DK155322C - PROCEDURE FOR THE PREPARATION OF 14-HYDROXYMORPHINAN DERIVATIVES AND PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS AND INTERMEDIATE USE FOR THE PROCEDURE - Google Patents

PROCEDURE FOR THE PREPARATION OF 14-HYDROXYMORPHINAN DERIVATIVES AND PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS AND INTERMEDIATE USE FOR THE PROCEDURE

Info

Publication number
DK155322C
DK155322C DK123877A DK123877A DK155322C DK 155322 C DK155322 C DK 155322C DK 123877 A DK123877 A DK 123877A DK 123877 A DK123877 A DK 123877A DK 155322 C DK155322 C DK 155322C
Authority
DK
Denmark
Prior art keywords
procedure
preparation
acid addition
addition salts
acceptable acid
Prior art date
Application number
DK123877A
Other languages
Danish (da)
Other versions
DK155322B (en
DK123877A (en
Inventor
Ivo Monkovic
Carol Bachand
Henry Wong
Gary Lim
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/669,795 external-priority patent/US4058531A/en
Priority claimed from US05/769,808 external-priority patent/US4139534A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of DK123877A publication Critical patent/DK123877A/en
Publication of DK155322B publication Critical patent/DK155322B/en
Application granted granted Critical
Publication of DK155322C publication Critical patent/DK155322C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DK123877A 1976-03-23 1977-03-21 PROCEDURE FOR THE PREPARATION OF 14-HYDROXYMORPHINAN DERIVATIVES AND PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS AND INTERMEDIATE USE FOR THE PROCEDURE DK155322C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66979576 1976-03-23
US05/669,795 US4058531A (en) 1976-03-23 1976-03-23 Process for the preparation of 14-hydroxymorphinan derivatives
US05/769,808 US4139534A (en) 1977-02-17 1977-02-17 Process for the preparation of 14-hydroxymorphinan derivatives
US76980877 1977-02-17

Publications (3)

Publication Number Publication Date
DK123877A DK123877A (en) 1977-09-24
DK155322B DK155322B (en) 1989-03-28
DK155322C true DK155322C (en) 1989-09-11

Family

ID=27100195

Family Applications (2)

Application Number Title Priority Date Filing Date
DK123877A DK155322C (en) 1976-03-23 1977-03-21 PROCEDURE FOR THE PREPARATION OF 14-HYDROXYMORPHINAN DERIVATIVES AND PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS AND INTERMEDIATE USE FOR THE PROCEDURE
DK597188A DK160987C (en) 1976-03-23 1988-10-27 9,10-DIHYDROXY-PERHYDROISOQUINOLINE DERIVATIVES USED AS INTERMEDIATE IN THE PREPARATION OF 14-HYDROXY-MORPHINANDER DERIVATIVES

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK597188A DK160987C (en) 1976-03-23 1988-10-27 9,10-DIHYDROXY-PERHYDROISOQUINOLINE DERIVATIVES USED AS INTERMEDIATE IN THE PREPARATION OF 14-HYDROXY-MORPHINANDER DERIVATIVES

Country Status (8)

Country Link
JP (1) JPS52136176A (en)
CA (1) CA1086723A (en)
CH (1) CH629783A5 (en)
DK (2) DK155322C (en)
FI (1) FI61486C (en)
LU (1) LU77000A1 (en)
NL (2) NL189846C (en)
SE (1) SE431749B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0373510U (en) * 1989-11-15 1991-07-24

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3634429A (en) * 1969-09-30 1972-01-11 Hoffmann La Roche Morphinan derivatives and preparation thereof
CA919668A (en) * 1970-06-20 1973-01-23 Murakami Masuo Morphinan derivatives
BE788478A (en) * 1971-09-08 1973-03-06 Bristol Myers Co PROCESS FOR PREPARING ANALGESIC COMPOUNDS
US3775414A (en) * 1972-05-10 1973-11-27 Bristol Myers Co Process for the preparation of 14-hydroxymorphinan derivatives

Also Published As

Publication number Publication date
NL960022I1 (en) 1996-12-02
DK155322B (en) 1989-03-28
SE7703236L (en) 1977-09-24
SE431749B (en) 1984-02-27
DK160987B (en) 1991-05-13
DK597188D0 (en) 1988-10-27
NL189846B (en) 1993-03-16
JPS52136176A (en) 1977-11-14
DK160987C (en) 1991-11-11
FI770865A (en) 1977-09-24
CH629783A5 (en) 1982-05-14
JPS6139938B2 (en) 1986-09-06
DK123877A (en) 1977-09-24
FI61486B (en) 1982-04-30
CA1086723A (en) 1980-09-30
LU77000A1 (en) 1977-10-03
DK597188A (en) 1988-10-27
FI61486C (en) 1982-08-10
NL7703000A (en) 1977-09-27
NL189846C (en) 1993-08-16

Similar Documents

Publication Publication Date Title
DK157860C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF BENZYLIMIDAZOLD DERIVATIVES AND PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF
DK129477A (en) PROCEDURE FOR THE PREPARATION OF ALKYLOXIM DERIVATIVES OF 7-AMINOTHIAZOLYLACETAMIDOCEPHALOSPORANIC ACID
DK149895C (en) PROCEDURE FOR THE PREPARATION OF ALFA-AMINOACYLPROLYL-NG-CARBOXY ARGINALDEHYDE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.
DK178379A (en) PROCEDURE FOR THE PREPARATION OF N-SUBSTITUTED MORANOLIN DERIVATIVES OR ACID ADDITIONAL SALTS THEREOF
DK56077A (en) PROCEDURE FOR THE PREPARATION OF 3-QUINOLINCARBOXYLIC ACID DERIVATIVES OR ADDITIONAL SALTS THEREOF
DK129578A (en) PROCEDURE FOR THE PREPARATION OF OXIMI DERIVATIVES OF 3-ACETOXYMETHYL-7-AMINOTHIAZOLYLACETAMIDOCEPHALOSPORANIC ACID
DK23677A (en) PROCEDURE FOR THE PREPARATION OF OXIMI DERIVATIVES OF 7-AMINOTHIAZOLYL-ACETAMIDOCEPHALOSPORANIC ACID
DK281777A (en) PROCEDURE FOR THE PREPARATION OF 4-HYDROXYPHENYLETHYLAMINE COMPOUNDS OR ACID ADDITIONAL SALTS THEREOF AND INTERMEDIATE PRODUCTS
DK496977A (en) PROCEDURE FOR THE PREPARATION OF 0-ALKYLED HYDROXYLAMINS AND ACID ADDITIONAL SALTS THEREOF
DK11480A (en) PROCEDURE FOR THE PREPARATION OF ANTHRACYCLINE DERIVATIVES AND ACID ADDITIONAL SALTS THEREOF
DK129678A (en) PROCEDURE FOR THE PREPARATION OF OXIMI DERIVATIVES OF 7-AMINOTHIAZOLYLACETAMIDOCEPHALOSPORANIC ACID
DK537677A (en) PROPHIC ACID DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION
DK12477A (en) PROCEDURE FOR THE PREPARATION OF 7-AMINOTHIAZOLYLACETAMIDOCEPHALOSPORANIC ACID DERIVATIVES
DK359577A (en) PROCEDURE FOR THE PREPARATION OF 2-PHENYLAMINOIMIDAZOLINE (2) AND ACID ADDITION SALTS
DK232777A (en) PROCEDURE FOR THE PREPARATION OF IMIDAZOTHIAZINES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK149077C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF ENCEPHALIN ANALOGUE PENTAPEPTIDAMIDE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF
DK290080A (en) PROCEDURE FOR THE PREPARATION OF A Aqueous MAGIC ACID URBANATING AGENT
DK49777A (en) PROCEDURE FOR THE PREPARATION OF THERAPEUTIC CONTAINERS CONTAINING CHOLANIC ACID DERIVATIVES
DK369677A (en) PROCEDURE FOR THE PREPARATION OF OXIMIDE DERIVATIVES OF 3-CARBAMOYLOXYMETHYL-7-AMINOTHIAZOLYLACETAMIDOCEPHALOSPHONIC ACID
DK232877A (en) PROCEDURE FOR THE PREPARATION OF 2-IMINO-3-AMINOTHIAZOLIDINES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK39581A (en) PROCEDURE FOR THE PREPARATION OF BENZODIAZEPINE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF AND THE PROCEDURES USED BY THE PROCEDURE
DK68978A (en) PROCEDURE FOR THE PREPARATION OF OXIMI DERIVATIVES OF 3-THIADIAZOLYTHIOMETHYL-7-AMINOTHIAZOLYLACETAMIDOCEPHALOSPORANIC ACID
DK319178A (en) PROCEDURE FOR THE PREPARATION OF ACYLAMIDO-2-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS AND SALTS
DK86277A (en) PROCEDURE FOR THE PREPARATION OF CLAVULAMIC ACID DERIVATIVES
DK62878A (en) PROCEDURE FOR THE PREPARATION OF BENZOHETEROCYCLYLGLYOXYLIC ACID DERIVATIVES AND SALTS THEREOF

Legal Events

Date Code Title Description
PUP Patent expired