DK123877A - PROCEDURE FOR THE PREPARATION OF 14-HYDROXYMORPHINAN DERIVATIVES - Google Patents

PROCEDURE FOR THE PREPARATION OF 14-HYDROXYMORPHINAN DERIVATIVES

Info

Publication number
DK123877A
DK123877A DK123877A DK123877A DK123877A DK 123877 A DK123877 A DK 123877A DK 123877 A DK123877 A DK 123877A DK 123877 A DK123877 A DK 123877A DK 123877 A DK123877 A DK 123877A
Authority
DK
Denmark
Prior art keywords
procedure
preparation
hydroxymorphinan derivatives
hydroxymorphinan
derivatives
Prior art date
Application number
DK123877A
Other languages
Danish (da)
Other versions
DK155322B (en
DK155322C (en
Inventor
I Monkovic
C Bachand
H Wong
G Lim
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/669,795 external-priority patent/US4058531A/en
Priority claimed from US05/769,808 external-priority patent/US4139534A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of DK123877A publication Critical patent/DK123877A/en
Publication of DK155322B publication Critical patent/DK155322B/en
Application granted granted Critical
Publication of DK155322C publication Critical patent/DK155322C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DK123877A 1976-03-23 1977-03-21 PROCEDURE FOR THE PREPARATION OF 14-HYDROXYMORPHINAN DERIVATIVES AND PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS AND INTERMEDIATE USE FOR THE PROCEDURE DK155322C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US05/669,795 US4058531A (en) 1976-03-23 1976-03-23 Process for the preparation of 14-hydroxymorphinan derivatives
US66979576 1976-03-23
US76980877 1977-02-17
US05/769,808 US4139534A (en) 1977-02-17 1977-02-17 Process for the preparation of 14-hydroxymorphinan derivatives

Publications (3)

Publication Number Publication Date
DK123877A true DK123877A (en) 1977-09-24
DK155322B DK155322B (en) 1989-03-28
DK155322C DK155322C (en) 1989-09-11

Family

ID=27100195

Family Applications (2)

Application Number Title Priority Date Filing Date
DK123877A DK155322C (en) 1976-03-23 1977-03-21 PROCEDURE FOR THE PREPARATION OF 14-HYDROXYMORPHINAN DERIVATIVES AND PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS AND INTERMEDIATE USE FOR THE PROCEDURE
DK597188A DK160987C (en) 1976-03-23 1988-10-27 9,10-DIHYDROXY-PERHYDROISOQUINOLINE DERIVATIVES USED AS INTERMEDIATE IN THE PREPARATION OF 14-HYDROXY-MORPHINANDER DERIVATIVES

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK597188A DK160987C (en) 1976-03-23 1988-10-27 9,10-DIHYDROXY-PERHYDROISOQUINOLINE DERIVATIVES USED AS INTERMEDIATE IN THE PREPARATION OF 14-HYDROXY-MORPHINANDER DERIVATIVES

Country Status (8)

Country Link
JP (1) JPS52136176A (en)
CA (1) CA1086723A (en)
CH (1) CH629783A5 (en)
DK (2) DK155322C (en)
FI (1) FI61486C (en)
LU (1) LU77000A1 (en)
NL (2) NL189846C (en)
SE (1) SE431749B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0373510U (en) * 1989-11-15 1991-07-24

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3634429A (en) * 1969-09-30 1972-01-11 Hoffmann La Roche Morphinan derivatives and preparation thereof
CA919668A (en) * 1970-06-20 1973-01-23 Murakami Masuo Morphinan derivatives
BE788478A (en) * 1971-09-08 1973-03-06 Bristol Myers Co PROCESS FOR PREPARING ANALGESIC COMPOUNDS
US3775414A (en) * 1972-05-10 1973-11-27 Bristol Myers Co Process for the preparation of 14-hydroxymorphinan derivatives

Also Published As

Publication number Publication date
CA1086723A (en) 1980-09-30
CH629783A5 (en) 1982-05-14
FI770865A (en) 1977-09-24
NL189846B (en) 1993-03-16
FI61486C (en) 1982-08-10
NL960022I1 (en) 1996-12-02
DK597188D0 (en) 1988-10-27
JPS6139938B2 (en) 1986-09-06
DK597188A (en) 1988-10-27
FI61486B (en) 1982-04-30
NL7703000A (en) 1977-09-27
DK155322B (en) 1989-03-28
LU77000A1 (en) 1977-10-03
DK155322C (en) 1989-09-11
SE7703236L (en) 1977-09-24
JPS52136176A (en) 1977-11-14
SE431749B (en) 1984-02-27
NL189846C (en) 1993-08-16
DK160987C (en) 1991-11-11
DK160987B (en) 1991-05-13

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Legal Events

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PUP Patent expired