060698B2 (en) | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| EP1831187A1 (fr) | 2004-12-14 | 2007-09-12 | AstraZeneca AB | Nouvelles sondes moleculaires |
-
2003
- 2003-09-29 TW TW092126851A patent/TW200502221A/zh unknown
- 2003-09-30 AR ARP030103560A patent/AR041440A1/es not_active Application Discontinuation
- 2003-10-02 AT AT03799234T patent/ATE374187T1/de not_active IP Right Cessation
- 2003-10-02 PT PT03799234T patent/PT1554250E/pt unknown
- 2003-10-02 WO PCT/SE2003/001534 patent/WO2004031154A1/fr active IP Right Grant
- 2003-10-02 EP EP07012660A patent/EP1845089A1/fr not_active Withdrawn
- 2003-10-02 EP EP03799234A patent/EP1554250B1/fr not_active Expired - Lifetime
- 2003-10-02 DK DK03799234T patent/DK1554250T3/da active
- 2003-10-02 JP JP2004541383A patent/JP4637584B2/ja not_active Expired - Fee Related
- 2003-10-02 DE DE60316588T patent/DE60316588T2/de not_active Expired - Lifetime
- 2003-10-02 ES ES03799234T patent/ES2291743T3/es not_active Expired - Lifetime
- 2003-10-02 AU AU2003265202A patent/AU2003265202A1/en not_active Abandoned
- 2003-10-02 US US10/528,640 patent/US7294622B2/en not_active Expired - Fee Related
-
2007
- 2007-08-24 US US11/844,451 patent/US20080076752A1/en not_active Abandoned
-
2009
- 2009-01-26 US US12/359,465 patent/US7858776B2/en not_active Expired - Fee Related
-
2010
- 2010-06-15 JP JP2010136105A patent/JP2010248216A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003265202A1 (en) | 2004-04-23 |
| US20060089346A1 (en) | 2006-04-27 |
| US7858776B2 (en) | 2010-12-28 |
| WO2004031154A1 (fr) | 2004-04-15 |
| US20080076752A1 (en) | 2008-03-27 |
| EP1554250B1 (fr) | 2007-09-26 |
| US7294622B2 (en) | 2007-11-13 |
| DE60316588T2 (de) | 2008-07-31 |
| DE60316588D1 (de) | 2007-11-08 |
| JP2006503862A (ja) | 2006-02-02 |
| ATE374187T1 (de) | 2007-10-15 |
| PT1554250E (pt) | 2007-11-15 |
| JP2010248216A (ja) | 2010-11-04 |
| JP4637584B2 (ja) | 2011-02-23 |
| AR041440A1 (es) | 2005-05-18 |
| TW200502221A (en) | 2005-01-16 |
| US20100160627A1 (en) | 2010-06-24 |
| EP1554250A1 (fr) | 2005-07-20 |
| EP1845089A1 (fr) | 2007-10-17 |
| ES2291743T3 (es) | 2008-03-01 |
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