DK1549628T3 - Fremgangsmåde til fremstilling af aminosyre-taxan-afledede og polymer-konjugater indeholdende disse - Google Patents

Fremgangsmåde til fremstilling af aminosyre-taxan-afledede og polymer-konjugater indeholdende disse

Info

Publication number
DK1549628T3
DK1549628T3 DK03797886T DK03797886T DK1549628T3 DK 1549628 T3 DK1549628 T3 DK 1549628T3 DK 03797886 T DK03797886 T DK 03797886T DK 03797886 T DK03797886 T DK 03797886T DK 1549628 T3 DK1549628 T3 DK 1549628T3
Authority
DK
Denmark
Prior art keywords
amino acid
taxane
derived
polymer conjugates
conjugates containing
Prior art date
Application number
DK03797886T
Other languages
English (en)
Inventor
Hong Zhao
Richard B Greenwald
Original Assignee
Enzon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzon Inc filed Critical Enzon Inc
Application granted granted Critical
Publication of DK1549628T3 publication Critical patent/DK1549628T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
  • Medicinal Preparation (AREA)
DK03797886T 2002-09-20 2003-09-05 Fremgangsmåde til fremstilling af aminosyre-taxan-afledede og polymer-konjugater indeholdende disse DK1549628T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/252,024 US6649778B1 (en) 2002-09-20 2002-09-20 Methods of preparing amino acid taxane derivatives and polymer conjugates containing the same
PCT/US2003/027941 WO2004026230A2 (en) 2002-09-20 2003-09-05 Method of preparing amino acid taxane derivatives and polymer conjugates containing the same

Publications (1)

Publication Number Publication Date
DK1549628T3 true DK1549628T3 (da) 2009-08-24

Family

ID=29420121

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03797886T DK1549628T3 (da) 2002-09-20 2003-09-05 Fremgangsmåde til fremstilling af aminosyre-taxan-afledede og polymer-konjugater indeholdende disse

Country Status (10)

Country Link
US (1) US6649778B1 (da)
EP (1) EP1549628B1 (da)
JP (2) JP5162078B2 (da)
AT (1) ATE429424T1 (da)
AU (1) AU2003265960A1 (da)
CA (1) CA2499536C (da)
DE (1) DE60327337D1 (da)
DK (1) DK1549628T3 (da)
ES (1) ES2325832T3 (da)
WO (1) WO2004026230A2 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6649778B1 (en) * 2002-09-20 2003-11-18 Enzon, Inc. Methods of preparing amino acid taxane derivatives and polymer conjugates containing the same
JP4920593B2 (ja) * 2004-10-25 2012-04-18 インテザイン テクノロジーズ， インコーポレイテッド ヘテロ二官能性ポリ（エチレングリコール）およびそれらの使用
US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
AU2007226937A1 (en) * 2006-03-21 2007-09-27 Dr. Reddy's Laboratories Ltd. Docetaxel polymorphs and processes
US7560588B2 (en) 2006-04-27 2009-07-14 Intezyne Technologies, Inc. Poly(ethylene glycol) containing chemically disparate endgroups
MX2009008549A (es) * 2007-02-09 2009-08-18 Enzon Pharmaceuticals Inc Tratamiento de canceres resistentes o refractarios con conjugados polimericos de brazos multiples de 7-etil-10-hidroxicamptotecina.
JP5588983B2 (ja) 2008-08-11 2014-09-10 ウェルズ ファーゴ バンク ナショナル アソシエイション マルチアームポリマーアルカノエートコンジュゲート
US20100056555A1 (en) * 2008-08-29 2010-03-04 Enzon Pharmaceuticals, Inc. Method of treating ras associated cancer
CN102215688A (zh) * 2008-10-21 2011-10-12 安龙制药公司 用7-乙基-10-羟基喜树碱的多臂聚合物对神经母细胞瘤的治疗
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US9199954B2 (en) 2010-12-22 2015-12-01 Nektar Therapeutics Non-ring hydroxy substituted taxanes and methods for synthesizing the same
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
EP2913064A1 (en) 2014-02-26 2015-09-02 celares GmbH Branched drug-linker conjugates for the coupling to biological targeting molecules

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
JP2964474B2 (ja) * 1994-06-28 1999-10-18 田辺製薬株式会社 タキソール誘導体及びその製法
JPH09235225A (ja) * 1995-12-26 1997-09-09 Tanabe Seiyaku Co Ltd 医薬組成物
JP2003026673A (ja) * 1999-03-05 2003-01-29 Asahi Kasei Corp 骨形成促進剤
US6649778B1 (en) * 2002-09-20 2003-11-18 Enzon, Inc. Methods of preparing amino acid taxane derivatives and polymer conjugates containing the same

Also Published As

Publication number Publication date
ATE429424T1 (de) 2009-05-15
US6649778B1 (en) 2003-11-18
WO2004026230A3 (en) 2004-07-08
AU2003265960A1 (en) 2004-04-08
WO2004026230A2 (en) 2004-04-01
EP1549628A4 (en) 2007-05-02
CA2499536C (en) 2011-03-29
AU2003265960A8 (en) 2004-04-08
EP1549628A2 (en) 2005-07-06
JP2006508926A (ja) 2006-03-16
DE60327337D1 (de) 2009-06-04
JP5162078B2 (ja) 2013-03-13
ES2325832T3 (es) 2009-09-21
CA2499536A1 (en) 2004-04-01
JP2011093921A (ja) 2011-05-12
EP1549628B1 (en) 2009-04-22

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