DK160987C - 9,10-DIHYDROXY-PERHYDROISOQUINOLINE DERIVATIVES USED AS INTERMEDIATE IN THE PREPARATION OF 14-HYDROXY-MORPHINANDER DERIVATIVES - Google Patents

9,10-DIHYDROXY-PERHYDROISOQUINOLINE DERIVATIVES USED AS INTERMEDIATE IN THE PREPARATION OF 14-HYDROXY-MORPHINANDER DERIVATIVES

Info

Publication number
DK160987C
DK160987C DK597188A DK597188A DK160987C DK 160987 C DK160987 C DK 160987C DK 597188 A DK597188 A DK 597188A DK 597188 A DK597188 A DK 597188A DK 160987 C DK160987 C DK 160987C
Authority
DK
Denmark
Prior art keywords
derivatives
morphinander
perhydroisoquinoline
dihydroxy
hydroxy
Prior art date
Application number
DK597188A
Other languages
Danish (da)
Other versions
DK160987B (en
DK597188D0 (en
DK597188A (en
Inventor
Ivo Monkovic
Carol Bachand
Henry Wong
Gary Lim
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/669,795 external-priority patent/US4058531A/en
Priority claimed from US05/769,808 external-priority patent/US4139534A/en
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DK597188D0 publication Critical patent/DK597188D0/en
Publication of DK597188A publication Critical patent/DK597188A/en
Publication of DK160987B publication Critical patent/DK160987B/en
Application granted granted Critical
Publication of DK160987C publication Critical patent/DK160987C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
DK597188A 1976-03-23 1988-10-27 9,10-DIHYDROXY-PERHYDROISOQUINOLINE DERIVATIVES USED AS INTERMEDIATE IN THE PREPARATION OF 14-HYDROXY-MORPHINANDER DERIVATIVES DK160987C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US05/669,795 US4058531A (en) 1976-03-23 1976-03-23 Process for the preparation of 14-hydroxymorphinan derivatives
US66979576 1976-03-23
US76980877 1977-02-17
US05/769,808 US4139534A (en) 1977-02-17 1977-02-17 Process for the preparation of 14-hydroxymorphinan derivatives

Publications (4)

Publication Number Publication Date
DK597188D0 DK597188D0 (en) 1988-10-27
DK597188A DK597188A (en) 1988-10-27
DK160987B DK160987B (en) 1991-05-13
DK160987C true DK160987C (en) 1991-11-11

Family

ID=27100195

Family Applications (2)

Application Number Title Priority Date Filing Date
DK123877A DK155322C (en) 1976-03-23 1977-03-21 PROCEDURE FOR THE PREPARATION OF 14-HYDROXYMORPHINAN DERIVATIVES AND PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS AND INTERMEDIATE USE FOR THE PROCEDURE
DK597188A DK160987C (en) 1976-03-23 1988-10-27 9,10-DIHYDROXY-PERHYDROISOQUINOLINE DERIVATIVES USED AS INTERMEDIATE IN THE PREPARATION OF 14-HYDROXY-MORPHINANDER DERIVATIVES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK123877A DK155322C (en) 1976-03-23 1977-03-21 PROCEDURE FOR THE PREPARATION OF 14-HYDROXYMORPHINAN DERIVATIVES AND PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS AND INTERMEDIATE USE FOR THE PROCEDURE

Country Status (8)

Country Link
JP (1) JPS52136176A (en)
CA (1) CA1086723A (en)
CH (1) CH629783A5 (en)
DK (2) DK155322C (en)
FI (1) FI61486C (en)
LU (1) LU77000A1 (en)
NL (2) NL189846C (en)
SE (1) SE431749B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0373510U (en) * 1989-11-15 1991-07-24

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3634429A (en) * 1969-09-30 1972-01-11 Hoffmann La Roche Morphinan derivatives and preparation thereof
CA919668A (en) * 1970-06-20 1973-01-23 Murakami Masuo Morphinan derivatives
BE788478A (en) * 1971-09-08 1973-03-06 Bristol Myers Co PROCESS FOR PREPARING ANALGESIC COMPOUNDS
US3775414A (en) * 1972-05-10 1973-11-27 Bristol Myers Co Process for the preparation of 14-hydroxymorphinan derivatives

Also Published As

Publication number Publication date
NL960022I1 (en) 1996-12-02
CH629783A5 (en) 1982-05-14
DK160987B (en) 1991-05-13
DK155322B (en) 1989-03-28
SE431749B (en) 1984-02-27
JPS6139938B2 (en) 1986-09-06
DK597188D0 (en) 1988-10-27
NL7703000A (en) 1977-09-27
SE7703236L (en) 1977-09-24
DK155322C (en) 1989-09-11
DK597188A (en) 1988-10-27
FI61486B (en) 1982-04-30
JPS52136176A (en) 1977-11-14
DK123877A (en) 1977-09-24
NL189846B (en) 1993-03-16
FI770865A (en) 1977-09-24
FI61486C (en) 1982-08-10
CA1086723A (en) 1980-09-30
NL189846C (en) 1993-08-16
LU77000A1 (en) 1977-10-03

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