DK1545217T3 - Induktion af genekspression ved anvendelse af en højkoncentrationssukkerblanding - Google Patents
Induktion af genekspression ved anvendelse af en højkoncentrationssukkerblandingInfo
- Publication number
- DK1545217T3 DK1545217T3 DK03796327.9T DK03796327T DK1545217T3 DK 1545217 T3 DK1545217 T3 DK 1545217T3 DK 03796327 T DK03796327 T DK 03796327T DK 1545217 T3 DK1545217 T3 DK 1545217T3
- Authority
- DK
- Denmark
- Prior art keywords
- induction
- gene expression
- high concentration
- sugar mixture
- concentration sugar
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/12—Disaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
- C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
- C12N9/2445—Beta-glucosidase (3.2.1.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01021—Beta-glucosidase (3.2.1.21)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Botany (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Surgery (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40946602P | 2002-09-10 | 2002-09-10 | |
PCT/US2003/028438 WO2004035070A1 (en) | 2002-09-10 | 2003-09-10 | Induction of gene expression using a high concentration sugar mixture |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1545217T3 true DK1545217T3 (da) | 2013-06-03 |
Family
ID=32107864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03796327.9T DK1545217T3 (da) | 2002-09-10 | 2003-09-10 | Induktion af genekspression ved anvendelse af en højkoncentrationssukkerblanding |
Country Status (9)
Country | Link |
---|---|
US (3) | US7713725B2 (da) |
EP (1) | EP1545217B1 (da) |
JP (1) | JP5366286B2 (da) |
CN (2) | CN1688198A (da) |
AU (1) | AU2003298577A1 (da) |
CA (1) | CA2498213C (da) |
DK (1) | DK1545217T3 (da) |
ES (1) | ES2403933T3 (da) |
WO (1) | WO2004035070A1 (da) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7045331B2 (en) * | 2001-12-18 | 2006-05-16 | Genencor International, Inc. | EGVII endoglucanase and nucleic acids encoding the same |
JP5366286B2 (ja) * | 2002-09-10 | 2013-12-11 | ジェネンコー・インターナショナル・インク | 高濃度糖類混合物を用いた遺伝子発現の誘発 |
US7238440B2 (en) * | 2003-10-03 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Membrane free fuel cell |
US7968691B2 (en) | 2006-08-23 | 2011-06-28 | Danisco Us Inc. | Pullulanase variants with increased productivity |
CA2661808A1 (en) | 2006-08-29 | 2008-03-06 | Danisco Us, Inc., Genencor Division | Compositions and methods for improved protein production |
ES2385064T5 (es) * | 2006-11-13 | 2018-12-07 | Danisco Us Inc. | Procedimiento para mejorar el rendimiento de los procedimientos de conversión de celulosa |
US8012713B2 (en) | 2007-01-11 | 2011-09-06 | Danisco Us Inc. | Enzyme production in culture medium comprising raw glycerol |
US20100221784A1 (en) * | 2007-09-07 | 2010-09-02 | Fujdala Meredith K | Beta-Glucosidase Enhanced Filamentous Fungal Whole Cellulase Compositions and Methods Of Use |
BRPI0817541A2 (pt) * | 2007-10-12 | 2014-11-25 | Danisco Us Inc | Métodos e composições para a produção otimizada de substâncias orgânicas de micro-organismos de fermentação |
CA2742144A1 (en) | 2008-11-03 | 2010-06-03 | Iogen Energy Corporation | Hosts and fermentation processes for cellulase production |
WO2010111143A2 (en) | 2009-03-23 | 2010-09-30 | Danisco Us Inc. | Cal a-related acyltransferases and methods of use, thereof |
MX2011011228A (es) * | 2009-04-30 | 2011-11-18 | Danisco Us Inc | Alteracion del equilibrio enzimatico a traves de las condiciones de fermentacion. |
KR20120103431A (ko) | 2009-06-25 | 2012-09-19 | 대니스코 에이/에스 | 단백질 |
DK3296394T3 (da) | 2009-09-23 | 2020-12-21 | Danisco Us Inc | Hidtil ukendte glycosylhydrolaseenzymer og anvendelser heraf |
EP3859017A1 (en) | 2010-06-26 | 2021-08-04 | Virdia, Inc. | Methods for production of sugar mixtures |
IL206678A0 (en) | 2010-06-28 | 2010-12-30 | Hcl Cleantech Ltd | A method for the production of fermentable sugars |
IL207329A0 (en) | 2010-08-01 | 2010-12-30 | Robert Jansen | A method for refining a recycle extractant and for processing a lignocellulosic material and for the production of a carbohydrate composition |
JP5707494B2 (ja) * | 2010-08-25 | 2015-04-30 | ダニスコ・ユーエス・インク | 粘性の表現型を変化させた糸状菌 |
IL207945A0 (en) | 2010-09-02 | 2010-12-30 | Robert Jansen | Method for the production of carbohydrates |
CN103797114A (zh) | 2011-02-23 | 2014-05-14 | 杜邦营养生物科学有限公司 | 生产能够水解叶绿素或叶绿素衍生物的重组酶的方法 |
EP3401322B1 (en) | 2011-04-07 | 2022-06-08 | Virdia, LLC | Lignocellulose conversion processes and products |
US9206407B2 (en) | 2011-06-25 | 2015-12-08 | Sophoro Biotechnologies, Llc | Chemically modified sophorolipids and uses thereof |
CN103946369A (zh) | 2011-09-22 | 2014-07-23 | 丹尼斯科美国公司 | 降低dna含量的内源性dna酶活性 |
WO2013055785A1 (en) | 2011-10-10 | 2013-04-18 | Virdia Ltd | Sugar compositions |
US9834804B2 (en) | 2011-12-14 | 2017-12-05 | Iogen Energy Corporation | Fungal cells and fermentation processes |
AU2013217568B2 (en) | 2012-02-07 | 2018-09-27 | Danisco Us Inc. | Glycosylation as a stabilizer for phytase |
CN103305426B (zh) * | 2012-03-16 | 2015-12-02 | 中国科学院天津工业生物技术研究所 | 产纤维素酶的突变菌株、高效表达目的蛋白的突变菌株及其构建方法与应用 |
CA2871140A1 (en) * | 2012-05-21 | 2013-11-28 | Danisco Us Inc. | Trichoderma hydrophobin production |
WO2014015179A1 (en) | 2012-07-20 | 2014-01-23 | Sophoro Biotechnologies, Llc | Carbohydrate esters as inducers for gene expression |
FR3000106B1 (fr) * | 2012-12-20 | 2015-01-30 | Ifp Energies Now | Procede de production d'oligosaccharides a partir de biomasse lignocellulosique |
US20160029882A1 (en) * | 2013-06-11 | 2016-02-04 | New York University | Vaginal speculum |
CN105980554B (zh) | 2013-11-14 | 2022-05-13 | 丹尼斯科美国公司 | 通过减少糖化得到的稳定酶 |
CN103695393B (zh) * | 2013-12-17 | 2015-07-15 | 宁夏夏盛实业集团有限公司 | 一种利用β-葡萄糖苷酶生产纤维素酶的方法及应用 |
CN105505901A (zh) * | 2014-09-26 | 2016-04-20 | 中国科学院天津工业生物技术研究所 | 一种诱导真菌高产纤维素酶的组合物及其使用方法 |
CN107108543A (zh) | 2015-01-07 | 2017-08-29 | 威尔迪亚公司 | 萃取和转化半纤维素糖的方法 |
BR112017020847A2 (pt) | 2015-03-31 | 2018-07-10 | Xyleco, Inc. | composições para aumento de produção de enzimas |
FR3035406B1 (fr) * | 2015-04-23 | 2019-12-20 | IFP Energies Nouvelles | Promoteurs inductibles de trichoderma reesei |
US20180148683A1 (en) * | 2015-07-07 | 2018-05-31 | Danisco Us Inc. | Induction of gene expression using a high concentration sugar mixture |
CN105505903B (zh) * | 2016-01-05 | 2019-03-22 | 中国科学院天津工业生物技术研究所 | 利用酵母细胞制备诱导糖并诱导纤维素酶合成的方法 |
CN109661402B (zh) | 2016-02-22 | 2022-06-28 | 丹尼斯科美国公司 | 真菌的高水平蛋白质生产系统 |
CN105925551A (zh) * | 2016-05-11 | 2016-09-07 | 上海交通大学 | 基于葡萄糖转苷反应制备混合物高效生产纤维素酶的方法 |
CN109790510B (zh) | 2016-10-04 | 2024-04-12 | 丹尼斯科美国公司 | 在不存在诱导底物下丝状真菌细胞中的蛋白产生 |
WO2018106656A1 (en) | 2016-12-06 | 2018-06-14 | Danisco Us Inc | Truncated lpmo enzymes and use thereof |
EP3375884B1 (en) * | 2017-03-15 | 2020-05-06 | Clariant International Ltd | Process for producing proteins under inducing conditions |
BR112020005799A2 (pt) | 2017-09-25 | 2020-09-24 | Ajinomoto Co., Inc. | métodos para produzir uma proteína alvo e um dissacarídeo. |
MX2021004771A (es) | 2018-10-26 | 2021-07-15 | Danisco Us Inc | Composicion microbiana estable y proceso de secado. |
EP4063511A4 (en) | 2019-11-18 | 2024-03-27 | Kao Corp | MUTANT FILAMENTOUS FUNGUS AND METHOD FOR PRODUCING PROTEIN USING SAME |
JP2022161526A (ja) | 2021-04-09 | 2022-10-21 | 花王株式会社 | 改変糸状菌、及びそれを用いたタンパク質の製造方法 |
EP4373943A2 (en) | 2021-07-19 | 2024-05-29 | Danisco Us Inc | Compositions and methods for enhanced protein production in fungal cells |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3972775A (en) * | 1974-06-28 | 1976-08-03 | The United States Of America As Represented By The United States Energy Research And Development Administration | Conversion of cellulosic materials to sugar |
DE3009104C2 (de) * | 1980-03-10 | 1990-10-04 | Odenwald-Chemie GmbH, 6901 Schönau | Verwendung eines Epoxydharzes zur Herstellung von feuerhemmenden Schichten oder Überzügen und Verfahren zur Herstellung derselben |
CA1338400C (en) | 1983-08-31 | 1996-06-18 | David H. Gelfand | Recombinant fungal cellulases |
US5472864A (en) * | 1984-04-19 | 1995-12-05 | Genencor International, Inc. | Method of preparing solution enriched in EG III using low molecular weight alcohol, organic salt and inorganic salt |
AU607398B2 (en) | 1985-08-29 | 1991-03-07 | Genencor Inc. | Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same |
US5610034A (en) * | 1987-04-29 | 1997-03-11 | Alko Group Ltd. | Immunoglobulin production by trichoderma |
JPH01256394A (ja) * | 1988-04-06 | 1989-10-12 | Natl Food Res Inst | セロオリゴ糖の酵素的製造方法 |
FI903443A (fi) * | 1990-07-06 | 1992-01-07 | Valtion Teknillinen | Framstaellning av lackas genom rekombinantorganismer. |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
WO1992001797A1 (en) * | 1990-07-16 | 1992-02-06 | Oy Alko Ab | IMMUNOGLOBULIN PRODUCTION BY $i(TRICHODERMA) |
US5183462A (en) * | 1990-08-21 | 1993-02-02 | Associated Synapse Biologics | Controlled administration of chemodenervating pharmaceuticals |
JPH05211883A (ja) * | 1992-01-31 | 1993-08-24 | Meiji Seika Kaisha Ltd | ソホロースの製造方法 |
ATE256179T1 (de) * | 1993-09-01 | 2003-12-15 | Genencor Int | Verfahren zur herstellung von immobilisierten enzymkonjugaten und so erhaltene immobilisierte enzymkonjugate |
US6268196B1 (en) | 1993-12-17 | 2001-07-31 | Genencor International, Inc. | Method and compositions for treating cellulose containing fabrics using truncated cellulase enzyme compositions |
FR2736359B1 (fr) * | 1995-07-06 | 1997-10-03 | Agronomique Inst Nat Rech | Beta-glucosidase de champignons filamenteaux, et ses utilisations |
CN1201373A (zh) * | 1995-11-06 | 1998-12-09 | 诺沃挪第克公司 | 动物饲料添加剂 |
DK0956338T3 (da) * | 1996-09-19 | 2006-05-08 | Novozymes As | Værtsceller og fremgangsmåder til produktion af proteiner |
JP4307563B2 (ja) * | 1997-04-07 | 2009-08-05 | ユニリーバー・ナームローゼ・ベンノートシャープ | 糸状菌、特にアスペルギルス属に属する糸状菌のアグロバクテリウム媒介性形質転換 |
US6287839B1 (en) * | 1997-11-19 | 2001-09-11 | Genencor International, Inc. | Cellulase producing actinomycetes, cellulase produced therefrom and method of producing same |
US6407046B1 (en) * | 1998-09-03 | 2002-06-18 | Genencor International, Inc. | Mutant EGIII cellulase, DNA encoding such EGIII compositions and methods for obtaining same |
US6268328B1 (en) * | 1998-12-18 | 2001-07-31 | Genencor International, Inc. | Variant EGIII-like cellulase compositions |
US6579841B1 (en) * | 1998-12-18 | 2003-06-17 | Genencor International, Inc. | Variant EGIII-like cellulase compositions |
FI120310B (fi) * | 2001-02-13 | 2009-09-15 | Valtion Teknillinen | Parannettu menetelmä erittyvien proteiinien tuottamiseksi sienissä |
JP5366286B2 (ja) * | 2002-09-10 | 2013-12-11 | ジェネンコー・インターナショナル・インク | 高濃度糖類混合物を用いた遺伝子発現の誘発 |
-
2003
- 2003-09-10 JP JP2004544737A patent/JP5366286B2/ja not_active Expired - Fee Related
- 2003-09-10 CN CNA038238438A patent/CN1688198A/zh active Pending
- 2003-09-10 CN CN2012100493599A patent/CN102604916A/zh active Pending
- 2003-09-10 CA CA2498213A patent/CA2498213C/en not_active Expired - Fee Related
- 2003-09-10 EP EP03796327A patent/EP1545217B1/en not_active Revoked
- 2003-09-10 ES ES03796327T patent/ES2403933T3/es not_active Expired - Lifetime
- 2003-09-10 US US10/660,123 patent/US7713725B2/en not_active Expired - Lifetime
- 2003-09-10 WO PCT/US2003/028438 patent/WO2004035070A1/en active Application Filing
- 2003-09-10 AU AU2003298577A patent/AU2003298577A1/en not_active Abandoned
- 2003-09-10 DK DK03796327.9T patent/DK1545217T3/da active
-
2009
- 2009-07-06 US US12/498,102 patent/US20100009408A1/en not_active Abandoned
-
2011
- 2011-02-17 US US13/029,940 patent/US9034628B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US9034628B2 (en) | 2015-05-19 |
JP5366286B2 (ja) | 2013-12-11 |
CA2498213C (en) | 2013-07-16 |
US20110207913A1 (en) | 2011-08-25 |
EP1545217B1 (en) | 2013-02-27 |
CA2498213A1 (en) | 2004-04-29 |
CN1688198A (zh) | 2005-10-26 |
US20040121446A1 (en) | 2004-06-24 |
WO2004035070A9 (en) | 2004-09-10 |
AU2003298577A8 (en) | 2004-05-04 |
EP1545217A4 (en) | 2006-12-13 |
AU2003298577A1 (en) | 2004-05-04 |
CN102604916A (zh) | 2012-07-25 |
US20100009408A1 (en) | 2010-01-14 |
EP1545217A1 (en) | 2005-06-29 |
WO2004035070A1 (en) | 2004-04-29 |
JP2006506980A (ja) | 2006-03-02 |
US7713725B2 (en) | 2010-05-11 |
ES2403933T3 (es) | 2013-05-22 |
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